LOCUS       NM_001364708            3695 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens SPEM family member 3 (SPEM3), transcript variant 1,
            mRNA.
ACCESSION   NM_001364708 XM_011523796 XM_024452593
VERSION     NM_001364708.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3695)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113189.11 and HY033016.1.
            
            On or before Jun 30, 2018 this sequence version replaced
            XM_024452593.1, XM_011523796.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968968,
                              SAMEA2148093 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000636696.4/ ENSP00000490274.1
            RefSeq Select criteria    :: based on manual assertion, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AC113189.11        78940-78943
            5-242               HY033016.1         2-239
            243-341             AC113189.11        79451-79549
            342-572             HY033016.1         240-470
            573-3695            AC113189.11        79781-82903
FEATURES             Location/Qualifiers
     source          1..3695
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..3695
                     /gene="SPEM3"
                     /note="SPEM family member 3"
                     /db_xref="GeneID:107983988"
                     /db_xref="HGNC:HGNC:53651"
     exon            1..184
                     /gene="SPEM3"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..3637
                     /gene="SPEM3"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="uncharacterized protein SPEM3 isoform 1"
                     /protein_id="NP_001351637.1"
                     /db_xref="CCDS:CCDS92248.1"
                     /db_xref="GeneID:107983988"
                     /db_xref="HGNC:HGNC:53651"
                     /translation="MGERAYHGAQVCSGTNPRKCQDLGDSILLLLGSFILLNVWINVV
                     TLLWKHLKSSLRILFRHFFPKDKQPSGSHPICICSSVDPKNLCSKVSSRVHPRPGFLL
                     RRVNHLDSWIPDTNDEKVSACCCVPPKCGHAGVPRESARGLYKAGMMGGGEAPQVTAS
                     KAQASLLSRPETSSQFPKMSKLDTGPCHLPQESKTKTPDCAPAEAPAQAQVHSPTHTP
                     VCTPTHPWTRSTDHTAVHTPAHSWTHSKARTPEGTHSQAQDTSAQAQAHTSAPTPAQT
                     PAHIQAHTPAPTPAKASAHTKAHTSAQAQTHSPPHTPEYTHSQAHSPEHTSAHSPAQA
                     PMPVPAHPQAHAPEYTSAHAPAYIPDHSHLVRSSVPVPTSAPAPPGTLAPATTPVLAP
                     TPAPVPASAPSPAPALVMALTTTPVPDPVPATTPAPIITPIPSTPPAFSHDLSTGHVV
                     YDARREKQNFFHMSSPQNPEYSRKDLATLFRPQEGQDLVSSGISEQTKQCSGDSAKLP
                     AGSILGYLELRNMEWKNSDDAKDKFPQTKTSPYCSFHPCSSEKNTDSQAPFYPKFLAY
                     SRDTACAKTCFHSATTAQSSVCTLPPPFTLSLPLVPPRSFVPPQPTNHQRPSTLIQTP
                     TVLPTSKSPQSILTSQFPIPSLFATISQPLIQPQCPECHESLGLTQDSGLQRTPGPSK
                     DSRVPRNLDLAQNPDLYKNPGLTQDPGLHENPGLAPNQGLHEFPGLPQDSYLCQNPSP
                     SQDFGLHKNSGITQDSHPQKNTGLTQEAGILRSPCLTQSPGLHKKTPFTQTSDLQRSS
                     GFTQDSGIYRNLEPNQETVIYKNQDLSQATDHQKNLGSSKDSGGHKNTGNVQDPGVCS
                     TAGLTEDSGSQKGPYVPQDSEVNKSSGVIQESFLHKSPGLVQTSGLPKCSGLTQNSGD
                     YKNPGLIQDCGGHKVKGLTQDSNLPSLTQATKVERRFSLPQDVGVYRSSEHSQDSNLH
                     KCPGINQDPGPHKDPALVQDSGLPKISGLTQESGPYKSSCLIPDPSLYKNPSPALGSD
                     FVQLLSLLQTPKSTLSLMKSSVPEKAAQKEDAQRHVLWARVQLNENSCPSKAQVVSND
                     LQTFSEVPVLIELQSSSWRAGSQHGAYRPVDTVPSGYQNYRQMSMPTHINWKSHCPGP
                     GTQAGHVVFDARQRRLAVGKDKCEALSPRRLHQEAPSNSGKPSRSGDIRM"
     exon            185..242
                     /gene="SPEM3"
                     /inference="alignment:Splign:2.1.0"
     exon            243..3695
                     /gene="SPEM3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3677..3682
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPEM3"
                     /note="hexamer: AATAAA"
     polyA_site      3695
                     /gene="SPEM3"
                     /note="major polyA site"
ORIGIN      
        1 gactgtgtga gggccggggg cctaggcagt cctgggaccc caggccatgg gtgagcgagc
       61 ctatcatggg gcccaggtgt gctctggcac caaccccagg aagtgccagg acttaggaga
      121 ctcgattctt cttcttctgg gcagcttcat cttgctcaac gtgtggatca atgtggtgac
      181 tctgctctgg aagcatctga agagctcctt gcggattctt ttccgtcatt ttttccccaa
      241 agacaagcag cccagcggca gccatcccat atgtatttgc tcctccgtgg atcccaagaa
      301 cctgtgctca aaagtctctt cccgcgtcca tcctcgccca ggcttcctgc tcaggcgcgt
      361 taaccacctt gactcctgga taccagacac gaacgatgag aaggtttctg cgtgctgctg
      421 cgtgccccct aaatgtggac atgccggcgt tcccagggag tctgcacggg gactgtacaa
      481 ggcggggatg atgggcgggg gagaagcccc tcaggtcaca gcctcaaagg ctcaagcctc
      541 cttgctctcc aggccagaga catcttccca gttcccaaag atgagcaagt tggacacggg
      601 tccatgccac ctgccccaag agagcaagac taagacccca gactgtgccc cagccgaggc
      661 cccagctcag gcccaggtcc actccccaac ccacactcct gtgtgcaccc caacccaccc
      721 ctggacccgc tccacggacc acaccgctgt gcacacccct gcccactcct ggacccactc
      781 caaagcccgc acccctgagg gcacccactc ccaggcccag gacacctcag cccaggccca
      841 agcccacacc tcagccccta ccccagctca gacgccagcc cacatccaag ctcacacccc
      901 agcccctaca ccggccaagg cctcagctca cactaaagcc catacgtcag cccaggccca
      961 aacccactct ccgccccaca cccctgagta tactcactcc caggcccaca gccctgaaca
     1021 cacctcagcc cactccccag cccaggctcc tatgcctgtc ccagcccacc cccaggccca
     1081 tgcccctgag tacacctcag cccatgcccc agcgtatatc ccagaccact ctcatctagt
     1141 ccgcagctcc gttcctgtcc caacctctgc cccagctcct cccggaactc ttgccccagc
     1201 cactactcct gtcctagctc caacaccagc ccctgtccca gcctctgccc ccagccctgc
     1261 tccagcactg gtcatggccc tgactaccac tcctgtccct gatcctgtcc ctgccaccac
     1321 ccctgcccct atcataactc ctataccctc taccccacct gccttcagcc atgacctctc
     1381 cactggccat gtggtctatg atgcccgcag ggaaaagcag aatttcttcc atatgtccag
     1441 cccccagaac cctgagtatt caagaaaaga cttggctacc ctcttcaggc cccaagaggg
     1501 tcaggacctg gtgagttctg gcatatctga gcaaacaaag caatgcagtg gggatagtgc
     1561 caagcttcct gcaggatcca tactgggcta cctggagttg aggaatatgg aatggaagaa
     1621 ctcagatgat gccaaagata agttccccca gaccaagact tccccttact gcagcttcca
     1681 tccttgcagt tctgagaaga acacagactc ccaggctcca ttctacccca aattccttgc
     1741 ctactcccgg gatactgcat gtgccaagac ttgctttcat tctgcaacca ctgcccagag
     1801 ctcagtgtgc acccttcctc caccgttcac tctttccctg cctctcgttc ctcccagatc
     1861 ctttgtccct cctcaaccca ccaaccatca gaggccttcc accttaatac aaacccctac
     1921 tgttcttcca acctccaagt ctcctcagtc catcctcact tcccaattcc ccatcccttc
     1981 cctgttcgcc accatttccc aacccctgat ccaaccccaa tgccctgaat gtcatgagag
     2041 tctaggcctt acccaagatt ctggccttca aaggacccca ggcccttcaa aagactccag
     2101 agttcccagg aatctggacc ttgcccaaaa cccagacctc tacaagaacc caggccttac
     2161 ccaagatcca ggcctccacg agaacccagg tcttgctcca aatcaaggcc tacatgagtt
     2221 cccaggcctt ccccaagatt cttatctctg ccagaatcca agcccttctc aagactttgg
     2281 tcttcacaag aattcaggca ttactcaaga ttcccacccc caaaagaaca caggtctgac
     2341 tcaagaagct ggtatcctta ggagcccatg tctcacccaa tcccctggcc tccacaagaa
     2401 aacaccattt acccaaactt ctgatcttca gaggagctca ggctttacac aagactctgg
     2461 aatctatagg aatcttgaac caaaccaaga gactgtgatc tacaaaaatc aagatctctc
     2521 ccaagcaact gaccaccaaa agaacctagg ctcttctaaa gattctggag gtcacaagaa
     2581 tacaggcaat gtccaagatc caggagtctg tagtaccgca ggccttactg aagattctgg
     2641 atcacagaag ggtccgtatg ttccccaaga ctctgaagtc aataagagct caggagttat
     2701 ccaggaatct tttctccaca agagcccagg ccttgtccaa acctctggcc tcccaaagtg
     2761 ctcaggcctt acccaaaact caggagacta caagaatcca ggacttatcc aagattgtgg
     2821 tggccacaaa gttaaaggcc ttactcaaga ttccaacctc ccaagcctta cccaagccac
     2881 taaagttgaa agaagattta gccttcccca agatgttgga gtttacagga gctcagaaca
     2941 tagccaagac tctaatctcc acaagtgccc aggaattaat caagatcctg gcccccataa
     3001 agacccagcc cttgtccaag actctggcct ccccaagatt tcaggcctta cccaggaatc
     3061 tggcccctac aagagctcat gcctcatccc agatcccagc ctctacaaga acccaagccc
     3121 tgccctaggt tctgattttg tccagctttt gtccctgctt cagaccccaa agtccacact
     3181 gtccctgatg aagtcatctg tgcctgagaa ggctgctcag aaggaggacg cacagcggca
     3241 cgtcctctgg gctcgtgtcc aactcaatga gaactcctgc ccttccaagg cccaagtggt
     3301 ctccaatgac ctgcagacct tctcagaggt acctgtatta attgagctgc agtcatcctc
     3361 ctggcgggca ggcagccagc acggggcgta ccgccctgtg gatacagttc cttcaggcta
     3421 ccagaactat cgtcagatgt ctatgcctac ccatatcaac tggaagtccc actgccctgg
     3481 accaggcacc caggcagggc atgtggtttt tgatgcccgt cagagacggt tggcagtggg
     3541 caaggacaag tgtgaagctc tgtctcctag gcgccttcat caagaggcac ccagcaactc
     3601 ggggaaacca tcaaggagtg gggatatcag aatgtgatga gaaccttgga caaagagggg
     3661 acaaaagtgc atcaggaata aagaggcgag agaaa
//
