LOCUS       NM_015330               6763 bp    mRNA    linear   PRI 15-JUL-2024
DEFINITION  Homo sapiens sperm antigen with calponin homology and coiled-coil
            domains 1 like (SPECC1L), transcript variant 1, mRNA.
ACCESSION   NM_015330 XM_037759
VERSION     NM_015330.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6763)
  AUTHORS   Branciamore,S., Gogoshin,G., Rodin,A.S. and Myers,A.J.
  TITLE     Changes in expression of VGF, SPECC1L, HLA-DRA and RANBP3L act with
            APOE E4 to alter risk for late onset Alzheimer's disease
  JOURNAL   Sci Rep 14 (1), 14954 (2024)
   PUBMED   38942763
  REMARK    GeneRIF: Changes in expression of VGF, SPECC1L, HLA-DRA and RANBP3L
            act with APOE E4 to alter risk for late onset Alzheimer's disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6763)
  AUTHORS   Saadi,I., Goering,J.P., Hufft-Martinez,B.M. and Tran,P.V.
  TITLE     SPECC1L: a cytoskeletal protein that regulates embryonic tissue
            dynamics
  JOURNAL   Biochem Soc Trans 51 (3), 949-958 (2023)
   PUBMED   37345651
  REMARK    GeneRIF: SPECC1L: a cytoskeletal protein that regulates embryonic
            tissue dynamics.
REFERENCE   3  (bases 1 to 6763)
  AUTHORS   Mehta,V., Decan,N., Ooi,S., Gaudreau-Lapierre,A., Copeland,J.W. and
            Trinkle-Mulcahy,L.
  TITLE     SPECC1L binds the myosin phosphatase complex MYPT1/PP1beta and can
            regulate its distribution between microtubules and filamentous
            actin
  JOURNAL   J Biol Chem 299 (2), 102893 (2023)
   PUBMED   36634848
  REMARK    GeneRIF: SPECC1L binds the myosin phosphatase complex MYPT1/PP1beta
            and can regulate its distribution between microtubules and
            filamentous actin.
REFERENCE   4  (bases 1 to 6763)
  AUTHORS   Migliore,C., Vendramin,A., McKee,S., Prontera,P., Faravelli,F.,
            Sachdev,R., Dias,P., Mascaro,M., Licastro,D. and Meroni,G.
  TITLE     SPECC1L Mutations Are Not Common in Sporadic Cases of Opitz G/BBB
            Syndrome
  JOURNAL   Genes (Basel) 13 (2), 252 (2022)
   PUBMED   35205294
  REMARK    GeneRIF: SPECC1L Mutations Are Not Common in Sporadic Cases of
            Opitz G/BBB Syndrome.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6763)
  AUTHORS   Fang,S.G., Xia,T.L., Fu,J.C., Li,T., Zhong,Q. and Han,F.
  TITLE     BCL6-SPECC1L: A Novel Fusion Gene in Nasopharyngeal Carcinoma
  JOURNAL   Technol Cancer Res Treat 21, 15330338221139981 (2022)
   PUBMED   36412101
  REMARK    GeneRIF: BCL6-SPECC1L: A Novel Fusion Gene in Nasopharyngeal
            Carcinoma.
REFERENCE   6  (bases 1 to 6763)
  AUTHORS   Navarini,A.A., Simpson,M.A., Weale,M., Knight,J., Carlavan,I.,
            Reiniche,P., Burden,D.A., Layton,A., Bataille,V., Allen,M.,
            Pleass,R., Pink,A., Creamer,D., English,J., Munn,S., Walton,S.,
            Willis,C., Deret,S., Voegel,J.J., Spector,T., Smith,C.H.,
            Trembath,R.C. and Barker,J.N.
  CONSRTM   Acne Genetic Study Group
  TITLE     Genome-wide association study identifies three novel susceptibility
            loci for severe Acne vulgaris
  JOURNAL   Nat Commun 5, 4020 (2014)
   PUBMED   24927181
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 6763)
  AUTHORS   Djebali,S., Lagarde,J., Kapranov,P., Lacroix,V., Borel,C.,
            Mudge,J.M., Howald,C., Foissac,S., Ucla,C., Chrast,J., Ribeca,P.,
            Martin,D., Murray,R.R., Yang,X., Ghamsari,L., Lin,C., Bell,I.,
            Dumais,E., Drenkow,J., Tress,M.L., Gelpi,J.L., Orozco,M.,
            Valencia,A., van Berkum,N.L., Lajoie,B.R., Vidal,M.,
            Stamatoyannopoulos,J., Batut,P., Dobin,A., Harrow,J., Hubbard,T.,
            Dekker,J., Frankish,A., Salehi-Ashtiani,K., Reymond,A.,
            Antonarakis,S.E., Guigo,R. and Gingeras,T.R.
  TITLE     Evidence for transcript networks composed of chimeric RNAs in human
            cells
  JOURNAL   PLoS One 7 (1), e28213 (2012)
   PUBMED   22238572
  REMARK    GeneRIF: The authors use rapid amplification of cDNA ends, tiling
            arrays, and deep RNA sequencing to identify chimeric transcripts on
            human chromosomes 21 and 22. They found that for 492 protein coding
            genes studied, 85% of these genes had boundaries that extended
            beyond the current annotated termini.
REFERENCE   8  (bases 1 to 6763)
  AUTHORS   Saadi,I., Alkuraya,F.S., Gisselbrecht,S.S., Goessling,W.,
            Cavallesco,R., Turbe-Doan,A., Petrin,A.L., Harris,J., Siddiqui,U.,
            Grix,A.W. Jr., Hove,H.D., Leboulch,P., Glover,T.W., Morton,C.C.,
            Richieri-Costa,A., Murray,J.C., Erickson,R.P. and Maas,R.L.
  TITLE     Deficiency of the cytoskeletal protein SPECC1L leads to oblique
            facial clefting
  JOURNAL   Am J Hum Genet 89 (1), 44-55 (2011)
   PUBMED   21703590
  REMARK    GeneRIF: SPECC1L functions in actin-cytoskeleton reorganization and
            is required for proper facial morphogenesis.
REFERENCE   9  (bases 1 to 6763)
  AUTHORS   Scanlan,M.J., Gordan,J.D., Williamson,B., Stockert,E., Bander,N.H.,
            Jongeneel,V., Gure,A.O., Jager,D., Jager,E., Knuth,A., Chen,Y.T.
            and Old,L.J.
  TITLE     Antigens recognized by autologous antibody in patients with
            renal-cell carcinoma
  JOURNAL   Int J Cancer 83 (4), 456-464 (1999)
   PUBMED   10508479
REFERENCE   10 (bases 1 to 6763)
  AUTHORS   Dasouki,M., Barr,M. Jr., Erickson,R.P. and Cox,B.
  TITLE     Translocation (1;22) in a child with bilateral oblique facial
            clefts
  JOURNAL   J Med Genet 25 (6), 427-429 (1988)
   PUBMED   3398011
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY105216.1, AL832425.1,
            BC013085.1, AP000354.1, BC021132.1 and BM126792.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 25, 2020 this sequence version replaced NM_015330.5.
            
            Summary: This gene encodes a coiled-coil domain containing protein.
            The encoded protein may play a critical role in actin-cytoskeletal
            reorganization during facial morphogenesis. Mutations in this gene
            are a cause of oblique facial clefting-1. Alternatively spliced
            transcript variants encoding multiple isoforms have been observed
            for this gene. A read-through transcript composed of SPECC1L (sperm
            antigen with calponin homology and coiled-coil domains 1-like) and
            the downstream ADORA2A (adenosine A2a receptor) gene sequence has
            been identified, but it is thought to be non-coding. [provided by
            RefSeq, Jun 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1 and 2 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL832425.1, SRR11853564.18270.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000314328.14/ ENSP00000325785.8
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                HY105216.1         15-81
            68-1417             AL832425.1         1-1350
            1418-1418           BC013085.1         750-750
            1419-3144           AL832425.1         1352-3077
            3145-3145           AP000354.1         144028-144028
            3146-4723           AL832425.1         3079-4656
            4724-6271           BC021132.1         98-1645
            6272-6763           BM126792.1         6-497               c
FEATURES             Location/Qualifiers
     source          1..6763
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.23"
     gene            1..6763
                     /gene="SPECC1L"
                     /gene_synonym="CYTSA; GBBB2; OBLFC1; TBHS; TBHS1"
                     /note="sperm antigen with calponin homology and
                     coiled-coil domains 1 like"
                     /db_xref="GeneID:23384"
                     /db_xref="HGNC:HGNC:29022"
                     /db_xref="MIM:614140"
     exon            1..153
                     /gene="SPECC1L"
                     /gene_synonym="CYTSA; GBBB2; OBLFC1; TBHS; TBHS1"
                     /inference="alignment:Splign:2.1.0"
     exon            154..257
                     /gene="SPECC1L"
                     /gene_synonym="CYTSA; GBBB2; OBLFC1; TBHS; TBHS1"
                     /inference="alignment:Splign:2.1.0"
     exon            258..447
                     /gene="SPECC1L"
                     /gene_synonym="CYTSA; GBBB2; OBLFC1; TBHS; TBHS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             295..3648
                     /gene="SPECC1L"
                     /gene_synonym="CYTSA; GBBB2; OBLFC1; TBHS; TBHS1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cytokinesis and spindle organization A; renal carcinoma
                     antigen NY-REN-22; cytospin-A; SPECC1-like protein"
                     /codon_start=1
                     /product="cytospin-A isoform 1"
                     /protein_id="NP_056145.5"
                     /db_xref="CCDS:CCDS33619.1"
                     /db_xref="GeneID:23384"
                     /db_xref="HGNC:HGNC:29022"
                     /db_xref="MIM:614140"
                     /translation="MKKASRSVGSVPKVSAISKTQTAEKIKPENSSSASTGGKLVKPG
                     TAASLSKTKSSDDLLAGMAGGVTVTNGVKGKKSTCPSAAPSASAPAMTTVENKSKIST
                     GTASSTKRSTSTGNKESSSTRERLRERTRLNQSKKLPSAGQGANDMALAKRSRSRTAT
                     ECDVRMSKSKSDNQISDRAALEAKVKDLLTLAKTKDVEILHLRNELRDMRAQLGINED
                     HSEGDEKSEKETIMAHQPTDVESTLLQLQEQNTAIREELNQLKNENRMLKDRLNALGF
                     SLEQRLDNSEKLFGYQSLSPEITPGNQSDGGGTLTSSVEGSAPGSVEDLLSQDENTLM
                     DHQHSNSMDNLDSECSEVYQPLTSSDDALDAPSSSESEGIPSIERSRKGSSGNASEVS
                     VACLTERIHQMEENQHSTSEELQATLQELADLQQITQELNSENERLGEEKVILMESLC
                     QQSDKLEHFSRQIEYFRSLLDEHHISYVIDEDVKSGRYMELEQRYMDLAENARFEREQ
                     LLGVQQHLSNTLKMAEQDNKEAQEMIGALKERSHHMERIIESEQKGKAALAATLEEYK
                     ATVASDQIEMNRLKAQLENEKQKVAELYSIHNSGDKSDIQDLLESVRLDKEKAETLAS
                     SLQEDLAHTRNDANRLQDAIAKVEDEYRAFQEEAKKQIEDLNMTLEKLRSDLDEKETE
                     RSDMKETIFELEDEVEQHRAVKLHDNLIISDLENTVKKLQDQKHDMEREIKTLHRRLR
                     EESAEWRQFQADLQTAVVIANDIKSEAQEEIGDLKRRLHEAQEKNEKLTKELEEIKSR
                     KQEEERGRVYNYMNAVERDLAALRQGMGLSRRSSTSSEPTPTVKTLIKSFDSASQVPN
                     PAAAAIPRTPLSPSPMKTPPAAAVSPMQRHSISGPISTSKPLTALSDKRPNYGEIPVQ
                     EHLLRTSSASRPASLPRVPAMESAKTLSVSRRSSEEVKRDISAQEGASPASLMAMGTT
                     SPQLSLSSSPTASVTPTTRSRIREERKDPLSALAREYGGSKRNALLKWCQKKTEGYQN
                     IDITNFSSSWNDGLAFCALLHTYLPAHIPYQELNSQDKRRNFMLAFQAAESVGIKSTL
                     DINEMVRTERPDWQNVMLYVTAIYKYFET"
     exon            448..601
                     /gene="SPECC1L"
                     /gene_synonym="CYTSA; GBBB2; OBLFC1; TBHS; TBHS1"
                     /inference="alignment:Splign:2.1.0"
     exon            602..2232
                     /gene="SPECC1L"
                     /gene_synonym="CYTSA; GBBB2; OBLFC1; TBHS; TBHS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2233..2440
                     /gene="SPECC1L"
                     /gene_synonym="CYTSA; GBBB2; OBLFC1; TBHS; TBHS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2441..2514
                     /gene="SPECC1L"
                     /gene_synonym="CYTSA; GBBB2; OBLFC1; TBHS; TBHS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2515..2690
                     /gene="SPECC1L"
                     /gene_synonym="CYTSA; GBBB2; OBLFC1; TBHS; TBHS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2691..2854
                     /gene="SPECC1L"
                     /gene_synonym="CYTSA; GBBB2; OBLFC1; TBHS; TBHS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2855..2946
                     /gene="SPECC1L"
                     /gene_synonym="CYTSA; GBBB2; OBLFC1; TBHS; TBHS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2947..3037
                     /gene="SPECC1L"
                     /gene_synonym="CYTSA; GBBB2; OBLFC1; TBHS; TBHS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3038..3121
                     /gene="SPECC1L"
                     /gene_synonym="CYTSA; GBBB2; OBLFC1; TBHS; TBHS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3122..3278
                     /gene="SPECC1L"
                     /gene_synonym="CYTSA; GBBB2; OBLFC1; TBHS; TBHS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3279..3381
                     /gene="SPECC1L"
                     /gene_synonym="CYTSA; GBBB2; OBLFC1; TBHS; TBHS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3382..3498
                     /gene="SPECC1L"
                     /gene_synonym="CYTSA; GBBB2; OBLFC1; TBHS; TBHS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3499..3558
                     /gene="SPECC1L"
                     /gene_synonym="CYTSA; GBBB2; OBLFC1; TBHS; TBHS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3559..6763
                     /gene="SPECC1L"
                     /gene_synonym="CYTSA; GBBB2; OBLFC1; TBHS; TBHS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6257..6262
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPECC1L"
                     /gene_synonym="CYTSA; GBBB2; OBLFC1; TBHS; TBHS1"
                     /note="hexamer: ATTAAA"
     polyA_site      6278
                     /gene="SPECC1L"
                     /gene_synonym="CYTSA; GBBB2; OBLFC1; TBHS; TBHS1"
                     /note="major polyA site"
     regulatory      6744..6749
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPECC1L"
                     /gene_synonym="CYTSA; GBBB2; OBLFC1; TBHS; TBHS1"
                     /note="hexamer: GATAAA"
     polyA_site      6763
                     /gene="SPECC1L"
                     /gene_synonym="CYTSA; GBBB2; OBLFC1; TBHS; TBHS1"
ORIGIN      
        1 gcccgcgagg gaggccgggc ggcccggcaa gcggcgctgc ggggtaggct gctttcctga
       61 ggccggactc aacgggtctc ggctgagcca ccgggtgagc tcaccgccca gcccaaacca
      121 ggagattgcg agggagcgat gcggtgcagc gcgtgttctt ggggaagatc ccgactaagc
      181 cattttccag tggcacctct tccatcatga gttcctgagg cagtccgatg gggctacttt
      241 attccagaac aatcacaatt tgcttgtaaa tgcatcacga agaggcagcc cagaatgaag
      301 aaagcaagca ggagtgttgg ctcagtgcct aaagtgtctg caataagtaa aacgcaaaca
      361 gcagaaaaaa ttaaacctga aaacagctct tcagcatcta cgggaggcaa acttgtaaaa
      421 cctggaacag cagcatcatt gtcaaagacc aagagcagtg atgacctttt agctggaatg
      481 gccggagggg taacggtgac taatggtgtt aaaggaaaga aaagcacctg cccatctgca
      541 gcaccttcag catctgcccc tgccatgacc accgtggaga acaaatccaa gattagcaca
      601 ggcacagctt cttcaaccaa gcggagcact tctacaggta ataaagaatc cagttctact
      661 agagaaagat tacgtgaacg tacccgatta aaccagagca aaaaactacc ttctgcaggt
      721 cagggagcta atgacatggc attggccaaa cgttcccgca gtcgaactgc tacagaatgt
      781 gacgttcgta tgagcaagtc taagtcagac aatcagatca gtgacagagc tgctttggag
      841 gccaaagtga aggatcttct cacgctggca aaaaccaaag acgtagaaat tttacatttg
      901 agaaatgaac tgcgagacat gcgtgcccag ctgggcatta atgaggatca ttctgagggt
      961 gatgaaaaat ctgagaagga aactattatg gctcaccagc cgactgatgt ggagtccact
     1021 ttattgcagt tgcaggaaca gaatactgcc atccgtgaag aactcaacca gctgaaaaat
     1081 gaaaacagaa tgttaaagga caggttgaat gcattgggct tttccctaga gcagaggtta
     1141 gacaattctg aaaaactgtt tggctatcag tccctgagcc cagaaatcac ccctggtaac
     1201 cagagcgatg gaggaggaac tctgacttct tcagtggaag gctctgcccc tggctcagtg
     1261 gaggatctct tgagtcagga tgaaaataca ctaatggacc atcagcacag taactccatg
     1321 gacaatttag acagtgagtg cagtgaggtc taccagcccc tcacatcgag cgatgatgcg
     1381 ctggatgcac catcctcctc agagtcggaa ggcatcccca gcatagagcg ctcccggaag
     1441 gggagcagcg ggaatgccag tgaagtgtcc gtggcttgcc tgactgaacg gatacaccag
     1501 atggaagaga accaacacag tacaagtgag gaactccagg caaccctgca agagctagct
     1561 gatttacagc agattaccca ggaactgaat agtgaaaacg aaaggcttgg agaagagaag
     1621 gttattctga tggagtcttt atgtcagcag agcgataagt tggaacactt tagtcgacag
     1681 attgaatact tccgctctct tctagatgag catcacattt cttatgtcat agatgaagat
     1741 gtaaaaagtg ggcgctatat ggaattagag caacgttaca tggacctcgc tgagaatgcc
     1801 cgttttgaac gggagcagct tcttggtgtc cagcagcatt taagcaatac tttgaaaatg
     1861 gcagaacaag acaataagga agctcaagaa atgatagggg cactcaaaga acgcagtcac
     1921 catatggagc gaattattga gtctgagcag aaaggaaaag cagccttggc agccacgtta
     1981 gaggaataca aagccacagt ggccagtgac cagatagaga tgaatcgcct gaaggctcag
     2041 ctggagaatg aaaagcagaa agtggcagag ctgtattcta tccataactc tggagacaaa
     2101 tctgatattc aggacctcct ggagagtgtc aggctggaca aagaaaaagc agagactttg
     2161 gctagtagct tgcaggaaga tctggctcat acccgaaatg atgccaatcg attacaggat
     2221 gccattgcta aggtagagga tgaataccga gccttccaag aagaagctaa gaaacaaatt
     2281 gaagatttga atatgacgtt agaaaaatta agatcagacc tggatgaaaa agaaacagaa
     2341 aggagtgaca tgaaagaaac catctttgaa cttgaagatg aagtagaaca acatcgtgct
     2401 gtgaaacttc atgacaacct cattatttct gatctagaga atacagttaa aaaactccag
     2461 gaccaaaagc acgacatgga aagagaaata aagacactcc acagaagact tcgggaagaa
     2521 tctgcggaat ggcggcagtt tcaggctgat ctccagactg cagtagtcat tgcaaatgac
     2581 attaaatctg aagcccaaga ggagattggt gatctaaagc gccggttaca tgaggctcaa
     2641 gaaaaaaatg agaaactcac aaaagaattg gaggaaataa agtcacgcaa gcaagaggag
     2701 gagcgaggcc gggtatacaa ttacatgaat gccgttgaga gagatttggc agccttaagg
     2761 cagggaatgg gactgagtag aaggtcctcg acttcctcag agccaactcc tacagtaaaa
     2821 accctcatca agtcctttga cagtgcatct caagtaccaa accctgctgc agctgcaatt
     2881 cctcgaacgc ccctgagccc aagtcctatg aaaacccctc ctgcagcagc tgtgtcccct
     2941 atgcagagac attccataag tggaccaatc tcaacatcca aacccctgac agccctgtca
     3001 gataagagac caaactatgg ggaaatccct gttcaagagc atctgttaag aacatcttca
     3061 gccagccggc ctgcttccct gccaagagtg cctgcgatgg aaagtgccaa gaccctctca
     3121 gtgtctcgac gaagtagtga agaagtgaaa cgggacattt ctgcacagga gggagcgtcg
     3181 ccagcctctc tgatggctat gggaaccacg tctccacagc tttccctgtc ctcttctcca
     3241 acggcatctg tgactcccac cacccgaagc cgaataagag aagaaaggaa agaccctctc
     3301 tcagcattgg ccagagaata tggaggatca aagaggaacg ccttgctgaa gtggtgtcag
     3361 aagaaaacag aaggctatca gaatattgac attacaaact tcagcagcag ctggaatgat
     3421 gggctggcct tctgtgccct cctgcataca tatctccctg cccacattcc atatcaagaa
     3481 ctgaacagcc aggataagag aaggaacttc atgctggctt tccaggcagc tgaaagtgtc
     3541 ggcatcaaat ccacactgga cattaatgaa atggtacgga ctgaacgacc cgactggcag
     3601 aacgtgatgc tgtatgtgac ggcgatctac aagtactttg agacctgagc atgccgggag
     3661 gagccgcccc aatagcgggg gtacccctcc acagcgaccg agcgacaccg acgccattag
     3721 ctacgcaccc ctgtaaagct tccagcaact ctgggctgcc ccacagcgtg tgagcctcca
     3781 gctcggggct tccgtattgg aagaactcag ccgtgtggcc cacagctccc accagggccc
     3841 ctcccacatg acccgtccat tcaggtcatg tgggctcagc acacatcctg caggccggtg
     3901 gctgctggag ttttccttct gaagagaata ttgaactaca ctagtgctcc agggcaccaa
     3961 acaaaaaggg ctcatgcaca gctgaatttg ggaaaaggga ttcagttctg tgggaaactc
     4021 actagggttg atgaaggctc ggccgcggca cttcctgact attggctggg gtgggttccg
     4081 gtgctggtga gaacccagaa ggagagtcag cgcctggcag ttcccagcgc cctgggccct
     4141 tcaccgtcct agtttggagg agcatgttca ccacagacgt gggtcagctg ccccacacct
     4201 gacggggctg tcccggccga cacaatccag gcgtgttcag cctgagctag gagagtatct
     4261 agagggcgtg gtgcgggcac gccagggctg gggtgctgct gctgcactca cgcggctggg
     4321 ctttctggcg ggaagcagtt acgggggccc cttgcctgga ctcagcgacc tgtcttccag
     4381 cctggaaggg gtttggagtc ccagctctgg ctttagattt cttcatcata aggagttttt
     4441 ctagttaaca tttttgtttt gttacgagca atgctggaaa aggtcgctcc tgttctgtta
     4501 gtaccaaagt tacattgttt caataagcat agaaatctaa acaacatctg tacattagca
     4561 tggtgagagc aaggaataaa gcaggaaata ggagaaaagt aaacaacttt agggagccca
     4621 ggcagtgtca tttaaactca ctgagtcact aagacataat tctcctaggc cagagttaaa
     4681 gaaagtgcct taactcttct tgtgagggca gccactgccc tccgtggcca aggcaggacc
     4741 tccaagactc agtggttgag ttgtctccta ccaccatgcc cgccctcccc aggtactggg
     4801 tccatgcccc ctgtgcccac cctccccagg tgctgggtcc atgctgtttg aaccaaagcc
     4861 ttatttaaag gtggtcactg gagatgctct caggccagaa ctcaacagct atttttggga
     4921 atagggatct cccgtgtgcc taacgcagta gctattggtt tgaacaatgt ccagacaaga
     4981 cctgtacctt tgagaatata actgtgtttg gcacctgcat agcaccatga ggaagaccag
     5041 ccaccagtgg aagcggggtc actgccccac agactggatg caatgagggg ctcacaggag
     5101 gcccagccag cccgattgtg ggctgagggg tctgcattca agcacgatgt tctagaatag
     5161 gagtttaacg tgtctacgta acctagaatg tggttattag gaaaggggct gtgcatgtgg
     5221 gtgcagctgg cggcacacct ggtcaccaga tggccagaag ctgcccatca gccctgccca
     5281 gatgtcagcc tgggagctca ggctgctgcc gctggctgga tgccctttgg tgaaatgcct
     5341 gttttcagct aagaaaggag aggccaggca agcaaagtca tgccacaaag catatcagag
     5401 acccccgcag actcctggcc ccgtcccgcc ccctgtctga gttgtgtttt tgttgctgtt
     5461 cctctgttga tggccagctc tgctgttggc atgagccact gatgttcatg tgagaattac
     5521 tgtttttaag tgtctctcca cttaggtgtc ctcagttccc acttttgctc tcatttgcct
     5581 tcacagaggc cactccacct gtccggatcc agctgtctgg tcatggtttg gtttatttat
     5641 tttgtccttc aggggctgtt ttgccctaag aatgaggggg cttcccctgg tctgcagttc
     5701 ccaactttat cccttgctgg ccatgcgagc ccagccctgg tgcctcatgg gatggggggg
     5761 taggggtccc caggatcttc tggaggaagg tggccatgga tggatgggct gtatctgtgt
     5821 tttccctctg ggagtctcat gggtccagca tcaggcctga ggtcagcaac agggaaagag
     5881 ggtgggcacg gggagggctt ggccccgcct atctagaggc ttgcctcggg cccctccttg
     5941 gggaaggttt gcgtgcagag ctgcaaggga gagggttcca gaagcattgc cttttgcctc
     6001 gtctaatagg atccttagga cactgtgggc tttaggaatg actatagatg ctcacacgtg
     6061 tttaaagtga catttggaga tgctctcagt cctgtggcat ctggcacgaa gtctccaaga
     6121 agccactttg cctcttctcc cttcaagcac aagctttact gcaaaagggc cagtcgcgtt
     6181 tctatttctc tcgatcccag gcttctgcgg accgacgata cgtttaaatg ttgttctagt
     6241 aaatattctt gaatgtatta aaatggctga aacaacaagc ttgggctttt ctagcttgcc
     6301 ctccactccc tgccgtccct ctgacgtcgc ataaaccaga acccagctcc ctcctgggac
     6361 tggctgtgga gagaagggca cctctgagcc agcctgtggc cctaccccaa ggcgcacttc
     6421 ctcatgtggg cagatcctga ccaggagtcc agggtggcct cccctgggcc acagcacatc
     6481 accgtgtggc ctggggctgt gggacagtga gccctgtaac cactagggtt ctgtgacaga
     6541 tgccaagacc ccagagaccg tggcagagct acccccagga gagcggaagc ccctacacag
     6601 cccagacaca tgccttccct gggggctggg gagtgtgtct cgaggggttt tgtttgtttt
     6661 gaggcatgta tcatcttgga aataattgtc aggatgtata aaatagagaa aaagaaaaaa
     6721 ggtatcctac ccagaggcaa ccagataaac ttttttgcct gtg
//
