LOCUS       NM_001008778            1042 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens speedy/RINGO cell cycle regulator family member C
            (SPDYC), mRNA.
ACCESSION   NM_001008778 XM_370631
VERSION     NM_001008778.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1042)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1042)
  AUTHORS   Mouron,S., de Carcer,G., Seco,E., Fernandez-Miranda,G.,
            Malumbres,M. and Nebreda,A.R.
  TITLE     RINGO C is required to sustain the spindle-assembly checkpoint
  JOURNAL   J Cell Sci 123 (Pt 15), 2586-2595 (2010)
   PUBMED   20605920
  REMARK    GeneRIF: Results indicate a role for RINGO C in the mitotic
            checkpoint, which might be mediated by defective recruitment of SAC
            components and deregulation of the activity of Aurora kinase B.
REFERENCE   3  (bases 1 to 1042)
  AUTHORS   Cheng,A. and Solomon,M.J.
  TITLE     Speedy/Ringo C regulates S and G2 phase progression in human cells
  JOURNAL   Cell Cycle 7 (19), 3037-3047 (2008)
   PUBMED   18802405
  REMARK    GeneRIF: CDK-Speedy/Ringo C complexes positively regulate cell
            cycle progression during the late S and G(2) phases of the cell
            cycle.
REFERENCE   4  (bases 1 to 1042)
  AUTHORS   Cheng,A., Xiong,W., Ferrell,J.E. Jr. and Solomon,M.J.
  TITLE     Identification and comparative analysis of multiple mammalian
            Speedy/Ringo proteins
  JOURNAL   Cell Cycle 4 (1), 155-165 (2005)
   PUBMED   15611625
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP003068.3.
            
            On Jul 14, 2021 this sequence version replaced NM_001008778.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC144548.1, AY820305.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000377185.3/
                                                ENSP00000366390.3
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression,
                                                longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AP003068.3         130298-130326
            30-202              AP003068.3         131392-131564
            203-261             AP003068.3         132008-132066
            262-347             AP003068.3         132311-132396
            348-519             AP003068.3         132499-132670
            520-850             AP003068.3         132749-133079
            851-1042            AP003068.3         133248-133439
FEATURES             Location/Qualifiers
     source          1..1042
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..1042
                     /gene="SPDYC"
                     /gene_synonym="Ringo2; RINGOC; SPDYE4"
                     /note="speedy/RINGO cell cycle regulator family member C"
                     /db_xref="GeneID:387778"
                     /db_xref="HGNC:HGNC:32681"
                     /db_xref="MIM:614030"
     exon            1..29
                     /gene="SPDYC"
                     /gene_synonym="Ringo2; RINGOC; SPDYE4"
                     /inference="alignment:Splign:2.1.0"
     exon            30..202
                     /gene="SPDYC"
                     /gene_synonym="Ringo2; RINGOC; SPDYE4"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..885
                     /gene="SPDYC"
                     /gene_synonym="Ringo2; RINGOC; SPDYE4"
                     /note="RINGO C; hSpy/Ringo C; speedy homolog C; rapid
                     inducer of G2/M progression in oocytes C"
                     /codon_start=1
                     /product="speedy protein C"
                     /protein_id="NP_001008778.2"
                     /db_xref="CCDS:CCDS31606.2"
                     /db_xref="GeneID:387778"
                     /db_xref="HGNC:HGNC:32681"
                     /db_xref="MIM:614030"
                     /translation="MSDSQDPTTSPVVTTQVELGGCSRQGGGNGFLRFRQHQEVQAFL
                     SLLEDSFVQEFLSKDPCFQISDKYLLAMVLVYFQRAHLKLSEYTHSSLFLALYLANDM
                     EEDLEGPKCEIFPWALGKDWCLRVGKFLHQRDKLWARMGFRAVVSRQCCEEVMAKEPF
                     HWAWTRDRRPHHGGVQRVCPQVPVRLPRGPGLSPPHCSPCGLPQHCSSHLLKPVSSKC
                     PSLTSECHRPPSQNYLSRVKNAWGGDFLIVLPPQMQLEPGTYSLRIFPKPPARPGH"
     exon            203..261
                     /gene="SPDYC"
                     /gene_synonym="Ringo2; RINGOC; SPDYE4"
                     /inference="alignment:Splign:2.1.0"
     exon            262..347
                     /gene="SPDYC"
                     /gene_synonym="Ringo2; RINGOC; SPDYE4"
                     /inference="alignment:Splign:2.1.0"
     exon            348..519
                     /gene="SPDYC"
                     /gene_synonym="Ringo2; RINGOC; SPDYE4"
                     /inference="alignment:Splign:2.1.0"
     exon            520..850
                     /gene="SPDYC"
                     /gene_synonym="Ringo2; RINGOC; SPDYE4"
                     /inference="alignment:Splign:2.1.0"
     exon            851..1042
                     /gene="SPDYC"
                     /gene_synonym="Ringo2; RINGOC; SPDYE4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1011..1016
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPDYC"
                     /gene_synonym="Ringo2; RINGOC; SPDYE4"
                     /note="hexamer: AATAAA"
     polyA_site      1042
                     /gene="SPDYC"
                     /gene_synonym="Ringo2; RINGOC; SPDYE4"
                     /note="major polyA site"
ORIGIN      
        1 gttatgctct gggccattcc tgagctcggg tcaccctgcc ccatctccat ctcctatgag
       61 atgagtgact cccaagaccc caccacttcc cctgtagtta ccacccaggt agagctgggg
      121 ggctgcagcc ggcaaggtgg gggcaatggg ttcctccgtt ttcgccagca ccaggaggtc
      181 caggccttcc tcagccttct ggaggacagt tttgtccagg aattcctctc caaagacccc
      241 tgcttccaga tttcagataa gtatctcctg gccatggtgc tggtctactt ccagcgcgcc
      301 cacctgaagc tcagcgagta tacccacagc agcctgttct tggccctgta ccttgcaaac
      361 gacatggagg aggacctgga gggccccaaa tgtgagattt ttccatgggc cctgggaaaa
      421 gattggtgtt tacgagtggg gaaattcctg caccagaggg ataagctttg ggcacggatg
      481 ggtttccggg ctgttgtgag ccgccagtgc tgtgaggagg tcatggcaaa ggagccattc
      541 cactgggctt ggactcggga ccggcgcccc caccatggtg gggttcagag ggtctgtcca
      601 caggtccctg ttcgccttcc ccggggccct ggcctctcgc cgccccactg ttccccctgt
      661 ggtttgcccc agcactgcag cagccacttg cttaagcctg tgtcatccaa gtgcccttct
      721 ctgacctctg aatgtcatcg ccctccctcc caaaattatc tctcaagggt caaaaacgcc
      781 tggggtgggg actttctcat cgtcttgcct ccccagatgc aactggaacc aggcacctac
      841 tccctccgca tcttcccaaa gcctccggca cgccctgggc actgaagctc tgcagggtga
      901 agaacagcac gcctgctggc ccactgactg acacaccatt ggctgtgctc ccacccctgc
      961 cccttcctcc cagcctgcag cttgtgccca ctctggtgcc agtcccctct aataaattca
     1021 tgtccacagg acaccaactg tg
//
