LOCUS       NM_198572               2170 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens spermatogenesis and centriole associated 1 (SPATC1),
            transcript variant 1, mRNA.
ACCESSION   NM_198572 XM_351789
VERSION     NM_198572.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2170)
  AUTHORS   Goto,M., O'Brien,D.A. and Eddy,E.M.
  TITLE     Speriolin is a novel human and mouse sperm centrosome protein
  JOURNAL   Hum Reprod 25 (8), 1884-1894 (2010)
   PUBMED   20542897
  REMARK    GeneRIF: Speriolin is a novel centrosomal protein present in the
            connecting piece region of human sperm that is transmitted to the
            zygote and can be detected throughout the first mitotic division.
REFERENCE   2  (bases 1 to 2170)
  AUTHORS   Goto,M. and Eddy,E.M.
  TITLE     Speriolin is a novel spermatogenic cell-specific centrosomal
            protein associated with the seventh WD motif of Cdc20
  JOURNAL   J Biol Chem 279 (40), 42128-42138 (2004)
   PUBMED   15280373
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC206437.3, DB052198.1, AB092352.1 and BC053547.1.
            
            On May 17, 2019 this sequence version replaced NM_198572.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053547.1, AB092352.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377470.8/ ENSP00000366690.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               AC206437.3         10132-10265
            135-146             DB052198.1         1-12
            147-428             AB092352.1         1-282
            429-1653            BC053547.1         270-1494
            1654-2085           AB092352.1         1508-1939
            2086-2170           BC053547.1         1927-2011
FEATURES             Location/Qualifiers
     source          1..2170
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..2170
                     /gene="SPATC1"
                     /gene_synonym="SPATA15"
                     /note="spermatogenesis and centriole associated 1"
                     /db_xref="GeneID:375686"
                     /db_xref="HGNC:HGNC:30510"
                     /db_xref="MIM:610874"
     exon            1..447
                     /gene="SPATC1"
                     /gene_synonym="SPATA15"
                     /inference="alignment:Splign:2.1.0"
     CDS             237..2012
                     /gene="SPATC1"
                     /gene_synonym="SPATA15"
                     /note="isoform 1 is encoded by transcript variant 1;
                     spermatogenesis-associated protein 15; spermatogenic
                     cell-specific Cdc20-binding protein; spermatogenesis and
                     centriole-associated protein 1; testicular tissue protein
                     Li 181"
                     /codon_start=1
                     /product="speriolin isoform 1"
                     /protein_id="NP_940974.2"
                     /db_xref="CCDS:CCDS6413.2"
                     /db_xref="GeneID:375686"
                     /db_xref="HGNC:HGNC:30510"
                     /db_xref="MIM:610874"
                     /translation="MSLLTNYEGLRHQIERLVRENEELKKLVRLIRENHELKSAIKTQ
                     AGGLGISGFTSGLGEATAGLSSRQNNGVFLPPSPAVANERVLEEVGIMALAPLAEMLT
                     SLQPSATPGSLMSPLTGTLSTLLSGPAPTSQSSPLTSFLTSPIAGPLTGTLASSLGLP
                     STGTLTPSSLVAGPVAMSQSSPLIAPVMGTVAVSLSSPLLSSTATPPGVSQNLLANPM
                     SNLVLPEAPRLRLAEPLRGGPTGPQSPACVVPTATTKVPLSTEPPQSTQDPEPLSMAF
                     AGAPLQTSTPIGAMGTPAPKTAFSFNTSDTQAQPSAAQEQVVPASVPTSPTTSPTVTV
                     LASAPALAPQVATSYTPSSTTHIAQGAPHPPSRMHNSPTQNLPVPHCPPHNAHSPPRT
                     SSSPASVNDSRGPRTTEPSTKSMMEVERKLAHRKTSKFPENPRESKQLAWERLVGEIA
                     FQLDRRILSSIFPERVRLYGFTVSNIPEKIIQASLNPSDHKLDEKLCQRLTQRYVSVM
                     NRLQSLGYNGRVHPALTEQLVNAYGILRERPELAASEGGPYTVDFLQRVVVETVHPGM
                     LADALLLLSCLSQLAHDDGKPMFIW"
     exon            448..1002
                     /gene="SPATC1"
                     /gene_synonym="SPATA15"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1542
                     /gene="SPATC1"
                     /gene_synonym="SPATA15"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1682
                     /gene="SPATC1"
                     /gene_synonym="SPATA15"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..2170
                     /gene="SPATC1"
                     /gene_synonym="SPATA15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2066..2071
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPATC1"
                     /gene_synonym="SPATA15"
                     /note="hexamer: ATTAAA"
     polyA_site      2085
                     /gene="SPATC1"
                     /gene_synonym="SPATA15"
                     /note="major polyA site"
ORIGIN      
        1 acattccagg ccgaggcaag gcctgtgtac aggcctggtg gcatggagag ctgagggtgt
       61 tagagcagag agggcaagga agagggcaca gcctctgacc tcacaatacc cagggcccac
      121 tgggccagcc ttgcagactc tgcaccctcc ttcagcccag gcaaggcctg gggccctggg
      181 cagcctccag gtgcagtgcc ctcccgtggg ccgcaccctt gccactgccc cagggcatgt
      241 ctctactcac caattatgaa gggcttcggc atcagataga gaggctggtg cgggaaaatg
      301 aggaactgaa gaagttggtg cggctcattc gggagaatca cgagctcaag tcagcgatca
      361 agactcaggc aggcgggctc ggcatcagcg ggttcacgag tgggcttggt gaggcaacag
      421 caggcctttc ctcacgccag aacaatggtg tcttcctgcc cccgtcccca gcagtggcaa
      481 acgaacgagt cctcgaagaa gtggggatca tggccttggc acccctggcc gagatgctaa
      541 ccagcttgca gcccagcgcc acaccgggct cactcatgag ccccctgaca ggcaccctca
      601 gcacgctgct gtctggccca gcacccacgt cacagagcag ccccctcacc agcttcctga
      661 ccagtcccat tgcgggaccc ctaacaggca cactggccag ttccctgggc ctgccctcca
      721 ctggcaccct gactcccagc agcctcgtgg caggccctgt ggccatgtcc cagagcagcc
      781 ccctgatagc ccctgtgatg ggcacggtgg ctgtctctct gagcagcccc ctcctcagct
      841 ccactgccac cccaccaggg gtctctcaga acctgctggc caaccccatg agcaacctgg
      901 tcctgccaga ggccccaagg ctgcggctgg ctgagccact ccgcggaggc cccactgggc
      961 cccagtcccc agcttgcgtg gtacccactg ccaccaccaa agtcccactc tccactgagc
     1021 ccccccagtc gacccaggac ccagagcctc tcagcatggc gtttgcagga gcacccctcc
     1081 agacctccac ccctatcgga gccatgggca cacctgctcc caagacggcc ttctccttca
     1141 acacttcgga cacacaggcc cagcccagtg ccgcccagga acaagtggtc cctgcatctg
     1201 tccccacctc ccccaccacc tcccccacgg tcaccgtcct tgcctctgcc cccgcccttg
     1261 ccccccaggt tgccaccagc tacacaccct caagcaccac ccacatcgcc cagggtgccc
     1321 cccatccccc ttcccgaatg cataattccc caacccagaa cctgcctgtc ccccactgtc
     1381 ctccacacaa cgcccactcc ccacctcgta cctcatcctc cccggcttca gtcaatgact
     1441 ctcgaggtcc acgcaccaca gaaccgtcga cgaagagcat gatggaggtg gaacggaagc
     1501 tggcccaccg caagaccagc aagttccccg agaacccccg agagtcgaag cagctggcct
     1561 gggagaggct ggtgggtgag attgccttcc agctggaccg caggatcctg tccagcatct
     1621 tcccagagcg cgtacggctc tacggcttca ctgtctccaa catcccagag aagatcatcc
     1681 aggcttccct gaaccccagt gaccacaagc tggatgagaa gctgtgccag aggctcacac
     1741 agcgctatgt gagcgtcatg aacaggctgc agagtctggg ctacaacggg cgggtgcacc
     1801 ctgcgctgac cgagcagctg gtgaacgctt atggcatcct gcgagagcgc ccggagctgg
     1861 cggcgtctga gggcggcccc tacaccgtgg acttcctgca gcgtgtggtg gtggagaccg
     1921 tgcaccccgg catgctcgcc gacgcgctgc tgctgctctc ctgcctcagc cagctggcgc
     1981 acgatgacgg caagcccatg ttcatctggt gacgctggag ctgggaggtc caggctcgct
     2041 cagccccaca gccctgtgca cggccattaa agcttcccac agacactggt cgctgggcct
     2101 gtgccagcgc tcctgggtgg tgctgcctcc tctggggtgg ctcaccgggc cccggcaccg
     2161 tgccccttca
//
