LOCUS       NM_014041               3786 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens signal peptidase complex subunit 1 (SPCS1), mRNA.
ACCESSION   NM_014041
VERSION     NM_014041.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3786)
  AUTHORS   Alzahrani,N., Wu,M.J., Sousa,C.F., Kalinina,O.V., Welsch,C. and
            Yi,M.
  TITLE     SPCS1-Dependent E2-p7 processing determines HCV Assembly efficiency
  JOURNAL   PLoS Pathog 18 (2), e1010310 (2022)
   PUBMED   35130329
  REMARK    GeneRIF: SPCS1-Dependent E2-p7 processing determines HCV Assembly
            efficiency.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3786)
  AUTHORS   Liaci,A.M., Steigenberger,B., Telles de Souza,P.C., Tamara,S.,
            Grollers-Mulderij,M., Ogrissek,P., Marrink,S.J., Scheltema,R.A. and
            Forster,F.
  TITLE     Structure of the human signal peptidase complex reveals the
            determinants for signal peptide cleavage
  JOURNAL   Mol Cell 81 (19), 3934-3948 (2021)
   PUBMED   34388369
REFERENCE   3  (bases 1 to 3786)
  AUTHORS   Ma,L., Li,F., Zhang,J.W., Li,W., Zhao,D.M., Wang,H., Hua,R.H. and
            Bu,Z.G.
  TITLE     Host Factor SPCS1 Regulates the Replication of Japanese
            Encephalitis Virus through Interactions with Transmembrane Domains
            of NS2B
  JOURNAL   J Virol 92 (12), e00197-18 (2018)
   PUBMED   29593046
  REMARK    GeneRIF: the results demonstrate that SPCS1 affects viral
            replication by interacting with NS2B, thereby influencing the
            posttranslational processing of Japanese Encephalitis Virus
            proteins and the assembly of virions.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3786)
  AUTHORS   Zhang,R., Miner,J.J., Gorman,M.J., Rausch,K., Ramage,H.,
            White,J.P., Zuiani,A., Zhang,P., Fernandez,E., Zhang,Q., Dowd,K.A.,
            Pierson,T.C., Cherry,S. and Diamond,M.S.
  TITLE     A CRISPR screen defines a signal peptide processing pathway
            required by flaviviruses
  JOURNAL   Nature 535 (7610), 164-168 (2016)
   PUBMED   27383988
REFERENCE   5  (bases 1 to 3786)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
REFERENCE   6  (bases 1 to 3786)
  AUTHORS   Gee,F., Clubbs,C.F., Raine,E.V., Reynard,L.N. and Loughlin,J.
  TITLE     Allelic expression analysis of the osteoarthritis susceptibility
            locus that maps to chromosome 3p21 reveals cis-acting eQTLs at GNL3
            and SPCS1
  JOURNAL   BMC Med Genet 15, 53 (2014)
   PUBMED   24886551
  REMARK    GeneRIF: cis-acting regulatory polymorphisms acting on GNL3 and
            SPCS1 contribute to the OA association signal at chromosome 3p21,
            and these genes therefore merit further investigation.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3786)
  AUTHORS   Ripke,S., O'Dushlaine,C., Chambert,K., Moran,J.L., Kahler,A.K.,
            Akterin,S., Bergen,S.E., Collins,A.L., Crowley,J.J., Fromer,M.,
            Kim,Y., Lee,S.H., Magnusson,P.K., Sanchez,N., Stahl,E.A.,
            Williams,S., Wray,N.R., Xia,K., Bettella,F., Borglum,A.D.,
            Bulik-Sullivan,B.K., Cormican,P., Craddock,N., de Leeuw,C.,
            Durmishi,N., Gill,M., Golimbet,V., Hamshere,M.L., Holmans,P.,
            Hougaard,D.M., Kendler,K.S., Lin,K., Morris,D.W., Mors,O.,
            Mortensen,P.B., Neale,B.M., O'Neill,F.A., Owen,M.J.,
            Milovancevic,M.P., Posthuma,D., Powell,J., Richards,A.L.,
            Riley,B.P., Ruderfer,D., Rujescu,D., Sigurdsson,E., Silagadze,T.,
            Smit,A.B., Stefansson,H., Steinberg,S., Suvisaari,J., Tosato,S.,
            Verhage,M., Walters,J.T., Levinson,D.F., Gejman,P.V., Kendler,K.S.,
            Laurent,C., Mowry,B.J., O'Donovan,M.C., Owen,M.J., Pulver,A.E.,
            Riley,B.P., Schwab,S.G., Wildenauer,D.B., Dudbridge,F., Holmans,P.,
            Shi,J., Albus,M., Alexander,M., Campion,D., Cohen,D., Dikeos,D.,
            Duan,J., Eichhammer,P., Godard,S., Hansen,M., Lerer,F.B.,
            Liang,K.Y., Maier,W., Mallet,J., Nertney,D.A., Nestadt,G.,
            Norton,N., O'Neill,F.A., Papadimitriou,G.N., Ribble,R.,
            Sanders,A.R., Silverman,J.M., Walsh,D., Williams,N.M., Wormley,B.,
            Arranz,M.J., Bakker,S., Bender,S., Bramon,E., Collier,D.,
            Crespo-Facorro,B., Hall,J., Iyegbe,C., Jablensky,A., Kahn,R.S.,
            Kalaydjieva,L., Lawrie,S., Lewis,C.M., Lin,K., Linszen,D.H.,
            Mata,I., McIntosh,A., Murray,R.M., Ophoff,R.A., Powell,J.,
            Rujescu,D., Van Os,J., Walshe,M., Weisbrod,M., Wiersma,D.,
            Donnelly,P., Barroso,I., Blackwell,J.M., Bramon,E., Brown,M.A.,
            Casas,J.P., Corvin,A.P., Deloukas,P., Duncanson,A., Jankowski,J.,
            Markus,H.S., Mathew,C.G., Palmer,C.N., Plomin,R., Rautanen,A.,
            Sawcer,S.J., Trembath,R.C., Viswanathan,A.C., Wood,N.W.,
            Spencer,C.C., Band,G., Bellenguez,C., Freeman,C., Hellenthal,G.,
            Giannoulatou,E., Pirinen,M., Pearson,R.D., Strange,A., Su,Z.,
            Vukcevic,D., Donnelly,P., Langford,C., Hunt,S.E., Edkins,S.,
            Gwilliam,R., Blackburn,H., Bumpstead,S.J., Dronov,S., Gillman,M.,
            Gray,E., Hammond,N., Jayakumar,A., McCann,O.T., Liddle,J.,
            Potter,S.C., Ravindrarajah,R., Ricketts,M.,
            Tashakkori-Ghanbaria,A., Waller,M.J., Weston,P., Widaa,S.,
            Whittaker,P., Barroso,I., Deloukas,P., Mathew,C.G., Blackwell,J.M.,
            Brown,M.A., Corvin,A.P., McCarthy,M.I., Spencer,C.C., Bramon,E.,
            Corvin,A.P., O'Donovan,M.C., Stefansson,K., Scolnick,E.,
            Purcell,S., McCarroll,S.A., Sklar,P., Hultman,C.M. and
            Sullivan,P.F.
  CONSRTM   Multicenter Genetic Studies of Schizophrenia Consortium; Psychosis
            Endophenotypes International Consortium; Wellcome Trust Case
            Control Consortium 2
  TITLE     Genome-wide association analysis identifies 13 new risk loci for
            schizophrenia
  JOURNAL   Nat Genet 45 (10), 1150-1159 (2013)
   PUBMED   23974872
REFERENCE   8  (bases 1 to 3786)
  AUTHORS   Suzuki,R., Matsuda,M., Watashi,K., Aizaki,H., Matsuura,Y.,
            Wakita,T. and Suzuki,T.
  TITLE     Signal peptidase complex subunit 1 participates in the assembly of
            hepatitis C virus through an interaction with E2 and NS2
  JOURNAL   PLoS Pathog 9 (8), e1003589 (2013)
   PUBMED   24009510
  REMARK    GeneRIF: SPCS1 plays a key role in the formation of the
            membrane-associated NS2-E2 complex via its interaction with NS2 and
            E2, which leads to a coordinating interaction between the
            structural and non-structural proteins
REFERENCE   9  (bases 1 to 3786)
  CONSRTM   Psychiatric GWAS Consortium Bipolar Disorder Working Group
  TITLE     Large-scale genome-wide association analysis of bipolar disorder
            identifies a new susceptibility locus near ODZ4
  JOURNAL   Nat Genet 43 (10), 977-983 (2011)
   PUBMED   21926972
  REMARK    Erratum:[Nat Genet. 2012 Sep;44(9):1072. Fullerton, Janice M
            [added]; Hyoun, Phil L [corrected to Lee, Phil H]; Meng, Fan Guo
            [corrected to Meng, Fan]]
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 3786)
  AUTHORS   Kalies,K.U. and Hartmann,E.
  TITLE     Membrane topology of the 12- and the 25-kDa subunits of the
            mammalian signal peptidase complex
  JOURNAL   J Biol Chem 271 (7), 3925-3929 (1996)
   PUBMED   8632014
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB459917.1, AK027426.1, BC000884.1, CA309210.1 and AC104446.2.
            
            On Nov 22, 2018 this sequence version replaced NM_014041.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AA995358.1, SRR1660807.4398.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000619898.5/ ENSP00000478310.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 DB459917.1         265-270
            7-551               AK027426.1         1-545
            552-808             BC000884.1         526-782
            809-820             CA309210.1         16-27               c
            821-3786            AC104446.2         160948-163913
FEATURES             Location/Qualifiers
     source          1..3786
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.1"
     gene            1..3786
                     /gene="SPCS1"
                     /gene_synonym="HSPC033; SPC1; SPC12; YJR010C-A"
                     /note="signal peptidase complex subunit 1"
                     /db_xref="GeneID:28972"
                     /db_xref="HGNC:HGNC:23401"
                     /db_xref="MIM:610358"
     exon            1..177
                     /gene="SPCS1"
                     /gene_synonym="HSPC033; SPC1; SPC12; YJR010C-A"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..450
                     /gene="SPCS1"
                     /gene_synonym="HSPC033; SPC1; SPC12; YJR010C-A"
                     /EC_number="3.4.-.-"
                     /note="signal peptidase 12kDa; SPase 12 kDa subunit;
                     microsomal signal peptidase 12 kDa subunit; signal
                     peptidase complex subunit 1 homolog; signal peptidase
                     complex 12 kDa subunit"
                     /codon_start=1
                     /product="signal peptidase complex subunit 1"
                     /protein_id="NP_054760.4"
                     /db_xref="CCDS:CCDS33769.3"
                     /db_xref="GeneID:28972"
                     /db_xref="HGNC:HGNC:23401"
                     /db_xref="MIM:610358"
                     /translation="MLEHLSSLPTQMDYKGQKLAEQMFQGIILFSAIVGFIYGYVAEQ
                     FGWTVYIVMAGFAFSCLLTLPPWPIYRRHPLKWLPVQESSTDDKKPGERKIKRHAKNN
                     "
     exon            178..237
                     /gene="SPCS1"
                     /gene_synonym="HSPC033; SPC1; SPC12; YJR010C-A"
                     /inference="alignment:Splign:2.1.0"
     exon            238..324
                     /gene="SPCS1"
                     /gene_synonym="HSPC033; SPC1; SPC12; YJR010C-A"
                     /inference="alignment:Splign:2.1.0"
     exon            325..3786
                     /gene="SPCS1"
                     /gene_synonym="HSPC033; SPC1; SPC12; YJR010C-A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      788..793
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPCS1"
                     /gene_synonym="HSPC033; SPC1; SPC12; YJR010C-A"
                     /note="hexamer: ATTAAA"
     polyA_site      806
                     /gene="SPCS1"
                     /gene_synonym="HSPC033; SPC1; SPC12; YJR010C-A"
                     /note="major polyA site"
     regulatory      857..862
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPCS1"
                     /gene_synonym="HSPC033; SPC1; SPC12; YJR010C-A"
                     /note="hexamer: AATAAA"
     polyA_site      876
                     /gene="SPCS1"
                     /gene_synonym="HSPC033; SPC1; SPC12; YJR010C-A"
     regulatory      1287..1292
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPCS1"
                     /gene_synonym="HSPC033; SPC1; SPC12; YJR010C-A"
                     /note="hexamer: AATAAA"
     polyA_site      1309
                     /gene="SPCS1"
                     /gene_synonym="HSPC033; SPC1; SPC12; YJR010C-A"
     regulatory      3736..3741
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPCS1"
                     /gene_synonym="HSPC033; SPC1; SPC12; YJR010C-A"
                     /note="hexamer: AATAAA"
     regulatory      3745..3750
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPCS1"
                     /gene_synonym="HSPC033; SPC1; SPC12; YJR010C-A"
                     /note="hexamer: AACAAA"
     polyA_site      3754
                     /gene="SPCS1"
                     /gene_synonym="HSPC033; SPC1; SPC12; YJR010C-A"
     polyA_site      3786
                     /gene="SPCS1"
                     /gene_synonym="HSPC033; SPC1; SPC12; YJR010C-A"
ORIGIN      
        1 gccgccatcg ctctcccggg cttagaaggc ccggctactg acgcgcagtg ccagacctta
       61 cccctcacgg tccttaagtc tcggtcgccc tcgcctcgca gcctgccacc cgcgctcagc
      121 tgcccgcctc ctcagccagc catgctggag catctgagct cgctgcccac gcagatggat
      181 tacaagggcc agaagctagc tgaacagatg tttcagggaa ttattctttt ttctgcaata
      241 gttggattta tctacgggta cgtggctgaa cagttcgggt ggactgtcta tatagttatg
      301 gccggatttg ctttttcatg tttgctgaca cttcctccat ggcccatcta tcgccggcat
      361 cctctcaagt ggttacctgt tcaagaatca agcacagacg acaagaaacc aggggaaaga
      421 aaaattaaga ggcatgctaa aaataattga ggttttcatg attcagcacc tgcttttgtt
      481 tctgtgagat gagctaaatt gctttcatac cccagataag agctaaaacc acctaatgct
      541 cttatggcac agctgtgtat agatttagtt ctctttatac ttcatttcta gcccagttgg
      601 gttttgattt atataagtag tttagacctt ctcttcataa tcttgctctg agatggggaa
      661 cagaacacac aagtatgaag tttctttcag gtgtaaataa tgaaaaataa atgcctcata
      721 aatgatagta caatgtaact atcaaagttt tataattcat tatgagttaa ccattttaat
      781 gtttccaatt aaacctcata gtgcaagttc tttgtctaaa gggtcttctg ttgattattc
      841 tgcaaggaag ataattaata aaagcctaag ttagaagttc gtgcttctgg ccaggtgcag
      901 tggctctcac ctataatccc agcacttgag gaggctaagg caggaggatg acttgagccc
      961 aggagtttga gacatttcat ggtatgtaat taatagttgt cattagaaca ttagttccat
     1021 gagaacgggg actttgtttt gctcactgct gtctacccag tacatagaag agtacacgat
     1081 gcattgttaa gtacttaaga tttattgaat gagaactgca ttgtacaata tggtgccact
     1141 agacacgtct atttaattaa aattaaaata taaaactcta aaactagcca tgattcaaag
     1201 gttcaatagc tatatgtgac tagtggctac catataaaac atttccatca caaagttcca
     1261 tttatcagat cttatataga accttgaata aaatttaata gacaagtgat tttgtattta
     1321 acatttcacc tttattgaat gcctataagg ccatttgaat aacggatcat gtacaaagca
     1381 acaggaaaaa aaaaactgca agcagtaaag gttgtgcagg tgatattcag taacactgca
     1441 gtgtagccag agcaaggaca taaaacttcc ttagctttgt aagtctgtgg aaatcaaaac
     1501 ttctaaaaga gaaaaccgaa atcagaatta ctgacacttt aggccaggca tggtgcctca
     1561 agcctgtaat cccagcattt agggaggcca aggcaggcag atcacctgag gtcaggagtt
     1621 caagaccagc ctggccaaca tggtgaaact ccatctctac taaaaataac gaaaatcagc
     1681 caggcatggt ggtgtgtgcc tgtaatccca gctactcggg aggctgaggg aggggaactt
     1741 gaacccagga ggcgtaggct gcagtgagcc aagatcgcac cactgtactc cagcctgggc
     1801 aacaagaaga ctccatctca aaaaaaaaaa aaaaagaatg attgacattt tagaaccaat
     1861 gccaaaagag taacacatca aagtctctga actgtggcca aaggtatatt cggaagaaaa
     1921 ttcacagtct taaagatgag tttttaaatt aatttaggaa gatgaattaa gcactcaagt
     1981 aaaaacgata aaagtgggaa gaaaagatgt ttaaacaaaa taaaaatata cagtatggta
     2041 attaataaga aagtatgggg gaagtcaggt gtggtggttc atgcctataa tcccagcact
     2101 ttcagaggcc gatgcaggag gactgcttga atgcagtttg agaccagcct gggcaacaca
     2161 gacttcctct ccacaaaaaa ttttaaaaat tagccaggtg tggtggtgca tgcctgtggt
     2221 cctagctact tgaggggctg aggtgggagg atcacttaag cccaggaggt caaggctgca
     2281 gtgagctatg atcacctcac tgcactccag gctgggtgac agagcaagac cctgtctcaa
     2341 aaaaaaaaaa aaaaaaaaaa gatatgggtg agattccttt aattctaata aaatacctac
     2401 tttataccaa tacattagaa aaattaagta aaactgatga ctctccagaa cgatgtggat
     2461 ttccaaaaca tgcacggaaa ggtgaatagc tcaaggatac caagtttgcc aaagatttgt
     2521 tcccaactgg gcattgggac ttgatggttt tgcaagttga gttctagcaa acccttcaaa
     2581 gtgaaaataa gagttatcag aaaccaggct gtgagcactg taaaagggca ggaagtattg
     2641 ttttattcac cactatatcc ccagctcctg gcagagaacc tggcacacag taaactctaa
     2701 ataaaaatct gttaagtgtg ccgggcgcgg tggctcacgc ctgtaatccc agcactttgg
     2761 gaggccgagg cgggcagatc acgaggtcag gagattgaga ccatcctggc taacacggtg
     2821 aaaccctgtc tctactaaaa aaatacaaaa aaattagccg ggcatggtgg cgggcaactg
     2881 tagtcccagc tactcgagag gatgaggtag gagaatggag tgaacctggg aggcggagct
     2941 tgcagtgatc tgagattggg ccactgcact tcagcctggg tgacagagca agactgtgtc
     3001 ttaaaaaaaa aaaaaaattg ttaagtggct gtaaagggaa catttcatta gagtatttgt
     3061 gtgtgtgtgt aattttcaaa gatagatata tttttagtta tagaaactga aaacagggct
     3121 gggcacagtg gctcattcct gtaatcctgg cactttggga ggctgaggtg agtggattgc
     3181 ttgagcccag gagttctgag atcagcctgg gcaatgtggt gtaaccctgt ctctacaaaa
     3241 aatacaaaaa ctagccaggt gtggtggcac acgcctgtgg tctcagctac tagggaggct
     3301 caggcaggaa taccacttga gccccagaag tggaggttgc agtgagttga gatcatgcca
     3361 ctgcactcca gcctgactga cagagtgaaa ctctgtctca aaaaaaaaac acctgaaaac
     3421 atttctggag caatatttat ttttagagtc cctcgaatac agaagtgaaa atgtactatt
     3481 caagacttgt atttaacttc ataaaatttc tttcctagat gggtattacc tcttattaaa
     3541 caactaataa aatatgtgct atataatcat acatttaaaa catggaaaga caactaatat
     3601 cttacagtac atgaagacaa acttcaggag acaaacatta aatatatcca aaaactaaat
     3661 ggacctggac tttgcttaca aattgcttaa atggaaatga aatttgtgtt taagaaatgt
     3721 tttcactgat ggaaaaataa atctaacaaa accattatgt aaaaacatac tgatttacaa
     3781 agccaa
//
