LOCUS       NM_022827               2634 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens spermatogenesis associated 20 (SPATA20), transcript
            variant 1, mRNA.
ACCESSION   NM_022827
VERSION     NM_022827.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2634)
  AUTHORS   Wang,X., Jiang,C., Dai,S., Shen,G., Yang,Y. and Shen,Y.
  TITLE     Identification of nonfunctional SPATA20 causing acephalic
            spermatozoa syndrome in humans
  JOURNAL   Clin Genet 103 (3), 310-319 (2023)
   PUBMED   36415156
  REMARK    GeneRIF: Identification of nonfunctional SPATA20 causing acephalic
            spermatozoa syndrome in humans.
REFERENCE   2  (bases 1 to 2634)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 2634)
  AUTHORS   Shen,J., Wang,W., Wu,J., Feng,B., Chen,W., Wang,M., Tang,J.,
            Wang,F., Cheng,F., Pu,L., Tang,Q., Wang,X. and Li,X.
  TITLE     Comparative proteomic profiling of human bile reveals SSP411 as a
            novel biomarker of cholangiocarcinoma
  JOURNAL   PLoS One 7 (10), e47476 (2012)
   PUBMED   23118872
  REMARK    GeneRIF: SSP411 has potential as a biomarker for the diagnosis of
            Cholangiocarcinoma
REFERENCE   4  (bases 1 to 2634)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   5  (bases 1 to 2634)
  AUTHORS   Lehner,B. and Sanderson,C.M.
  TITLE     A protein interaction framework for human mRNA degradation
  JOURNAL   Genome Res 14 (7), 1315-1323 (2004)
   PUBMED   15231747
REFERENCE   6  (bases 1 to 2634)
  AUTHORS   Shi,H.J., Wu,A.Z., Santos,M., Feng,Z.M., Huang,L., Chen,Y.M.,
            Zhu,K. and Chen,C.L.
  TITLE     Cloning and characterization of rat spermatid protein SSP411: a
            thioredoxin-like protein
  JOURNAL   J Androl 25 (4), 479-493 (2004)
   PUBMED   15223837
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM787432.1 and BC025255.1.
            
            On Nov 23, 2018 this sequence version replaced NM_022827.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.56810.1,
                                           SRR1803614.139544.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000006658.11/ ENSP00000006658.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                BM787432.1         49-75
            28-2634             BC025255.1         1-2607
FEATURES             Location/Qualifiers
     source          1..2634
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.33"
     gene            1..2634
                     /gene="SPATA20"
                     /gene_synonym="HEL-S-98; SSP411; Tisp78"
                     /note="spermatogenesis associated 20"
                     /db_xref="GeneID:64847"
                     /db_xref="HGNC:HGNC:26125"
                     /db_xref="MIM:613939"
     exon            1..112
                     /gene="SPATA20"
                     /gene_synonym="HEL-S-98; SSP411; Tisp78"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..2444
                     /gene="SPATA20"
                     /gene_synonym="HEL-S-98; SSP411; Tisp78"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; transcript increased in spermiogenesis 78;
                     sperm protein SSP411; spermatogenesis-associated protein
                     20; sperm-specific protein 411; epididymis secretory
                     protein Li 98"
                     /codon_start=1
                     /product="spermatogenesis-associated protein 20 isoform 1
                     precursor"
                     /protein_id="NP_073738.2"
                     /db_xref="CCDS:CCDS11571.1"
                     /db_xref="GeneID:64847"
                     /db_xref="HGNC:HGNC:26125"
                     /db_xref="MIM:613939"
                     /translation="MLGARAWLGRVLLLPRAGAGLAASRRCPGVWPRTWPHRSPSRGS
                     SSRDKDRSATVSSSVPMPAGGKGSHPSSTPQRVPNRLIHEKSPYLLQHAYNPVDWYPW
                     GQEAFDKARKENKPIFLSVGYSTCHWCHMMEEESFQNEEIGRLLSEDFVSVKVDREER
                     PDVDKVYMTFVQATSSGGGWPMNVWLTPNLQPFVGGTYFPPEDGLTRVGFRTVLLRIR
                     EQWKQNKNTLLENSQRVTTALLARSEISVGDRQLPPSAATVNNRCFQQLDEGYDEEYG
                     GFAEAPKFPTPVILSFLFSYWLSHRLTQDGSRAQQMALHTLKMMANGGIRDHVGQGFH
                     RYSTDRQWHVPHFEKMLYDQAQLAVAYSQAFQLSGDEFYSDVAKGILQYVARSLSHRS
                     GGFYSAEDADSPPERGQRPKEGAYYVWTVKEVQQLLPEPVLGATEPLTSGQLLMKHYG
                     LTEAGNISPSQDPKGELQGQNVLTVRYSLELTAARFGLDVEAVRTLLNSGLEKLFQAR
                     KHRPKPHLDSKMLAAWNGLMVSGYAVTGAVLGQDRLINYATNGAKFLKRHMFDVASGR
                     LMRTCYTGPGGTVEHSNPPCWGFLEDYAFVVRGLLDLYEASQESAWLEWALRLQDTQD
                     KLFWDSQGGGYFCSEAELGAGLPLRLKDDQDGAEPSANSVSAHNLLRLHGFTGHKDWM
                     DKCVCLLTAFSERMRRVPVALPEMVRALSAQQQTLKQIVICGDRQAKDTKALVQCVHS
                     VYIPNKVLILADGDPSSFLSRQLPFLSTLRRLEDQATAYVCENQACSVPITDPCELRK
                     LLHP"
     exon            113..160
                     /gene="SPATA20"
                     /gene_synonym="HEL-S-98; SSP411; Tisp78"
                     /inference="alignment:Splign:2.1.0"
     exon            161..331
                     /gene="SPATA20"
                     /gene_synonym="HEL-S-98; SSP411; Tisp78"
                     /inference="alignment:Splign:2.1.0"
     exon            332..396
                     /gene="SPATA20"
                     /gene_synonym="HEL-S-98; SSP411; Tisp78"
                     /inference="alignment:Splign:2.1.0"
     exon            397..551
                     /gene="SPATA20"
                     /gene_synonym="HEL-S-98; SSP411; Tisp78"
                     /inference="alignment:Splign:2.1.0"
     exon            552..695
                     /gene="SPATA20"
                     /gene_synonym="HEL-S-98; SSP411; Tisp78"
                     /inference="alignment:Splign:2.1.0"
     exon            696..897
                     /gene="SPATA20"
                     /gene_synonym="HEL-S-98; SSP411; Tisp78"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1028
                     /gene="SPATA20"
                     /gene_synonym="HEL-S-98; SSP411; Tisp78"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1133
                     /gene="SPATA20"
                     /gene_synonym="HEL-S-98; SSP411; Tisp78"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1208
                     /gene="SPATA20"
                     /gene_synonym="HEL-S-98; SSP411; Tisp78"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1418
                     /gene="SPATA20"
                     /gene_synonym="HEL-S-98; SSP411; Tisp78"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1611
                     /gene="SPATA20"
                     /gene_synonym="HEL-S-98; SSP411; Tisp78"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..1780
                     /gene="SPATA20"
                     /gene_synonym="HEL-S-98; SSP411; Tisp78"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..1992
                     /gene="SPATA20"
                     /gene_synonym="HEL-S-98; SSP411; Tisp78"
                     /inference="alignment:Splign:2.1.0"
     exon            1993..2192
                     /gene="SPATA20"
                     /gene_synonym="HEL-S-98; SSP411; Tisp78"
                     /inference="alignment:Splign:2.1.0"
     exon            2193..2273
                     /gene="SPATA20"
                     /gene_synonym="HEL-S-98; SSP411; Tisp78"
                     /inference="alignment:Splign:2.1.0"
     exon            2274..2634
                     /gene="SPATA20"
                     /gene_synonym="HEL-S-98; SSP411; Tisp78"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2608..2613
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPATA20"
                     /gene_synonym="HEL-S-98; SSP411; Tisp78"
                     /note="hexamer: AATAAA"
     polyA_site      2634
                     /gene="SPATA20"
                     /gene_synonym="HEL-S-98; SSP411; Tisp78"
                     /note="major polyA site"
ORIGIN      
        1 gtcctcagcg gccgggccca cggccccgag cagccatgct gggcgcgcgg gcctggttgg
       61 gccgcgtcct tctgctgccc cgcgccggtg caggcctcgc cgcgagccgc aggtgtcctg
      121 gagtctggcc caggacctgg ccccacagga gtcccagcag gggtagctcc tcccgggaca
      181 aggaccgaag tgcgacggtc agtagttcag tgcccatgcc tgctggaggg aaaggaagcc
      241 atccttcatc tacaccccag agggtcccca accgcctgat ccacgagaag tcaccatacc
      301 tcctacaaca tgcctacaat cctgtggact ggtacccctg gggacaggaa gccttcgaca
      361 aggccaggaa ggaaaacaag ccgattttcc tctcagtcgg gtactccacc tgccactggt
      421 gccacatgat ggaagaggag tccttccaga atgaggagat tggccgcctg ctcagtgagg
      481 actttgtgag tgtgaaggta gaccgtgagg agcggcctga cgtggacaag gtgtacatga
      541 cgttcgtgca ggccaccagc agcggcgggg gctggcccat gaatgtgtgg ctgactccca
      601 acctccagcc ctttgtcggg ggcacctatt tccctcctga ggatggcttg acccgagtcg
      661 gcttccgcac agtgttgctg agaatacgag aacagtggaa acagaacaag aacaccctgc
      721 tagaaaatag ccagcgtgtc accactgccc tgctggcccg atcagagatc agcgtgggtg
      781 accgccagct gccgccctct gccgccaccg tgaacaatcg ctgcttccag cagctggatg
      841 agggctatga tgaggaatac ggtggcttcg ctgaggcccc caagtttccc acgccggtga
      901 tcctgagctt cctgttctcc tactggctca gccatcgact gactcaggat ggctctcggg
      961 cccagcagat ggccttgcat accctgaaaa tgatggctaa cgggggcatc cgggaccatg
     1021 tggggcaggg ctttcaccgc tactccacag accgccagtg gcacgtccct cactttgaga
     1081 agatgctcta tgaccaggca cagctcgctg tggcctattc gcaggccttc cagctctctg
     1141 gtgatgaatt ctactctgac gtggccaaag gcatcctgca gtacgtggct cggagcctga
     1201 gccaccggtc cggaggcttc tatagcgcag aagatgcaga ctcgccccca gagcggggcc
     1261 agcggcccaa agagggcgcc tactatgtgt ggacggtcaa agaggttcag cagctcctcc
     1321 cggagcctgt gttgggtgcc accgagccgc tgacctcagg ccagctcctc atgaagcact
     1381 acggcctcac agaggctggt aacatcagcc ccagtcagga ccccaagggg gagctgcagg
     1441 gccagaatgt gctgaccgtc cggtactcgc tggagctgac tgctgcccgc tttggcttgg
     1501 atgtggaggc cgtgcggacc ttgctcaatt cagggctgga gaagctcttc caggcccgga
     1561 agcatcggcc caagccgcac ctggacagca agatgctggc tgcctggaat ggcttgatgg
     1621 tgtcaggcta tgctgtgact ggggctgtcc tgggccaaga caggctgatc aactatgcca
     1681 ccaatggtgc caagttcctg aagcggcaca tgtttgatgt ggccagtggc cgcctgatgc
     1741 ggacctgcta caccggccct ggggggactg tggagcacag caacccaccc tgctggggct
     1801 tcctggagga ctacgccttc gtggtgcggg gcctgctgga cctgtatgag gcctcacagg
     1861 agagtgcgtg gctcgagtgg gctctgcggc tgcaggacac acaggacaag ctcttttggg
     1921 actcccaggg tggcggctac ttctgcagtg aggctgagct gggggctggc ctgcccctgc
     1981 gtctgaagga cgaccaggat ggagcagagc ccagcgccaa ttccgtgtca gcccacaacc
     2041 tgctccggct gcatggcttc acgggccaca aggactggat ggacaagtgt gtgtgcctat
     2101 tgaccgcctt ttccgagcgc atgcgtcgtg tcccggtggc gttgcccgag atggtccgcg
     2161 ccctctcagc ccagcagcag accctcaagc agatcgtgat ctgtggagac cgtcaggcca
     2221 aggacaccaa ggccctggtg cagtgcgtcc actctgtcta cattcctaac aaggtgctga
     2281 ttctggctga tggggacccc tcgagcttcc tgtcccgcca gctgcctttc ctgagtaccc
     2341 tccgacggtt ggaagaccag gccactgcat atgtgtgtga gaatcaagcc tgctcagtgc
     2401 ccatcactga tccctgcgaa ttacgaaaac tactacatcc atgactgccc caaccccctt
     2461 ggggtggggc agaaggtgaa gcatcccaac tgactagaga ctcaggccct gcagggccct
     2521 atagaacctg tggccatccc tgagcaccct gccaccaggt gacctcggcc atactcactg
     2581 ccccccttgg gcacccactc accctagaat aaacttaaca gtgtcccgtg gtaa
//
