LOCUS       NM_001271907            1460 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens spermatogenesis associated 33 (SPATA33), transcript
            variant 1, mRNA.
ACCESSION   NM_001271907
VERSION     NM_001271907.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1460)
  AUTHORS   Miyata,H., Oura,S., Morohoshi,A., Shimada,K., Mashiko,D., Oyama,Y.,
            Kaneda,Y., Matsumura,T., Abbasi,F. and Ikawa,M.
  TITLE     SPATA33 localizes calcineurin to the mitochondria and regulates
            sperm motility in mice
  JOURNAL   Proc Natl Acad Sci U S A 118 (35) (2021)
   PUBMED   34446558
REFERENCE   2  (bases 1 to 1460)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1460)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1460)
  AUTHORS   Monsef,L., Borjian Boroujeni,P., Totonchi,M., Sabbaghian,M. and
            Mohseni Meybodi,A.
  TITLE     Gene alterations and expression spectrum of SPATA33 in
            nonobstructive azoospermic Iranian men
  JOURNAL   Mol Reprod Dev 85 (10), 760-767 (2018)
   PUBMED   30098056
  REMARK    GeneRIF: the current study illustrated that alterations in SPATA33
            gene, at least those found in this study, may not impair
            spermatogenesis in patients with nonobstructive azoospermia.
REFERENCE   5  (bases 1 to 1460)
  AUTHORS   Chen,H., Yi,M., Sheng,Y., Cheng,H. and Zhou,R.
  TITLE     A novel testis-enriched gene Spata33 is expressed during
            spermatogenesis
  JOURNAL   PLoS One 8 (7), e67882 (2013)
   PUBMED   23844118
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1460)
  AUTHORS   Hao,Y., Liu,X., Lu,X., Yang,X., Wang,L., Chen,S., Li,H., Li,J.,
            Cao,J., Chen,J., Li,Y., Zhao,L., Shi,Y., Shen,C., Yan,W., He,J.,
            Huang,J. and Gu,D.
  TITLE     Genome-wide association study in Han Chinese identifies three novel
            loci for human height
  JOURNAL   Hum Genet 132 (6), 681-689 (2013)
   PUBMED   23456168
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010538.9 and KF459565.1.
            
            On Sep 25, 2020 this sequence version replaced NM_001271907.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK303024.1, DC374690.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000579310.6/ ENSP00000462996.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               AC010538.9         83726-83838         c
            114-217             KF459565.1         1-104               c
            218-287             AC010538.9         83253-83322         c
            288-1460            AC010538.9         71216-72388         c
FEATURES             Location/Qualifiers
     source          1..1460
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q24.3"
     gene            1..1460
                     /gene="SPATA33"
                     /gene_synonym="C16orf55"
                     /note="spermatogenesis associated 33"
                     /db_xref="GeneID:124045"
                     /db_xref="HGNC:HGNC:26463"
                     /db_xref="MIM:615409"
     exon            1..113
                     /gene="SPATA33"
                     /gene_synonym="C16orf55"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..499
                     /gene="SPATA33"
                     /gene_synonym="C16orf55"
                     /note="isoform a is encoded by transcript variant 1;
                     spermatogenesis-associated protein 33"
                     /codon_start=1
                     /product="spermatogenesis-associated protein 33 isoform a"
                     /protein_id="NP_001258836.1"
                     /db_xref="CCDS:CCDS62012.1"
                     /db_xref="GeneID:124045"
                     /db_xref="HGNC:HGNC:26463"
                     /db_xref="MIM:615409"
                     /translation="MGLSKSKEKPRKGEEQKKGSTYSVPKSKEKLMEKHSQEARQADR
                     ESEKPVDSLHPGAGTAKHPPPAASLEEKPDVKQKSSRKKVVVPQIIITRASNETLVSC
                     SSSGSDQQRTIREPEDWGPYRRHRNPSTADAYNSHLKE"
     exon            114..287
                     /gene="SPATA33"
                     /gene_synonym="C16orf55"
                     /inference="alignment:Splign:2.1.0"
     exon            288..1460
                     /gene="SPATA33"
                     /gene_synonym="C16orf55"
                     /inference="alignment:Splign:2.1.0"
     regulatory      495..500
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPATA33"
                     /gene_synonym="C16orf55"
                     /note="hexamer: AATAAA"
     polyA_site      519
                     /gene="SPATA33"
                     /gene_synonym="C16orf55"
                     /note="major polyA site"
     regulatory      1435..1440
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPATA33"
                     /gene_synonym="C16orf55"
                     /note="hexamer: AATAAA"
     polyA_site      1460
                     /gene="SPATA33"
                     /gene_synonym="C16orf55"
                     /note="major polyA site"
ORIGIN      
        1 gtgagtcgct cccggctccg cggccgcgga ggtgtgggga cccgggcttg cgtcggaggg
       61 ggcggtgggc tcacccatgg gcctttccaa aagcaaagag aaacccagga aaggtgagga
      121 gcaaaagaag ggatccacct attcagttcc aaaatctaag gagaagttga tggagaagca
      181 ttcccaggaa gccaggcagg cagacaggga gtcggagaag cctgtggaca gcctccaccc
      241 gggggccggg acagccaagc acccgccgcc ggcagcttcg ctggaagaga aacctgatgt
      301 aaagcaaaag tccagcagga agaaagtggt cgttccacag atcatcatca cgcgagcgtc
      361 gaatgagacg ctagtcagtt gcagttccag cgggagtgac cagcagagaa ccattcggga
      421 gccggaggac tggggcccct accggcggca caggaacccc agtacagcag acgcctataa
      481 ttcacatctc aaagaataaa caagcacctt tgcatggcac tcgctactcc ctgcgatagg
      541 cgtctcggga acagccgcct caccctgtga gaagccgagg ccccttctcc agtgctctcg
      601 gggaggttgc accaggccca ccccaccctg tgagaaactg cagccccctt ctccagtgct
      661 ttcggggagg gtgcaccagg cccgccccac cttgtgagaa gccgtggccc ccttctccag
      721 tgctctcagg gagggtgcac caggcctgcc cccgccgtga gaaactgcag tccccttctc
      781 cagtgctctc ggggagggtg caccaggccc accccaccct gtgagaacct gcagccccct
      841 tctccaatgc tctcggggag ggtacaccag ggttgcccca ccctgtgaga agccaccgcc
      901 cccttctcca gtgctctcgg ggagggtgca ccagggctgc cccacgctgt aagaagccgc
      961 cgcccccttc tccagtgctc tccagcccgc cccaccctgt gagaagccat ggccccttct
     1021 ccagtgcttt tggggagggt gcaccagggc caccccaccc tgtgagaagc cgtggccccc
     1081 ttctccagtg ctttcgggga gggtacacca ggcccgcccc accctgtgag aagccgtggc
     1141 ccccttctcc cgtgctctca gggagggtgc accaggcctg cccccgcctt gagaaactgc
     1201 agcccccttc tccagtgctc tgggggaggg tgcaccaggc ctgcccaccc tgtgagaaac
     1261 tgcaccccct tctccagtgc tctcggggag ggtgcaccag gcccgcccca ccctgtgaga
     1321 agccgcagcc cgttctccat tgccatttgg tcctgccttc cccagagctg ctagcagctc
     1381 ggtcgaggca agagtgactg gctcagagag cgagctttgt ggtattgata aatgaataaa
     1441 ttagtatgtt catgttggaa
//
