LOCUS       NM_001351351            2900 bp    mRNA    linear   PRI 10-DEC-2024
DEFINITION  Homo sapiens speedy/RINGO cell cycle regulator family member E17
            (SPDYE17), mRNA.
ACCESSION   NM_001351351 XM_006716212
VERSION     NM_001351351.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2900)
  AUTHORS   Chauhan,S., Zheng,X., Tan,Y.Y., Tay,B.H., Lim,S., Venkatesh,B. and
            Kaldis,P.
  TITLE     Evolution of the Cdk-activator Speedy/RINGO in vertebrates
  JOURNAL   Cell Mol Life Sci 69 (22), 3835-3850 (2012)
   PUBMED   22763696
REFERENCE   2  (bases 1 to 2900)
  AUTHORS   Gopinathan,L., Ratnacaram,C.K. and Kaldis,P.
  TITLE     Established and novel Cdk/cyclin complexes regulating the cell
            cycle and development
  JOURNAL   Results Probl Cell Differ 53, 365-389 (2011)
   PUBMED   21630153
  REMARK    Review article
REFERENCE   3  (bases 1 to 2900)
  AUTHORS   Nebreda,A.R.
  TITLE     CDK activation by non-cyclin proteins
  JOURNAL   Curr Opin Cell Biol 18 (2), 192-198 (2006)
   PUBMED   16488127
  REMARK    Review article
REFERENCE   4  (bases 1 to 2900)
  AUTHORS   Dinarina,A., Perez,L.H., Davila,A., Schwab,M., Hunt,T. and
            Nebreda,A.R.
  TITLE     Characterization of a new family of cyclin-dependent kinase
            activators
  JOURNAL   Biochem J 386 (Pt 2), 349-355 (2005)
   PUBMED   15574121
REFERENCE   5  (bases 1 to 2900)
  AUTHORS   Cheng,A., Xiong,W., Ferrell,J.E. Jr. and Solomon,M.J.
  TITLE     Identification and comparative analysis of multiple mammalian
            Speedy/Ringo proteins
  JOURNAL   Cell Cycle 4 (1), 155-165 (2005)
   PUBMED   15611625
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC007000.2 and AC114737.3.
            
            On May 11, 2021 this sequence version replaced NM_001351351.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA1968968, SAMEA2144335
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000671986.3/ ENSP00000501236.1
            RefSeq Select criteria    :: based on manual assertion, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-122               AC007000.2         8838-8959           c
            123-705             AC007000.2         7039-7621           c
            706-924             AC007000.2         5831-6049           c
            925-983             AC007000.2         4740-4798           c
            984-1069            AC007000.2         3427-3512           c
            1070-1313           AC007000.2         1466-1709           c
            1314-1418           AC007000.2         1239-1343           c
            1419-1803           AC007000.2         1-385               c
            1804-2900           AC114737.3         96131-97227         c
FEATURES             Location/Qualifiers
     source          1..2900
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q11.23"
     gene            1..2900
                     /gene="SPDYE17"
                     /note="speedy/RINGO cell cycle regulator family member
                     E17"
                     /db_xref="GeneID:102723849"
                     /db_xref="HGNC:HGNC:51513"
     exon            1..122
                     /gene="SPDYE17"
                     /inference="alignment:Splign:2.1.0"
     exon            123..705
                     /gene="SPDYE17"
                     /inference="alignment:Splign:2.1.0"
     CDS             576..1373
                     /gene="SPDYE17"
                     /codon_start=1
                     /product="putative speedy protein E17"
                     /protein_id="NP_001338280.1"
                     /db_xref="CCDS:CCDS94130.1"
                     /db_xref="GeneID:102723849"
                     /db_xref="HGNC:HGNC:51513"
                     /translation="MGQILGKIMMSHQPQPQEERSPQRSTSGYPLQEVVDDEVSGPSA
                     PGVDPSPPRRSLGWKRKRECLDESDDEPEKELAPEPEETWVAETLCGLKMKAKRRRVS
                     LVLPEYYEAFNRLLEDPVIKRLLAWDKDLRVSDKYLLAMVIAYFSRAGLPSWQYQRIH
                     FFLALYLANDMEEDDEAPKQNIFYFLYEETRSHIPLLSELWFQLCRYMNPRARKNCSQ
                     IALFRKYRFHFFCSMRCRAWVSLEELEEIQAYDPEHWVWARDRAHLS"
     exon            706..924
                     /gene="SPDYE17"
                     /inference="alignment:Splign:2.1.0"
     exon            925..983
                     /gene="SPDYE17"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1069
                     /gene="SPDYE17"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1313
                     /gene="SPDYE17"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1418
                     /gene="SPDYE17"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..2900
                     /gene="SPDYE17"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aacaatggga cttccatagc aatgggattt ccttccgcat tcagtttgtg cctttcccat
       61 gagcgagaga ctcctaggag agccgcagcc cgttaggaag ccatgtggga actcatccac
      121 agactggact ctgaaacggg catgtacaga gaagaggaga ccccaacacg cttcaagctt
      181 tgagtggaga ggacacagcc tctgctggga cagggaacag agggatgcgg agaccctgaa
      241 gatgcttttg gacagtggtc tgaggttggg acagtggcag gagataccat tcacccagga
      301 tctccaggac aagagatcag cctggcagtt acatgtgttt tttttcaaac tggttgccag
      361 gttggcatga gcgatgacat cagagattcc gaccttcctg attggaggga ccggactctg
      421 tcggcacctg ggagttcagt tggacaacag taacttctca gagctgttct ccactcctga
      481 cttctcccag cctcgagaat tgataacaca ctcttctgga tcccagcagt gtccagaaga
      541 agaccaagga cagaacagag actaggtttg gtgagatggg acagattttg ggaaagatca
      601 tgatgagcca tcaaccgcag ccccaggaag agcggagccc ccagcggagc acctcagggt
      661 accccctcca ggaggtggtg gatgatgaag tgtcgggacc atcagcccct ggggtagatc
      721 ccagcccccc acgtaggtcc cttggctgga aaaggaagag ggaatgtttg gatgaatctg
      781 atgatgagcc agagaaggag ctcgcccctg agcctgagga gacctgggtg gcggagacgc
      841 tgtgtggcct caagatgaag gcgaagcgac ggcgagtgtc gctcgtgctc cctgagtact
      901 acgaggcctt caacaggctg cttgaggatc ctgtcattaa aagactcctg gcctgggaca
      961 aagatctgag ggtgtcggac aagtatctcc tggctatggt catagcgtat ttcagccggg
     1021 ccggcctccc ctcctggcaa taccaacgca ttcatttctt cctggctctc tatctggcca
     1081 atgacatgga ggaggacgac gaggccccca aacaaaacat cttctacttc ctgtacgagg
     1141 agacccgctc tcatataccc ttgctcagtg agctttggtt ccagttatgc cgttacatga
     1201 acccgagggc caggaagaac tgctctcaga tagccttgtt ccggaagtat cggttccact
     1261 tcttttgttc catgcgctgc agggcttggg tttccctgga ggagttggaa gagatccagg
     1321 cttatgaccc agagcactgg gtgtgggcgc gagatcgcgc ccacctttcc tagagctcca
     1381 gggaccgtgg aggcctgagg tcatcggcct gagagaagaa caccggaccc aggggagatg
     1441 tggattttca gcaggaactt tattccaatg ctaatggcag acatcaggaa ggaggagagg
     1501 aaccatttgt gcagatcatc tagaagaacc tggaccattc ttgatggagc tgaatacagt
     1561 gatcacgttg tcctccaagg agcaggggtg gggtggggta cttctaggag tccttggaga
     1621 aaagtaagaa accaggagtg tttccagttc caccctttcc tgcggcacca cctccctttt
     1681 tatattgctg aatgccaacc tccctggggc ggaacctgga ggtcctgttt cttatggact
     1741 tggttgccac agtccaggag catttgaagg cacagtgcaa gggctcagat tggcacagaa
     1801 ttctttgtga aatatgagtg ccacagactg taacagatag cttcatgcac actatgcatt
     1861 ttattggttt gtttggaaaa tgttggccat tgaattatta ataggtttat ttcaaatagt
     1921 ttggaaattg ttgtactttt gaaaacatgc tgttcctgta gagttttttg atgagagtta
     1981 tagttgttat atatacataa agataatttt cttttcattt ttaagtgaga attcttttta
     2041 tcctaaatct tttattatct ttaaattttt ttctgtatta ttatatgtgc tcctgaagcg
     2101 agcactcttt ttatctatga tacttccata ataatctctt ctatttatag ctattggtag
     2161 ttccccacca gaaaaaaaca taattctggt gatagaaatt tttatttgct gtttaggttt
     2221 gtgactgaat tgtgagaatt cagttgtgat ttttaacatg tctcagatat atatactaac
     2281 acgtctaatg tatactatct attttattgg tttattttga aaaacatggg tacagaatta
     2341 tttaaatatt attttattta ttgaaatatt tattaaatat atttatttat ttaaatatta
     2401 ttattacttt aaatattatt ttaaatattt tggaaatact ggtatttttg aatagatgct
     2461 gtttctataa agctgtgtga tgggtgttat aactgttgta tacacataca tataattttg
     2521 ttttcctttt taagagagga ttcttttcat cctaaatctt ttacctttca atctttgtat
     2581 ctattattac acgtgctgct gaagggagca tggtttttat ctatgatact tagttaacat
     2641 atatattaca tttatagcta tgtggtagtt cccctaaatt cttgtaaaaa taaattttta
     2701 tttgatattt agtgtatgtt tgaaatgtga gaattcagat ggaatttttt atcttgtttt
     2761 ggcatgtttg tatgttactt taaagaggat gtgtgttcta aaggaggaca tgagctgtgt
     2821 gttttcaaga gaacagtgca gtgcatctct tggggaaaca taataaagat gaacttttct
     2881 caccttcaca gtgagtgtga
//
