LOCUS       NM_012391               1910 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens SAM pointed domain containing ETS transcription factor
            (SPDEF), transcript variant 1, mRNA.
ACCESSION   NM_012391
VERSION     NM_012391.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1910)
  AUTHORS   Vatanmakanian,M., Steffan,J.J., Koul,S., Ochoa,A.C.,
            Chaturvedi,L.S. and Koul,H.K.
  TITLE     Regulation of SPDEF expression by DNA methylation in advanced
            prostate cancer
  JOURNAL   Front Endocrinol (Lausanne) 14, 1156120 (2023)
   PUBMED   37900138
  REMARK    GeneRIF: Regulation of SPDEF expression by DNA methylation in
            advanced prostate cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1910)
  AUTHORS   Hou,Y., Zheng,S., Zou,F., Wang,D., Da,H., Zhou,Y., Fan,X., Liu,J.,
            Zhao,H., He,J., Li,H., Sun,X. and Liu,Y.
  TITLE     Lactobacillus rhamnosus 76 alleviates airway inflammation in
            ovalbumin-allergic mice and improves mucus secretion by
            down-regulating STAT6/SPDEF pathway
  JOURNAL   Immunobiology 228 (5), 152712 (2023)
   PUBMED   37515878
  REMARK    GeneRIF: Lactobacillus rhamnosus 76 alleviates airway inflammation
            in ovalbumin-allergic mice and improves mucus secretion by
            down-regulating STAT6/SPDEF pathway.
REFERENCE   3  (bases 1 to 1910)
  AUTHORS   Li,J., Wan,X., Xie,D., Yuan,H., Pei,Q., Luo,Y., Chen,Y., Xian,J.
            and Ye,T.
  TITLE     SPDEF enhances cancer stem cell-like properties and tumorigenesis
            through directly promoting GALNT7 transcription in luminal breast
            cancer
  JOURNAL   Cell Death Dis 14 (8), 569 (2023)
   PUBMED   37633945
  REMARK    GeneRIF: SPDEF enhances cancer stem cell-like properties and
            tumorigenesis through directly promoting GALNT7 transcription in
            luminal breast cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1910)
  AUTHORS   Bao,K.C. and Wang,F.F.
  TITLE     The role of SPDEF in cancer: promoter or suppressor
  JOURNAL   Neoplasma 69 (6), 1270-1276 (2022)
   PUBMED   35951453
  REMARK    GeneRIF: The role of SPDEF in cancer: promoter or suppressor.
            Review article
REFERENCE   5  (bases 1 to 1910)
  AUTHORS   Wang,Y., Ren,X., Li,W., Cao,R., Liu,S., Jiang,L., Cheng,B. and
            Xia,J.
  TITLE     SPDEF suppresses head and neck squamous cell carcinoma progression
            by transcriptionally activating NR4A1
  JOURNAL   Int J Oral Sci 13 (1), 33 (2021)
   PUBMED   34667150
  REMARK    GeneRIF: SPDEF suppresses head and neck squamous cell carcinoma
            progression by transcriptionally activating NR4A1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1910)
  AUTHORS   Thompson,H.G., Harris,J.W., Wold,B.J., Lin,F. and Brody,J.P.
  TITLE     p62 overexpression in breast tumors and regulation by
            prostate-derived Ets factor in breast cancer cells
  JOURNAL   Oncogene 22 (15), 2322-2333 (2003)
   PUBMED   12700667
  REMARK    GeneRIF: PDEF upregulates p62 promoter activity at 2 sites. PSI
            downregulates PDEF-induced p62 promoter activation through one of
            these sites.
REFERENCE   7  (bases 1 to 1910)
  AUTHORS   Chen,H., Nandi,A.K., Li,X. and Bieberich,C.J.
  TITLE     NKX-3.1 interacts with prostate-derived Ets factor and regulates
            the activity of the PSA promoter
  JOURNAL   Cancer Res 62 (2), 338-340 (2002)
   PUBMED   11809674
  REMARK    GeneRIF: NKX-3.1 interacts with prostate-derived Ets factor and
            regulates the activity of the PSA promoter.
REFERENCE   8  (bases 1 to 1910)
  AUTHORS   Oettgen,P., Finger,E., Sun,Z., Akbarali,Y., Thamrongsak,U.,
            Boltax,J., Grall,F., Dube,A., Weiss,A., Brown,L., Quinn,G., Kas,K.,
            Endress,G., Kunsch,C. and Libermann,T.A.
  TITLE     PDEF, a novel prostate epithelium-specific ets transcription
            factor, interacts with the androgen receptor and activates
            prostate-specific antigen gene expression
  JOURNAL   J Biol Chem 275 (2), 1216-1225 (2000)
   PUBMED   10625666
REFERENCE   9  (bases 1 to 1910)
  AUTHORS   Yamada,N., Tamai,Y., Miyamoto,H. and Nozaki,M.
  TITLE     Cloning and expression of the mouse Pse gene encoding a novel Ets
            family member
  JOURNAL   Gene 241 (2), 267-274 (2000)
   PUBMED   10675039
REFERENCE   10 (bases 1 to 1910)
  AUTHORS   Johannessen,J.V. and Finseth,I.
  TITLE     Electron micrographs in five minutes
  JOURNAL   Ultrastruct Pathol 4 (1), 97-100 (1983)
   PUBMED   6857767
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK301543.1 and BC021299.2.
            
            On Nov 22, 2018 this sequence version replaced NM_012391.2.
            
            Summary: The protein encoded by this gene belongs to the ETS family
            of transcription factors. It is highly expressed in the prostate
            epithelial cells, and functions as an androgen-independent
            transactivator of prostate-specific antigen (PSA) promoter. Higher
            expression of this protein has also been reported in brain, breast,
            lung and ovarian tumors, compared to the corresponding normal
            tissues, and it shows better tumor-association than other
            cancer-associated molecules, making it a more suitable target for
            developing specific cancer therapies. Alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Nov 2011].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021299.2, AF071538.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA1968832 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374037.8/ ENSP00000363149.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AK301543.1         5-23
            20-1910             BC021299.2         1-1891
FEATURES             Location/Qualifiers
     source          1..1910
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.31"
     gene            1..1910
                     /gene="SPDEF"
                     /gene_synonym="bA375E1.3; PDEF"
                     /note="SAM pointed domain containing ETS transcription
                     factor"
                     /db_xref="GeneID:25803"
                     /db_xref="HGNC:HGNC:17257"
                     /db_xref="MIM:608144"
     exon            1..401
                     /gene="SPDEF"
                     /gene_synonym="bA375E1.3; PDEF"
                     /inference="alignment:Splign:2.1.0"
     exon            402..866
                     /gene="SPDEF"
                     /gene_synonym="bA375E1.3; PDEF"
                     /inference="alignment:Splign:2.1.0"
     CDS             431..1438
                     /gene="SPDEF"
                     /gene_synonym="bA375E1.3; PDEF"
                     /note="isoform 1 is encoded by transcript variant 1;
                     prostate epithelium-specific Ets transcription factor; SAM
                     pointed domain-containing Ets transcription factor;
                     prostate-specific Ets; prostate-derived Ets factor"
                     /codon_start=1
                     /product="SAM pointed domain-containing Ets transcription
                     factor isoform 1"
                     /protein_id="NP_036523.1"
                     /db_xref="CCDS:CCDS4794.1"
                     /db_xref="GeneID:25803"
                     /db_xref="HGNC:HGNC:17257"
                     /db_xref="MIM:608144"
                     /translation="MGSASPGLSSVSPSHLLLPPDTVSRTGLEKAAAGAVGLERRDWS
                     PSPPATPEQGLSAFYLSYFDMLYPEDSSWAAKAPGASSREEPPEEPEQCPVIDSQAPA
                     GSLDLVPGGLTLEEHSLEQVQSMVVGEVLKDIETACKLLNITADPMDWSPSNVQKWLL
                     WTEHQYRLPPMGKAFQELAGKELCAMSEEQFRQRSPLGGDVLHAHLDIWKSAAWMKER
                     TSPGAIHYCASTSEESWTDSEVDSSCSGQPIHLWQFLKELLLKPHSYGRFIRWLNKEK
                     GIFKIEDSAQVARLWGIRKNRPAMNYDKLSRSIRQYYKKGIIRKPDISQRLVYQFVHP
                     I"
     exon            867..1064
                     /gene="SPDEF"
                     /gene_synonym="bA375E1.3; PDEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1112
                     /gene="SPDEF"
                     /gene_synonym="bA375E1.3; PDEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1259
                     /gene="SPDEF"
                     /gene_synonym="bA375E1.3; PDEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1910
                     /gene="SPDEF"
                     /gene_synonym="bA375E1.3; PDEF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1889..1894
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPDEF"
                     /gene_synonym="bA375E1.3; PDEF"
                     /note="hexamer: AATAAA"
     polyA_site      1910
                     /gene="SPDEF"
                     /gene_synonym="bA375E1.3; PDEF"
                     /note="major polyA site"
ORIGIN      
        1 cttcatctcg cggctgtctg acttcctccc agcacattcc tgcactctgc cgtgtccaca
       61 ctgccccaca gacccagtcc tccaagcctg ctgccagctc cctgcaagcc cctcaggttg
      121 ggccttgcca cggtgccagc aggcagccct gggctggggg taggggactc cctacaggca
      181 cgcagccctg agacctcaga gggccacccc ttgagggtgg ccaggccccc agtggccaac
      241 ctgagtgctg cctctgccac cagccctgct ggcccctggt tccgctggcc ccccagatgc
      301 ctggctgaga cacgccagtg gcctcagctg cccacacctc ttcccggccc ctgaagttgg
      361 cactgcagca gacagctccc tgggcaccag gcagctaaca gacacagccg ccagcccaaa
      421 cagcagcggc atgggcagcg ccagcccggg tctgagcagc gtatccccca gccacctcct
      481 gctgcccccc gacacggtgt cgcggacagg cttggagaag gcggcagcgg gggcagtggg
      541 tctcgagaga cgggactgga gtcccagtcc acccgccacg cccgagcagg gcctgtccgc
      601 cttctacctc tcctactttg acatgctgta ccctgaggac agcagctggg cagccaaggc
      661 ccctggggcc agcagtcggg aggagccacc tgaggagcct gagcagtgcc cggtcattga
      721 cagccaagcc ccagcgggca gcctggactt ggtgcccggc gggctgacct tggaggagca
      781 ctcgctggag caggtgcagt ccatggtggt gggcgaagtg ctcaaggaca tcgagacggc
      841 ctgcaagctg ctcaacatca ccgcagatcc catggactgg agccccagca atgtgcagaa
      901 gtggctcctg tggacagagc accaataccg gctgcccccc atgggcaagg ccttccagga
      961 gctggcgggc aaggagctgt gcgccatgtc ggaggagcag ttccgccagc gctcgcccct
     1021 gggtggggat gtgctgcacg cccacctgga catctggaag tcagcggcct ggatgaaaga
     1081 gcggacttca cctggggcga ttcactactg tgcctcgacc agtgaggaga gctggaccga
     1141 cagcgaggtg gactcatcat gctccgggca gcccatccac ctgtggcagt tcctcaagga
     1201 gttgctactc aagccccaca gctatggccg cttcattagg tggctcaaca aggagaaggg
     1261 catcttcaaa attgaggact cagcccaggt ggcccggctg tggggcatcc gcaagaaccg
     1321 tcccgccatg aactacgaca agctgagccg ctccatccgc cagtattaca agaagggcat
     1381 catccggaag ccagacatct cccagcgcct cgtctaccag ttcgtgcacc ccatctgagt
     1441 gcctggccca gggcctgaaa cccgccctca ggggcctctc tcctgcctgc cctgcctcag
     1501 ccaggccctg agatggggga aaacgggcag tctgctctgc tgctctgacc ttccagagcc
     1561 caaggtcagg gaggggcaac caactgcccc agggggatat gggtcctctg gggccttcgg
     1621 gaccctgggg caggggtgct tcctcctcag gcccagctgc tcccctggag gacagaggga
     1681 gacagggctg ctccccaaca cctgcctctg accccagcat ttccagagca gagcctacag
     1741 aagggcagtg actcgacaaa ggccacaggc agtccaggcc tctctctgct ccatccccct
     1801 gcctcccatt ctgcaccaca cctggcatgg tgcagggaga catctgcacc cctgagttgg
     1861 gcagccagga gtgcccccgg gaatggataa taaagatact agagaactga
//
