LOCUS       NM_019073               5003 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens spermatogenesis associated 6 (SPATA6), transcript
            variant 1, mRNA.
ACCESSION   NM_019073
VERSION     NM_019073.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5003)
  AUTHORS   Wang,X., Jiang,C., Dai,S., Shen,G., Yang,Y. and Shen,Y.
  TITLE     Identification of nonfunctional SPATA20 causing acephalic
            spermatozoa syndrome in humans
  JOURNAL   Clin Genet 103 (3), 310-319 (2023)
   PUBMED   36415156
  REMARK    GeneRIF: Identification of nonfunctional SPATA20 causing acephalic
            spermatozoa syndrome in humans.
REFERENCE   2  (bases 1 to 5003)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 5003)
  AUTHORS   Sujit,K.M., Singh,V., Trivedi,S., Singh,K., Gupta,G. and
            Rajender,S.
  TITLE     Increased DNA methylation in the spermatogenesis-associated (SPATA)
            genes correlates with infertility
  JOURNAL   Andrology 8 (3), 602-609 (2020)
   PUBMED   31838782
  REMARK    GeneRIF: Increased DNA methylation in the
            spermatogenesis-associated (SPATA) genes correlates with
            infertility.
REFERENCE   4  (bases 1 to 5003)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 5003)
  AUTHORS   Huo,S., Du,W., Shi,P., Si,Y. and Zhao,S.
  TITLE     The role of spermatogenesis-associated protein 6 in testicular germ
            cell tumors
  JOURNAL   Int J Clin Exp Pathol 8 (8), 9119-9125 (2015)
   PUBMED   26464655
  REMARK    GeneRIF: SPATA6 may play an important role in testicular germ cell
            tumors, and down-regulation of SPATA6 could lead to apoptosis of
            testicular germ cell tumors.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5003)
  AUTHORS   Ficarro,S., Chertihin,O., Westbrook,V.A., White,F., Jayes,F.,
            Kalab,P., Marto,J.A., Shabanowitz,J., Herr,J.C., Hunt,D.F. and
            Visconti,P.E.
  TITLE     Phosphoproteome analysis of capacitated human sperm. Evidence of
            tyrosine phosphorylation of a kinase-anchoring protein 3 and
            valosin-containing protein/p97 during capacitation
  JOURNAL   J Biol Chem 278 (13), 11579-11589 (2003)
   PUBMED   12509440
REFERENCE   7  (bases 1 to 5003)
  AUTHORS   Yamano,Y., Ohyama,K., Sano,T., Ohta,M., Shimada,A., Hirakawa,Y.,
            Sugimoto,M. and Morishima,I.
  TITLE     A novel spermatogenesis-related factor-1 gene expressed in maturing
            rat testis
  JOURNAL   Biochem Biophys Res Commun 289 (4), 888-893 (2001)
   PUBMED   11735130
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL356968.41, AK000869.1, AL359959.9 and BC040655.1.
            
            On Nov 23, 2018 this sequence version replaced NM_019073.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.218080.1,
                                           SRR1660803.42446.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371847.8/ ENSP00000360913.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                AL356968.41        145865-145895       c
            32-1770             AK000869.1         1-1739
            1771-4894           AL359959.9         14022-17145         c
            4895-5003           BC040655.1         1310-1418
FEATURES             Location/Qualifiers
     source          1..5003
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p33"
     gene            1..5003
                     /gene="SPATA6"
                     /gene_synonym="HASH; SRF-1; SRF1"
                     /note="spermatogenesis associated 6"
                     /db_xref="GeneID:54558"
                     /db_xref="HGNC:HGNC:18309"
                     /db_xref="MIM:613947"
     exon            1..247
                     /gene="SPATA6"
                     /gene_synonym="HASH; SRF-1; SRF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..1663
                     /gene="SPATA6"
                     /gene_synonym="HASH; SRF-1; SRF1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; spermatogenesis-associated protein 6;
                     spermatogenesis-related factor-1; testicular tissue
                     protein Li 178"
                     /codon_start=1
                     /product="spermatogenesis-associated protein 6 isoform 1
                     precursor"
                     /protein_id="NP_061946.1"
                     /db_xref="CCDS:CCDS551.1"
                     /db_xref="GeneID:54558"
                     /db_xref="HGNC:HGNC:18309"
                     /db_xref="MIM:613947"
                     /translation="MPKVKALQCALALEISSVTCPGVVLKDKEDIYLSICVFGQYKKT
                     QCVPATFPLVFNARMVFEKVFPDAVDPGDVVTQLEYDTAVFELIQLVPPVGETLSTYD
                     ENTRDFMFPGPNQMSGHHDSNRQVTMRRISGLRGNAPRLEFSTTSVITECLISSRKCH
                     TQDKFIYHLAPVEKSHGRLQNRTSRSQKKKSKSPERSKYCINAKNYEQPTISSKSHSP
                     SPYTKRRMCELSEDTRRRLAHLNLGPYEFKKETDKPPFVIRHVDPPSPRADTLLGSSG
                     RDCERDGWSRVHNDHSHLGCCRPKDYKVIRTPHGRDFDDSLEKCEEYLSPRSCSKPRH
                     SARTLLVHSAPSTMPKHSPSPVLNRASLRERFHSDWCSPSNCDEIHDRVKNVLKSHQA
                     HQRHLYDERDLEKDDELELKRSLLCRDSAYDSDPEYSSCQQPRGTFHLDDGEYWSNRA
                     ASYKGKSHRPIFENSMDKMYRNLYKKACSSASHTQESF"
     exon            248..385
                     /gene="SPATA6"
                     /gene_synonym="HASH; SRF-1; SRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            386..434
                     /gene="SPATA6"
                     /gene_synonym="HASH; SRF-1; SRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            435..476
                     /gene="SPATA6"
                     /gene_synonym="HASH; SRF-1; SRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            477..601
                     /gene="SPATA6"
                     /gene_synonym="HASH; SRF-1; SRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            602..682
                     /gene="SPATA6"
                     /gene_synonym="HASH; SRF-1; SRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            683..976
                     /gene="SPATA6"
                     /gene_synonym="HASH; SRF-1; SRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1064
                     /gene="SPATA6"
                     /gene_synonym="HASH; SRF-1; SRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1105
                     /gene="SPATA6"
                     /gene_synonym="HASH; SRF-1; SRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1290
                     /gene="SPATA6"
                     /gene_synonym="HASH; SRF-1; SRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1390
                     /gene="SPATA6"
                     /gene_synonym="HASH; SRF-1; SRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1482
                     /gene="SPATA6"
                     /gene_synonym="HASH; SRF-1; SRF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..5003
                     /gene="SPATA6"
                     /gene_synonym="HASH; SRF-1; SRF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4130..4135
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPATA6"
                     /gene_synonym="HASH; SRF-1; SRF1"
                     /note="hexamer: AGTAAA"
     polyA_site      4150
                     /gene="SPATA6"
                     /gene_synonym="HASH; SRF-1; SRF1"
                     /note="major polyA site"
     regulatory      4352..4357
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPATA6"
                     /gene_synonym="HASH; SRF-1; SRF1"
                     /note="hexamer: AATAAA"
     polyA_site      4372
                     /gene="SPATA6"
                     /gene_synonym="HASH; SRF-1; SRF1"
                     /note="major polyA site"
     regulatory      4860..4865
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPATA6"
                     /gene_synonym="HASH; SRF-1; SRF1"
                     /note="hexamer: TATAAA"
     polyA_site      4885
                     /gene="SPATA6"
                     /gene_synonym="HASH; SRF-1; SRF1"
     regulatory      4982..4987
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPATA6"
                     /gene_synonym="HASH; SRF-1; SRF1"
                     /note="hexamer: AATAAT"
     polyA_site      5003
                     /gene="SPATA6"
                     /gene_synonym="HASH; SRF-1; SRF1"
ORIGIN      
        1 atgacaacga gtctgcgccc cgcgctcagc tgcttctccg gcggaaccca ggctggaccg
       61 cgggccccgg cctgggggcc actgctgcca ccgccgccgc cacctcgtct cctccccgtc
      121 cccgcccagc cccaggtctc cccgcctcac tcgggcccgt ggccggggtc actccccgcc
      181 gcccctcccc gcacggatgc cgaaggtgaa ggcgctgcag tgcgccctgg cgctggagat
      241 cagctcagta acttgcccag gagtcgtgct taaagacaaa gaggacatct atcttagcat
      301 ctgtgtgttt ggccaataca aaaagacaca atgtgtccca gccacttttc ccctggtctt
      361 caatgccaga atggtgtttg aaaaggtgtt cccggacgca gtagatcctg gagatgtggt
      421 tacacagctt gaatatgata cagcagtgtt cgagttgata cagctagttc caccagtggg
      481 tgaaacactg tctacgtatg acgaaaatac acgagatttc atgtttccgg gtccaaacca
      541 aatgtctgga caccatgatt caaaccgcca ggttaccatg aggaggattt ctggccttcg
      601 aggaaatgct ccaaggctgg aattttctac gacttcagtg attactgaat gtctgataag
      661 ttcaaggaaa tgccacactc aggataaatt tatttaccat ttggctccag ttgaaaaatc
      721 acatggcaga ctgcaaaaca gaacatcaag atcacaaaag aaaaaatcca agtcacctga
      781 gagaagtaaa tactgtataa atgcaaaaaa ctacgaacag cctacaattt cttcaaaatc
      841 acactctcca tctccctaca caaaaagacg catgtgtgag ctatctgaag acaccaggcg
      901 gcggctggcc catttaaatc tgggacccta tgagttcaaa aaagaaacag ataaacctcc
      961 atttgtgatt agacatgttg atcccccaag tcccagggct gatactttat tgggatcttc
     1021 tggaagagac tgtgaaagag atggatggtc aagggtgcac aatgatcatt ctcatcttgg
     1081 ctgctgccga cccaaggatt ataaggttat caggacaccc catgggagag acttcgatga
     1141 ctctttagaa aaatgtgaag agtatttgag cccaaggtcg tgtagtaagc cccggcattc
     1201 agcgaggacc ttgctagtcc attcagcacc ctcaacaatg ccaaagcatt ctccaagccc
     1261 tgtgttaaat agagcttctc tcagggaaag atttcattct gattggtgtt caccttcaaa
     1321 ctgcgatgag atccatgacc gggtaaaaaa tgtcttgaaa tcacatcagg ctcatcaaag
     1381 acatttatat gatgagagag acctagagaa agatgatgaa ctggaactga aaagaagtct
     1441 tttatgtaga gactctgcct atgacagtga ccccgagtat agctcatgtc agcagccacg
     1501 tggcactttc catttggatg acggtgaata ctggtccaac agggcagcct cttataaggg
     1561 aaaatcccac cgacccatct ttgagaacag catggacaag atgtacagga acttatacaa
     1621 aaaggcctgt agttctgctt cacatacaca ggaaagcttc tgagaccatc catgataaac
     1681 ctcattagtg tccgtgtcaa tttctcaatg aaaatgtttg atgtgatcaa tatctgtatt
     1741 ccttttttta aaaaaaatgg gattataact aagtacaata gttatacttg aataagttca
     1801 ttacttcaaa tggtaaatta tcataggcaa gccttttaaa ataattatta cagaagagtc
     1861 tgctgtgtta caaacattag agctctgtca cacaatcaca acttccaata tgtgacaagg
     1921 atattctgtt acatgtacac ctcatattcc atctgcaaat ccaagaatag ttcctttcta
     1981 gaaatgtttt ttttgcctta ctcaccttgc aattttcttc tcatctactt aactggttat
     2041 cttgcctgtg taagatttaa ttaatattga ctaccttttc ttggtgatga acaaaatgat
     2101 atcctataca gaaatgaatt tcctaagggt ttaaaccctg ttttcactaa cattttctac
     2161 tttttccttt ttcagaacag gctattctat ttcttagctc ataggctttc tttttaaaga
     2221 ctatatgatc attcactcct ttttctctgg aagaactgtg taagttgctt aaaatgcata
     2281 gcagttagct agaaatatca gtgccatgga tgatcaaaaa tttgaataac taatttttaa
     2341 agataaaatt ctttgcatga ttttttttct agggccatac cttttggtgc aaccagaatc
     2401 agaaaatggc ctctgttagt aagcttatag aaacctaaaa ataataatgg aattatattg
     2461 taatttgact gcttggaatt tgtgtaagta ccatatggcc caaggcacta ttatagtatc
     2521 ctcactttaa aaaaaaaaac acttggaacc acaatgtgag taaaatatta tagcagaacg
     2581 ctttgtggta gacactgaaa atgttgttga ttgatggata gaattaactt ctcctccccc
     2641 accccagcac acacctgtga agccaatgat actataaaga cataaagaaa tcagctactt
     2701 tatatttaat agagagtgag gggagggaaa ggagagtgta ggaataagtg aactgggctt
     2761 atagtcttga agagttgcct aaaagataat attttctcat tgactctgtt tttgattaat
     2821 tttacagtta tgattgaaaa agaacaaaat gaacttcctt taaaatgaaa ttaaaatgtg
     2881 aaacttgctg acttattttt gtagtagaac ttgttaacat catgttaagg gtgctttagt
     2941 atcacagtct gtgatatatc agaaagggca ttagagctat ctctatgagc caggagtcct
     3001 aggctttagt atcccatgtc tgccgttttc tagctgagtc tatttaattc tcagatcctt
     3061 tgtttcctca gctatcaaat gataagaatg tagtagaccc caaactatgt tctgtggacc
     3121 aagatcactg ttttaggaga taatcgtagg aatgtaggta taagtatgta attggccatc
     3181 taagtttagg aaaatctgtt tgctacacac atacacacac acacacacac acacacacac
     3241 acacacacac ctcttagaga gtcatatgta ggattataga ggtaaaaaga gatgatatta
     3301 atgctggaat agcgcctgta aactggggct gtctacagca aattaggata tatggtcact
     3361 gtgctcattg tgaacagtag cttgttcgag gctttaagaa aattctggta taaatctgtc
     3421 ttactctgca tctagtagac agcctggcat gtaattgatg ttccttaaat atttatcgaa
     3481 ttaacccaga attttctaaa ctaaatttag catgtaccac tatttgttat tcttgccacc
     3541 accccccatt cccctagctc ctcacactac ctgccaatgt catcctaagg tacatgtgga
     3601 tacctaggtt gtagaaatgc tggactacac aattgctgag ttactctctg gctgtagatt
     3661 atatgatgag gtattttaca atcagctttt gaaggtcaac attgaataat gctcttttaa
     3721 aaaaattata tcctcagtgt ttttccatgg aaaaataagt gaaaattctt ttaagagttg
     3781 ctgtttggtg aaaagaacaa acatgacttt caaagaaaat gttttactat caccaaaatc
     3841 tcccaagtga ataagtacca cagaaattac ttattgcacc tgtatctgcc attggctgtg
     3901 aaaaaggctg caaaaagtag ggctgaaagg gaaactttag aaactaatac tctgaaagat
     3961 gttttcctat ggattaaatt tagtgtcttt ctgaaagttg ggggcaaatt cccagatact
     4021 aatagcatct ttgctaagtg tctgattatc ttctatcccc taggaggaaa gagtggtcca
     4081 tgttgctgta actactacta tgagtgctta tgctgtattg tttttaaaga gtaaaacctt
     4141 taagtactaa tagttgtctt ttctcattca caggagcaga aaggtgcagt tgtttattct
     4201 cttagccttt tttttttcct gtatttccca caaatctaga aataattatt ggagttaata
     4261 tgaaagataa ataggctttt ctttttactt tttaattttt ttctttaaat cataaaaaac
     4321 cttgggattt agaaaaatgt caaaatcgac aaataaagat gaatcattgg aatgagactc
     4381 ttccttggtt ctactagcta gttatataac cttatttaag tcatttatgc ttcttggagc
     4441 tcagttttct caccaacaag gtgataaaag ggttaattta gaatgatcct ttgacatttc
     4501 ataattgtac aattaatatg tacgatcagg aagtcctagg caggcagagt tgttttctga
     4561 tttccaaaga ttaagcccct gatgaaaaat ctggaacaaa tagagaattt tcattattgt
     4621 gttcatttgc taataatagc tttattgaga tataattcac tctgaaaaag tatacaatta
     4681 agtggttttt actatattca cagagttgtg caacaataac cactcactaa ttacagaata
     4741 ttttataact cccaaaagaa atcctgtaac cattagtgat cacttcccac tacctcctcc
     4801 ccacaactcc tggaaaccac tatatgcttt ttgtctccat gcctattctg gacatttcat
     4861 ataaatggaa ccatacaaca tgtgacctat tgtatgtggc ttctttcact tagcaaaata
     4921 ttttgagagt tcatgcatgt tgtaacacgt atgaatactt cattcctttt tattactaaa
     4981 taataatcca tcatatgaat ata
//
