LOCUS       NM_144644               1142 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens spermatogenesis associated 4 (SPATA4), mRNA.
ACCESSION   NM_144644
VERSION     NM_144644.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1142)
  AUTHORS   Li,Z., Xu,K., Zhao,S., Guo,Y., Chen,H., Ni,J., Liu,Q. and Wang,Z.
  TITLE     SPATA4 improves aging-induced metabolic dysfunction through
            promotion of preadipocyte differentiation and adipose tissue
            expansion
  JOURNAL   Aging Cell 20 (1), e13282 (2021)
   PUBMED   33314576
  REMARK    GeneRIF: SPATA4 improves aging-induced metabolic dysfunction
            through promotion of preadipocyte differentiation and adipose
            tissue expansion.
REFERENCE   2  (bases 1 to 1142)
  AUTHORS   Sujit,K.M., Singh,V., Trivedi,S., Singh,K., Gupta,G. and
            Rajender,S.
  TITLE     Increased DNA methylation in the spermatogenesis-associated (SPATA)
            genes correlates with infertility
  JOURNAL   Andrology 8 (3), 602-609 (2020)
   PUBMED   31838782
  REMARK    GeneRIF: Increased DNA methylation in the
            spermatogenesis-associated (SPATA) genes correlates with
            infertility.
REFERENCE   3  (bases 1 to 1142)
  AUTHORS   Jiang,J., Li,L., Xie,M., Fuji,R., Liu,S., Yin,X., Li,G. and Wang,Z.
  TITLE     SPATA4 Counteracts Etoposide-Induced Apoptosis via Modulating Bcl-2
            Family Proteins in HeLa Cells
  JOURNAL   Biol Pharm Bull 38 (10), 1458-1463 (2015)
   PUBMED   26424010
  REMARK    GeneRIF: SPATA4 protects HeLa cells against etoposide-induced
            apoptosis through the mitochondrial apoptotic pathway, providing
            further evidence that SPATA4 plays a role in regulating apoptosis
REFERENCE   4  (bases 1 to 1142)
  AUTHORS   Albee,A.J., Kwan,A.L., Lin,H., Granas,D., Stormo,G.D. and
            Dutcher,S.K.
  TITLE     Identification of cilia genes that affect cell-cycle progression
            using whole-genome transcriptome analysis in Chlamydomonas
            reinhardtti
  JOURNAL   G3 (Bethesda) 3 (6), 979-991 (2013)
   PUBMED   23604077
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1142)
  AUTHORS   Duarte,D.T., Hul,S. and Sacher,M.
  TITLE     A yeast two hybrid screen identifies SPATA4 as a TRAPP interactor
  JOURNAL   FEBS Lett 585 (17), 2676-2681 (2011)
   PUBMED   21827752
  REMARK    GeneRIF: Results suggest a role for SPATA4 in membrane traffic and
            a specialized function for TRAPP in spermatocytes.
REFERENCE   6  (bases 1 to 1142)
  AUTHORS   Liu,S.F., Ai,C., Ge,Z.Q., Liu,H.L., Liu,B.W., He,S. and Wang,Z.
  TITLE     Molecular cloning and bioinformatic analysis of SPATA4 gene
  JOURNAL   J Biochem Mol Biol 38 (6), 739-747 (2005)
   PUBMED   16336790
  REMARK    GeneRIF: analysis of SPATA4 expression and variation in promotor
            sequences
REFERENCE   7  (bases 1 to 1142)
  AUTHORS   Liu,S.F., Lu,G.X., Liu,G., Xing,X.W., Li,L.Y. and Wang,Z.
  TITLE     Cloning of a full-length cDNA of human testis-specific
            spermatogenic cell apoptosis inhibitor TSARG2 as a candidate
            oncogene
  JOURNAL   Biochem Biophys Res Commun 319 (1), 32-40 (2004)
   PUBMED   15158438
  REMARK    GeneRIF: TSARG2 may play an important role in the development of
            cryptorchid testis and be a testis-specific apoptosis candidate
            oncogene
REFERENCE   8  (bases 1 to 1142)
  AUTHORS   Liu,S.F., Li,L.Y., Fu,J.J., Liu,G., Xing,X.W. and Lu,G.X.
  TITLE     [Rapid identification of human testis spermatocyte
            apoptosis-related gene, TSARG2, by nested PCR and draft human
            genome searching]
  JOURNAL   Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 34 (3),
            378-382 (2002)
   PUBMED   12019456
  REMARK    GeneRIF: expressed in many tissues and mapped to chromosome
            4q33-34.1 by database analyses
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY040204.3.
            
            On May 17, 2019 this sequence version replaced NM_144644.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029428.1, AY040204.3 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968968,
                                           SAMEA1970526 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000280191.7/ ENSP00000280191.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1142              AY040204.3         87-1228
FEATURES             Location/Qualifiers
     source          1..1142
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q34.2"
     gene            1..1142
                     /gene="SPATA4"
                     /gene_synonym="CFAP178; FAP178; SPEF1B; TSARG2"
                     /note="spermatogenesis associated 4"
                     /db_xref="GeneID:132851"
                     /db_xref="HGNC:HGNC:17333"
                     /db_xref="MIM:609879"
     exon            1..241
                     /gene="SPATA4"
                     /gene_synonym="CFAP178; FAP178; SPEF1B; TSARG2"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..941
                     /gene="SPATA4"
                     /gene_synonym="CFAP178; FAP178; SPEF1B; TSARG2"
                     /note="testis and spermatogenesis cell related protein 2;
                     testis spermatocyte apoptosis-related gene 2 protein"
                     /codon_start=1
                     /product="spermatogenesis-associated protein 4"
                     /protein_id="NP_653245.2"
                     /db_xref="CCDS:CCDS3826.1"
                     /db_xref="GeneID:132851"
                     /db_xref="HGNC:HGNC:17333"
                     /db_xref="MIM:609879"
                     /translation="MAAAGQEKGYLTQTAAALDKSPSLSPQLAAPIRGRPKKCLVYPH
                     APKSSRLSRSVLRWLQGLDLSFFPRNINRDFSNGFLIAEIFCIYYPWELELSSFENGT
                     SLKVKLDNWAQLEKFLARKKFKLPKELIHGTIHCKAGVPEILIEEVYTLLTHREIKSI
                     QDDFVNFTDYSYQMRLPLVSRSTVSKSIKDNIRLSELLSNPNMLTNELKAEFLILLHM
                     LQRKLGRKLNPEWFDVKPTVGEVTLNHLPAQASGRRYNLKVKRGRVVPVLPNIGSGGS
                     SHREIHVKQAGQHSYYSAMKPIRNMDKKP"
     exon            242..371
                     /gene="SPATA4"
                     /gene_synonym="CFAP178; FAP178; SPEF1B; TSARG2"
                     /inference="alignment:Splign:2.1.0"
     exon            372..490
                     /gene="SPATA4"
                     /gene_synonym="CFAP178; FAP178; SPEF1B; TSARG2"
                     /inference="alignment:Splign:2.1.0"
     exon            491..711
                     /gene="SPATA4"
                     /gene_synonym="CFAP178; FAP178; SPEF1B; TSARG2"
                     /inference="alignment:Splign:2.1.0"
     exon            712..828
                     /gene="SPATA4"
                     /gene_synonym="CFAP178; FAP178; SPEF1B; TSARG2"
                     /inference="alignment:Splign:2.1.0"
     exon            829..1142
                     /gene="SPATA4"
                     /gene_synonym="CFAP178; FAP178; SPEF1B; TSARG2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1038..1043
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPATA4"
                     /gene_synonym="CFAP178; FAP178; SPEF1B; TSARG2"
                     /note="hexamer: AATAGA"
     polyA_site      1058
                     /gene="SPATA4"
                     /gene_synonym="CFAP178; FAP178; SPEF1B; TSARG2"
                     /note="major polyA site"
ORIGIN      
        1 gccgcagcaa cccagaaagc gtcatggctg ccgccggcca ggaaaaaggg tatttgacac
       61 agactgcggc agccctagac aagtcaccgt cactttcgcc acagctagca gctcccatcc
      121 gagggaggcc taagaagtgt ctggtctatc cgcatgcgcc gaagagctcc cgcttgtctc
      181 gttccgttct gcgttggctt cagggtctgg atctcagctt cttccccagg aacatcaaca
      241 gagatttttc aaatggcttc ctaattgcag aaatattctg tatatattac ccctgggaac
      301 ttgaattatc atcctttgaa aacgggacct ctttaaaagt caagttggat aactgggcac
      361 agttggagaa gttcctggca agaaaaaaat ttaaattacc taaagaacta atccatggaa
      421 caattcattg taaagctgga gtgcctgaaa tattgataga agaggtttac actttattaa
      481 cacatcgaga aattaaaagt atccaggatg actttgtgaa tttcacggac tatagctacc
      541 agatgcgttt acccctggtt tccaggtcta cagtttcgaa gtctattaaa gataacatta
      601 ggttatcaga attactaagc aatcccaaca tgctgaccaa tgaacttaaa gcggagttcc
      661 tcatcctttt acatatgttg caaagaaaat taggcagaaa attgaatcca gaatggtttg
      721 atgtgaaacc aacagtggga gaagttactc tcaatcacct tcctgcccaa gcctctgggc
      781 gcagatataa tttaaaagtt aaaagaggaa gagttgtccc tgttttacca aatataggta
      841 gtggtggcag ttcacataga gaaatacatg tgaagcaagc tggacaacat tcttattact
      901 ctgctatgaa acctatcaga aacatggaca agaaaccttg aaaagcacct gtcaaatggc
      961 tttgaagaag tgatgccacc atctctagcc ataataaaga aacagaatca cctagtattg
     1021 gatgtatttc aataataaat agagtggtgt cttttccata attgtgttaa agaacatttc
     1081 ttttccattc aatttgttta ttaaactcct atgccaggca ttgttgaaaa tacaaaatta
     1141 aa
//
