LOCUS       NM_001100423            6212 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens spermatogenesis associated serine rich 2 like
            (SPATS2L), transcript variant 3, mRNA.
ACCESSION   NM_001100423
VERSION     NM_001100423.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6212)
  AUTHORS   Li,F., Ye,W., Yao,Y., Wei,W., Lin,X., Zhuang,H., Li,C., Li,X.,
            Ling,Q., Hu,C., Huang,X., Qian,Y., Mao,S., Huang,J., Lu,Y. and
            Jin,J.
  TITLE     Spermatogenesis associated serine rich 2 like plays a prognostic
            factor and therapeutic target in acute myeloid leukemia by
            regulating the JAK2/STAT3/STAT5 axis
  JOURNAL   J Transl Med 21 (1), 115 (2023)
   PUBMED   36774517
  REMARK    GeneRIF: Spermatogenesis associated serine rich 2 like plays a
            prognostic factor and therapeutic target in acute myeloid leukemia
            by regulating the JAK2/STAT3/STAT5 axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6212)
  AUTHORS   Wang,T., Sun,W., Wu,H., Cheng,Y., Li,Y., Meng,F. and Ni,C.
  TITLE     Respiratory traits and coal workers' pneumoconiosis: Mendelian
            randomisation and association analysis
  JOURNAL   Occup Environ Med 78 (2), 137-141 (2021)
   PUBMED   33097673
  REMARK    GeneRIF: Respiratory traits and coal workers' pneumoconiosis:
            Mendelian randomisation and association analysis.
REFERENCE   3  (bases 1 to 6212)
  AUTHORS   Tse,S.M., Krajinovic,M., Chauhan,B.F., Zemek,R., Gravel,J.,
            Chalut,D., Poonai,N., Quach,C., Laberge,S. and Ducharme,F.M.
  CONSRTM   DOORWAY research group of the Pediatric Emergency Research in
            Canada (PERC) network
  TITLE     Genetic determinants of acute asthma therapy response in children
            with moderate-to-severe asthma exacerbations
  JOURNAL   Pediatr Pulmonol 54 (4), 378-385 (2019)
   PUBMED   30644648
  REMARK    GeneRIF: While controlling for clinical determinants, in acute
            asthma therapy response, SNP rs295137 in SPATS2L (OR = 1.77, 95%CI:
            1.17, 2.68) was significantly associated with increased odds of
            emergency department (ED) management failure. Two SNPs in IL33 were
            associated with decreased odds of ED management failure: rs7037276
            (OR = 0.55, 95%CI: 0.33, 0.90), and rs1342326 (OR = 0.52, 95%CI:
            0.32, 0.86).
REFERENCE   4  (bases 1 to 6212)
  AUTHORS   Reddy,S.Y., Rasmussen,N.A., Fourie,N.H., Berger,R.S., Martino,A.C.,
            Gill,J., Longchamps,R., Wang,X.M., Heitkemper,M.M. and
            Henderson,W.A.
  TITLE     Sleep quality, BDNF genotype and gene expression in individuals
            with chronic abdominal pain
  JOURNAL   BMC Med Genomics 7, 61 (2014)
   PUBMED   25358868
  REMARK    GeneRIF: Down-regulation of SPATS2L expression may be related to
            the etiology of poor sleep quality and chronic abdominal pain.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6212)
  AUTHORS   Arking,D.E., Pulit,S.L., Crotti,L., van der Harst,P., Munroe,P.B.,
            Koopmann,T.T., Sotoodehnia,N., Rossin,E.J., Morley,M., Wang,X.,
            Johnson,A.D., Lundby,A., Gudbjartsson,D.F., Noseworthy,P.A.,
            Eijgelsheim,M., Bradford,Y., Tarasov,K.V., Dorr,M.,
            Muller-Nurasyid,M., Lahtinen,A.M., Nolte,I.M., Smith,A.V.,
            Bis,J.C., Isaacs,A., Newhouse,S.J., Evans,D.S., Post,W.S.,
            Waggott,D., Lyytikainen,L.P., Hicks,A.A., Eisele,L., Ellinghaus,D.,
            Hayward,C., Navarro,P., Ulivi,S., Tanaka,T., Tester,D.J.,
            Chatel,S., Gustafsson,S., Kumari,M., Morris,R.W., Naluai,A.T.,
            Padmanabhan,S., Kluttig,A., Strohmer,B., Panayiotou,A.G.,
            Torres,M., Knoflach,M., Hubacek,J.A., Slowikowski,K.,
            Raychaudhuri,S., Kumar,R.D., Harris,T.B., Launer,L.J.,
            Shuldiner,A.R., Alonso,A., Bader,J.S., Ehret,G., Huang,H.,
            Kao,W.H., Strait,J.B., Macfarlane,P.W., Brown,M., Caulfield,M.J.,
            Samani,N.J., Kronenberg,F., Willeit,J., Smith,J.G., Greiser,K.H.,
            Meyer Zu Schwabedissen,H., Werdan,K., Carella,M., Zelante,L.,
            Heckbert,S.R., Psaty,B.M., Rotter,J.I., Kolcic,I., Polasek,O.,
            Wright,A.F., Griffin,M., Daly,M.J., Arnar,D.O., Holm,H.,
            Thorsteinsdottir,U., Denny,J.C., Roden,D.M., Zuvich,R.L.,
            Emilsson,V., Plump,A.S., Larson,M.G., O'Donnell,C.J., Yin,X.,
            Bobbo,M., D'Adamo,A.P., Iorio,A., Sinagra,G., Carracedo,A.,
            Cummings,S.R., Nalls,M.A., Jula,A., Kontula,K.K., Marjamaa,A.,
            Oikarinen,L., Perola,M., Porthan,K., Erbel,R., Hoffmann,P.,
            Jockel,K.H., Kalsch,H., Nothen,M.M., den Hoed,M., Loos,R.J.,
            Thelle,D.S., Gieger,C., Meitinger,T., Perz,S., Peters,A.,
            Prucha,H., Sinner,M.F., Waldenberger,M., de Boer,R.A., Franke,L.,
            van der Vleuten,P.A., Beckmann,B.M., Martens,E., Bardai,A.,
            Hofman,N., Wilde,A.A., Behr,E.R., Dalageorgou,C., Giudicessi,J.R.,
            Medeiros-Domingo,A., Barc,J., Kyndt,F., Probst,V., Ghidoni,A.,
            Insolia,R., Hamilton,R.M., Scherer,S.W., Brandimarto,J.,
            Margulies,K., Moravec,C.E., del Greco,M. F, Fuchsberger,C.,
            O'Connell,J.R., Lee,W.K., Watt,G.C., Campbell,H., Wild,S.H., El
            Mokhtari,N.E., Frey,N., Asselbergs,F.W., Mateo Leach,I., Navis,G.,
            van den Berg,M.P., van Veldhuisen,D.J., Kellis,M., Krijthe,B.P.,
            Franco,O.H., Hofman,A., Kors,J.A., Uitterlinden,A.G.,
            Witteman,J.C., Kedenko,L., Lamina,C., Oostra,B.A., Abecasis,G.R.,
            Lakatta,E.G., Mulas,A., Orru,M., Schlessinger,D., Uda,M.,
            Markus,M.R., Volker,U., Snieder,H., Spector,T.D., Arnlov,J.,
            Lind,L., Sundstrom,J., Syvanen,A.C., Kivimaki,M., Kahonen,M.,
            Mononen,N., Raitakari,O.T., Viikari,J.S., Adamkova,V., Kiechl,S.,
            Brion,M., Nicolaides,A.N., Paulweber,B., Haerting,J.,
            Dominiczak,A.F., Nyberg,F., Whincup,P.H., Hingorani,A.D.,
            Schott,J.J., Bezzina,C.R., Ingelsson,E., Ferrucci,L., Gasparini,P.,
            Wilson,J.F., Rudan,I., Franke,A., Muhleisen,T.W., Pramstaller,P.P.,
            Lehtimaki,T.J., Paterson,A.D., Parsa,A., Liu,Y., van Duijn,C.M.,
            Siscovick,D.S., Gudnason,V., Jamshidi,Y., Salomaa,V., Felix,S.B.,
            Sanna,S., Ritchie,M.D., Stricker,B.H., Stefansson,K., Boyer,L.A.,
            Cappola,T.P., Olsen,J.V., Lage,K., Schwartz,P.J., Kaab,S.,
            Chakravarti,A., Ackerman,M.J., Pfeufer,A., de Bakker,P.I. and
            Newton-Cheh,C.
  CONSRTM   CARe Consortium; COGENT Consortium; DCCT/EDIC; eMERGE Consortium;
            HRGEN Consortium
  TITLE     Genetic association study of QT interval highlights role for
            calcium signaling pathways in myocardial repolarization
  JOURNAL   Nat Genet 46 (8), 826-836 (2014)
   PUBMED   24952745
REFERENCE   6  (bases 1 to 6212)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   7  (bases 1 to 6212)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 6212)
  AUTHORS   De Moor,M.H., Liu,Y.J., Boomsma,D.I., Li,J., Hamilton,J.J.,
            Hottenga,J.J., Levy,S., Liu,X.G., Pei,Y.F., Posthuma,D.,
            Recker,R.R., Sullivan,P.F., Wang,L., Willemsen,G., Yan,H., De
            Geus,E.J. and Deng,H.W.
  TITLE     Genome-wide association study of exercise behavior in Dutch and
            American adults
  JOURNAL   Med Sci Sports Exerc 41 (10), 1887-1895 (2009)
   PUBMED   19727025
REFERENCE   9  (bases 1 to 6212)
  AUTHORS   Zhu,C.H., Kim,J., Shay,J.W. and Wright,W.E.
  TITLE     SGNP: an essential Stress Granule/Nucleolar Protein potentially
            involved in 5.8s rRNA processing/transport
  JOURNAL   PLoS One 3 (11), e3716 (2008)
   PUBMED   19005571
  REMARK    GeneRIF: SGNP is localized in both the cytoplasm and nucleolus and
            defines a non-nucleolar compartment containing 5.8S rRNA. Under
            oxidative stress, SGNP nucleolar localization decreases and it
            rapidly co-localizes with stress granules.
REFERENCE   10 (bases 1 to 6212)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB454965.1, AL525852.3, AF193059.1, AC012459.7 and BQ030316.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001100423.1.
            
            Transcript Variant: This variant (3) has an alternate 5' UTR exon,
            compared to variant 1. Variants 1, 2, 3 and 5 encode the same
            isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF193059.1, SRR1803617.280121.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000409140.8/ ENSP00000386730.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                DB454965.1         65-118
            55-56               AL525852.3         88-89
            57-575              AF193059.1         52-570
            576-2478            AF193059.1         572-2474
            2479-6206           AC012459.7         86862-90589         c
            6207-6211           BQ030316.1         15-19               c
            6212-6212           AC012459.7         86856-86856         c
FEATURES             Location/Qualifiers
     source          1..6212
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q33.1"
     gene            1..6212
                     /gene="SPATS2L"
                     /gene_synonym="DNAPTP6; SGNP"
                     /note="spermatogenesis associated serine rich 2 like"
                     /db_xref="GeneID:26010"
                     /db_xref="HGNC:HGNC:24574"
                     /db_xref="MIM:613817"
     exon            1..230
                     /gene="SPATS2L"
                     /gene_synonym="DNAPTP6; SGNP"
                     /inference="alignment:Splign:2.1.0"
     exon            231..280
                     /gene="SPATS2L"
                     /gene_synonym="DNAPTP6; SGNP"
                     /inference="alignment:Splign:2.1.0"
     exon            281..341
                     /gene="SPATS2L"
                     /gene_synonym="DNAPTP6; SGNP"
                     /inference="alignment:Splign:2.1.0"
     CDS             303..1979
                     /gene="SPATS2L"
                     /gene_synonym="DNAPTP6; SGNP"
                     /note="isoform a is encoded by transcript variant 3;
                     SPATS2-like protein; stress granule and nucleolar protein;
                     DNA polymerase-transactivated protein 6"
                     /codon_start=1
                     /product="SPATS2-like protein isoform a"
                     /protein_id="NP_001093893.1"
                     /db_xref="CCDS:CCDS46483.1"
                     /db_xref="GeneID:26010"
                     /db_xref="HGNC:HGNC:24574"
                     /db_xref="MIM:613817"
                     /translation="MAELNTHVNVKEKIYAVRSVVPNKSNNEIVLVLQQFDFNVDKAV
                     QAFVDGSAIQVLKEWNMTGKKKNNKRKRSKSKQHQGNKDAKDKVERPEAGPLQPQPPQ
                     IQNGPMNGCEKDSSSTDSANEKPALIPREKKISILEEPSKALRGVTEGNRLLQQKLSL
                     DGNPKPIHGTTERSDGLQWSAEQPCNPSKPKAKTSPVKSNTPAAHLEIKPDELAKKRG
                     PNIEKSVKDLQRCTVSLTRYRVMIKEEVDSSVKKIKAAFAELHNCIIDKEVSLMAEMD
                     KVKEEAMEILTARQKKAEELKRLTDLASQMAEMQLAELRAEIKHFVSERKYDEELGKA
                     ARFSCDIEQLKAQIMLCGEITHPKNNYSSRTPCSSLLPLLNAHAATSGKQSNFSRKSS
                     THNKPSEGKAANPKMVSSLPSTADPSHQTMPANKQNGSSNQRRRFNPQYHNNRLNGPA
                     KSQGSGNEAEPLGKGNSRHEHRRQPHNGFRPKNKGGAKNQEASLGMKTPEAPAHSEKP
                     RRRQHAADTSEARPFRGSVGRVSQCNLCPTRIEVSTDAAVLSVPAVTLVA"
     exon            342..450
                     /gene="SPATS2L"
                     /gene_synonym="DNAPTP6; SGNP"
                     /inference="alignment:Splign:2.1.0"
     exon            451..500
                     /gene="SPATS2L"
                     /gene_synonym="DNAPTP6; SGNP"
                     /inference="alignment:Splign:2.1.0"
     exon            501..747
                     /gene="SPATS2L"
                     /gene_synonym="DNAPTP6; SGNP"
                     /inference="alignment:Splign:2.1.0"
     exon            748..954
                     /gene="SPATS2L"
                     /gene_synonym="DNAPTP6; SGNP"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1090
                     /gene="SPATS2L"
                     /gene_synonym="DNAPTP6; SGNP"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1149
                     /gene="SPATS2L"
                     /gene_synonym="DNAPTP6; SGNP"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1259
                     /gene="SPATS2L"
                     /gene_synonym="DNAPTP6; SGNP"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1362
                     /gene="SPATS2L"
                     /gene_synonym="DNAPTP6; SGNP"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1583
                     /gene="SPATS2L"
                     /gene_synonym="DNAPTP6; SGNP"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..6212
                     /gene="SPATS2L"
                     /gene_synonym="DNAPTP6; SGNP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2458..2463
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPATS2L"
                     /gene_synonym="DNAPTP6; SGNP"
                     /note="hexamer: ATTAAA"
     polyA_site      2478
                     /gene="SPATS2L"
                     /gene_synonym="DNAPTP6; SGNP"
                     /note="major polyA site"
     regulatory      2586..2591
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPATS2L"
                     /gene_synonym="DNAPTP6; SGNP"
                     /note="hexamer: AATAAA"
     polyA_site      2611
                     /gene="SPATS2L"
                     /gene_synonym="DNAPTP6; SGNP"
     regulatory      6195..6200
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPATS2L"
                     /gene_synonym="DNAPTP6; SGNP"
                     /note="hexamer: AATAAA"
     polyA_site      6212
                     /gene="SPATS2L"
                     /gene_synonym="DNAPTP6; SGNP"
ORIGIN      
        1 agttgtgtca gtgaaggaat ccagtccggg ggccgagctg gctgcgccct ccgctgcaag
       61 cgccggcagc gcggggcgag ctccggacgg cgcgcggccc aggcagcggc tcccgctcgg
      121 cccgccctcc gagccgcagg ggccgccacc gccgcggcgc ctcccctggc gaccgcgccc
      181 ccgggccccg gctccggccc gggacggagg agccggcgct cgacacagag agctcttcag
      241 aaaccaggct gctttcagga acattgctgt ggattcccag ggcctattcc actagaagca
      301 agatggctga actcaatact catgtgaatg tcaaggaaaa gatctatgca gttagatcag
      361 ttgttcccaa caaaagcaat aatgaaatag tcctggtgct ccaacagttt gattttaatg
      421 tggataaagc cgtgcaagcc tttgtggatg gcagtgcaat tcaagttcta aaagaatgga
      481 atatgacagg aaaaaagaag aacaataaaa gaaaaagaag caagtccaag cagcatcaag
      541 gcaacaaaga tgctaaagac aaggtggaga ggcctgaggc agggcccctg cagccgcagc
      601 caccacagat tcaaaacggc cccatgaatg gctgcgagaa ggacagctcg tccacagatt
      661 ctgctaacga aaaaccagcc cttatccctc gtgagaaaaa gatctcgata cttgaggaac
      721 cttcaaaggc acttcgtggg gtcacagaag gcaacagact actgcaacag aaactatcct
      781 tagatgggaa ccccaaacct atacatggaa caacagagag gtcagatggc ctacagtggt
      841 cagctgagca gccttgtaac ccaagcaagc ctaaggcaaa aacatctcct gttaagtcca
      901 atacccctgc agctcatctt gaaataaagc cagatgagtt ggcaaagaaa agaggcccaa
      961 atattgagaa atcagtgaag gatttgcaac gctgcaccgt ttctctaact agatatcgcg
     1021 tcatgattaa ggaagaagtg gatagttccg tgaagaagat caaagctgcc tttgctgaat
     1081 tacacaactg catcattgac aaagaagttt cattaatggc agaaatggat aaagttaaag
     1141 aagaagccat ggaaatcctg actgctcgtc agaagaaagc agaagaacta aagagactca
     1201 ctgaccttgc cagtcagatg gcagagatgc agctggccga actcagggca gaaattaagc
     1261 actttgtcag cgagcgtaaa tatgacgagg agctcgggaa agctgcccgg ttttcctgtg
     1321 acatcgaaca gctgaaggcc caaatcatgc tctgcggaga aattacacat ccaaagaaca
     1381 actattcctc aagaactccc tgcagctccc tgctgcctct gctgaatgcg cacgcagcaa
     1441 cctctgggaa acagagtaac ttttcccgaa aatcatccac tcacaataag ccctctgaag
     1501 gcaaagcggc aaaccccaaa atggtgagca gtctccccag caccgccgac ccctctcacc
     1561 agaccatgcc ggccaacaag cagaatggat cttctaacca aagacggaga tttaatccac
     1621 agtatcataa caacaggcta aatgggcctg ccaagtcgca gggcagtggg aatgaagccg
     1681 agccactggg aaagggcaac agccgccacg aacacagaag acagccgcac aacggcttcc
     1741 ggcccaaaaa caaaggcggt gccaaaaatc aagaggcttc cttggggatg aagacccccg
     1801 aggccccggc ccattctgaa aagccccggc gaaggcagca cgctgcagac acctcggagg
     1861 ccaggccctt ccggggtagt gtcggtaggg tttcacagtg caatctctgc cccacgagaa
     1921 tagaagtttc cacagatgca gcagttctct cagtcccggc tgtgacgttg gtggcctgag
     1981 ctaggaggaa aaagagcagt tttcactcag ttttggttcc ctgcccgagg tgctgaccca
     2041 attcgctgcc aaaagagtgt caatcagaat atacaaatcc cgtatggttg tgtcatcctc
     2101 tcttaatcat ttttactaat tctaataatc agctctagct tgcttcataa ttttcatggc
     2161 tttgcttgat ctgttgatgc tttctctcat caagactttg cagcatttta gccaggcagt
     2221 atttactcat tattaggaaa atcaagatgt ggctgaagat cagaggctca gttagcaacc
     2281 tgtgttgtag cagtgatgtc agtccattga ttgtctttag agagttaatg ttacaaaaaa
     2341 gaattcttaa taatcagaca aacatgatct gctgaggaca catgcgcttt tgtagaattt
     2401 aacatctggt gtttttctga aaaaatatat atacatatat tgctttattt gaaacaaatt
     2461 aaaatatgct gcatttgaca cctggctagt ttcttttatt gatacccacc tagttattga
     2521 atgtactgtt tagtgctttc aaaaaaaact ttagagacta gaggttgtgg tgcaaagctg
     2581 tgtacaataa atactgtttc tgttgagaca agtactcttt caggaaaata tatatatgcc
     2641 ctttcaatta gattacacaa atagatggat atgcaccctg atcatcttag acacaccatg
     2701 tggcagttgg gcagttggaa acattggttg caagtactac aaacctcagc tgagcctagc
     2761 ttcaacaata agaatttatt ggttcagtga gtgaaaagtc cagttggtcc aatttgatca
     2821 ggatttcagc tcccatctct tttttttttt tcttttttct ttttcttttt ttgagacagt
     2881 cttgctttgt cacccaggtg gagtgcaatg gcatgatctc ggctcactgc aacctccgcc
     2941 tcctgggttc aagccattct cctgcccggc cttccgagta gctgggatta caggcatgtg
     3001 ccaccacgcc ctgctaattt ttatattatt agtacagaca ggatttcacc atgttgtcca
     3061 ggctggtctc aaacccctga cctcaggtga tccacctgct ttggcctccg aaactgccgg
     3121 aattacaggc atgagccacc gtacccggcc agctcccatc tcttaattat cttagctctc
     3181 ctttcctcct tgggttgaca ttgcattcag aattgtggca aagggccacc atgctcttaa
     3241 gactcaagtc tattttccac actgtccaga ggagagaagt tatcctagta gcttctacac
     3301 agagcaagtg tctttctcag aaatcccagc aaaggtcttg cataccattg ctggtaggcc
     3361 tgtctcttaa accaatcatg aaagggggga gagaagtgaa tgggatgaac taatttgcat
     3421 agactaatta gagcccaccc ctggagcctg ggtgtggcca tcttcccaga gttcctgagc
     3481 tagatggaga aggggtactt ctcagaaagg gaaaatggat acccaatggc ccaaacccaa
     3541 aatagcccca gttcccctaa ctttgactac agggcagtcc agtttgggtg ccgcttccgt
     3601 tgcactcaca tgtcctacat atctgttgac tactcacaag tgcaaatgct tattctcaac
     3661 tcaacattaa cattttttct ggcaacccag gttcactggt tctcttccac agagcggccc
     3721 tgagcagctg agcctgcaag ccacgcaagc atctgtttct tcttttgcca agtacaggag
     3781 gatgtttgct ctctctgtag agagctttct gaggtctctg ggtgtaccca gagatttaat
     3841 agaaattctt aacgttaagt cacattccag gaaggaagga agagttgttc gttcaaataa
     3901 gaaagataaa tgttcggcac tgtaggccct gtttacccca tctgaggccc tgaattcata
     3961 tattacaaga cggaaggatt ttgcacagtt ttttatgtag caagattttg ctcaccactg
     4021 aaaaatgtca gtgtaaatgt gaccgcttta aagatgagtc aagtaattct tggaacaggg
     4081 aaaaaaatga atttgccagg tcaggagttc acctgccttt gtcagagttg aacccaacca
     4141 ctcttgacct cgactcactc ccttagggtt aagaaagccc aaacacattc ctgagcacag
     4201 agcaaacact cccatgtcac tgaaaagaaa caaaagaatg ctaaaaagtg ctcagacctg
     4261 atcacatttt ttccaatatt ttttcctttt tttttttttt tttgagacag ggtcttgctc
     4321 tatcacctag gctggagtgc atgtttttga gacagggtct tgctctatca cctaggctgg
     4381 agtgcatgat catggctcac tatagccttg aactcctggg ctcaagccat cctcagcctc
     4441 ccaagttgcg aggactacag gtgtgcacca caacgtccca gctacttttt aaatttttag
     4501 tagaaacgag gtctcactat ggtgcccaga ctggtctcga actccggagc tcaagtgatc
     4561 ttcctgcttt ggcctcccaa agtgttagaa ttacaggcat gagccacctc gcctggctgg
     4621 tttttgcctt tcttatagac cctgggcatg taagcattta ttagtttgca tttttgaaac
     4681 agtaatttca atattttagt gccaatgtca ggccgcttaa acactgtatt acatatcttc
     4741 atctgtctgg tggaactatt ggtgtgatcc tagagaactg agtcctattc tgccattcat
     4801 ttaaagtgtt ttaaactcta atctctctac ttaatgcaca gtagtcagat tattctctta
     4861 aacatttgcc tagtagaggt taaaatagtt taatccttat gaagatggaa taacttcaaa
     4921 ctcacattgt ggcacttaga tcttccacca agacttcatc cgtgaaatcc acacctccct
     4981 gttgggttcc caattacatt ccaaatttac atttcttttg agaatctctg catactccag
     5041 ctctgtcctg ttgatcctat tctagaagtg cttaatgcag caagacacag aaagttaaac
     5101 gcaaattgct gcaaaattca ccctcagtgg aggactagaa acacaacatg tccaatttaa
     5161 agctcagttc acaagcagtt caattctgct ggcatcagaa aaggagattc taattaaaca
     5221 ttcttaggga aggacatcaa atgaggttaa tgggaaacgt taccagatta aaagcagttt
     5281 tttgacaaag taacagattt ggaaattctg actctctgaa agccttgatt tgaacctcaa
     5341 acttgatttc accatgagaa gtggggatca agggcctgcg cagttctttt cctaaatcga
     5401 ttcggtgctc cccaccccga cgcaggcaca ggtccgcaac cagataggga gatgcctgaa
     5461 tttcaggcta cctttgacaa agctttcttc ctccctccct ccctttgcac gctgcatccc
     5521 acgctgcctg cttaaagcgc cctcatgtgt ctacagatgg taaaacgttt atttctcaac
     5581 agacattcca gtgatagcat ccaatgacct atgtaacggc accctttttt gctgtacgcg
     5641 ttttttgaga tggagtctcg ctctgtcgcc caggctggag tgcagtggcg cggtctcggc
     5701 tcactgcaag ctccgcctcc cgggttcacg ccattctcct gcctcagcct cccgagtagc
     5761 tgggactaca ggcacccgcc accacacctg gctaattttt tgtattttta gtagatacag
     5821 ggtttcaccg tgttagccag gatggttttg atctcctgac ctcgtgatcc acccccctcg
     5881 gcctcccaaa gtgctgggat tacaggggtg agccactgcg cccggcccca gtcacttgtt
     5941 cttaagtttc ttaagcaaac tataaaatag caaaagacca aaaaaaaagg aaaaaaagca
     6001 gttcgcctaa tacattgttc cagcatttcc ttgaaagtac tgagccatct caattgctct
     6061 gattttgtga gaaaattatg aagagttgca aagtcccagt gattctcttg ttacttagct
     6121 aagaatttga aatgtaattt aaatactatt ctttacaatc cattataagg attttaaaat
     6181 ctttttgctt ctttaataaa ttctaacaaa gt
//
