LOCUS       NM_001394953            3077 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens speedy/RINGO cell cycle regulator family member E18
            (SPDYE18), transcript variant 1, mRNA.
ACCESSION   NM_001394953
VERSION     NM_001394953.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3077)
  AUTHORS   Rose,J.E., Behm,F.M., Drgon,T., Johnson,C. and Uhl,G.R.
  TITLE     Personalized smoking cessation: interactions between nicotine dose,
            dependence and quit-success genotype score
  JOURNAL   Mol Med 16 (7-8), 247-253 (2010)
   PUBMED   20379614
  REMARK    GeneRIF: Clinical trial of gene-disease association and
            gene-environment interaction. (HuGE Navigator)
            Erratum:[Mol Med. 2012;18(1):729]
REFERENCE   2  (bases 1 to 3077)
  AUTHORS   Dias Neto,E., Correa,R.G., Verjovski-Almeida,S., Briones,M.R.,
            Nagai,M.A., da Silva,W. Jr., Zago,M.A., Bordin,S., Costa,F.F.,
            Goldman,G.H., Carvalho,A.F., Matsukuma,A., Baia,G.S., Simpson,D.H.,
            Brunstein,A., de Oliveira,P.S., Bucher,P., Jongeneel,C.V.,
            O'Hare,M.J., Soares,F., Brentani,R.R., Reis,L.F., de Souza,S.J. and
            Simpson,A.J.
  TITLE     Shotgun sequencing of the human transcriptome with ORF expressed
            sequence tags
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3491-3496 (2000)
   PUBMED   10737800
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC007000.2.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR5189667.205565.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA1965299,
                                    SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000510091.4/ ENSP00000509550.1
            RefSeq Select criteria    :: based on manual assertion, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                AC007000.2         39094-39156         c
            64-644              AC007000.2         36951-37531         c
            645-863             AC007000.2         35778-35996         c
            864-1094            AC007000.2         34235-34465         c
            1095-1153           AC007000.2         33148-33206         c
            1154-1239           AC007000.2         31834-31919         c
            1240-1483           AC007000.2         29558-29801         c
            1484-1588           AC007000.2         29331-29435         c
            1589-3077           AC007000.2         26989-28477         c
FEATURES             Location/Qualifiers
     source          1..3077
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q11.23"
     gene            1..3077
                     /gene="SPDYE18"
                     /note="speedy/RINGO cell cycle regulator family member
                     E18"
                     /db_xref="GeneID:100505767"
                     /db_xref="HGNC:HGNC:51514"
     exon            1..63
                     /gene="SPDYE18"
                     /inference="alignment:Splign:2.1.0"
     exon            64..644
                     /gene="SPDYE18"
                     /inference="alignment:Splign:2.1.0"
     CDS             485..1543
                     /gene="SPDYE18"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Speedy protein E18"
                     /codon_start=1
                     /product="speedy protein E18 isoform 1"
                     /protein_id="NP_001381882.1"
                     /db_xref="CCDS:CCDS94131.1"
                     /db_xref="GeneID:100505767"
                     /db_xref="HGNC:HGNC:51514"
                     /translation="MDRTKTRFRKRGQITGKITTSRQPHPQNEQSLQRSTSGYPLQEV
                     VDDEVLGPSAPGVDPSPPCRSLGWKRKKEWSDESEEEPEKELAPEPEETWVVEMLCGL
                     KMKLKQQRVSPILPEHHKDFNSQLAPGVDPSPPHRSFCWKRKREWWDESEESLEEEPR
                     KVLAPEPEEIWVAEMLCGLKMKLKRRRVSLVLPEHHEAFNRLLEDPVIKRFLAWDKDL
                     RVSDKYLLAMVIAYFSRAGLPSWQYQRIHFFLALYLANDMEEDDEDPKQNIFYFLYGK
                     TRSRIPLVRNRRFQLCRCLNPRARKNRSQIALFQKLRFQFFCSMSGRAWVSREELEEI
                     QAYDPEHWVWARDRARLS"
     exon            645..863
                     /gene="SPDYE18"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1094
                     /gene="SPDYE18"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1153
                     /gene="SPDYE18"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1239
                     /gene="SPDYE18"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1483
                     /gene="SPDYE18"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1588
                     /gene="SPDYE18"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..3077
                     /gene="SPDYE18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3039..3044
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPDYE18"
                     /note="hexamer: AATAAA"
     regulatory      3045..3050
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPDYE18"
                     /note="hexamer: AATGAA"
     polyA_site      3065
                     /gene="SPDYE18"
                     /note="major polyA site"
     polyA_site      3077
                     /gene="SPDYE18"
                     /note="major polyA site"
ORIGIN      
        1 accctcagca gagacagacc ccagatctgg gcccaggact ttgtgcaggg aggggaaatg
       61 cagactggac tctgaaatgg gcatgtacag agatgaagag accccaacat gcttcaggct
      121 ttgagtggag aggacacagc ctctgctggg acagggaaca cagggatgtg gagtccctga
      181 agatgctttt ggacaatggt ctgaggttgg gacagtggca ggagatacca ttcacccagg
      241 atctccagga caagagatca gcctggcagt tacatgtgtt ttttttcaaa ctggttgcca
      301 ggttggcatg aacgatgaca tcagagattc cgaccttcct gattggaggg accggactcc
      361 gtggtgcctg gagatcagtt ggacaacagt atcttctcag agctgttctc cactcctgac
      421 ttctcctagg cttgagaatt gataacatac tcttctggat cctagcagtg tccagaagaa
      481 ggccatggac agaacgaaga ctaggttccg taagagggga cagattacgg gaaagatcac
      541 gaccagccgt caaccgcacc cccagaatga gcagagtctc cagcggagca cctcggggta
      601 ccccctccag gaggtggtgg atgatgaagt gttgggacca tcagcccctg gggtagatcc
      661 cagcccccca tgtaggtccc ttggctggaa aaggaagaag gagtggtcag atgaatctga
      721 ggaggagccg gagaaggagc tcgcccctga gcctgaggag acctgggtag tggagatgct
      781 gtgtgggctc aagatgaagc tgaagcaaca gcgagtgtca cccatcctcc ctgagcacca
      841 caaggacttc aacagtcagc ttgcccctgg ggtagatccc agccccccgc ataggtcctt
      901 ttgctggaaa aggaagaggg agtggtggga cgaatctgag gagtcgttgg aggaggagcc
      961 acggaaggtg ctcgcccctg agcctgagga gatctgggtg gcggagatgc tgtgtggcct
     1021 caagatgaag ctgaagcgac ggcgagtgtc gctcgtgctc cctgagcacc acgaggcctt
     1081 caacaggctg cttgaggatc ctgtcattaa aagattcctg gcctgggaca aagatctgag
     1141 ggtgtcggac aagtatctcc tggctatggt catagcgtat ttcagccggg ccggcctccc
     1201 ctcctggcaa taccaacgca ttcatttctt cctggctctc tacctggcca atgacatgga
     1261 ggaggacgac gaggacccca aacaaaacat cttctacttc ctgtatggga agacccgctc
     1321 tcgcataccc ttggtccgta accgtcggtt ccagttatgc cgttgcttga acccgagggc
     1381 caggaagaac cgctctcaga tagccctgtt ccagaaactt cggttccagt tcttctgttc
     1441 catgagcggc agggcttggg tttcccggga ggagttggag gagatccagg cttatgaccc
     1501 agagcactgg gtgtgggcgc gagatcgcgc tcgcctttcc tagagctcca gggaccgtgg
     1561 aggcctgagg tcatcggcct gagagaagaa caccggaccc aggggagatg tggattttca
     1621 gcaggaactt tattccaatg ctaatggcag acaacaggaa agaggagagg aaccatttgt
     1681 gcagatcatc tagaagaacc tggaccattc ttgatggagc tgaatacagt gatcacgttg
     1741 tcctcctggg agcaggggtg gggggagggg ggtggggtcc ttctaggagt ccttggagaa
     1801 aagtaagaaa acaggagtgt ttccagttcc accctttcct gcggcaccac caccctttct
     1861 atattgctga attccaacct ccctgggccg gaacctggag gtcctgtttc ttacagactt
     1921 ggttgccaca gtccaggagc atttgaaggc acaatgcagg ggctcagatt ggcacagaat
     1981 tcttttgtga aatatcagtg ccacagattg taacagatag cttcatgcac actctgcatt
     2041 ttattggttt gtttggaaat gttggccatt gaattattca tagatttatt tcaaatagtt
     2101 tggaaattgt tgtacttttg aaaacatgct gttcctgtag ttttttgatg agagttatag
     2161 ttgttatata tacataaaga taattttctt ttcattttta agagacaatt ctttttatcc
     2221 taaatatttt attatcttta aatttgtttc tgtattatta tatgtgctcc tgaagcgagc
     2281 actcttttta tctatgatac ttccataaaa atctcttcta tttatagcta ttggtagttc
     2341 cccaccagaa aaaaacataa ttctggtgat agaaattttt atttgctgtt taggtttgtg
     2401 actgaattgt gagaattcag ttgtgatttt taacatgtct cagatatata tactaacacg
     2461 tctaatacat actatctaat ttattggttt attttgaaaa acatgggtat agaattattt
     2521 aagtattatt ttatttattg aaatatttat taaatatatt tatttattta aatattatta
     2581 ttactttaaa tattatttta aatattttgg aaatactggt atttttgaat agatgctgtt
     2641 tctataaagc tgtgtgatgg gtgttataac tattatatac acatacatat aattttgttt
     2701 tcctttttaa gagaggattc ttttcatcct aaatctttta cctttcaatc tttgtatcta
     2761 ttattacacg tgctgctgaa gggagcatgg tttttatctg tgatacttag ttaacatata
     2821 tattacattt atagctatgt agtagttccc ctaaattctt gtaaaaataa atttttattt
     2881 gatatttcat atatgtttga aatgtgagaa ttcagatgta attttttacc ttgttttggc
     2941 atctttgtat gttactttaa agaggatgtg tgttctaaag gaggacatga gctgtgtgtt
     3001 ttcaagagaa caatagagtg cgtctcttgt ggaaacataa taaaaatgaa cttttctcac
     3061 cttcacagca actgtga
//
