LOCUS       NM_199339               1018 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens spermatid maturation 1 (SPEM1), mRNA.
ACCESSION   NM_199339
VERSION     NM_199339.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1018)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1018)
  AUTHORS   Hashemi,M.S., Mozdarani,H., Ghaedi,K. and Nasr-Esfahani,M.H.
  TITLE     Among seven testis-specific molecular markers, SPEM1 appears to
            have a significant clinical value for prediction of sperm retrieval
            in azoospermic men
  JOURNAL   Andrology 6 (6), 890-895 (2018)
   PUBMED   30054974
  REMARK    GeneRIF: SPEM1 appears to have a significant clinical value for
            prediction of sperm retrieval in azoospermic men.
REFERENCE   3  (bases 1 to 1018)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 1018)
  AUTHORS   Bao,J., Wu,Q., Song,R., Jie,Z., Zheng,H., Xu,C. and Yan,W.
  TITLE     RANBP17 is localized to the XY body of spermatocytes and interacts
            with SPEM1 on the manchette of elongating spermatids
  JOURNAL   Mol Cell Endocrinol 333 (2), 134-142 (2011)
   PUBMED   21184802
REFERENCE   5  (bases 1 to 1018)
  AUTHORS   Bao,J., Zhang,J., Zheng,H., Xu,C. and Yan,W.
  TITLE     UBQLN1 interacts with SPEM1 and participates in spermiogenesis
  JOURNAL   Mol Cell Endocrinol 327 (1-2), 89-97 (2010)
   PUBMED   20558241
REFERENCE   6  (bases 1 to 1018)
  AUTHORS   Zheng,H., Stratton,C.J., Morozumi,K., Jin,J., Yanagimachi,R. and
            Yan,W.
  TITLE     Lack of Spem1 causes aberrant cytoplasm removal, sperm deformation,
            and male infertility
  JOURNAL   Proc Natl Acad Sci U S A 104 (16), 6852-6857 (2007)
   PUBMED   17426145
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113189.11 and BC033882.1.
            
            On Nov 22, 2018 this sequence version replaced NM_199339.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC033882.1, SRR5189667.86767.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000323675.4/ ENSP00000315554.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                AC113189.11        70407-70442
            37-1018             BC033882.1         1-982
FEATURES             Location/Qualifiers
     source          1..1018
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..1018
                     /gene="SPEM1"
                     /gene_synonym="C17orf83"
                     /note="spermatid maturation 1"
                     /db_xref="GeneID:374768"
                     /db_xref="HGNC:HGNC:32429"
                     /db_xref="MIM:615116"
     exon            1..205
                     /gene="SPEM1"
                     /gene_synonym="C17orf83"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..991
                     /gene="SPEM1"
                     /gene_synonym="C17orf83"
                     /codon_start=1
                     /product="spermatid maturation protein 1"
                     /protein_id="NP_955371.2"
                     /db_xref="CCDS:CCDS42254.1"
                     /db_xref="GeneID:374768"
                     /db_xref="HGNC:HGNC:32429"
                     /db_xref="MIM:615116"
                     /translation="MAMVERPRPEWASYHNCNSNSCQDLGNSVLLLLGLIICINISIN
                     IVTLLWSRFRGVLYQVFHDTICEKEAPKSSLLRKQTQPPKKQSSPAVHLRCTMDPVMM
                     TVSPPPAHRHRRRGSPTRCAHCPVAWAPDTDDEKPHQYPAICSYHWDVPEDWEGFQHT
                     QGTWVPWSQDAPESPPQTIRFQPTVEERPLKTGIWSELGLRAYVYPVNPPPPSPEAPS
                     HKNGGEGAVPEAEAAQYQPVPAPTLGPAVIPEFSRHRSSGRIVYDARDMRRRLRELTR
                     EVEALSGCYPLASGSSTAEETSKNWVYRSLTGR"
     exon            206..266
                     /gene="SPEM1"
                     /gene_synonym="C17orf83"
                     /inference="alignment:Splign:2.1.0"
     exon            267..1018
                     /gene="SPEM1"
                     /gene_synonym="C17orf83"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1001..1006
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPEM1"
                     /gene_synonym="C17orf83"
                     /note="hexamer: AATAAA"
     polyA_site      1018
                     /gene="SPEM1"
                     /gene_synonym="C17orf83"
                     /note="major polyA site"
ORIGIN      
        1 agtggacact gtcggcacgg tgggctgggg gcgtaagggc cccggtggtc ctagggaccc
       61 catggccatg gttgagcggc cgaggcccga gtgggcctcg tatcacaact gcaacagcaa
      121 cagctgccag gacctgggca actctgtcct gttgctgctg ggcctcatca tctgcattaa
      181 cattagcatc aatatagtga ccctgctctg gagccgattc cgtggtgtct tataccaagt
      241 gttccatgat accatttgtg agaaagaagc tcccaagtca tcattactca gaaagcagac
      301 ccagccccct aagaagcaga gttctcctgc agtccatctt cggtgcacca tggaccctgt
      361 gatgatgact gtgtccccgc ccccagctca ccgccatcgc cgtcgaggct ctcccacacg
      421 ctgtgctcac tgcccagtag cttgggctcc tgacactgat gacgagaagc ctcatcagta
      481 cccagccatc tgctcctacc actgggatgt ccctgaggac tgggaaggct tccaacacac
      541 tcaggggacc tgggttccct ggtctcagga tgccccagag tcccctcccc agaccatccg
      601 cttccagcct accgtagagg aaaggcccct caaaacaggc atatggtccg agctgggcct
      661 aagggcctat gtgtatcctg tgaacccccc acctcccagc cctgaggctc ctagccacaa
      721 gaacggtggg gagggggcgg tgccagaggc agaggcggct cagtaccagc ctgtcccagc
      781 tcccaccctg ggcccagcag tcatccctga attttcccgg caccgctcct caggccgaat
      841 agtgtatgat gcccgggaca tgagacggcg gcttcgggaa ctgacccggg aggtggaggc
      901 cctgtccggc tgctaccccc tagcctctgg atccagcact gccgaggaga caagcaagaa
      961 ttgggtgtac cgttccctaa ctgggaggtg actggaaaaa aataaaaagg agagagga
//
