LOCUS       NM_175734               1650 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens SPEM family member 2 (SPEM2), mRNA.
ACCESSION   NM_175734
VERSION     NM_175734.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1650)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC031286.1 and BC044816.1.
            
            On Nov 23, 2018 this sequence version replaced NM_175734.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031286.1, ERR279872.2924.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000333870.8/ ENSP00000328061.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1297              BC031286.1         1-1297
            1298-1650           BC044816.1         935-1287
FEATURES             Location/Qualifiers
     source          1..1650
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..1650
                     /gene="SPEM2"
                     /gene_synonym="C17orf74"
                     /note="SPEM family member 2"
                     /db_xref="GeneID:201243"
                     /db_xref="HGNC:HGNC:27315"
     exon            1..211
                     /gene="SPEM2"
                     /gene_synonym="C17orf74"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..1579
                     /gene="SPEM2"
                     /gene_synonym="C17orf74"
                     /note="uncharacterized protein C17orf74"
                     /codon_start=1
                     /product="uncharacterized protein SPEM2"
                     /protein_id="NP_783861.3"
                     /db_xref="CCDS:CCDS42255.1"
                     /db_xref="GeneID:201243"
                     /db_xref="HGNC:HGNC:27315"
                     /translation="MENQLWHNTVRCCNQYQESPHDAEDILLLLLGLIVLVNIGINVA
                     TMMWHGLQNALDKMIDWATQKNEIQASESPPSGPPDKAQDVHIHCILDPVQVKMSRPT
                     QYSSFSCHHFSNHHSSSLLRCVRRRRRRHRRCRRRCCNHQQRPQNYRQIPHSHSVFRN
                     PHRSQKMSQLHRVPFFDQEDPDSYLEEEDNLPFPYPKYPRRGWGGFYQRAGLPSNVGL
                     WGHQGGILASLPPPSLYLSPELRCMPKRVEARSELRLQSYGRHGSQSRLWGNVEAEQW
                     ASSPPPPHRLPPNPSWVPVGHSPYPSVGWMLYDSWDQRRRGTEGFERPPASVSRNARP
                     EAQGCREHHSPQSHQQSLLGHAYGQSHRSPHPSTEPLGYSSQDPREVRRRAADWAEAL
                     PAWRPLTTSASLTVLDEASHQRTPAPSSVLVPHSSQPWPKVQAADPAPPPTMFVPLSR
                     NPGGNANYQVYDSLELKRQVQKSRARSSSLPPASTSTLRPSLHRSQTEKLN"
     exon            212..269
                     /gene="SPEM2"
                     /gene_synonym="C17orf74"
                     /inference="alignment:Splign:2.1.0"
     exon            270..1650
                     /gene="SPEM2"
                     /gene_synonym="C17orf74"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1625..1630
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPEM2"
                     /gene_synonym="C17orf74"
                     /note="hexamer: AATAAA"
     polyA_site      1650
                     /gene="SPEM2"
                     /gene_synonym="C17orf74"
                     /note="major polyA site"
ORIGIN      
        1 agtgcagtgt gggttggggc cgggggtggg gggcagaggg gggtggccca ggtggcccta
       61 ggaccccccc tccatggaaa accagctatg gcataacacc gtgagatgtt gcaatcaata
      121 ccaagaaagc ccccacgatg ccgaggacat cttactcctg ctgctgggcc tcatcgttct
      181 tgtcaacatt ggcatcaacg tggcaactat gatgtggcat ggactccaga acgccttaga
      241 caagatgatt gattgggcta ctcagaaaaa tgaaattcag gccagtgaaa gtcccccaag
      301 tggtccccca gacaaggctc aggatgtcca catccactgc atcctggacc ctgtgcaggt
      361 gaagatgtcc cgacccacgc agtactcctc tttctcctgc caccatttct ccaaccatca
      421 cagtagcagt cttcttcgct gtgttcgtcg ccgccgccgc cgccaccgcc gttgtcgccg
      481 tcgctgctgc aaccaccagc agcggccgca gaactacaga caaatccccc atagccactc
      541 agtcttccgt aacccacatc gcagccaaaa gatgtcacaa ctacaccgag tgcctttctt
      601 tgatcaggag gacccggatt cctacctgga ggaggaggac aacctgccct tcccgtatcc
      661 caagtaccca cgtcgcggct ggggcgggtt ttatcagaga gcgggcctgc cctccaatgt
      721 ggggctgtgg ggccaccagg gtggtatcct ggccagtctg ccaccaccct ctctctacct
      781 gtcacctgag ctgcgctgca tgcccaagcg tgtagaggcc aggtctgagc tgaggctgca
      841 gtcctatggg cgccacggtt cccaatcccg actgtggggc aatgtggagg ctgagcagtg
      901 ggcctcgtct ccaccacctc cccaccggct gccccctaac ccctcttggg tccccgtggg
      961 gcacagccct tacccctcag tgggctggat gctgtatgac tcctgggatc agcggcgtcg
     1021 tggcacggag ggctttgagc gcccccctgc ctcggtgtcc cggaacgccc ggcctgaggc
     1081 ccagggctgc cgggagcacc actccccaca gtcccaccag cagagcctgc ttggtcacgc
     1141 ctatggccag tcccaccgca gtccccaccc atccacggaa cccttgggct acagctccca
     1201 ggacccccgt gaggtgcggc gtcgggcagc tgactgggct gaggctctgc ccgcctggcg
     1261 tcctctgact acctctgcct ccctcacggt gttggacgag gcctcccatc aacggacccc
     1321 agctccaagc tcagtgctgg tcccccattc ctcccagccc tggcccaaag tccaggctgc
     1381 ggaccctgcc cctcccccga ccatgtttgt cccactcagc cggaatccag ggggcaatgc
     1441 caactaccag gtgtacgaca gcctggagct gaagcggcag gtgcagaaga gcagagccag
     1501 gtccagctca ctgccaccgg cttccacctc caccttgagg ccctctctgc acaggagcca
     1561 gaccgagaaa ctcaactgac cagcaggcgg atgtggggtg tggggcaggg catggaggga
     1621 gaggaataaa gagaaacaga gtccaggaaa
//
