LOCUS       NM_001146210            3151 bp    mRNA    linear   PRI 11-OCT-2024
DEFINITION  Homo sapiens speedy/RINGO cell cycle regulator family member E6
            (SPDYE6), mRNA.
ACCESSION   NM_001146210 XM_001131696 XM_930439
VERSION     NM_001146210.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3151)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3151)
  AUTHORS   Chauhan,S., Zheng,X., Tan,Y.Y., Tay,B.H., Lim,S., Venkatesh,B. and
            Kaldis,P.
  TITLE     Evolution of the Cdk-activator Speedy/RINGO in vertebrates
  JOURNAL   Cell Mol Life Sci 69 (22), 3835-3850 (2012)
   PUBMED   22763696
REFERENCE   3  (bases 1 to 3151)
  AUTHORS   Gopinathan,L., Ratnacaram,C.K. and Kaldis,P.
  TITLE     Established and novel Cdk/cyclin complexes regulating the cell
            cycle and development
  JOURNAL   Results Probl Cell Differ 53, 365-389 (2011)
   PUBMED   21630153
  REMARK    Review article
REFERENCE   4  (bases 1 to 3151)
  AUTHORS   Nebreda,A.R.
  TITLE     CDK activation by non-cyclin proteins
  JOURNAL   Curr Opin Cell Biol 18 (2), 192-198 (2006)
   PUBMED   16488127
  REMARK    Review article
REFERENCE   5  (bases 1 to 3151)
  AUTHORS   Dinarina,A., Perez,L.H., Davila,A., Schwab,M., Hunt,T. and
            Nebreda,A.R.
  TITLE     Characterization of a new family of cyclin-dependent kinase
            activators
  JOURNAL   Biochem J 386 (Pt 2), 349-355 (2005)
   PUBMED   15574121
REFERENCE   6  (bases 1 to 3151)
  AUTHORS   Cheng,A., Xiong,W., Ferrell,J.E. Jr. and Solomon,M.J.
  TITLE     Identification and comparative analysis of multiple mammalian
            Speedy/Ringo proteins
  JOURNAL   Cell Cycle 4 (1), 155-165 (2005)
   PUBMED   15611625
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC091390.1 and HY053642.1.
            
            On May 17, 2019 this sequence version replaced NM_001146210.3.
            
            Summary: This gene encodes a cell cycle regulatory protein which
            plays an important role in cell cycle progression by binding and
            activating cyclin-dependent kinases. The encoded protein belongs to
            a family of cyclin-dependent kinase regulators that contain a
            speedy box domain which is required for cyclin-dependent kinase
            activation. [provided by RefSeq, Jul 2017].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            CCDS Note: This CCDS representation lacks full-length human
            transcript support. Its representation is therefore inferred, but
            it is supported by paralogous transcripts.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1968968, SAMEA1970526
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000563237.3/ ENSP00000485230.1
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-581               AC091390.1         32762-33342
            582-800             AC091390.1         34285-34503
            801-1031            AC091390.1         35818-36048
            1032-1090           AC091390.1         37082-37140
            1091-1176           AC091390.1         38393-38478
            1177-1570           AC091390.1         40529-40922
            1571-1675           AC091390.1         41045-41149
            1676-3150           AC091390.1         41985-43459
            3151-3151           HY053642.1         285-285
FEATURES             Location/Qualifiers
     source          1..3151
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..3151
                     /gene="SPDYE6"
                     /note="speedy/RINGO cell cycle regulator family member E6"
                     /db_xref="GeneID:729597"
                     /db_xref="HGNC:HGNC:35465"
     exon            1..581
                     /gene="SPDYE6"
                     /inference="alignment:Splign:2.1.0"
     CDS             422..1630
                     /gene="SPDYE6"
                     /note="Putative speedy protein E6; speedy homolog E6"
                     /codon_start=1
                     /product="speedy protein E6"
                     /protein_id="NP_001139682.2"
                     /db_xref="CCDS:CCDS78265.1"
                     /db_xref="GeneID:729597"
                     /db_xref="HGNC:HGNC:35465"
                     /translation="MDRTETRFRKRGQITGKITTSRQPHPQNEQSPQRSTSGYPLQEV
                     VDDEMLGPSAPGVDPSPPCRSLGWKRKREWSDESEEEPEKELAPEPEETWVVEMLCGL
                     KMKLKQQRVSSILPEHHKDFNSQLAPGVDPSPPHRSFCWKRKMEWWDESEESLEEEPR
                     KVLAPEPEEIWVAEMLCGLKMKLKRRRVSLVLPEHHEAFNRLLEDPVIKRFLAWDKDL
                     RVSDKYLLAMVIAYFSRAGFPSWQYQRIHFFLALYLANDMEEDDEDSKQNIFHFLYRK
                     NRSRIPLLRKRWFQLGHSMNPRARKNRSRIPLLRKRRFQLYRSTNPRARKNRSRIPLL
                     RKHRFQLYRSMNSRARKNRSQIVLFQKRRFHFFCSMSCRAWVSPEELEEIQAYDPEHW
                     VWARDRAHLS"
     exon            582..800
                     /gene="SPDYE6"
                     /inference="alignment:Splign:2.1.0"
     exon            801..1031
                     /gene="SPDYE6"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1090
                     /gene="SPDYE6"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1176
                     /gene="SPDYE6"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1570
                     /gene="SPDYE6"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1675
                     /gene="SPDYE6"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..3151
                     /gene="SPDYE6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actggactct gaaatgggca tgtacagaga cgaagagacc ccaacatgct tcaggctttg
       61 agtggagagg acacagcctc tgctgggaca gggaatagag ggatgtggag tccctgaaga
      121 tgcttttgga caatggtctg aggttgggac agtggcagga gataccattc acccaggatc
      181 tccaggacaa gagatcagcc tggcagttac atgtgttttt tttcaaactg gttgccaggt
      241 tggcatgaac gatgacatca gagattccga ccttcctgat tggagggacc ggactccgtg
      301 gtgcctggag atcagttgga caacagtatc ttctcagagc tgttctctac tcctgacttc
      361 tcctaggctt gagaattgat aacatactct tctggatcct agaagtgtcc agaagaaggc
      421 catggacaga acggagacta ggttccgtaa gaggggacag attacgggaa agatcacgac
      481 cagccgtcaa ccgcaccccc agaatgagca gagtccccag cggagcacct cggggtaccc
      541 cctccaggag gtggtggatg atgaaatgtt gggaccatca gcccctgggg tagatcccag
      601 ccccccatgt aggtcccttg gctggaaaag gaagagggag tggtcagatg aatctgagga
      661 ggagccggag aaggagctcg cccctgagcc tgaggagacc tgggtagtgg agatgctgtg
      721 tgggctcaag atgaagctga agcaacagcg agtgtcatcc atcctccctg agcaccacaa
      781 ggacttcaac agtcagcttg cccctggggt agatcccagc cccccgcata ggtccttttg
      841 ctggaaaagg aagatggagt ggtgggacga atctgaggag tcgttggagg aggagccacg
      901 gaaggtgctc gcccctgagc ctgaggagat ctgggtggcg gagatgctgt gtggcctcaa
      961 gatgaagctg aagcgacggc gagtgtcgct cgtgctccct gagcaccacg aggccttcaa
     1021 caggctgctt gaggatcctg tcattaaaag attcttggcc tgggacaaag atctgagggt
     1081 gtcggacaag tatctcctgg ctatggtcat agcgtatttc agccgggctg gcttcccctc
     1141 ctggcaatac caacgcattc atttcttcct ggctctctac ctggccaatg acatggagga
     1201 ggacgacgag gactccaaac aaaacatctt ccacttcctg tataggaaga accgctctcg
     1261 catacccttg ctccgtaagc gttggttcca gttaggccat tccatgaacc cgagggccag
     1321 gaagaaccgc tctcgcatac ccttgctccg taagcgtcgg ttccagttat accgttccac
     1381 gaacccgagg gccaggaaga accgctctcg catacccttg ctccgtaagc atcggttcca
     1441 gttataccgt tccatgaact cgagggccag gaagaaccgc tctcagatag tcctgttcca
     1501 gaaacgacgg ttccacttct tctgttccat gagctgcagg gcttgggttt ccccagagga
     1561 gttggaggag atccaggctt atgacccaga gcactgggtg tgggcgcgag atcgcgctca
     1621 cctttcctag agctccaggg accggggagg cctgaggtca tcggcctgag agaagaacac
     1681 cggacccagg ggagatgtgg attttcagca ggaactttat tccaatgcta atggcagaca
     1741 ccaggcagga ggagaggaac catttgtgca gatcatctag aagaacctgg accattcttg
     1801 atggagctga atacagtgat cacgttgtcc tcctaggagc aggggtgggg ggaggggggt
     1861 ggggtccttc taggagtcct tggagaaaag taagaaacca ggagcgtttc cagttccacc
     1921 ctttcctgcg gcaccaccac cctttttata ttgctgaatt ccaacctccc tggggcggaa
     1981 cctggaggtc ctgtttctta cggacttgca gtccaggagg atttgaaggc acaatgcagg
     2041 ggctcagatt gggacagaat tcttttgtga aatatcagtg ccacagattg taacagatag
     2101 cttcatgcac actctgcatt ttattggttt gtttggaaaa tgtcggccat tgaattattc
     2161 atagatttat ttcaaatagt ttggaaattg ttgtactttt gaaaacatgc tgttcctgta
     2221 gttttttgat gagagttata gttgttatat atacataaag ctaattttct tttcattttt
     2281 aagagacaat tcttttatcc taaatatttt attatcttta aatttgtttc tgtattatta
     2341 tatgtgctcc tgaagcgagc actcttttta tctatgatac ttccataata atctcttcta
     2401 tttatagcta ttggtagttc cccaccagaa aaatacataa ttctggtgat agaaattttt
     2461 atttgctgtt taggtttgtg actgaattgt gagaattcag ttgtgatttt taacatgtct
     2521 cagatatata tactaacacg tctaatatat actatctatt ttattggttt attttgaaaa
     2581 acatgggtat agaattattt aaatattatt ttatttattt aaatatttat taaatatatt
     2641 tatttattta aatattattt ttacattaaa tattatttta aatattttgg aaatactggt
     2701 atttttgaat agatgctgtt tctacaaagc tgtgtgatgg gtattataac tgttatatac
     2761 acatacatat aattttgttt tcctttttaa gagaggattc ttttcatcct aaatctttta
     2821 cctttcaatc tttgtatcta ttattacacg tgctgctgaa gggagcatgg attttatcta
     2881 tgatacttag ttaacatata tattacattt atagctatgt agtagttccc ctaaattctt
     2941 gtaaaaataa atttttattt gatatttcat atatgtttga aatgtgagaa ttcagatgta
     3001 attttttacc ttgttttggc atgtttgtat attactttaa agagaatgtg tgttctaaag
     3061 gaggacatga gctgtgtgtt ttcaagagaa caatagagtg ggtctcttgg ggaaacataa
     3121 taaaaatgaa cttttctcac cttcacagca a
//
