LOCUS       NM_001378423            3119 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens speedy/RINGO cell cycle regulator family member E1
            (SPDYE1), transcript variant 1, mRNA.
ACCESSION   NM_001378423 XM_005249719
VERSION     NM_001378423.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3119)
  AUTHORS   Dinarina,A., Perez,L.H., Davila,A., Schwab,M., Hunt,T. and
            Nebreda,A.R.
  TITLE     Characterization of a new family of cyclin-dependent kinase
            activators
  JOURNAL   Biochem J 386 (Pt 2), 349-355 (2005)
   PUBMED   15574121
REFERENCE   2  (bases 1 to 3119)
  AUTHORS   Merla,G., Ucla,C., Guipponi,M. and Reymond,A.
  TITLE     Identification of additional transcripts in the Williams-Beuren
            syndrome critical region
  JOURNAL   Hum Genet 110 (5), 429-438 (2002)
   PUBMED   12073013
  REMARK    GeneRIF: This paper mentioned accessions 'AF412025-2035' and
            'WBSCR16-WBSCR23', but AF412027 and WBSCR19 were not discussed in
            this paper, and the WBSCR19 information is not available from this
            paper.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC004951.5.
            
            On May 11, 2021 this sequence version replaced NM_001378423.1.
            
            Summary: This gene is located at chromosome 7p13 which is close to
            the Williams Beuren syndrome chromosome region 7q11.23. [provided
            by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968968,
                              SAMEA2148093 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000693451.1/ ENSP00000509569.1
            RefSeq Select criteria    :: based on manual assertion, longest
                                         protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                AC004951.5         19234-19296         c
            64-645              AC004951.5         17084-17665         c
            646-864             AC004951.5         15909-16127         c
            865-1092            AC004951.5         14376-14603         c
            1093-1151           AC004951.5         13282-13340         c
            1152-1237           AC004951.5         11966-12051         c
            1238-1556           AC004951.5         9607-9925           c
            1557-1661           AC004951.5         9380-9484           c
            1662-3119           AC004951.5         7069-8526           c
FEATURES             Location/Qualifiers
     source          1..3119
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p13"
     gene            1..3119
                     /gene="SPDYE1"
                     /gene_synonym="Ringo1; SPDYB2L2; SPDYE; WBSCR19"
                     /note="speedy/RINGO cell cycle regulator family member E1"
                     /db_xref="GeneID:285955"
                     /db_xref="HGNC:HGNC:16408"
                     /db_xref="MIM:617623"
     exon            1..63
                     /gene="SPDYE1"
                     /gene_synonym="Ringo1; SPDYB2L2; SPDYE; WBSCR19"
                     /inference="alignment:Splign:2.1.0"
     exon            64..645
                     /gene="SPDYE1"
                     /gene_synonym="Ringo1; SPDYB2L2; SPDYE; WBSCR19"
                     /inference="alignment:Splign:2.1.0"
     CDS             486..1616
                     /gene="SPDYE1"
                     /gene_synonym="Ringo1; SPDYB2L2; SPDYE; WBSCR19"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Speedy E; Williams Beuren syndrome chromosome region 19
                     protein; speedy protein E1; putative WBSCR19-like protein
                     6; williams-Beuren syndrome chromosomal region 19 protein;
                     speedy homolog E1"
                     /codon_start=1
                     /product="speedy protein E1 isoform 1"
                     /protein_id="NP_001365352.1"
                     /db_xref="CCDS:CCDS94090.1"
                     /db_xref="GeneID:285955"
                     /db_xref="HGNC:HGNC:16408"
                     /db_xref="MIM:617623"
                     /translation="MDRTETRFRKRGQITGKITTSRQPHRQNEQSPQRSTSGYPLQEV
                     VDDEVLGPSAPGVDPSPPCRSLGWKRKREWSDESEEEPEKELAPEPEETWVVETLCGL
                     KMKLKQQRVSPILLEHHKDFNSQLAPGVDPSPPHRSFCWKRKMEWWDKSEESEEEPRK
                     VLAPEPEEIWVAEMLCGLKMKLKRRRVSLVLPEHHEAFNRLLEDPVIKRFLAWDKDLR
                     VSDKYLLAMVIAYFSRAGFPSWQYQRLHFFLALYLANDMEEDDEDSKQNIFHFLYGKN
                     RSRIPLLRKRRFQLYRSMNPRARKNRSHIPLVRKRRFQLRRCMNPRARKNRSQIVLFQ
                     KRRFHFFCSMSCRAWVSPEELEEIQAYDPEHWVWARDRARLS"
     exon            646..864
                     /gene="SPDYE1"
                     /gene_synonym="Ringo1; SPDYB2L2; SPDYE; WBSCR19"
                     /inference="alignment:Splign:2.1.0"
     exon            865..1092
                     /gene="SPDYE1"
                     /gene_synonym="Ringo1; SPDYB2L2; SPDYE; WBSCR19"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1151
                     /gene="SPDYE1"
                     /gene_synonym="Ringo1; SPDYB2L2; SPDYE; WBSCR19"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1237
                     /gene="SPDYE1"
                     /gene_synonym="Ringo1; SPDYB2L2; SPDYE; WBSCR19"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1556
                     /gene="SPDYE1"
                     /gene_synonym="Ringo1; SPDYB2L2; SPDYE; WBSCR19"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1661
                     /gene="SPDYE1"
                     /gene_synonym="Ringo1; SPDYB2L2; SPDYE; WBSCR19"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..3119
                     /gene="SPDYE1"
                     /gene_synonym="Ringo1; SPDYB2L2; SPDYE; WBSCR19"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accctcagca gagacagacc ccagatctgg gcccaggact ttgtgcaggg aggggaaatg
       61 cagactggac tctgaaatgg gcacgtacag agacgaagag accccaacat gcttcaggct
      121 ttgagtggag aggacacagc ctctgctggg acagggaaca gagggatgtg gagtccctga
      181 agatgctttt ggacaatggt ctgaggttgg gacagtggca ggagatacca ttcacccagg
      241 atctccagga caagagatca gcctggcagt tacatgtgtt tttttttcaa actggttgcc
      301 aggttggcat gaacgatgac atcagagatt ccgaccttcc tgattggagg gaccggactc
      361 cgtggtgcct ggagatcagt tggacaacag tatcttctca gagctgttct ccactcctga
      421 cttctcctag gcttgagaat tgataacata ctcttctgga tcctagcagt gtccagaaga
      481 aggccatgga cagaacggag actaggttcc gtaagagggg acagattacg ggaaagatca
      541 cgaccagccg tcaaccgcac cgccagaatg agcagagtcc ccagcggagc acctcggggt
      601 accccctcca ggaggtggtg gatgatgaag tgttgggacc atcagcccct ggggtagatc
      661 ccagcccccc atgtaggtcc cttggctgga aaaggaagag ggagtggtca gatgaatctg
      721 aggaggagcc ggagaaggag ctcgcccctg agcctgagga gacctgggta gtggagacgc
      781 tgtgtgggct caagatgaag ctgaagcaac agcgagtgtc acccatcctc cttgagcacc
      841 acaaggactt caacagtcag cttgcccctg gggtagatcc cagccccccg cataggtcct
      901 tttgctggaa aaggaagatg gagtggtggg acaaatctga ggagtcggag gaggagccac
      961 ggaaggtgct cgcccctgag cctgaggaga tctgggtggc ggagatgctg tgtggcctca
     1021 agatgaagct gaagcgacgg cgagtgtcgc tcgtgctccc tgagcaccac gaggccttca
     1081 acaggctgct tgaggatcct gtcattaaaa gattcctggc ctgggacaaa gatctgaggg
     1141 tgtcggacaa gtatctcctt gctatggtca tagcgtattt cagccgagcc ggcttcccct
     1201 cctggcaata ccaacgcctt catttcttcc tggctctcta cctggccaat gacatggagg
     1261 aggacgacga ggactccaaa caaaacatct tccacttcct gtatgggaag aaccgctctc
     1321 gcataccctt gctccgtaag cgtcggttcc agttataccg ttccatgaac ccgagggcca
     1381 ggaagaaccg ctctcacata cccttggtcc gtaagcgtcg gttccagtta cgccgttgca
     1441 tgaacccgag ggccaggaag aaccgctctc agatagtcct gttccagaaa cgtcggttcc
     1501 acttcttctg ttccatgagc tgcagggctt gggtttcccc agaggagttg gaggagatcc
     1561 aggcttatga cccagagcac tgggtgtggg cgcgagatcg cgctcgcctt tcctagagct
     1621 ccagggaccg tggaggcctg aggtcatcgg cctgagagaa gaacaccgga cccaggggag
     1681 atgtggattt tcagcaggaa ctttattcca atgctaatgg cagacaccag gaaggaggag
     1741 aggaaccatt tgtgcagatc atctagaaga acctggacca ttcttgatgg agctgaatac
     1801 agtgatcacg ttgtcctcct aggagcaggg gtggggggag ggggatgggg tccttctagg
     1861 agtccttgga gaaaagtaag aaaccaggag tgtttccagt tccacccttt cctggggcac
     1921 caccaccctt tttatattgc tgaattccaa cctccctggg gcggaacctg gaggtcctgt
     1981 ttcttacgga cttggttgcc acagtccagg agcatttgaa ggcacaatgc aggggctcag
     2041 attggcacag aattcttttg tgaaatatca gtgccacaga ttgtaacaga tagcttcatg
     2101 cacactctgc attttattgg tttgtttgga aaatgttggc cattgaatta ttcatagatt
     2161 tatttcaaat agtttggaaa ttgttgtact tttgaaaaca tgctgttcct gtagtttttt
     2221 gatgagagtt atagttgtta tatatacata aagataattt tcttttcatt tttgagacaa
     2281 ttctttttat cctaaatatt ttatcatctt taaatttgtt tctgtattat tatatgtgct
     2341 cctgaagcga gcactctttt tatctatgat acttccataa taatctcttc tatttatagc
     2401 tattggtagt tcccctaaat tctgacgata gaaattttta tttgctgttt aggtttgtga
     2461 ctgaattgtg agaattcagt tgtgattttt aacatgtgtc agatatatat actaacacgt
     2521 ctaatatata ctattttatt ggtttatttt gaaaaacatg ggtatagaat tatttaaata
     2581 ttattttatt tatttaaata tttattaaat atatttattt atttaaatgt tattattact
     2641 ttaaatatta ttttaaatat tttggaaata ctggtatttt tgaatagatg ctgtttctat
     2701 aaagctgtgt gatggtatta taactgttat atacacatac atataatttt gttttccttt
     2761 ttaagagagg attcttttca tcctaaatct tttacctttc aatctttgta tctattatta
     2821 cacgtgctgc tgaagggagc atggttttta tctatgatac ttagttaaca tatatattac
     2881 atttatagct atgtagtagt tcccctaaat tcttgtaaaa ataaattttt atttgatatt
     2941 tcatctatgt ttgaaatgtg agaattcaga tgtaattttt taccttgatt tggcatgttt
     3001 gtatgttact ttaaagagga tgtgtgttct aaaggaggac atgagctgtg tgttttcaag
     3061 agaacaatag agtgtgtctc ttggggaaac gtaataaaaa tgaacttttc tcaccttca
//
