LOCUS       NM_145658               1406 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens sperm equatorial segment protein 1 (SPESP1), mRNA.
ACCESSION   NM_145658
VERSION     NM_145658.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1406)
  AUTHORS   Zhang,D., Fan,J., Liu,H., Qiu,G. and Cui,S.
  TITLE     Testosterone enhances taurine synthesis by upregulating androgen
            receptor and cysteine sulfinic acid decarboxylase expressions in
            male mouse liver
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 324 (4), G295-G304 (2023)
   PUBMED   36749568
  REMARK    GeneRIF: Testosterone enhances taurine synthesis by upregulating
            androgen receptor and cysteine sulfinic acid decarboxylase
            expressions in male mouse liver.
REFERENCE   2  (bases 1 to 1406)
  AUTHORS   Kosaka,A., Yajima,Y., Hatayama,M., Ikuta,K., Sasaki,T., Hirai,N.,
            Yasuda,S., Nagata,M., Hayashi,R., Harabuchi,S., Ohara,K., Ohara,M.,
            Kumai,T., Ishibashi,K., Hirata-Nozaki,Y., Nagato,T., Oikawa,K.,
            Harabuchi,Y., Celis,E., Okumura,T., Ohsaki,Y., Kobayashi,H. and
            Ohkuri,T.
  TITLE     A stealth antigen SPESP1, which is epigenetically silenced in
            tumors, is a suitable target for cancer immunotherapy
  JOURNAL   Cancer Sci 112 (7), 2705-2713 (2021)
   PUBMED   34009705
  REMARK    GeneRIF: A stealth antigen SPESP1, which is epigenetically silenced
            in tumors, is a suitable target for cancer immunotherapy.
REFERENCE   3  (bases 1 to 1406)
  AUTHORS   Wolkowicz,M.J., Digilio,L., Klotz,K., Shetty,J., Flickinger,C.J.
            and Herr,J.C.
  TITLE     Equatorial segment protein (ESP) is a human alloantigen involved in
            sperm-egg binding and fusion
  JOURNAL   J Androl 29 (3), 272-282 (2008)
   PUBMED   17978344
  REMARK    GeneRIF: human alloantigen involved in sperm-egg binding and fusion
REFERENCE   4  (bases 1 to 1406)
  AUTHORS   Wolkowicz,M.J., Shetty,J., Westbrook,A., Klotz,K., Jayes,F.,
            Mandal,A., Flickinger,C.J. and Herr,J.C.
  TITLE     Equatorial segment protein defines a discrete acrosomal
            subcompartment persisting throughout acrosomal biogenesis
  JOURNAL   Biol Reprod 69 (3), 735-745 (2003)
   PUBMED   12773409
  REMARK    GeneRIF: Equatorial segment protein (ESP), a novel 349-amino acid
            concanavalin-A-binding protein encoded by a two-exon gene (SP-ESP)
            located on chromosome 15 at q22, has been localized to the
            equatorial segment of ejaculated human sperm.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG720873.1, BC017998.1 and
            AY358983.1.
            
            On Nov 22, 2018 this sequence version replaced NM_145658.3.
            
            Summary: The encoded protein is a human alloantigen involved in
            sperm-egg binding and fusion. [provided by RefSeq, Apr 2010].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358983.1, SRR3476690.359168.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000310673.4/ ENSP00000312284.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 BG720873.1         23-23
            2-1404              BC017998.1         1-1403
            1405-1406           AY358983.1         1413-1414
FEATURES             Location/Qualifiers
     source          1..1406
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q23"
     gene            1..1406
                     /gene="SPESP1"
                     /gene_synonym="ESP; SP-ESP"
                     /note="sperm equatorial segment protein 1"
                     /db_xref="GeneID:246777"
                     /db_xref="HGNC:HGNC:15570"
                     /db_xref="MIM:609399"
     exon            1..193
                     /gene="SPESP1"
                     /gene_synonym="ESP; SP-ESP"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..1182
                     /gene="SPESP1"
                     /gene_synonym="ESP; SP-ESP"
                     /note="glycosylated 38 kDa sperm protein C-7/8; equatorial
                     segment protein"
                     /codon_start=1
                     /product="sperm equatorial segment protein 1 precursor"
                     /protein_id="NP_663633.1"
                     /db_xref="CCDS:CCDS10230.1"
                     /db_xref="GeneID:246777"
                     /db_xref="HGNC:HGNC:15570"
                     /db_xref="MIM:609399"
                     /translation="MKPLVLLVALLLWPSSVPAYPSITVTPDEEQNLNHYIQVLENLV
                     RSVPSGEPGREKKSNSPKHVYSIASKGSKFKELVTHGDASTENDVLTNPISEETTTFP
                     TGGFTPEIGKKKHTESTPFWSIKPNNVSIVLHAEEPYIENEEPEPEPEPAAKQTEAPR
                     MLPVVTESSTSPYVTSYKSPVTTLDKSTGIGISTESEDVPQLSGETAIEKPEEFGKHP
                     ESWNNDDILKKILDINSQVQQALLSDTSNPAYREDIEASKDHLKRSLALAAAAEHKLK
                     TMYKSQLLPVGRTSNKIDDIETVINMLCNSRSKLYEYLDIKCVPPEMREKAATVFNTL
                     KNMCRSRRVTALLKVY"
     exon            194..1406
                     /gene="SPESP1"
                     /gene_synonym="ESP; SP-ESP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1387..1392
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPESP1"
                     /gene_synonym="ESP; SP-ESP"
                     /note="hexamer: AATAAA"
     polyA_site      1406
                     /gene="SPESP1"
                     /gene_synonym="ESP; SP-ESP"
                     /note="major polyA site"
ORIGIN      
        1 gttgctgggt gtcccagggc ctgaggcagg acggtactcc gctgacacct tccctttcgg
       61 ccttgaggtt cccagcctgg tggccccagg acgttccggt cgcatggcag agtgctacgg
      121 acgacgccta tgaagccctt agtccttcta gttgcgcttt tgctatggcc ttcgtctgtg
      181 ccggcttatc cgagcataac tgtgacacct gatgaagagc aaaacttgaa tcattatata
      241 caagttttag agaacctagt acgaagtgtt ccctctgggg agccaggtcg tgagaaaaaa
      301 tctaactctc caaaacatgt ttattctata gcatcaaagg gatcaaaatt taaggagcta
      361 gttacacatg gagacgcttc aactgagaat gatgttttaa ccaatcctat cagtgaagaa
      421 actacaactt tccctacagg aggcttcaca ccggaaatag gaaagaaaaa acacacggaa
      481 agtaccccat tctggtcgat caaaccaaac aatgtttcca ttgttttgca tgcagaggaa
      541 ccttatattg aaaatgaaga gccagagcca gagccggagc cagctgcaaa acaaactgag
      601 gcaccaagaa tgttgccagt tgttactgaa tcatctacaa gtccatatgt tacctcatac
      661 aagtcacctg tcaccacttt agataagagc actggcattg ggatctctac agaatcagaa
      721 gatgttcctc agctctcagg tgaaactgcg atagaaaaac ccgaagagtt tggaaagcac
      781 ccagagagtt ggaataatga tgacattttg aaaaaaattt tagatattaa ttcacaagtg
      841 caacaggcac ttcttagtga caccagcaac ccagcatata gagaagatat tgaagcctct
      901 aaagatcacc taaaacgaag ccttgctcta gcagcagcag cagaacataa attaaaaaca
      961 atgtataagt cccagttatt gccagtagga cgaacaagta ataaaattga tgacatcgaa
     1021 actgttatta acatgctgtg taattctaga tctaaactct atgaatattt agatattaaa
     1081 tgtgttccac cagagatgag agaaaaagct gctacagtat tcaatacatt aaaaaatatg
     1141 tgtagatcaa ggagagtcac agccttatta aaagtttatt aaacaataat ataaaaattt
     1201 taaacctact tgatattcca taacaaagct gatttaagca aactgcattt tttcacagga
     1261 gaaataatca tattcgtaat ttcaaaagtt gtataaaaat attttctatt gtagttcaaa
     1321 tgtgccaaca tctttatgtg tcatgtgtta tgaacaattt tcatatgcac taaaaaccta
     1381 atttaaaata aaattttggt tcagga
//
