LOCUS       XM_047433145            4673 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens SPG11 vesicle trafficking associated,
            spatacsin (SPG11), transcript variant X4, mRNA.
ACCESSION   XM_047433145
VERSION     XM_047433145.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4673
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     gene            1..4673
                     /gene="SPG11"
                     /gene_synonym="ALS5; CMT2X; KIAA1840"
                     /note="SPG11 vesicle trafficking associated, spatacsin;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 1 mRNA, 26 ESTs, 1313 long SRA reads, 1
                     Protein, and 100% coverage of the annotated genomic
                     feature by RNAseq alignments, including 93 samples with
                     support for all annotated introns"
                     /db_xref="GeneID:80208"
                     /db_xref="HGNC:HGNC:11226"
                     /db_xref="MIM:610844"
     CDS             16..4623
                     /gene="SPG11"
                     /gene_synonym="ALS5; CMT2X; KIAA1840"
                     /codon_start=1
                     /product="spatacsin isoform X4"
                     /protein_id="XP_047289101.1"
                     /db_xref="GeneID:80208"
                     /db_xref="HGNC:HGNC:11226"
                     /db_xref="MIM:610844"
                     /translation="MAAEEGVASAASAGGSWGTAAMGRVLPMLLVPVPAEAMGQLGSR
                     AQLRTQPEALGSLTAAGSLQVLSLTPGSRGGGRCCLEGPFWHFLWEDSRNSSTPTEKP
                     KLLALGENYELLIYEFNLKDGRCDATILYSCSREALQKLIDDQDISISLLSLRILSFH
                     NNTSLLFINKCVILHIIFPERDAAIRVLNCFTLPLPAQAVDMIIDTQLCRGILFVLSS
                     LGWIYIFDVVDGTYVAHVDLALHKEDMCNEQQQEPAKISSFTSLKVSQDLDVAVIVSS
                     SNSAVALNLNLYFRQHPGHLLCERILEDLPIQGPKGVDEDDPVNSAYNMKLAKFSFQI
                     DRSWKAQLSSLNETIKNSKLEVSCCAPWFQDILHLESPESGNHSTSVQSWAFIPQDIM
                     HGQYNVLQKDHAKTSDPGRSWKIMHISEQEEPIELKCVSVTGFTALFTWEVERMGYTI
                     TLWDLETQGMQCFSLGTKCIPVDSSGDQQLCFVLTENGLSLILFGLTQEEFLNRLMIH
                     GSASTVDTLCHLNGWGRCSIPIHALEAGIENRQLDTVNFFLKSKENLFNPSSKSSVSD
                     QFDHLSSHLYLRNVEELIPALDLLCSAIRESYSEPQSKHFSEQLLNLTLSFLNNQIKE
                     LFIHTEELDEHLQKGVNILTSYINELRTFMIKFPWKLTDAIDEYDVHENVPKVKESNI
                     WKKLSFEEVIASAILNNKIPEAQTFFRIDSHSAQKLEELIGIGLNLVFDNLKKNNIKE
                     ASELLKNMGFDVKGQLLKICFYTTNKNIRDFLVEILKEKNYFSEKEKRTIDFVHQVEK
                     LYLGHFQENMQIQSFPRYWIKEQDFFKHKSVLDSFLKYDCKDEFNKQDHRIVLNWALW
                     WDQLTQESILLPRISPEEYKSYSPEALWRYLTARHDWLNIILWIGEFQTQHSYASLQQ
                     NKWPLLTVDVINQNTSCNNYMRNEILDKLARNGVFLASELEDFECFLLRLSRIGGVIQ
                     DTLPVQNYKTKEGWDFHSQFILYCLEHSLQHLLYVYLDCYKLSPENCPFLEKKELHEA
                     HPWFEFLVQCRQVASNLTDPKLIFQASLANAQILIPTNQASVSSMLLEGHTLLALATT
                     MYSPGGVSQVVQNEENENCLKKVDPQLLKMALTPYPKLKTALFPQCTPPSVLPSDITI
                     YHLIQSLSPFDPSRLFGWQSANTLAIGDAWSHLPHFSSPDLVNKYAIVERLNFAYYLH
                     NGRPSFAFGTFLVQELIKSKTPKQLIQQVGNEAYVIGLSSFHIPSIGAACVCFLELLG
                     LDSLKLRVDMKVANIILSYKCRNEDAQYSFIRESVAEKLSKLADGEKTTTEELLVLLE
                     EGTWNSIQQQEIKRLSSESSSQWALVVQFCRLHNMKLSISYLRECAKANDWLQFIIHS
                     QLHNYHPAEVKSLIQYFSPVIQDHLRLAFENLPSVPTSKMDSDQVCNKCPQELQGSKQ
                     EMTDLFEILLQCSEEPDSWHWLLVEAVKQQAPILSVLASCLQVRIMRSLKVPVPFLVS
                     VFGSSLLWRTMLQLKQWDTFRTQQRTIPGTLRIFQSSGEHY"
ORIGIN      
        1 aaccgccggg ccaagatggc tgcagaggaa ggggtcgcga gtgctgcttc cgccggcggt
       61 agctggggca ccgcggccat ggggcgggtt ctaccgatgc tgttggtgcc agtccccgcc
      121 gaggcgatgg ggcagctcgg ctcccgggcg cagctgcgca cacagccgga ggctctgggg
      181 agcctgacgg ctgcgggcag cctccaagtg ctttctttga cgcctggcag ccggggcggg
      241 ggtcgctgct gcctggaggg ccccttctgg cactttctat gggaggattc tcgtaacagc
      301 agcacaccaa ctgaaaagcc caaactgctc gctcttggtg aaaattatga actgcttatc
      361 tatgaattta atttgaaaga tggaagatgt gatgcaacca ttttgtatag ctgtagtagg
      421 gaggcattgc aaaagctcat tgacgatcaa gatatcagta tttccttatt gtctttgaga
      481 atcctgtcat ttcacaataa cacatcatta ctgttcatca acaaatgtgt catcctacat
      541 attatatttc ctgaaagaga tgctgcaatt agagtactca actgtttcac acttcccttg
      601 cctgcacagg cagtggacat gattattgac acgcagctct gcagaggaat tctttttgtt
      661 ttgagtagtt taggctggat ctacattttt gatgttgtgg atggtacata tgtagctcat
      721 gtggatttag cacttcacaa agaagacatg tgtaatgagc agcaacagga gccagccaag
      781 atttcttcat ttacttcact gaaagtttct caagacctcg atgttgcagt gattgtcagc
      841 tcctccaact ccgcagttgc tcttaactta aatttgtatt tcaggcaaca cccaggacac
      901 ctactgtgtg aaagaatact agaagatctt cctattcaag gacctaaggg cgtagatgaa
      961 gatgatcctg ttaactctgc ctacaacatg aaactggcca agttttcctt ccaaattgat
     1021 aggtcttgga aagcccagct atcatcattg aatgaaacaa taaagaactc caaactggag
     1081 gtttcctgtt gtgctccatg gttccaggat attttgcatt tggagtcacc tgaatctggt
     1141 aaccacagta caagtgtgca gagctgggcc ttcattccac aggacataat gcatgggcaa
     1201 tataatgttc tacagaaaga tcatgccaag accagtgatc caggaagatc atggaaaata
     1261 atgcacatca gtgaacaaga ggaacccata gagcttaaat gtgtgtctgt gacaggattc
     1321 actgcactgt ttacttggga agtggaaagg atgggctata ccattaccct ctgggatttg
     1381 gagacccagg gcatgcagtg tttttccctt ggcacaaagt gtattcctgt agacagtagt
     1441 ggagaccagc agctgtgctt tgttttgaca gagaatggac tctctctgat tttgtttggt
     1501 ttgactcaag aagagttttt aaacagactc atgatccatg gaagtgccag cactgtggac
     1561 actctttgtc atctcaatgg ctggggaagg tgctcaattc ccatacatgc actagaggcc
     1621 gggatagaaa atcgtcagct ggacacagta aatttctttt tgaagagcaa ggaaaatctt
     1681 tttaatccat cctcaaaatc ttctgtatct gatcagtttg atcacttgtc atcccattta
     1741 tatttaagaa atgtggaaga gctgatacca gcattggatt tactttgctc ggcaattaga
     1801 gaaagttatt ctgaacccca aagcaaacac ttttcagaac aattgcttaa tcttacactg
     1861 tctttcctta acaaccaaat aaaggagctt ttcattcaca ctgaagaact agatgaacat
     1921 ctgcaaaaag gagtgaacat tttgactagc tacattaatg aacttcgaac cttcatgata
     1981 aagtttcctt ggaagctaac agatgctata gatgaatatg atgtacatga aaatgtcccc
     2041 aaagtaaagg agagcaatat atggaagaaa ctcagctttg aggaagttat tgccagcgcc
     2101 attttaaaca acaaaatacc agaggcacag actttcttca ggattgatag tcattctgct
     2161 caaaaacttg aggagcttat tggcataggc ctaaatttgg tctttgacaa tttaaaaaag
     2221 aacaatataa aggaagcctc tgaacttttg aagaatatgg ggtttgatgt aaaaggccaa
     2281 ttgctcaaga tctgcttcta tacaactaat aaaaatatac gtgacttttt ggttgaaatt
     2341 ttaaaagaaa aaaattattt ttctgaaaaa gagaaaagaa ctatagactt cgtgcatcaa
     2401 gttgagaagc tttatttggg acatttccaa gaaaatatgc aaatccagtc atttcccagg
     2461 tactggataa aggaacaaga ttttttcaag cacaagtctg ttttggactc attcctgaaa
     2521 tatgattgta aagatgaatt taacaaacag gaccatagaa ttgtgttaaa ttgggctctg
     2581 tggtgggatc aactaacaca agaatccatc cttctcccca ggataagtcc agaagaatac
     2641 aaatcatatt cccctgaagc cctctggaga tacctcacag ctcgccatga ttggttaaac
     2701 attatcttat ggattggaga atttcaaacc cagcatagtt atgcttcact tcagcagaac
     2761 aaatggcccc ttctgactgt tgatgttatt aaccagaata cttcctgtaa caactacatg
     2821 aggaatgaaa ttttagataa gctggccagg aatggggttt ttttggcatc tgaactggaa
     2881 gactttgaat gcttcctcct aagactgagc cgtattggag gtgtaataca ggataccctc
     2941 cctgttcaaa actacaagac caaagaaggt tgggatttcc attctcaatt cattctctat
     3001 tgtttggagc acagtctgca gcatcttctt tatgtctacc ttgactgtta caaacttagt
     3061 cctgaaaatt gtcccttttt ggaaaaaaaa gagttacatg aagcacaccc ttggtttgaa
     3121 tttttagttc agtgtcgaca agttgccagt aacttaacag atcccaaact gatcttccag
     3181 gctagccttg caaatgctca gattttgatt cccaccaatc aggccagtgt aagcagtatg
     3241 ctattggaag gacataccct cctggccctt gctactacaa tgtattctcc tgggggtgtc
     3301 agtcaggttg ttcagaatga agaaaatgaa aactgtttga agaaagtgga tccccagcta
     3361 ttgaagatgg cattaactcc ttaccccaag ctaaaaactg ctctcttccc acagtgcact
     3421 cctcctagtg tcctgccatc tgatattaca atctaccacc ttattcagtc attatcaccc
     3481 tttgatccta gcagattgtt tggctggcag tctgctaaca cactagctat aggagatgca
     3541 tggagtcatc tcccacattt ctctagccct gacctggtta ataaatatgc tatagtggaa
     3601 cgtctgaatt ttgcttatta tttacataat gggcggccat catttgcatt tggtactttt
     3661 ctggtccagg aattaatcaa gagcaagact cccaagcagc tgatccagca agtaggcaat
     3721 gaagcctatg ttatagggct ctcctccttc cacatacctt caataggagc tgcatgtgtt
     3781 tgtttcttag aattgcttgg ccttgacagc ctcaagctca gagttgatat gaaagtggcc
     3841 aatataattt tgagctacaa gtgcagaaat gaagatgctc agtacagctt tatcagagag
     3901 tctgtagccg aaaaactatc taaactagct gatggtgaaa agacaaccac agaagaattg
     3961 cttgttctct tagaagaagg tacatggaac agcattcagc aacaggaaat aaagaggtta
     4021 tccagtgaat ctagcagcca atgggcatta gtggtgcagt tctgcaggct acacaatatg
     4081 aaactaagca tatcttacct tagagaatgt gccaaagcaa atgattggct gcagttcatt
     4141 attcacagcc aactccacaa ctaccaccca gcagaggtga aatcccttat ccagtacttc
     4201 agcccagtca ttcaagacca cttaaggctg gcttttgaga acttgccctc agtgcccacc
     4261 tccaaaatgg acagcgatca agtctgcaat aagtgccccc aggaacttca aggaagcaaa
     4321 caagagatga ccgatttatt tgaaattctg ctccaatgct cagaggagcc agactcctgg
     4381 cactggcttc tggttgaagc agtgaaacaa caggccccta tcctcagtgt tctggcctca
     4441 tgtctccagg tgaggatcat gagaagcctg aaggtgccag tgccatttct tgtctctgtg
     4501 tttggatcat cacttctgtg gaggacaatg ttgcaactga agcaatggga cacattcagg
     4561 actcaacaga ggaccatacc tggaaccttg aggatctttc agtcatctgg agaacattat
     4621 taacaagaca aaagagcaaa actctcatca gaggtttcca gcttttcttt aag
//
