LOCUS       XM_005256321            2690 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens SPG7 matrix AAA peptidase subunit,
            paraplegin (SPG7), transcript variant X5, mRNA.
ACCESSION   XM_005256321
VERSION     XM_005256321.5
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000016.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_005256321.4.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2690
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
     gene            1..2690
                     /gene="SPG7"
                     /gene_synonym="CAR; CMAR; PGN; SPG5C"
                     /note="SPG7 matrix AAA peptidase subunit, paraplegin;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 41 ESTs, 237 long SRA reads, 1 Protein, and
                     100% coverage of the annotated genomic feature by RNAseq
                     alignments, including 144 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:6687"
                     /db_xref="HGNC:HGNC:11237"
                     /db_xref="MIM:602783"
     CDS             31..1422
                     /gene="SPG7"
                     /gene_synonym="CAR; CMAR; PGN; SPG5C"
                     /codon_start=1
                     /product="mitochondrial inner membrane m-AAA protease
                     component paraplegin isoform X5"
                     /protein_id="XP_005256378.1"
                     /db_xref="GeneID:6687"
                     /db_xref="HGNC:HGNC:11237"
                     /db_xref="MIM:602783"
                     /translation="MAVLLLLLRALRRGPGPGPRPLWGPGPAWSPGFPARPGRGRPYM
                     ASRPPGDLAEAGGRALQSLQLRLLTPTFEGINGLLLKQHLVQNPVRLWQLLGGTFYFN
                     TSRLKQKNKEKDKSKGKAPEEDEEERRRRERDDQMYRERLRTLLVIAVVMSLLNALST
                     SGGSISWNDFVHEMLAKGEVQRVQVVPESDVVEVYLHPGAVVFGRPRLALMYRMQVAN
                     IDKFEEKLRAAEDELNIEAKDRIPVSYKRTGFFGNALYSVGMTAVGLAILWYVFRLAG
                     MTGREGGFSAFNQLKMARFTIVDGKMGKGVSFKDVAGMHEAKLEVREFVDYLKSPERF
                     LQLGAKVPKGALLLGPPGCGKTLLAKAVATEAQVPFLAMAGPEFVEVIGGLGAARVRS
                     LFKEARARAPCIVYIDEIDAVGKKRSTTMSGFSNTEEEQTLNQLLVEMDVFYAEIEEL
                     KLVYPYHGVLHSD"
ORIGIN      
        1 ggatcacgca ggcgcggctt tcaggccaac atggccgtgc tgctgctgct gctccgtgcc
       61 ctccgccggg gtccaggccc gggtcctcgg ccgctgtggg gcccaggccc ggcctggagt
      121 ccagggttcc ccgccaggcc cgggaggggg cggccgtaca tggccagcag gcctccgggg
      181 gacctcgccg aggctggagg ccgagctctg cagagcttac aattgagact gctaacccct
      241 acctttgaag ggatcaacgg attgttgttg aaacaacatt tagttcagaa tccagtcaga
      301 ctctggcaac ttttaggtgg tactttctat tttaacacct caaggttgaa gcagaagaat
      361 aaggagaagg ataagtcgaa ggggaaggcg cctgaagagg acgaagagga gaggagacgc
      421 cgtgagcggg acgaccagat gtaccgagag cggctgcgca ccttgctggt catcgcggtt
      481 gtcatgagcc tcctgaatgc tctcagcacc agcggaggca gcatttcctg gaacgacttt
      541 gtccacgaga tgctggccaa gggcgaggtg cagcgcgtcc aggtggtgcc tgagagcgac
      601 gtggtggaag tctacctgca ccctggagcc gtggtgtttg ggcggcctcg gctagccttg
      661 atgtaccgaa tgcaggttgc aaatattgac aagtttgaag agaagcttcg agcagctgaa
      721 gatgagctga atatcgaggc caaggacagg atcccagttt cctacaagcg aacaggattc
      781 tttggaaatg ccctgtactc tgtggggatg acggcagtgg gcctggccat cctgtggtat
      841 gttttccgtc tggccgggat gactggaagg gaaggtggat tcagtgcttt taatcagctt
      901 aaaatggctc gtttcaccat tgtggatggg aagatgggga aaggagtcag cttcaaagac
      961 gtggcaggaa tgcacgaagc caaactggaa gtccgcgagt ttgtggatta tctgaagagc
     1021 ccagaacgct tcctccagct tggcgccaag gtcccaaagg gcgcactgct gctcggcccc
     1081 cccggctgtg ggaagacgct gctggccaag gcggtggcca cggaggctca ggtgcccttc
     1141 ctggcgatgg ccggcccaga gttcgtggag gtcattggag gcctcggcgc tgcccgtgtg
     1201 cggagcctct ttaaggaagc ccgagcccgg gccccctgca tcgtctacat cgatgagatc
     1261 gacgcggtgg gcaagaagcg ctccaccacc atgtccggct tctccaacac ggaggaggag
     1321 cagacgctca accagcttct ggtagaaatg gatgtgttct acgcagaaat agaagagctg
     1381 aaactggtgt atccttatca cggcgttcta cacagcgact agaagagctg aaactggtgt
     1441 atccttatca cggtgttgta cgcagaaata gaagagctga aactggtgta tccttatcac
     1501 ggtgttgtac gcagaaatag aagagctgaa actggtgtat ccttatcacg gtgttctacg
     1561 cagaaataga agagctgaaa ctggtgtatc cttatcacgg tgttctacgc agaaatagaa
     1621 gagctgaaac tggtgtatcc ttatcacggt gttctacgca gcaatagaag agctgaaact
     1681 ggtgtatcct tatcatggtg ttctatgcag cagtagaagg aaactttctt cctgcagcaa
     1741 caaggaaatg acgcaaagtg agaagagcca ggcttagtat cgtatgactc cacttgtacg
     1801 aaattgtcaa aataacaaaa ttctggggat ggagaacggg ttactggttg tcagcagtta
     1861 ggggaggtct ccagggagga gggatgcctc tggggagggc ggttctgtgt cttgagggga
     1921 gatgctcgtt atgtgaacgt gcgtgtgaca caggtgtcca tctgtggagc acacacacag
     1981 gtgagagcac ataggagtgg gggcatctga gcaggggcct ggcgtttcca tgtcagtctc
     2041 ctggctttgc ctttgttttg cagctactga acgcacagct gctgggggac cagggccaaa
     2101 gggactgctc tgtgctgttt ttgcaatttg ttgtgtgtct gttaccatca gaatacaaaa
     2161 cttaaaaagt cacaccaggg atccggtccc agaaagtccg tatcctgaaa ccgcatgtcc
     2221 ctgacacata gctgcccagg gggagcatgt gtccagtccc aggaagtctg tatcctgaaa
     2281 ccacatgtcc ctgacacata gcggcccggt agggagcacg tgccctgcag ggtggccacc
     2341 ctgatacata gcggcccggt ggggagcacg tgccccgcag ggtggccatc ctaacacata
     2401 gcggcccggg gggagcacgt gccccgcagg gtggccatcc tgacacatag cccggtgggg
     2461 agcacgtgcc ccgcagggtg gctgggctct gctgaaggcc gagctgtgct tgaacccggc
     2521 gccgccccct ctaggagctc gcactgcacc tctttggcct ggctgctgtt tttctttgag
     2581 accggtgttc ctattacttt tcccattttt ttcactgttt atacaatctt tcagaattct
     2641 gtatccacag ccctggcctc tgcaaggaag gcgctccacg acactgagca
//
