LOCUS       NM_031952               1210 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens spermatogenesis associated 9 (SPATA9), transcript
            variant 1, mRNA.
ACCESSION   NM_031952 NM_173360
VERSION     NM_031952.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1210)
  AUTHORS   Soler Artigas,M., Loth,D.W., Wain,L.V., Gharib,S.A., Obeidat,M.,
            Tang,W., Zhai,G., Zhao,J.H., Smith,A.V., Huffman,J.E., Albrecht,E.,
            Jackson,C.M., Evans,D.M., Cadby,G., Fornage,M., Manichaikul,A.,
            Lopez,L.M., Johnson,T., Aldrich,M.C., Aspelund,T., Barroso,I.,
            Campbell,H., Cassano,P.A., Couper,D.J., Eiriksdottir,G.,
            Franceschini,N., Garcia,M., Gieger,C., Gislason,G.K., Grkovic,I.,
            Hammond,C.J., Hancock,D.B., Harris,T.B., Ramasamy,A.,
            Heckbert,S.R., Heliovaara,M., Homuth,G., Hysi,P.G., James,A.L.,
            Jankovic,S., Joubert,B.R., Karrasch,S., Klopp,N., Koch,B.,
            Kritchevsky,S.B., Launer,L.J., Liu,Y., Loehr,L.R., Lohman,K.,
            Loos,R.J., Lumley,T., Al Balushi,K.A., Ang,W.Q., Barr,R.G.,
            Beilby,J., Blakey,J.D., Boban,M., Boraska,V., Brisman,J.,
            Britton,J.R., Brusselle,G.G., Cooper,C., Curjuric,I., Dahgam,S.,
            Deary,I.J., Ebrahim,S., Eijgelsheim,M., Francks,C., Gaysina,D.,
            Granell,R., Gu,X., Hankinson,J.L., Hardy,R., Harris,S.E.,
            Henderson,J., Henry,A., Hingorani,A.D., Hofman,A., Holt,P.G.,
            Hui,J., Hunter,M.L., Imboden,M., Jameson,K.A., Kerr,S.M.,
            Kolcic,I., Kronenberg,F., Liu,J.Z., Marchini,J., McKeever,T.,
            Morris,A.D., Olin,A.C., Porteous,D.J., Postma,D.S., Rich,S.S.,
            Ring,S.M., Rivadeneira,F., Rochat,T., Sayer,A.A., Sayers,I.,
            Sly,P.D., Smith,G.D., Sood,A., Starr,J.M., Uitterlinden,A.G.,
            Vonk,J.M., Wannamethee,S.G., Whincup,P.H., Wijmenga,C.,
            Williams,O.D., Wong,A., Mangino,M., Marciante,K.D., McArdle,W.L.,
            Meibohm,B., Morrison,A.C., North,K.E., Omenaas,E., Palmer,L.J.,
            Pietilainen,K.H., Pin,I., Pola Sbreve Ek,O., Pouta,A., Psaty,B.M.,
            Hartikainen,A.L., Rantanen,T., Ripatti,S., Rotter,J.I., Rudan,I.,
            Rudnicka,A.R., Schulz,H., Shin,S.Y., Spector,T.D., Surakka,I.,
            Vitart,V., Volzke,H., Wareham,N.J., Warrington,N.M., Wichmann,H.E.,
            Wild,S.H., Wilk,J.B., Wjst,M., Wright,A.F., Zgaga,L., Zemunik,T.,
            Pennell,C.E., Nyberg,F., Kuh,D., Holloway,J.W., Boezen,H.M.,
            Lawlor,D.A., Morris,R.W., Probst-Hensch,N., Kaprio,J., Wilson,J.F.,
            Hayward,C., Kahonen,M., Heinrich,J., Musk,A.W., Jarvis,D.L.,
            Glaser,S., Jarvelin,M.R., Ch Stricker,B.H., Elliott,P.,
            O'Connor,G.T., Strachan,D.P., London,S.J., Hall,I.P., Gudnason,V.
            and Tobin,M.D.
  CONSRTM   International Lung Cancer Consortium; GIANT consortium
  TITLE     Genome-wide association and large-scale follow up identifies 16 new
            loci influencing lung function
  JOURNAL   Nat Genet 43 (11), 1082-1090 (2011)
   PUBMED   21946350
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1210)
  AUTHORS   Lu,Y., Huo,R., Yuan,Y., Li,J., Shi,Q. and Sha,J.
  TITLE     Human testicular protein NYD-SP16 is involved in sperm capacitation
            and the acrosome reaction
  JOURNAL   Fertil Steril 86 (4 Suppl), 1228-1234 (2006)
   PUBMED   16963046
  REMARK    GeneRIF: NYD-SP16 protein is component of sperm acrosome, which
            plays functional role in sperm capacitation and acrosome reaction
            and is consequently necessary for fertilization.
REFERENCE   3  (bases 1 to 1210)
  AUTHORS   Cheng,L.J., Li,J.M., Chen,J., Ge,Y.H., Yu,Z.R., Han,D.S., Zhou,Z.M.
            and Sha,J.H.
  TITLE     NYD-SP16, a novel gene associated with spermatogenesis of human
            testis
  JOURNAL   Biol Reprod 68 (1), 190-198 (2003)
   PUBMED   12493713
  REMARK    GeneRIF: may play an important role in testicular
            development/spermatogenesis and may be an important factor in male
            infertility
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC047333.1 and BQ013593.1.
            
            On Nov 22, 2018 this sequence version replaced NM_031952.3.
            
            Transcript Variant: This variant (1) represents the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: HM005492.1, BC047333.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000274432.13/ ENSP00000274432.8
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1095              BC047333.1         6-1100
            1096-1210           BQ013593.1         15-129              c
FEATURES             Location/Qualifiers
     source          1..1210
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q15"
     gene            1..1210
                     /gene="SPATA9"
                     /gene_synonym="NYD-SP16"
                     /note="spermatogenesis associated 9"
                     /db_xref="GeneID:83890"
                     /db_xref="HGNC:HGNC:22988"
                     /db_xref="MIM:608039"
     exon            1..198
                     /gene="SPATA9"
                     /gene_synonym="NYD-SP16"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..902
                     /gene="SPATA9"
                     /gene_synonym="NYD-SP16"
                     /note="isoform 1 is encoded by transcript variant 1;
                     spermatogenesis-associated protein 9; testis development
                     protein NYD-SP16; testicular tissue protein Li 179;
                     CTD-2154I11.2"
                     /codon_start=1
                     /product="spermatogenesis-associated protein 9 isoform 1"
                     /protein_id="NP_114158.2"
                     /db_xref="CCDS:CCDS4076.1"
                     /db_xref="GeneID:83890"
                     /db_xref="HGNC:HGNC:22988"
                     /db_xref="MIM:608039"
                     /translation="MPIKPVGWICGQVLKNFSGRIEGIQKAIMDLVDEFKDEFPTILR
                     LSQSNQKREPAQKTSKIRMAIALAKINRATLIRGLNSISRSSKSVAKLLHPQLACRLL
                     ELRDISGRLLREVNAPRQPLYNIQVRKGSLFEIISFPAKTALTSIIYASYAALIYLAV
                     CVNAVLKKVKNIFQEEESIRQNREESENCRKAFSEPVLSEPMFAEGEIKAKPYRSLPE
                     KPDISDYPKLLANKQSNNIQVLHSVFDQSAEMNEQI"
     exon            199..287
                     /gene="SPATA9"
                     /gene_synonym="NYD-SP16"
                     /inference="alignment:Splign:2.1.0"
     exon            288..515
                     /gene="SPATA9"
                     /gene_synonym="NYD-SP16"
                     /inference="alignment:Splign:2.1.0"
     exon            516..611
                     /gene="SPATA9"
                     /gene_synonym="NYD-SP16"
                     /inference="alignment:Splign:2.1.0"
     exon            612..1210
                     /gene="SPATA9"
                     /gene_synonym="NYD-SP16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1075..1080
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPATA9"
                     /gene_synonym="NYD-SP16"
                     /note="hexamer: AATGAA"
     polyA_site      1097
                     /gene="SPATA9"
                     /gene_synonym="NYD-SP16"
                     /note="major polyA site"
     regulatory      1188..1193
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPATA9"
                     /gene_synonym="NYD-SP16"
                     /note="hexamer: AATACA"
     polyA_site      1210
                     /gene="SPATA9"
                     /gene_synonym="NYD-SP16"
                     /note="major polyA site"
ORIGIN      
        1 agtgagctgt gagttctgtc cttgctggct ttcccaagtg gaaggctacc ctcatctttc
       61 actaatggca gactaggaca agcattaccc aggcctgcaa gcttgttaag gactaggaac
      121 ccaagcaaga actcaccatg ccaatcaaac ctgttgggtg gatatgtggg caggtgttga
      181 agaacttttc tggaagaatc gaggggatcc agaaagcaat catggacctt gtagatgagt
      241 ttaaagatga atttcccacc atcctaagat tatcacagtc taatcagaaa agagaacctg
      301 cgcagaaaac atccaaaatc aggatggcta ttgctttagc taagattaat cgagcaacat
      361 taattcgtgg attaaacagc atatccagat cctccaaatc agtggccaaa cttctgcatc
      421 ctcagcttgc atgcagactt ttagagctaa gggacatatc tggtcgtctg ctgagggaag
      481 ttaatgcgcc gaggcaaccc ctatataaca ttcaggtcag aaagggttct ttgtttgaaa
      541 tcatctcctt tccagcaaag actgctttaa ctagcataat atatgcttca tatgcagcac
      601 taatttattt ggcagtctgt gttaatgctg tgctgaagaa ggtaaagaac atcttccagg
      661 aagaagaatc cataaggcaa aacagagagg agagtgaaaa ttgtagaaaa gccttttctg
      721 agcctgtgct ttcggagcct atgtttgctg aaggtgaaat caaagcaaaa ccttataggt
      781 cattgccgga gaagccagac atttcagatt accccaagct tcttgctaat aagcagagta
      841 ataacatcca agttttacat tctgtgtttg accaatcagc tgaaatgaat gagcaaatct
      901 gaatacaggt atcactgaac agaacttaag agttatctat ttaatggcac atttcatctg
      961 acaaaactca gagtctagtt tacatattct gaattgctct gctttcttaa aaaaaagaga
     1021 agggggctac tattaaaatg tcattttcta gtatttacat gatagagtaa ataaaatgaa
     1081 tattgatgtg gaatatatgt actgactaca tacttttaat gaacaagaaa atccatcctc
     1141 tggtaggtta gactttacac tgtggtttat aatataagca tatttataat acattaatgt
     1201 ttttattaaa
//
