LOCUS       NM_001394956            2307 bp    mRNA    linear   PRI 06-AUG-2024
DEFINITION  Homo sapiens speedy/RINGO cell cycle regulator family member E4
            (SPDYE4), transcript variant 1, mRNA.
ACCESSION   NM_001394956 XM_005256633
VERSION     NM_001394956.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2307)
  AUTHORS   Alerasool,N., Leng,H., Lin,Z.Y., Gingras,A.C. and Taipale,M.
  TITLE     Identification and functional characterization of transcriptional
            activators in human cells
  JOURNAL   Mol Cell 82 (3), 677-695 (2022)
   PUBMED   35016035
REFERENCE   2  (bases 1 to 2307)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009451.21.
            
            On May 12, 2021 this sequence version replaced XM_005256633.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC146966.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA2148093 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000689094.1/ ENSP00000509506.1
            RefSeq Select criteria    :: based on manual assertion, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-273               AC009451.21        62695-62967
            274-504             AC009451.21        63749-63979
            505-563             AC009451.21        64805-64863
            564-649             AC009451.21        65636-65721
            650-818             AC009451.21        67752-67920
            819-922             AC009451.21        68044-68147
            923-2307            AC009451.21        69004-70388
FEATURES             Location/Qualifiers
     source          1..2307
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..2307
                     /gene="SPDYE4"
                     /note="speedy/RINGO cell cycle regulator family member E4"
                     /db_xref="GeneID:388333"
                     /db_xref="HGNC:HGNC:35463"
                     /db_xref="MIM:617628"
     exon            1..273
                     /gene="SPDYE4"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..878
                     /gene="SPDYE4"
                     /note="putative Speedy protein E4; speedy homolog E4"
                     /codon_start=1
                     /product="speedy protein E4"
                     /protein_id="NP_001381885.1"
                     /db_xref="CCDS:CCDS45609.1"
                     /db_xref="GeneID:388333"
                     /db_xref="HGNC:HGNC:35463"
                     /db_xref="MIM:617628"
                     /translation="MASGQARPPFEEESPQPSTTVRSPEVVVDDEVPGPSAPWIDPSP
                     QPQSLGLKRKSEWSDESEEELEEELELERAPEPEDTWVVETLCGLKMKLKRKRASSVL
                     PEHHEAFNRLLGDPVVQKFLAWDKDLRVSDKYLLAMVIAYFSRAGLFSWQYQRIHFFL
                     ALYLASDMEEDNQAPKQDIFSFLYGKNYSQRPLFHKLRYQLLCSMRWRTWVSPEEMEE
                     IQAYDPEHWVWARDRTLIS"
     exon            274..504
                     /gene="SPDYE4"
                     /inference="alignment:Splign:2.1.0"
     exon            505..563
                     /gene="SPDYE4"
                     /inference="alignment:Splign:2.1.0"
     exon            564..649
                     /gene="SPDYE4"
                     /inference="alignment:Splign:2.1.0"
     exon            650..818
                     /gene="SPDYE4"
                     /inference="alignment:Splign:2.1.0"
     exon            819..922
                     /gene="SPDYE4"
                     /inference="alignment:Splign:2.1.0"
     exon            923..2307
                     /gene="SPDYE4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2102..2107
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPDYE4"
                     /note="hexamer: AATAAA"
     polyA_site      2124
                     /gene="SPDYE4"
                     /note="major polyA site"
     regulatory      2281..2286
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPDYE4"
                     /note="hexamer: AATAAA"
     polyA_site      2307
                     /gene="SPDYE4"
ORIGIN      
        1 aggtggacaa cagcaacttc tcagaactac tcttcactcc taacttctcc cgagcctcta
       61 gaagagaaac gcactcttct gggtcctaac ggagtctgga agaaggcttt ggacagaaca
      121 gggactaggt tttgtggaca gaaacaaagt gtttgggaga gattatggcc agtggtcaag
      181 cgcgcccccc gtttgaggag gagagccccc agcctagcac aacggtacgg tcccccgagg
      241 tggtggtgga tgatgaagtg ccaggaccat cagccccttg gatagatccc agcccccagc
      301 ctcaatccct tggcctgaaa aggaagagcg aatggtcaga cgaatccgag gaggagctgg
      361 aggaggagct ggagttggag cgcgcccctg agcccgagga cacctgggtg gtggagacgc
      421 tgtgtgggct caagatgaag ctgaagcgaa agcgagcatc ctccgtgctc cctgagcacc
      481 acgaggcctt caacaggctc cttggggatc ctgtcgttca aaaattcctg gcctgggaca
      541 aagacctgag ggtgtcagac aagtatctcc tggctatggt catagcgtat tttagccgtg
      601 ccggcctctt ctcgtggcaa taccaacgca ttcatttctt cctggctctc tacctggcca
      661 gtgacatgga ggaggacaac caggccccga aacaagacat cttctccttc ctctacggga
      721 agaactactc ccagcgaccc ttgttccata agcttcgata ccagctcctc tgttccatgc
      781 gctggaggac gtgggtttcc ccagaggaga tggaggagat ccaggcttat gacccagagc
      841 actgggtgtg ggcccgagat cgcaccctca tttcctagag ctccggggac atggaggcct
      901 gaggtcatcg gcctgaggga agaacactgg gcccagggga gatgggaatt ttcagcagga
      961 agtttatcgc gacgctaatg ccagacacca ggaagggaga gaggagcctc ctgtgcagat
     1021 catctagaag aagctggact cttctagaag gggcaaaata gattgaccag gttttcctcc
     1081 taggagccat ggaggtattt ctaggagtca gtggagggaa agtgagaaac caggggtgtt
     1141 tctggttcca ccccttcctg cggcaaaacc tcccttttca cgttgctgaa tcccagcctc
     1201 ccctgggctg gaagctggag ttcctgtttc ctatggactt ggttgccaca gtccagagca
     1261 tttgaaggca cagcgcaggc actcagattg ttacggaatt ctttgtaaaa tatgaaatta
     1321 ctgccatagg attttaagag atagtttaat agatactgta cattttgttg gtttattttt
     1381 caaatgttgg ccatagaatt attactaggt tgatttaaaa tagtttgggg tttttgtagt
     1441 tttgaaaaca tgctgttcct atagagttct ctgacggttg ttatatacac ataaatataa
     1501 tttagttttc atttttaaga gaggattctt tttatcgtaa atgttttctc tttaaatcgt
     1561 tttatctatt attaaatgtg ctcctgaagc gagcactctt gtaatctatg atactgacct
     1621 aatatatcca ttatatttat agctaggtgg tagttcccct acattcttgc aaatagaaat
     1681 gtttattttc tgtttactgt ttgttactga attgtgagaa ttcagttgtg atttttaaca
     1741 tgccttccat atatactaac atgtccaata tatactatac attttatttg tttattttga
     1801 aaatgatggg catggcatta ttactacatt tatttaacta gtttagaaat acaagtattt
     1861 tttaaaagac actgttctta tgaagttgtg tgatgggtgt tacacctgtt atatacacat
     1921 agatataatt ctgttttcat ttttaagaga ggattctttt tatcctaaat gttttatttt
     1981 taaatctttt tatctgttat tacatgtgct gctgaaggga gcactgttat gacctagagt
     2041 agttacataa tatatctatt ctatttatag ctaggtggca tttccccgaa attcttgtaa
     2101 aaataaattt ttatttgatg ttgagtgttt gtttgttatt gaactgtgag aattcagacg
     2161 taatttttta gcttgtattg aaaggtttgt atgttacttt aaagaggaca tgtgtttgaa
     2221 aggaggacag gagctgtgtg tttcaaagag gacagtgcac tgcgctacct gggaaaatgc
     2281 aataaagatg aagttttctc atcttca
//
