LOCUS       XM_047434539            2613 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens SPG7 matrix AAA peptidase subunit,
            paraplegin (SPG7), transcript variant X4, mRNA.
ACCESSION   XM_047434539
VERSION     XM_047434539.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000016.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2613
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
     gene            1..2613
                     /gene="SPG7"
                     /gene_synonym="CAR; CMAR; PGN; SPG5C"
                     /note="SPG7 matrix AAA peptidase subunit, paraplegin;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 41 ESTs, 210 long SRA reads, 1 Protein, and
                     100% coverage of the annotated genomic feature by RNAseq
                     alignments, including 32 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:6687"
                     /db_xref="HGNC:HGNC:11237"
                     /db_xref="MIM:602783"
     CDS             31..1443
                     /gene="SPG7"
                     /gene_synonym="CAR; CMAR; PGN; SPG5C"
                     /codon_start=1
                     /product="mitochondrial inner membrane m-AAA protease
                     component paraplegin isoform X4"
                     /protein_id="XP_047290495.1"
                     /db_xref="GeneID:6687"
                     /db_xref="HGNC:HGNC:11237"
                     /db_xref="MIM:602783"
                     /translation="MAVLLLLLRALRRGPGPGPRPLWGPGPAWSPGFPARPGRGRPYM
                     ASRPPGDLAEAGGRALQSLQLRLLTPTFEGINGLLLKQHLVQNPVRLWQLLGGTFYFN
                     TSRLKQKNKEKDKSKGKAPEEDEEERRRRERDDQMYRERLRTLLVIAVVMSLLNALST
                     SGGSISWNDFVHEMLAKGEVQRVQVVPESDVVEVYLHPGAVVFGRPRLALMYRMQVAN
                     IDKFEEKLRAAEDELNIEAKDRIPVSYKRTGFFGNALYSVGMTAVGLAILWYVFRLAG
                     MTGREGGFSAFNQLKMARFTIVDGKMGKGVSFKDVAGMHEAKLEVREFVDYLKSPERF
                     LQLGAKVPKGALLLGPPGCGKTLLAKAVATEAQVPFLAMAGPEFVEVIGGLGAARVRS
                     LFKEARARAPCIVYIDEIDAVGKKRSTTMSGFSNTEEEQTLNQLLVEMDVFYAEIEEL
                     KLVNRRAETGVSLSRCCTQK"
ORIGIN      
        1 ggatcacgca ggcgcggctt tcaggccaac atggccgtgc tgctgctgct gctccgtgcc
       61 ctccgccggg gtccaggccc gggtcctcgg ccgctgtggg gcccaggccc ggcctggagt
      121 ccagggttcc ccgccaggcc cgggaggggg cggccgtaca tggccagcag gcctccgggg
      181 gacctcgccg aggctggagg ccgagctctg cagagcttac aattgagact gctaacccct
      241 acctttgaag ggatcaacgg attgttgttg aaacaacatt tagttcagaa tccagtcaga
      301 ctctggcaac ttttaggtgg tactttctat tttaacacct caaggttgaa gcagaagaat
      361 aaggagaagg ataagtcgaa ggggaaggcg cctgaagagg acgaagagga gaggagacgc
      421 cgtgagcggg acgaccagat gtaccgagag cggctgcgca ccttgctggt catcgcggtt
      481 gtcatgagcc tcctgaatgc tctcagcacc agcggaggca gcatttcctg gaacgacttt
      541 gtccacgaga tgctggccaa gggcgaggtg cagcgcgtcc aggtggtgcc tgagagcgac
      601 gtggtggaag tctacctgca ccctggagcc gtggtgtttg ggcggcctcg gctagccttg
      661 atgtaccgaa tgcaggttgc aaatattgac aagtttgaag agaagcttcg agcagctgaa
      721 gatgagctga atatcgaggc caaggacagg atcccagttt cctacaagcg aacaggattc
      781 tttggaaatg ccctgtactc tgtggggatg acggcagtgg gcctggccat cctgtggtat
      841 gttttccgtc tggccgggat gactggaagg gaaggtggat tcagtgcttt taatcagctt
      901 aaaatggctc gtttcaccat tgtggatggg aagatgggga aaggagtcag cttcaaagac
      961 gtggcaggaa tgcacgaagc caaactggaa gtccgcgagt ttgtggatta tctgaagagc
     1021 ccagaacgct tcctccagct tggcgccaag gtcccaaagg gcgcactgct gctcggcccc
     1081 cccggctgtg ggaagacgct gctggccaag gcggtggcca cggaggctca ggtgcccttc
     1141 ctggcgatgg ccggcccaga gttcgtggag gtcattggag gcctcggcgc tgcccgtgtg
     1201 cggagcctct ttaaggaagc ccgagcccgg gccccctgca tcgtctacat cgatgagatc
     1261 gacgcggtgg gcaagaagcg ctccaccacc atgtccggct tctccaacac ggaggaggag
     1321 cagacgctca accagcttct ggtagaaatg gatgtgttct acgcagaaat agaagagctg
     1381 aaactggtaa atagaagagc tgaaactggt gtatccttat cacggtgttg tacgcagaaa
     1441 tagaagagct gaaactggtg tatccttatc acggtgttct acgcagaaat agaagagctg
     1501 aaactggtgt atccttatca cggtgttcta cgcagaaata gaagagctga aactggtgta
     1561 tccttatcac ggtgttctac gcagcaatag aagagctgaa actggtgtat ccttatcatg
     1621 gtgttctatg cagcagtaga aggaaacttt cttcctgcag caacaaggaa atgacgcaaa
     1681 gtgagaagag ccaggcttag tatcgtatga ctccacttgt acgaaattgt caaaataaca
     1741 aaattctggg gatggagaac gggttactgg ttgtcagcag ttaggggagg tctccaggga
     1801 ggagggatgc ctctggggag ggcggttctg tgtcttgagg ggagatgctc gttatgtgaa
     1861 cgtgcgtgtg acacaggtgt ccatctgtgg agcacacaca caggtgagag cacataggag
     1921 tgggggcatc tgagcagggg cctggcgttt ccatgtcagt ctcctggctt tgcctttgtt
     1981 ttgcagctac tgaacgcaca gctgctgggg gaccagggcc aaagggactg ctctgtgctg
     2041 tttttgcaat ttgttgtgtg tctgttacca tcagaataca aaacttaaaa agtcacacca
     2101 gggatccggt cccagaaagt ccgtatcctg aaaccgcatg tccctgacac atagctgccc
     2161 agggggagca tgtgtccagt cccaggaagt ctgtatcctg aaaccacatg tccctgacac
     2221 atagcggccc ggtagggagc acgtgccctg cagggtggcc accctgatac atagcggccc
     2281 ggtggggagc acgtgccccg cagggtggcc atcctaacac atagcggccc ggggggagca
     2341 cgtgccccgc agggtggcca tcctgacaca tagcccggtg gggagcacgt gccccgcagg
     2401 gtggctgggc tctgctgaag gccgagctgt gcttgaaccc ggcgccgccc cctctaggag
     2461 ctcgcactgc acctctttgg cctggctgct gtttttcttt gagaccggtg ttcctattac
     2521 ttttcccatt tttttcactg tttatacaat ctttcagaat tctgtatcca cagccctggc
     2581 ctctgcaagg aaggcgctcc acgacactga gca
//
