LOCUS       NM_182581               1695 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens spermatogenesis associated 46 (SPATA46), mRNA.
ACCESSION   NM_182581
VERSION     NM_182581.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1695)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1695)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1695)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1695)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 1695)
  AUTHORS   Chen,J., Gu,Y., Zhang,Z., Zheng,W., Yang,L., Huang,W., Lin,S.,
            Li,Y., Guo,H., Luo,M., Ma,Q., Jiang,Z., Tang,A. and Gui,Y.
  TITLE     Deficiency of SPATA46, a Novel Nuclear Membrane Protein, Causes
            Subfertility in Male Mice
  JOURNAL   Biol Reprod 95 (3), 58 (2016)
   PUBMED   27488028
REFERENCE   6  (bases 1 to 1695)
  AUTHORS   Yamaguchi,A., Kaneko,T., Inai,T. and Iida,H.
  TITLE     Molecular cloning and subcellular localization of Tektin2-binding
            protein 1 (Ccdc 172) in rat spermatozoa
  JOURNAL   J Histochem Cytochem 62 (4), 286-297 (2014)
   PUBMED   24394471
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC032957.1 and AL512785.7.
            
            On May 17, 2019 this sequence version replaced NM_182581.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because transcript sequence consistent with
            the reference genome assembly was not available for all regions of
            the RefSeq transcript. The extent of this transcript is supported
            by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032957.1, DB447745.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874, SAMEA2158188
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367935.10/ ENSP00000356912.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-269               BC032957.1         8-276
            270-270             AL512785.7         62536-62536         c
            271-297             BC032957.1         278-304
            298-1173            AL512785.7         60960-61835         c
            1174-1695           AL512785.7         60438-60959         c
FEATURES             Location/Qualifiers
     source          1..1695
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.3"
     gene            1..1695
                     /gene="SPATA46"
                     /gene_synonym="C1orf111; HSD20; TEKT2BP2"
                     /note="spermatogenesis associated 46"
                     /db_xref="GeneID:284680"
                     /db_xref="HGNC:HGNC:27648"
                     /db_xref="MIM:617257"
     exon            1..167
                     /gene="SPATA46"
                     /gene_synonym="C1orf111; HSD20; TEKT2BP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..850
                     /gene="SPATA46"
                     /gene_synonym="C1orf111; HSD20; TEKT2BP2"
                     /note="uncharacterized protein C1orf111"
                     /codon_start=1
                     /product="spermatogenesis-associated protein 46"
                     /protein_id="NP_872387.2"
                     /db_xref="CCDS:CCDS1238.1"
                     /db_xref="GeneID:284680"
                     /db_xref="HGNC:HGNC:27648"
                     /db_xref="MIM:617257"
                     /translation="MENFSLLSISGPPISSSALSAFPDIMFSRATSLPDIAKTAVPTE
                     ASSPAQALPPQYQSIIVRQGIQNTALSPDCSLGDTQHGEKLRRNCTIYRPWFSPYSYF
                     VCADKESQLEAYDFPEVQQDEGKWDNCLSEDMAENICSSSSSPENTCPREATKKSRHG
                     LDSITSQDILMASRWHPAQQNGYKCVACCRMYPTLDFLKSHIKRGFREGFSCKVYYRK
                     LKALWSKEQKARLGDRLSSGSCQAFNSPAEHLRQIGGEAYLCL"
     exon            168..281
                     /gene="SPATA46"
                     /gene_synonym="C1orf111; HSD20; TEKT2BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            282..1695
                     /gene="SPATA46"
                     /gene_synonym="C1orf111; HSD20; TEKT2BP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      860..865
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPATA46"
                     /gene_synonym="C1orf111; HSD20; TEKT2BP2"
                     /note="hexamer: AATAAA"
     polyA_site      881
                     /gene="SPATA46"
                     /gene_synonym="C1orf111; HSD20; TEKT2BP2"
                     /note="major polyA site"
     regulatory      1003..1008
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPATA46"
                     /gene_synonym="C1orf111; HSD20; TEKT2BP2"
                     /note="hexamer: AATAAA"
     polyA_site      1021
                     /gene="SPATA46"
                     /gene_synonym="C1orf111; HSD20; TEKT2BP2"
                     /note="major polyA site"
ORIGIN      
        1 ggacaaacca gccagcctct ccagagcagg cgtgtgatct ctgtaccccc gcagtggtca
       61 gaatatggag aacttctcac tcctcagcat ctctggacct ccaatctctt cctccgccct
      121 gagtgctttt cccgacatta tgttctctcg tgccaccagc ctgccagaca ttgcaaagac
      181 agcagtaccc actgaggcat ccagcccagc tcaggccctg ccaccccagt accaaagcat
      241 cattgtcagg caagggatac agaacacagc gctctcacca gactgcagct tgggggatac
      301 ccagcacgga gagaagctga ggcggaactg cactatctac cggccctggt tctcccccta
      361 cagctacttc gtgtgtgcag acaaagagag ccagctggag gcctatgact tcccagaggt
      421 gcagcaggat gagggcaagt gggacaactg cctttctgag gacatggctg agaacatctg
      481 ttcgtcctct tcctccccag agaacacttg ccctcgagaa gccaccaaga aatccaggca
      541 tggcctggac tccatcacat cccaggacat cctaatggct tccaggtggc acccagcaca
      601 gcagaatggc tacaagtgcg tggcctgctg ccgcatgtac cccaccctgg acttcctcaa
      661 gagccacatc aagaggggct tcagggaggg cttcagctgc aaggtgtact accgcaagct
      721 caaagccctc tggagcaagg agcagaaggc ccggctggga gacaggctct cctccggcag
      781 ctgccaggcc ttcaatagtc ctgctgaaca ccttaggcaa attggcggtg aagcctactt
      841 atgtctctag agagatgcca ataaagttag tcacagcctt ctgtccagtc tgaggtcacc
      901 ccgcacagcc tgctgtcctt cccagaaccc ggctctcatc acctttggct aatggttgcc
      961 tagcaacacc aggcacacac cctccccttt ctctctttta aaaataaaga caatacttga
     1021 agtttgggaa aatcatctaa gatagaggtt ctcaaaggtg cccagctggc agtaccagca
     1081 acccctggga actctcaggc cctcctcaga cctactgaat cagaaactat gggtctgggg
     1141 ctggcggtct atgtcctaac cagccctcca ggtgactctg atgcagctca gctgtgagaa
     1201 gcactgctct aggattctgg cctctgcttg gtccctatgt ggtcagtcct tgccccaccc
     1261 tgggaagaag gggctggatg ccctttccta tttgcatggg gaagaatctc tgcagtttta
     1321 aaggcttctt tgacggtaga tcttctgagg ggggaatgtg gaggaaaata tgcctctgag
     1381 tataaggcag gtaagaggca gatggggctg agctcacccg ggactgagct ctcaggcact
     1441 accatcattc acttagaaca gccatccagt gctggggcag aatagaatca gttttgaccc
     1501 aggagacgtc ttttcttggc tgctttgagc caggtgaaaa taggcaggta aacatgggaa
     1561 cctattgctt cctgttacca agtaatgtgt ccagtgggca gccctgactc tgcctccatt
     1621 tctgagtgaa cctcctggtc catctgaccc agaaagatgg ataagcatca gggatgcagc
     1681 agagacatct atctt
//
