LOCUS       NM_023071               3240 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens spermatogenesis associated serine rich 2 (SPATS2),
            transcript variant 3, mRNA.
ACCESSION   NM_023071
VERSION     NM_023071.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3240)
  AUTHORS   Lin,J., Yan,J., Deng,X.L., Wang,C.S. and Wang,H.S.
  TITLE     SPATS2 is correlated with cell cycle progression and immune cells
            infiltration in hepatocellular carcinoma
  JOURNAL   BMC Gastroenterol 23 (1), 8 (2023)
   PUBMED   36631750
  REMARK    GeneRIF: SPATS2 is correlated with cell cycle progression and
            immune cells infiltration in hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3240)
  AUTHORS   Yan,J., Huang,Q.Y., Huang,Y.J., Wang,C.S. and Liu,P.X.
  TITLE     SPATS2 is positively activated by long noncoding RNA SNHG5 via
            regulating DNMT3a expression to promote hepatocellular carcinoma
            progression
  JOURNAL   PLoS One 17 (1), e0262262 (2022)
   PUBMED   35077478
  REMARK    GeneRIF: SPATS2 is positively activated by long noncoding RNA SNHG5
            via regulating DNMT3a expression to promote hepatocellular
            carcinoma progression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3240)
  AUTHORS   Dong,G., Zhang,S., Shen,S., Sun,L., Wang,X., Wang,H., Wu,J.,
            Liu,T., Wang,C., Wang,H., Lu,T., Rao,B. and Ren,Z.
  TITLE     SPATS2, negatively regulated by miR-145-5p, promotes hepatocellular
            carcinoma progression through regulating cell cycle
  JOURNAL   Cell Death Dis 11 (10), 837 (2020)
   PUBMED   33037180
  REMARK    GeneRIF: SPATS2, negatively regulated by miR-145-5p, promotes
            hepatocellular carcinoma progression through regulating cell cycle.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3240)
  AUTHORS   Xing,J., Tian,Y., Ji,W. and Wang,X.
  TITLE     Comprehensive evaluation of SPATS2 expression and its prognostic
            potential in liver cancer
  JOURNAL   Medicine (Baltimore) 99 (9), e19230 (2020)
   PUBMED   32118724
  REMARK    GeneRIF: Gene Set Enrichment Analysis (GSEA) was used to identify
            signaling pathways related to SPATS2 expression. SPATS2 expression
            could be a novel diagnostic and prognostic biomarker in liver
            cancer.
REFERENCE   5  (bases 1 to 3240)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 3240)
  AUTHORS   Seki,K., Koshi,R., Sugano,N., Masutani,S., Yoshinuma,N. and Ito,K.
  TITLE     Microarray analysis of bisphenol A-induced changes in gene
            expression in human oral epithelial cells
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 39 (11), 879-884 (2007)
   PUBMED   17989879
REFERENCE   7  (bases 1 to 3240)
  AUTHORS   Senoo,M., Hoshino,S., Mochida,N., Matsumura,Y. and Habu,S.
  TITLE     Identification of a novel protein p59(scr), which is expressed at
            specific stages of mouse spermatogenesis
  JOURNAL   Biochem Biophys Res Commun 292 (4), 992-998 (2002)
   PUBMED   11944913
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK095582.1, CN421379.1, AK023202.1, AB075515.1, DB305045.1 and
            AC009246.19.
            
            On Nov 30, 2019 this sequence version replaced NM_023071.3.
            
            Transcript Variant: This variant (3) differs in the 5' UTR,
            compared to variant 1. Variants 1, 2, and 3 encode the same
            protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK023202.1, SRR1803613.3995.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000552918.6/ ENSP00000447947.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-189               AK095582.1         558-746
            190-691             CN421379.1         173-674
            692-1135            AK095582.1         1249-1692
            1136-1758           AK023202.1         1092-1714
            1759-3046           AB075515.1         1344-2631
            3047-3239           DB305045.1         1-193               c
            3240-3240           AC009246.19        53539-53539
FEATURES             Location/Qualifiers
     source          1..3240
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.12"
     gene            1..3240
                     /gene="SPATS2"
                     /gene_synonym="Nbla00526; P59SCR; SCR59; SPATA10"
                     /note="spermatogenesis associated serine rich 2"
                     /db_xref="GeneID:65244"
                     /db_xref="HGNC:HGNC:18650"
                     /db_xref="MIM:611667"
     exon            1..126
                     /gene="SPATS2"
                     /gene_synonym="Nbla00526; P59SCR; SCR59; SPATA10"
                     /inference="alignment:Splign:2.1.0"
     exon            127..189
                     /gene="SPATS2"
                     /gene_synonym="Nbla00526; P59SCR; SCR59; SPATA10"
                     /inference="alignment:Splign:2.1.0"
     exon            190..457
                     /gene="SPATS2"
                     /gene_synonym="Nbla00526; P59SCR; SCR59; SPATA10"
                     /inference="alignment:Splign:2.1.0"
     CDS             433..2070
                     /gene="SPATS2"
                     /gene_synonym="Nbla00526; P59SCR; SCR59; SPATA10"
                     /note="serine-rich spermatocytes and round spermatid
                     protein; putative protein product of Nbla00526;
                     serine-rich spermatocytes and round spermatid 59 kDa
                     protein"
                     /codon_start=1
                     /product="spermatogenesis-associated serine-rich protein
                     2"
                     /protein_id="NP_075559.2"
                     /db_xref="CCDS:CCDS31794.1"
                     /db_xref="GeneID:65244"
                     /db_xref="HGNC:HGNC:18650"
                     /db_xref="MIM:611667"
                     /translation="MSRKQNQKDSSGFIFDLQSNTVLAQGGAFENMKEKINAVRAIVP
                     NKSNNEIILVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEP
                     SNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTESVDSLSEGLETLSIDARE
                     LEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQF
                     SNMGMEDVPLATSKKLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAE
                     LESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQMSEQQLVELRAD
                     IKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSL
                     SSPSDASAASSSTCASPPSLTSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRG
                     GQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIERGQTHSA
                     GTNGTGVSMEPSPPTPSFKKGLPQRKPRTSQTEAVNS"
     exon            458..537
                     /gene="SPATS2"
                     /gene_synonym="Nbla00526; P59SCR; SCR59; SPATA10"
                     /inference="alignment:Splign:2.1.0"
     exon            538..646
                     /gene="SPATS2"
                     /gene_synonym="Nbla00526; P59SCR; SCR59; SPATA10"
                     /inference="alignment:Splign:2.1.0"
     exon            647..696
                     /gene="SPATS2"
                     /gene_synonym="Nbla00526; P59SCR; SCR59; SPATA10"
                     /inference="alignment:Splign:2.1.0"
     exon            697..958
                     /gene="SPATS2"
                     /gene_synonym="Nbla00526; P59SCR; SCR59; SPATA10"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1135
                     /gene="SPATS2"
                     /gene_synonym="Nbla00526; P59SCR; SCR59; SPATA10"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1271
                     /gene="SPATS2"
                     /gene_synonym="Nbla00526; P59SCR; SCR59; SPATA10"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1330
                     /gene="SPATS2"
                     /gene_synonym="Nbla00526; P59SCR; SCR59; SPATA10"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1440
                     /gene="SPATS2"
                     /gene_synonym="Nbla00526; P59SCR; SCR59; SPATA10"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1543
                     /gene="SPATS2"
                     /gene_synonym="Nbla00526; P59SCR; SCR59; SPATA10"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1758
                     /gene="SPATS2"
                     /gene_synonym="Nbla00526; P59SCR; SCR59; SPATA10"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..3240
                     /gene="SPATS2"
                     /gene_synonym="Nbla00526; P59SCR; SCR59; SPATA10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3213..3218
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPATS2"
                     /gene_synonym="Nbla00526; P59SCR; SCR59; SPATA10"
                     /note="hexamer: AATAAA"
     polyA_site      3240
                     /gene="SPATS2"
                     /gene_synonym="Nbla00526; P59SCR; SCR59; SPATA10"
                     /note="major polyA site"
ORIGIN      
        1 ggcgacggcg gcggtggctc tagaagggga ggtggaggat ctcctttcct cttctcagac
       61 ccgggagcgt ccgggacgcg gagcccggag ctggggcgac gaggcgattg cgggggcctg
      121 ggctagctgc tggctaccaa tattctactt tctgtctcta tgaatgtgac taccctggtt
      181 acctcatata atctccctgg aaaaggagac atgaatgtct gcaatgatac ttcctgacaa
      241 gaagttgata caagaaaagg aaaggagatt aacagctagt gagcagaatt tcgaacagca
      301 ggatttcgta ttttttgctt ccaactgcac acttccgttg cccactttta aatcagagat
      361 acctacactc aaaacccaga caaggcaaaa ggatactttt cttgtatatt ttttgagatc
      421 gaagaaacga caatgtccag gaaacagaac cagaaggatt catcaggatt catttttgat
      481 ttgcagtcca ataccgtact ggcccaggga ggagcttttg agaacatgaa agagaagata
      541 aatgcggtac gtgcaatagt tcctaataag agcaacaatg aaattatcct ggttttgcag
      601 cactttgata actgtgtgga caaaacagta caagcattca tggaaggtag tgccagtgaa
      661 gtactcaaag aatggacagt aacaggcaag aaaaagaaca aaaagaagaa aaacaaaccg
      721 aaacctgccg cagaaccaag taacggcatc ccagattcca gtaaatcagt ttccattcaa
      781 gaggaacagt ctgcgccttc ctcagagaaa ggtggtatga atggctacca tgtcaatggt
      841 gccatcaatg acactgagtc tgtggactca ctcagtgaag gtttggagac actttcaata
      901 gatgccagag aattggagga tcccgagtct gccatgctag atacgctgga tagaacagga
      961 tccatgctgc agaatggtgt ctctgatttt gagaccaagt ctttgactat gcactctatt
     1021 cacaattctc aacaacccag gaatgctgcc aaatctctct caagacctac cacagaaact
     1081 cagttttcaa atatggggat ggaagatgtt cccctcgcca ccagtaaaaa gctaagttcc
     1141 aatattgaaa aatctgtaaa agacctccag cgctgcacag tgtctcttgc acggtatcga
     1201 gttgtagtta aagaagagat ggatgcctcc attaagaaaa tgaaacaagc ctttgctgaa
     1261 ttggagagct gtttaatgga tcgagaagtg gcgttgcttg ctgaaatgga caaagtgaaa
     1321 gctgaagcaa tggaaatttt gctcagccga caaaagaagg ctgaacttct aaagaagatg
     1381 actcatgtgg ctgttcaaat gtcagagcag caattggttg agctcagagc tgatatcaag
     1441 cactttgtta gtgaacgtaa atatgatgag gatctgggac gagtagcccg gttcacctgt
     1501 gatgtagaga ccctaaagaa gagcattgat tcatttggac aagtgtctca tccaaagaac
     1561 agctattcga ccagatcccg atgtagctca gttacatctg tgtccttgag tagcccaagt
     1621 gatgcctctg ctgcttcctc ttccacctgt gcctctcctc ccagccttac aagtgctaac
     1681 aagaaaaact ttgcaccggg agagactcct gcagccatag caaactccag tggccagccc
     1741 taccagccac ttcgggaggt attgccaggg aacagacgag gaggacaggg ctataggcca
     1801 caaggccaaa agtccaatga ccccatgaac caagggcggc atgacagtat gggtcgttac
     1861 agaaacagct cgtggtattc atctggttcc aggtatcaga gtgctccatc tcaggcacca
     1921 ggaaacacca ttgaaagagg ccagactcac tctgcaggga ccaatggaac tggagtcagc
     1981 atggagccca gccctcccac gccttcattc aaaaaggggc tcccccagcg caaacccagg
     2041 acctctcaga ctgaagccgt gaactcttga gagaaaatcc agttggcctc tctcctctat
     2101 ccacacaatt caacttgata actggacttt aggaaactta cagttagatg taataacaaa
     2161 aagaagttta tgcgtatcac tttttgtgcc attctaagta tttttggttt cttgtctcct
     2221 tatttcctct ttaccatttt tggaggggaa gctatttttt ttccttgatc tttcccagtg
     2281 atatggattg aatctggttg gtcatttcca ccaggaatca gaggcagctg ttaccaggtt
     2341 tcggccttcc agttgatccc tccactgtcc aggctgtctc aggaggaggt gaatcagagc
     2401 tagtctgtca cctttccaat ctaagccgaa gccacaggtg cctgacaggt tcccttctaa
     2461 caactatttg accaagagag gcaatcaggg ggttgtatac tgcactggat tcgccagaga
     2521 agggaaaatt taattagtga aaaggaaaga acactaggaa acatttgaga acctgcctct
     2581 atcccagaat gtgctggaga tttgacactc aaatcagtgt ttagtcttct gcttggcacc
     2641 atagcttaac ctgcagtttc ttcaaaatgc ccaatgcctt gtttcctatt accttagatt
     2701 gcaaaccagt ctagggaagt ctatgagaaa gtagcattta attaaagttt aaaaaaaaaa
     2761 aggttgggcg ttgtggctca tgcctgtaat cccagcactt tgggaggctg aggcgggtgg
     2821 atcactaggt caggagttca agaccagcct ggccaacatg gtgaaaccct gtctgtacta
     2881 aaaatacaaa aattagctga gcatggtggc gtgtgcctgt aatctcagct actcaggagg
     2941 ctgaggcagg agaatcgctt gaacccagga ggcggaggct gcagtgagct gagattgtgc
     3001 cactgcactc cagcctggga gacagagcaa gactcagtct caaaaaaaaa aaaaaaagca
     3061 tttttctgtt ttaatgtttg gagacttttt tttttgttct ctccctttcc tgaaccctat
     3121 tctgatcctg aaccaaattt atagcaatat aattagtgtt aatctaaggc attactcatc
     3181 aaaaaaattg ctgcagtctt tacagttgaa taaataaaaa caactgcata aatatgccca
//
