LOCUS       NM_001243439            8255 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens sperm antigen with calponin homology and coiled-coil
            domains 1 (SPECC1), transcript variant 6, mRNA.
ACCESSION   NM_001243439
VERSION     NM_001243439.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8255)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   2  (bases 1 to 8255)
  AUTHORS   D'Agostino,L. and Giordano,A.
  TITLE     A novel dual signaling axis for NSP 5a3a induced apoptosis in head
            and neck carcinoma
  JOURNAL   Oncotarget 2 (12), 1055-1074 (2011)
   PUBMED   22170762
  REMARK    GeneRIF: NSP 5a3a induces apoptosis in Head and Neck cell line HN30
            through p73-DAXX and TRAF2-TRADD.
REFERENCE   3  (bases 1 to 8255)
  AUTHORS   Saadi,I., Alkuraya,F.S., Gisselbrecht,S.S., Goessling,W.,
            Cavallesco,R., Turbe-Doan,A., Petrin,A.L., Harris,J., Siddiqui,U.,
            Grix,A.W. Jr., Hove,H.D., Leboulch,P., Glover,T.W., Morton,C.C.,
            Richieri-Costa,A., Murray,J.C., Erickson,R.P. and Maas,R.L.
  TITLE     Deficiency of the cytoskeletal protein SPECC1L leads to oblique
            facial clefting
  JOURNAL   Am J Hum Genet 89 (1), 44-55 (2011)
   PUBMED   21703590
REFERENCE   4  (bases 1 to 8255)
  AUTHORS   D'agostino,L. and Giordano,A.
  TITLE     NSP 5a3a: a potential novel cancer target in head and neck
            carcinoma
  JOURNAL   Oncotarget 1 (6), 423-435 (2010)
   PUBMED   21311098
  REMARK    GeneRIF: Loss of NSP 5a3a is associated with head and neck
            carcinoma.
REFERENCE   5  (bases 1 to 8255)
  AUTHORS   D'Agostino,L., Caracciolo,V. and Giordano,A.
  TITLE     NSP 5a3a's link to nuclear-cyto proteins B23 and hnRNP-L between
            normal and aberrant breast cell lines
  JOURNAL   Cell Cycle 9 (6), 1131-1142 (2010)
   PUBMED   20237420
  REMARK    GeneRIF: NSP 5a3a's novel interaction with B23 and ribonuclear
            protein hnRNP-L implicates NSP 5a3a in cellular processes such as
            ribosome biogenesis and rRNA transcription .
REFERENCE   6  (bases 1 to 8255)
  AUTHORS   D'Agostino,L. and Giordano,A.
  TITLE     Possible functional role of NSPs in cancer
  JOURNAL   Cell Cycle 7 (12), 1810-1827 (2008)
   PUBMED   18763323
REFERENCE   7  (bases 1 to 8255)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   8  (bases 1 to 8255)
  AUTHORS   Sang,N., Fath,D.M. and Giordano,A.
  TITLE     A gene highly expressed in tumor cells encodes novel structure
            proteins
  JOURNAL   Oncogene 23 (58), 9438-9446 (2004)
   PUBMED   15602574
REFERENCE   9  (bases 1 to 8255)
  AUTHORS   Morerio,C., Acquila,M., Rosanda,C., Rapella,A., Dufour,C.,
            Locatelli,F., Maserati,E., Pasquali,F. and Panarello,C.
  TITLE     HCMOGT-1 is a novel fusion partner to PDGFRB in juvenile
            myelomonocytic leukemia with t(5;17)(q33;p11.2)
  JOURNAL   Cancer Res 64 (8), 2649-2651 (2004)
   PUBMED   15087372
  REMARK    GeneRIF: PCR and fluoresecne in situ hybridization shows that
            HCMOGT-1 is a novel fusion partner to PDGFRB in juvenile
            myelomonocytic leukemia with t(5;17)(q33;p11.2).
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA058164.1, AK295093.1,
            AK304186.1, BP309862.1, AK301318.1, AY816329.1, CA427363.1 and
            AC008088.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001243439.1.
            
            Summary: The protein encoded by this gene belongs to the cytospin-A
            family. It is localized in the nucleus, and highly expressed in
            testis and some cancer cell lines. A chromosomal translocation
            involving this gene and platelet-derived growth factor receptor,
            beta gene (PDGFRB) may be a cause of juvenile myelomonocytic
            leukemia. Alternatively spliced transcript variants encoding
            different isoforms have been described for this gene. [provided by
            RefSeq, Aug 2011].
            
            Transcript Variant: This variant (6) contains an alternate 5'
            terminal non-coding exon compared to variant 1. Variants 1 and 6
            encode the same isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.210580.1,
                                           SRR1803616.217951.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395527.9/ ENSP00000378898.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 DA058164.1         59-62
            5-497               AK295093.1         1-493
            498-908             AK304186.1         293-703
            909-1055            BP309862.1         435-581
            1056-2948           AK304186.1         851-2743
            2949-3510           AK301318.1         1164-1725
            3511-3984           AY816329.1         3475-3948
            3985-3988           CA427363.1         19-22               c
            3989-8255           AC008088.8         67451-71717         c
FEATURES             Location/Qualifiers
     source          1..8255
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p11.2"
     gene            1..8255
                     /gene="SPECC1"
                     /gene_synonym="CYTSB; HCMOGT-1; HCMOGT1; NSP; NSP5"
                     /note="sperm antigen with calponin homology and
                     coiled-coil domains 1"
                     /db_xref="GeneID:92521"
                     /db_xref="HGNC:HGNC:30615"
                     /db_xref="MIM:608793"
     exon            1..66
                     /gene="SPECC1"
                     /gene_synonym="CYTSB; HCMOGT-1; HCMOGT1; NSP; NSP5"
                     /inference="alignment:Splign:2.1.0"
     exon            67..234
                     /gene="SPECC1"
                     /gene_synonym="CYTSB; HCMOGT-1; HCMOGT1; NSP; NSP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..3294
                     /gene="SPECC1"
                     /gene_synonym="CYTSB; HCMOGT-1; HCMOGT1; NSP; NSP5"
                     /note="isoform 1 is encoded by transcript variant 6;
                     cytokinesis and spindle organization B; sperm antigen with
                     calponin-like and coiled coil domains 1; sperm antigen
                     HCMOGT-1; cytospin-B; structure protein NSP5a3a; structure
                     protein NSP5a3b; structure protein NSP5b3a; structure
                     protein NSP5b3b; nuclear structure protein 5"
                     /codon_start=1
                     /product="cytospin-B isoform 1"
                     /protein_id="NP_001230368.1"
                     /db_xref="CCDS:CCDS32590.1"
                     /db_xref="GeneID:92521"
                     /db_xref="HGNC:HGNC:30615"
                     /db_xref="MIM:608793"
                     /translation="MRSAAKPWNPAIRAGGHGPDRVRPLPAASSGMKSSKSSTSLAFE
                     SRLSRLKRASSEDTLNKPGSTAASGVVRLKKTATAGAISELTESRLRSGTGAFTTTKR
                     TGIPAPREFSVTVSRERSVPRGPSNPRKSVSSPTSSNTPTPTKHLRTPSTKPKQENEG
                     GEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVS
                     PGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCP
                     TSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHI
                     TAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQ
                     ATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQER
                     VKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEM
                     IKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKAT
                     EASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEK
                     DYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHN
                     NQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKC
                     EAQQELRTVKRKLLEEEEKNARLQKELGDVQGHGRVVTSRAAPPPVDEEPESSEVDAA
                     GRWPGVCVSRTSPTPPESATTVKSLIKSFDLGRPGGAGQNISVHKTPRSPLSGIPVRT
                     APAAAVSPMQRHSTYSSVRPASRGVTQRLDLPDLPLSDILKGRTETLKPDPHLRKSPS
                     LESLSRPPSLGFGDTRLLSASTRAWKPQSKLSVERKDPLAALAREYGGSKRNALLKWC
                     QKKTQGYANIDITNFSSSWSDGLAFCALLHTYLPAHIPYQELNSQEKKRNLLLAFEAA
                     ESVGIKPSLELSEMLYTDRPDWQSVMQYVAQIYKYFET"
     exon            235..370
                     /gene="SPECC1"
                     /gene_synonym="CYTSB; HCMOGT-1; HCMOGT1; NSP; NSP5"
                     /inference="alignment:Splign:2.1.0"
     exon            371..1950
                     /gene="SPECC1"
                     /gene_synonym="CYTSB; HCMOGT-1; HCMOGT1; NSP; NSP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2158
                     /gene="SPECC1"
                     /gene_synonym="CYTSB; HCMOGT-1; HCMOGT1; NSP; NSP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2159..2232
                     /gene="SPECC1"
                     /gene_synonym="CYTSB; HCMOGT-1; HCMOGT1; NSP; NSP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2233..2438
                     /gene="SPECC1"
                     /gene_synonym="CYTSB; HCMOGT-1; HCMOGT1; NSP; NSP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2439..2584
                     /gene="SPECC1"
                     /gene_synonym="CYTSB; HCMOGT-1; HCMOGT1; NSP; NSP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2585..2685
                     /gene="SPECC1"
                     /gene_synonym="CYTSB; HCMOGT-1; HCMOGT1; NSP; NSP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2686..2767
                     /gene="SPECC1"
                     /gene_synonym="CYTSB; HCMOGT-1; HCMOGT1; NSP; NSP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2768..2924
                     /gene="SPECC1"
                     /gene_synonym="CYTSB; HCMOGT-1; HCMOGT1; NSP; NSP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2925..3027
                     /gene="SPECC1"
                     /gene_synonym="CYTSB; HCMOGT-1; HCMOGT1; NSP; NSP5"
                     /inference="alignment:Splign:2.1.0"
     exon            3028..3144
                     /gene="SPECC1"
                     /gene_synonym="CYTSB; HCMOGT-1; HCMOGT1; NSP; NSP5"
                     /inference="alignment:Splign:2.1.0"
     exon            3145..3204
                     /gene="SPECC1"
                     /gene_synonym="CYTSB; HCMOGT-1; HCMOGT1; NSP; NSP5"
                     /inference="alignment:Splign:2.1.0"
     exon            3205..8255
                     /gene="SPECC1"
                     /gene_synonym="CYTSB; HCMOGT-1; HCMOGT1; NSP; NSP5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3954..3959
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPECC1"
                     /gene_synonym="CYTSB; HCMOGT-1; HCMOGT1; NSP; NSP5"
                     /note="hexamer: AATAAA"
     polyA_site      3955
                     /gene="SPECC1"
                     /gene_synonym="CYTSB; HCMOGT-1; HCMOGT1; NSP; NSP5"
                     /note="major polyA site"
     polyA_site      3988
                     /gene="SPECC1"
                     /gene_synonym="CYTSB; HCMOGT-1; HCMOGT1; NSP; NSP5"
     regulatory      5436..5441
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPECC1"
                     /gene_synonym="CYTSB; HCMOGT-1; HCMOGT1; NSP; NSP5"
                     /note="hexamer: ATTAAA"
     polyA_site      5471
                     /gene="SPECC1"
                     /gene_synonym="CYTSB; HCMOGT-1; HCMOGT1; NSP; NSP5"
ORIGIN      
        1 gagcatcagt gagcgcccgg agccgtggcc gctgggggtt gcggcggcgc tgagccagcg
       61 gggccggaca gacccacgaa gtcaagcatg cggagtgcag ccaagccctg gaacccagcc
      121 atcagagcag ggggccacgg cccagaccgg gtgcggcctc tgcctgcagc ctcttccggc
      181 atgaagagtt ctaagtcttc aacttccttg gcttttgagt cccgactcag caggctcaag
      241 agggccagca gtgaggacac gctcaacaag ccaggaagta ccgctgcatc gggggtggtt
      301 cgcctgaaga agaccgccac tgccggagcc atctcggagc tcacggagag ccgcctgagg
      361 agcggcacag gggcctttac aacaactaaa cggacaggca ttccagcccc acgggaattt
      421 tcagtaactg tctcaagaga gaggtctgtg ccacgtggtc cctccaaccc caggaaatca
      481 gtgtccagtc caacttcttc caacactccc actcctacga aacacctgag gaccccttcc
      541 acaaagccca agcaagagaa tgaaggtgga gaaaaggctg cgcttgagtc ccaagttcgg
      601 gaacttttgg cagaagccaa agcaaaagat agtgaaatta acaggcttcg aagtgaacta
      661 aagaaataca aagagaaaag gactctgaac gctgagggga ctgatgcttt gggcccaaat
      721 gtcgatggaa catcagtctc cccaggtgac acggaaccta tgataagagc tcttgaggag
      781 aagaacaaga actttcagaa agagctttcc gatctagagg aagaaaaccg ggtcctgaag
      841 gagaaactga tctatcttga gcactcccca aattcagaag gggcagcaag tcacactggc
      901 gacagcagct gcccaacatc cataactcaa gagtcaagct tcggaagccc aactggaaat
      961 cagatgtcca gtgacattga tgagtataaa aaaaacatac atggaaatgc attacggaca
     1021 tcaggctcct caagtagcga tgttaccaaa gcttctttgt cgccagatgc ttccgacttt
     1081 gagcacatta cagcagagac accctcaagg cccctgtcct ccaccagtaa cccctttaag
     1141 agttcaaagt gttctactgc tgggagttcc ccaaacagcg taagtgaatt gtccctggct
     1201 tccctcacag agaagataca aaagatggaa gaaaaccacc atagcactgc agaagaacta
     1261 caggctactc tacaagaatt atcagaccag caacaaatgg tacaggaatt gacagctgaa
     1321 aatgagaagc tggtggatga aaagacgatt ttagagacat cctttcatca gcatcgagag
     1381 agggcagagc agctaagtca agaaaatgag aagctgatga atcttttaca agagcgagta
     1441 aagaatgaag agcccaccac tcaggaagga aaaattattg aactggagca gaagtgcaca
     1501 ggtattcttg aacagggccg ctttgaaaga gagaagctac tcaacattca gcagcagttg
     1561 acctgtagct tgcggaaggt tgaggaagaa aaccaaggag ctttagaaat gattaaacgt
     1621 ctgaaggaag aaaatgaaaa actgaatgag tttctagaac tggaacggca taataataac
     1681 atgatggcca aaactttgga agagtgtaga gttaccttgg aagggctaaa aatggagaat
     1741 ggatctttga agtctcattt gcagggtgag aagcagaaag ccacagaggc cagtgctgtg
     1801 gagcagacgg cagagagctg cgaagttcaa gaaatgttga aagtagcccg agcagagaaa
     1861 gatctactgg aactgtcttg caatgagctc agacaagaat tactaaaggc aaacggtgaa
     1921 attaaacatg tttccagtct gctggccaag gtggaaaagg attattcata cctgaaggag
     1981 atatgtgatc accaagccga acagctgagc agaaccagcc taaagctgca agaaaaagca
     2041 tcagagagtg atgcagagat caaagacatg aaagaaacca tatttgaatt ggaagatcag
     2101 gtggaacagc accgggctgt caagttacac aataatcaac tcatcagtga gctagaaagt
     2161 agtgtgatca agctggagga acagaagtca gacctggaga ggcagctgaa gactctgacc
     2221 aagcagatga aggaggagac cgaggaatgg aggcggttcc aggcggatct gcagaccgca
     2281 gtggtggtgg ccaatgacat caagtgtgag gcccagcagg agctgcgcac cgtgaagagg
     2341 aaactgctgg aggaggagga gaagaatgcc cggttgcaga aggagctggg ggatgtgcag
     2401 ggccacggca gggtggtcac cagcagagcc gcccctccac ctgtggatga agagccagag
     2461 tcctctgagg tcgatgctgc tggtcggtgg cctggtgtct gtgttagcag aacatctcca
     2521 acacccccag agtcggcaac caccgttaag tcacttatca agtcatttga cttgggacgc
     2581 ccaggtggag ctggacagaa tatttctgtc cataagaccc ccagaagtcc cctaagtggg
     2641 ataccagtga ggactgctcc agcagctgct gtctctccaa tgcagaggca ttcgacttac
     2701 agcagtgtgc ggccagccag cagaggggtg actcaacgct tggaccttcc tgaccttccc
     2761 ctctcagata ttctaaaggg aaggactgag accctgaagc cagaccccca cctccgcaag
     2821 agtccctcac tagagtcact gagcagaccc ccgtctctgg gctttgggga cacaagactg
     2881 ctgagtgctt ccacccgggc atggaaacca caaagcaaac tcagtgtgga aagaaaagac
     2941 cctctggcag ccttggcccg ggaatacggt ggttccaagc gcaatgctct actgaaatgg
     3001 tgccagaaga agacacaagg ttatgcgaac attgacatca ccaatttcag cagcagctgg
     3061 agcgatggcc tggccttctg tgctctgctc cacacctacc tgcctgccca catcccctac
     3121 caggagctga atagtcagga gaaaaagagg aatctcttgt tggcatttga agcggctgaa
     3181 agtgtaggca tcaaacccag cctggaactc agcgagatgc tgtacacaga ccggcccgac
     3241 tggcagagtg tgatgcagta cgtggcccaa atctacaagt actttgagac gtaaccctgg
     3301 agggcctggg gcagccacca ttgccaccta ctgcagcttt tcctggaagc gcctgattac
     3361 tgtccactga ccctgctctg cccaccaccc agctgcctag acttcaaaga caggctcaat
     3421 ccaagtggac caacacccaa ataagaaaca gagtgggtcc cacgatgtac ctgtctgaaa
     3481 tgcaaatgca gctggactgt aaattgggga ctctttgatc tcttgtggga tgcttctaaa
     3541 gagggcagcc tccctccttc cagaccaaga ccccacaccc aggcttgttt tgctgattat
     3601 attgggtggc tgaacgaaca cattatctgc agaaattcag acaaagaaca tctccaaatc
     3661 agtcttttgg ttgctgttgt taaaaatatc ccggctttgc ctttatgaaa cctttgccct
     3721 tggctgggtg tggtagctcg tggctgtaat cccagcactt taggaagcca aggcagtagg
     3781 atcgtttgag cccaggagtt cgaggctgca gtgagctatg agcataccac tgcactccag
     3841 cctgtgtgaa agagccagac cctgtctcaa aaaaatgata aaacccaaaa ctttgccctt
     3901 gtgaaccctc ccttcccccc tcccccccca aaaaaaaaca acaaaacaca aaaaataaac
     3961 atttgttcca gggcaacctg gaaacgtgcg tgcgcactca gccttttggg gaaaaatggg
     4021 agttctaggt aacaatgtta acacctggaa cttgattcac ttttagctct caccatccct
     4081 tatttgattt attgtagcaa aaggaaagcc tgtgagaatg caagggagcc cctggctgct
     4141 ttgctggagt ccctgggagg tgccccacac ctctgccacc aaagtctgtg tgctcctgag
     4201 cagctcgcgg ctttcacagt agggaaaccg cagtcctcgt cacctgcgcc tttgtcctcc
     4261 cattcgttta ccctcccgtt cacatccaca caggcttgta ccccacagaa cttgacagga
     4321 ggtcacatgt gtgaatggcc tgtgtctgct ttacagggtt gagcaggctg agggtgtgtg
     4381 cctctgggga tgctgggctg acagcaaatc ccaacagtat ttcggctctg gactgatttg
     4441 gcctttagtg cttccccagg cctctttcat cggcatggga aaagccctta ggggtgggcg
     4501 gtgagggcac atttataact aacaaagaag aatgcagttg ccccagcatc ctactggtca
     4561 ccttaagtgg cagcagagcc ctccccagcg gtgccccagt ccctcagaag tgctcagtcc
     4621 ggcccgagtg cccatctggt ggctctgccg tgttcttctg ggcggatctg tgtgcactac
     4681 acagcgagtg agggcgtggc tcacacagtt gtttgaggga aatgggtaat gcccatccct
     4741 tgctgtttta agtgccaaat agcgtgttag cgcccctcca acaaaggatc atccttccag
     4801 tgagtcaccg agaatgacag tgactgccat tactattcaa agtacatctc tgattgctga
     4861 tctgagccac tggttcagag ccaggttcta gaggctgcag gtccagcccc ttaccattcc
     4921 tggagaggta ggagctcagt cccttcctcc aagccagacc tttgcagagg tggcaactgg
     4981 gctgcacggg tcagcagatc cctgattctc aagccacctt gagacaagaa ctccgccccc
     5041 ctgttagtgc atcccagctg cagctctgca tcagaaccta cagtggaccc ttttgaaaac
     5101 actcttggct gccctagttg gttaacttca gaatgtctgg aatgggacca gagatgcagt
     5161 tcacatgttt tgtaagttct ttaggcgact gaagcacagc tgcttggaga accactgagg
     5221 ggtggacacc ttcccctggc agccacaagg caggcagcct gcgggagctc ctgagcagct
     5281 gttgggcgat ggtcattaca tcacccatgc ctttgtattt aaatgaaact cgacacatag
     5341 aaccaattca acctgaaagt tactacttct gctgattcag gcacttgttt gaagcatttt
     5401 ttttttatta accctgtact tcttctttgc ccaccattaa agtgggggaa agtaatatcc
     5461 caagtagttg agttgagctg ttggttgtta gatttaagct ggaattagtc cagggtttta
     5521 tgtggggagg cagttgctgt cttgggatac ccggagtggg agtgggtgtt ttctgtgatt
     5581 ggttctgttt tttattttta cttatttatt ttgagatgga gtttcatcct tattgcccag
     5641 gctggagggc aatagcaccg tctcagctca ctgcaacctc cgccgcccgt gtttaagcga
     5701 ttctcctgcc tcagcctccc atgtggctgg gattacaggt gcccatcacc acacccagct
     5761 aatgtttttg tatttttagt aaagaggggg tttcaccatg ttggcccggc tggtctcgaa
     5821 ctcctgatgg caaggtgatc tgcctgcctc agcctcccaa agtgctggga ttacaggcat
     5881 gagccactga gcccggctgt ttttttgtgt tttttttgtt gttgtttgtt tgtttttttt
     5941 tttgagacag agtcttgctc tgtcgcccag gctggagtgc cagtggcgcg atttcagctc
     6001 actcaggagt gagccaccac acctggcctg tgattggctc tattttgagt gattacgtgt
     6061 aaatcatcta gaaccagctc tgagcaatgg cgttgcggtg tccctccctc cccgctgggg
     6121 ccataccagc ccctctccac tgggagccca agttgccaat gactgtggcc aaactccccc
     6181 atttttgtct gtatcctgct ctctttaggt taaaaagaag gaaagaaaca tgaaaggcca
     6241 tgtacaattt atttttacaa ctccaggagt ttccccgact accatttttt ttttttttat
     6301 ttgccagtgg tgtgcatgta gaagaggaat gccatgtcct gtccatagaa atacacatgg
     6361 tggtcaggca tggtggctca tgcctataat cccagcactt tgggaggctg aggtgggagg
     6421 attgcttgag cccaggagtt tgagaccagc ctgggcaaca tggcaagacc tctgactcta
     6481 taaaaaaatt tttttttttt tttttttttg agagagcgtc tcacttctct gtcacccagg
     6541 ctagagtagt gtgatcttgg cttattacaa cttccgcctc ccaggttcaa gagattctcc
     6601 tgccttagcc tcctaagtag ctgggattat aggcacatgc caccatgcct ggcatatttt
     6661 tgtattttta gtagaaacag tttcaccatg ttggccaggc tggtcttgaa ctcctgacct
     6721 caagtgataa gcctgcctca acctcccaaa gtgctgggac tacaggggta agccaccgcg
     6781 cctggcccaa aattttgttt tttaattagc tgggtacaat gataggcacc tgtaatctca
     6841 gctgcttggg aggctgaggt gggagcatca cttgagccca ggagtttgag gctgcagtaa
     6901 gctgtgtttg tgccactgca ctctggcctg ggccaaagag caagaccctg tcacacacac
     6961 acacaaaaaa aagaaataca ggtggtgttt tggggaaggg aaggttctgc tggggtcctg
     7021 gaactgtgac tgatggcctc aggagtccag gaataggcct tctagcacag cagctagtag
     7081 ggctccccca agccatccgc tggcgtgtgg aggtgcagga cctgggggag gcagtcccca
     7141 acccagctag gccaaggggt agggttttta ggtctgtttt taacagagct cagagcacca
     7201 ggtgaaggtg gaaagttggc aggaaaacaa ggtcagcatc ttattttttc tatactcagc
     7261 agagtgtgcc attcccagtt tctgtcctga ggatttcaaa gaccacaaca gccacatttc
     7321 tttccatctt ccctcagcca gtagtcattt aaaattcttc agttgttctg aagatccttt
     7381 ttttaatgta tcatttttac atgaaagaca gctgcaaaat gcaagcccca gtagagttgg
     7441 agagtttttc aaggtgagaa gtcgctgttc tctgcattga acatggattg aattttcctt
     7501 gtctgatggt aacccatggc ccccgccctg cggggataac attctcagga gcttctcttg
     7561 tcctagcccc ttctcatttc aaaaatatta gtcttttatt ttcctttttc attcagtttt
     7621 tgttttacag cttttgtaga gaccaaccca agtagatgca ggtgggtgtt agataaaaac
     7681 acacatcccc aggggacaag ccatccagcg gtgaggaatc tctgccatgt tctcttccct
     7741 gctgcccaca aacgttacgg agactccctt agcctccccc tcctcttccc cactgagggg
     7801 cagcttgtgg agatggagga ctcgggccca tagatgcaga ccccctacca aatctagcaa
     7861 tagttctcac ccttccaaag ctcgagtgcc attttgagat gacctaccaa tgacatgcag
     7921 taaaggacat aacctcacag cctttttaga agcatttcga atatctacag ttgcctcaat
     7981 tcacggggca tttcactcct ctgatccagg ttagaatttt gctaaatctg tagcatcctg
     8041 aatagcacac taattttttt ttttagcaca ctaactttaa ctacattagt tgagtgtagt
     8101 tgatacatct gtggcctcgt gtctataaag agcacactag attgtaccca gcacttttgg
     8161 atatgacatg ctaattagat gtatttaact attcatagga aagtgtatga taaatgactg
     8221 taatatttct aataaatata ttttgtttct aatta
//
