LOCUS       NM_182756               1817 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens speedy/RINGO cell cycle regulator family member A
            (SPDYA), transcript variant 1, mRNA.
ACCESSION   NM_182756 XM_351427
VERSION     NM_182756.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1817)
  AUTHORS   Chen,Y., Wang,Y., Chen,J., Zuo,W., Fan,Y., Huang,S., Liu,Y.,
            Chen,G., Li,Q., Li,J., Wu,J., Bian,Q., Huang,C. and Lei,M.
  TITLE     The SUN1-SPDYA interaction plays an essential role in meiosis
            prophase I
  JOURNAL   Nat Commun 12 (1), 3176 (2021)
   PUBMED   34039995
  REMARK    GeneRIF: The SUN1-SPDYA interaction plays an essential role in
            meiosis prophase I.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1817)
  AUTHORS   Kaya,Y., Kucukvardar,S. and Yildiz,A.
  TITLE     Speedy/RINGO protein interacts with ERK/MAPK and PI3K/AKT pathways
            in SH-SY5Y neuroblastoma cells
  JOURNAL   Mol Cell Biochem 473 (1-2), 133-141 (2020)
   PUBMED   32602013
  REMARK    GeneRIF: Speedy/RINGO protein interacts with ERK/MAPK and PI3K/AKT
            pathways in SH-SY5Y neuroblastoma cells.
REFERENCE   3  (bases 1 to 1817)
  AUTHORS   Arziman,S., Tanriverdi,O., Kucukvardar,S., Citil,N. and Yildiz,A.
  TITLE     Salicylidene acylhydrazides attenuate survival of SH-SY5Y
            neuroblastoma cells through affecting mitotic regulator
            Speedy/RINGO and ERK/MAPK-PI3K/AKT signaling
  JOURNAL   Med Oncol 37 (8), 65 (2020)
   PUBMED   32691165
  REMARK    GeneRIF: Salicylidene acylhydrazides attenuate survival of SH-SY5Y
            neuroblastoma cells through affecting mitotic regulator
            Speedy/RINGO and ERK/MAPK-PI3K/AKT signaling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1817)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1817)
  AUTHORS   Fifield,B.A., Qemo,I., Kirou,E., Cardiff,R.D. and Porter,L.A.
  TITLE     The atypical cyclin-like protein Spy1 overrides p53-mediated tumour
            suppression and promotes susceptibility to breast tumourigenesis
  JOURNAL   Breast Cancer Res 21 (1), 140 (2019)
   PUBMED   31829284
  REMARK    GeneRIF: This mouse model demonstrates for the first time that
            degradation of the cyclin-like protein Spy1 is an essential
            component of p53-mediated tumour suppression. Targeting cyclin-like
            protein activity may therefore represent a mechanism of
            re-sensitizing cells to important cell cycle checkpoints in a
            therapeutic setting.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1817)
  AUTHORS   Gastwirt,R.F., Slavin,D.A., McAndrew,C.W. and Donoghue,D.J.
  TITLE     Spy1 expression prevents normal cellular responses to DNA damage:
            inhibition of apoptosis and checkpoint activation
  JOURNAL   J Biol Chem 281 (46), 35425-35435 (2006)
   PUBMED   16951407
  REMARK    GeneRIF: This study reports that Spy1 expression allows cells to
            evade checkpoints and apoptosis and suggest that Spy1 regulation of
            CDK2 is important for the response to DNA damage.
REFERENCE   7  (bases 1 to 1817)
  AUTHORS   Cheng,A., Xiong,W., Ferrell,J.E. Jr. and Solomon,M.J.
  TITLE     Identification and comparative analysis of multiple mammalian
            Speedy/Ringo proteins
  JOURNAL   Cell Cycle 4 (1), 155-165 (2005)
   PUBMED   15611625
REFERENCE   8  (bases 1 to 1817)
  AUTHORS   Porter,L.A., Kong-Beltran,M. and Donoghue,D.J.
  TITLE     Spy1 interacts with p27Kip1 to allow G1/S progression
  JOURNAL   Mol Biol Cell 14 (9), 3664-3674 (2003)
   PUBMED   12972555
REFERENCE   9  (bases 1 to 1817)
  AUTHORS   Barnes,E.A., Porter,L.A., Lenormand,J.L., Dellinger,R.W. and
            Donoghue,D.J.
  TITLE     Human Spy1 promotes survival of mammalian cells following DNA
            damage
  JOURNAL   Cancer Res 63 (13), 3701-3707 (2003)
   PUBMED   12839962
  REMARK    GeneRIF: This protein mediates protection of mammalian cells
            against DNA damage.
REFERENCE   10 (bases 1 to 1817)
  AUTHORS   Porter,L.A., Dellinger,R.W., Tynan,J.A., Barnes,E.A., Kong,M.,
            Lenormand,J.L. and Donoghue,D.J.
  TITLE     Human Speedy: a novel cell cycle regulator that enhances
            proliferation through activation of Cdk2
  JOURNAL   J Cell Biol 157 (3), 357-366 (2002)
   PUBMED   11980914
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC093005.1, BC047224.1 and AY820304.1.
            
            On Nov 22, 2018 this sequence version replaced NM_182756.3.
            
            Transcript Variant: This variant (1) lacks a segment in the 5' UTR,
            compared to variant 3. Variants 1 and 3 both encode the longer
            protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.122914.1, BC047224.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334056.10/ ENSP00000335628.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               BC093005.1         1-114
            115-351             BC047224.1         98-334
            352-973             AY820304.1         146-767
            974-1817            BC047224.1         956-1799
FEATURES             Location/Qualifiers
     source          1..1817
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.2"
     gene            1..1817
                     /gene="SPDYA"
                     /gene_synonym="RINGO3; RINGOA; SPDY1; SPY1"
                     /note="speedy/RINGO cell cycle regulator family member A"
                     /db_xref="GeneID:245711"
                     /db_xref="HGNC:HGNC:30613"
                     /db_xref="MIM:614029"
     exon            1..114
                     /gene="SPDYA"
                     /gene_synonym="RINGO3; RINGOA; SPDY1; SPY1"
                     /inference="alignment:Splign:2.1.0"
     exon            115..188
                     /gene="SPDYA"
                     /gene_synonym="RINGO3; RINGOA; SPDY1; SPY1"
                     /inference="alignment:Splign:2.1.0"
     exon            189..441
                     /gene="SPDYA"
                     /gene_synonym="RINGO3; RINGOA; SPDY1; SPY1"
                     /inference="alignment:Splign:2.1.0"
     CDS             207..1148
                     /gene="SPDYA"
                     /gene_synonym="RINGO3; RINGOA; SPDY1; SPY1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     speedy protein A; RINGO A; speedy-1; hSpy/Ringo A; rapid
                     inducer of G2/M progression in oocytes A; speedy homolog
                     A; epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="speedy protein A isoform 1"
                     /protein_id="NP_877433.2"
                     /db_xref="CCDS:CCDS1767.2"
                     /db_xref="GeneID:245711"
                     /db_xref="HGNC:HGNC:30613"
                     /db_xref="MIM:614029"
                     /translation="MRHNQMCCETPPTVTVYVKSGSNRSHQPKKPITLKRPICKDNWQ
                     AFEKNTHNNNKSKRPKGPCLVIQRQDMTAFFKLFDDDLIQDFLWMDCCCKIADKYLLA
                     MTFVYFKRAKFTISEHTRINFFIALYLANTVEEDEEETKYEIFPWALGKNWRKLFPNF
                     LKLRDQLWDRIDYRAIVSRRCCEEVMAIAPTHYIWQRERSVHHSGAVRNYNRDEVQLP
                     RGPSATPVDCSLCGKKRRYVRLGLSSSSSLSSHTAGVTEKHSQDSYNSLSMDIIGDPS
                     QAYTGSEVVNDHQSNKGKKTNFLKKDKSMEWFTGSEE"
     exon            442..500
                     /gene="SPDYA"
                     /gene_synonym="RINGO3; RINGOA; SPDY1; SPY1"
                     /inference="alignment:Splign:2.1.0"
     exon            501..586
                     /gene="SPDYA"
                     /gene_synonym="RINGO3; RINGOA; SPDY1; SPY1"
                     /inference="alignment:Splign:2.1.0"
     exon            587..758
                     /gene="SPDYA"
                     /gene_synonym="RINGO3; RINGOA; SPDY1; SPY1"
                     /inference="alignment:Splign:2.1.0"
     exon            759..1056
                     /gene="SPDYA"
                     /gene_synonym="RINGO3; RINGOA; SPDY1; SPY1"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1817
                     /gene="SPDYA"
                     /gene_synonym="RINGO3; RINGOA; SPDY1; SPY1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1792..1797
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPDYA"
                     /gene_synonym="RINGO3; RINGOA; SPDY1; SPY1"
                     /note="hexamer: AATAAA"
     polyA_site      1817
                     /gene="SPDYA"
                     /gene_synonym="RINGO3; RINGOA; SPDY1; SPY1"
                     /note="major polyA site"
ORIGIN      
        1 gggtaccgct gctggctagc gaccgacgag caaccgtctg aggccaggag cgctgcgacg
       61 gagccttgac cgccgttgcc cggccctctc ccgcgcagcc ccgggcttcc gcagtccttc
      121 cttcagaagg gaaatttctg agggtcagga aggggaatct gtacctcact ccttgaacac
      181 caaggaagga atattgggaa accaaaatga ggcacaatca gatgtgttgt gagacaccac
      241 ctactgtcac tgtttatgta aaatcagggt caaatagatc acatcagcct aaaaagccca
      301 ttactctgaa gcgtcctatt tgtaaagata attggcaagc atttgaaaaa aatacacata
      361 ataacaacaa atctaaacgc cccaaaggac cttgtctggt tatacagcgt caggatatga
      421 ctgctttctt taaattattt gatgacgatt taattcaaga tttcttgtgg atggactgct
      481 gctgtaaaat tgcagacaag tatcttttgg ctatgacctt tgtttatttc aagagggcta
      541 aatttactat aagtgagcat accaggataa atttctttat tgctctgtat ctggctaata
      601 cagttgaaga agatgaagaa gaaaccaagt acgaaatttt tccatgggct ttagggaaaa
      661 actggagaaa attgttccct aatttcttaa agttaaggga ccagctctgg gatagaattg
      721 actatagggc tattgtaagc aggcgatgtt gtgaggaggt tatggccatt gcaccaaccc
      781 attatatctg gcaaagagaa cgttctgttc atcacagtgg agctgtcaga aactacaaca
      841 gagatgaagt tcagctgccc cggggaccta gtgccacacc agtagattgt tcactctgtg
      901 gtaaaaaaag aagatatgtt agactgggat tgtcttcatc atcatcttta tccagtcata
      961 cagcaggggt gacagaaaaa cattctcagg actcatacaa ctcactgtca atggacataa
     1021 taggtgatcc ttctcaagct tatactggtt ctgaagtagt caatgaccat caatcaaata
     1081 aaggaaagaa aactaatttc ttgaagaaag acaaatctat ggagtggttt acaggaagtg
     1141 aagaatgaga tggcccaact aaaccaattt ggaatcatta actacaaaat gtcaaactaa
     1201 ctgcaagaca agtgtcaaaa tgggatgttt aagcagtttt gctatgttat acatctttta
     1261 gttgttattt tcaaaattat atgtataagt tatataagtc atagtaatag ctaaaaatgc
     1321 caatctatgg aagcagtgat tttcaatata aagttctatt ttgatatttt tccatcttca
     1381 agtcagttac tgtcatctgg agtactcagt taagttgtgg tttgaccttc ctcaacttga
     1441 caagaaaagc taatttaaga gaagaaaaac ataaagtcat tatattaatt aaaagaaaaa
     1501 acaccattta atatgttctg aaaacattac tcacctgtat gaccaggttg ccagtgtact
     1561 ggtctagcaa catagggaaa tgatccatat ggaaaatcag aatgcgattc ttctgttgta
     1621 aaaaaatata tgtactataa gctacataaa atattttcta tttttttcac aaaactgtta
     1681 aaatatgagt tactctcttt attgtaagtt ttttctttat ttatttcctt gcatatgttt
     1741 tagagctact ctgccagtta ttatacagaa actatttgtc aatgattatg taataaacat
     1801 atgattttat aaccaaa
//
