LOCUS       NM_194296                680 bp    mRNA    linear   PRI 30-JAN-2025
DEFINITION  Homo sapiens spermatogenesis associated 24 (SPATA24), mRNA.
ACCESSION   NM_194296 XM_001721173 XM_114430 XM_940745
VERSION     NM_194296.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 680)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 680)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 680)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 680)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 680)
  AUTHORS   Graubert,T.A., Payton,M.A., Shao,J., Walgren,R.A., Monahan,R.S.,
            Frater,J.L., Walshauser,M.A., Martin,M.G., Kasai,Y. and Walter,M.J.
  TITLE     Integrated genomic analysis implicates haploinsufficiency of
            multiple chromosome 5q31.2 genes in de novo myelodysplastic
            syndromes pathogenesis
  JOURNAL   PLoS One 4 (2), e4583 (2009)
   PUBMED   19240791
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 680)
  AUTHORS   Song,X.X., Li,Y.C., Shi,Y.Q., Hu,X.Q., Hu,Z.Y., Han,C.S. and
            Liu,Y.X.
  TITLE     Cloning and characterization of a novel spermiogenesis-related
            gene, T6441, in rat testis
  JOURNAL   Front Biosci 11, 143-150 (2006)
   PUBMED   16146721
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 680)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC135457.2, BM785501.1, BC040037.1 and AA399058.1.
            
            On May 20, 2020 this sequence version replaced NM_194296.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC040037.1, BQ426104.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000450845.7/ ENSP00000414920.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC135457.2         40430-40431         c
            3-22                BM785501.1         2-21
            23-553              BC040037.1         1-531
            554-560             AA399058.1         119-125             c
            561-680             BC040037.1         539-658
FEATURES             Location/Qualifiers
     source          1..680
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.2"
     gene            1..680
                     /gene="SPATA24"
                     /gene_synonym="CCDC161; T6441"
                     /note="spermatogenesis associated 24"
                     /db_xref="GeneID:202051"
                     /db_xref="HGNC:HGNC:27322"
                     /db_xref="MIM:621086"
     exon            1..146
                     /gene="SPATA24"
                     /gene_synonym="CCDC161; T6441"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..647
                     /gene="SPATA24"
                     /gene_synonym="CCDC161; T6441"
                     /note="coiled-coil domain containing 161; testis protein
                     T6441 homolog"
                     /codon_start=1
                     /product="spermatogenesis-associated protein 24"
                     /protein_id="NP_919272.1"
                     /db_xref="CCDS:CCDS47274.1"
                     /db_xref="GeneID:202051"
                     /db_xref="HGNC:HGNC:27322"
                     /db_xref="MIM:621086"
                     /translation="MATPLGWSKAGSGSVCLALDQLRDVIESQEELIHQLRNVMVLQD
                     ENFVSKEEFQAVEKKLVEEKAAHAKTKVLLAKEEEKLQFALGEVEVLSKQLEKEKLAF
                     EKALSSVKSKVLQESSKKDQLITKCNEIESHIIKQEDILNGKENEIKELQQVISQQKQ
                     IFRNHMSDFRIQKQQESYMAQVLDQKHKKASGTRQARSHQHPREK"
     exon            147..212
                     /gene="SPATA24"
                     /gene_synonym="CCDC161; T6441"
                     /inference="alignment:Splign:2.1.0"
     exon            213..343
                     /gene="SPATA24"
                     /gene_synonym="CCDC161; T6441"
                     /inference="alignment:Splign:2.1.0"
     exon            344..414
                     /gene="SPATA24"
                     /gene_synonym="CCDC161; T6441"
                     /inference="alignment:Splign:2.1.0"
     exon            415..517
                     /gene="SPATA24"
                     /gene_synonym="CCDC161; T6441"
                     /inference="alignment:Splign:2.1.0"
     exon            518..680
                     /gene="SPATA24"
                     /gene_synonym="CCDC161; T6441"
                     /inference="alignment:Splign:2.1.0"
     regulatory      643..648
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPATA24"
                     /gene_synonym="CCDC161; T6441"
                     /note="hexamer: AATAAA"
     polyA_site      680
                     /gene="SPATA24"
                     /gene_synonym="CCDC161; T6441"
                     /note="major polyA site"
ORIGIN      
        1 catttccaac tagctggcgg gggcggaaga tggcgacgcc cctcgggtgg tcgaaggcgg
       61 ggtcaggatc tgtgtgtctc gctttagatc aactgcggga cgtgattgag tctcaggagg
      121 aactaatcca ccagctgagg aacgtgatgg ttctccagga cgaaaatttt gtcagtaaag
      181 aagagttcca ggcagtggag aagaagctgg tggaagagaa agctgcccat gccaaaacca
      241 aggtcctcct ggccaaggaa gaggagaagt tacagtttgc cctcggagag gtagaggtgc
      301 tatccaagca gctggagaaa gagaagctgg cctttgaaaa agcgctctcc agtgtcaaga
      361 gcaaagtcct tcaggagtcc agcaagaagg accagctcat caccaagtgc aatgagattg
      421 agtctcacat tataaagcaa gaagatatac ttaatggcaa agagaatgag attaaagagt
      481 tgcagcaagt tatcagccag cagaaacaga tcttcaggaa tcacatgtct gacttccgga
      541 tccagaagca gcaggagagc tacatggccc aggtgctgga ccagaagcat aagaaagcct
      601 cagggacacg tcaggcccgc agccaccagc atcccaggga aaaataaaat ggccgccgct
      661 ttcctgttct ctggctgtaa
//
