LOCUS       NM_006038               4043 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens spermatogenesis associated 2 (SPATA2), transcript
            variant 1, mRNA.
ACCESSION   NM_006038
VERSION     NM_006038.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4043)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 4043)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4043)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4043)
  AUTHORS   Wieser,V., Tsibulak,I., Degasper,C., Welponer,H., Leitner,K.,
            Parson,W., Zeimet,A.G., Marth,C. and Fiegl,H.
  TITLE     Tumor necrosis factor receptor modulator spermatogenesis-associated
            protein 2 is a novel predictor of outcome in ovarian cancer
  JOURNAL   Cancer Sci 110 (3), 1117-1126 (2019)
   PUBMED   30697874
  REMARK    GeneRIF: A role of SPATA2 in tumorigenesis.
REFERENCE   5  (bases 1 to 4043)
  AUTHORS   Elliott,P.R., Leske,D., Hrdinka,M., Bagola,K., Fiil,B.K.,
            McLaughlin,S.H., Wagstaff,J., Volkmar,N., Christianson,J.C.,
            Kessler,B.M., Freund,S.M., Komander,D. and Gyrd-Hansen,M.
  TITLE     SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC
            Signaling
  JOURNAL   Mol Cell 63 (6), 990-1005 (2016)
   PUBMED   27591049
  REMARK    GeneRIF: The data reveal SPATA2 as a high-affinity binding partner
            of CYLD and HOIP, and a regulatory component of linear ubiquitin
            chain assembly complex-mediated NF-kappaB signaling.
REFERENCE   6  (bases 1 to 4043)
  AUTHORS   Sauce,D., Larsen,M., Abbott,R.J., Hislop,A.D., Leese,A.M., Khan,N.,
            Papagno,L., Freeman,G.J. and Rickinson,A.B.
  TITLE     Upregulation of interleukin 7 receptor alpha and programmed death 1
            marks an epitope-specific CD8+ T-cell response that disappears
            following primary Epstein-Barr virus infection
  JOURNAL   J Virol 83 (18), 9068-9078 (2009)
   PUBMED   19605492
  REMARK    GeneRIF: disappearance of TLD epitope reactivity from an otherwise
            stable EBV-specific response reflects selective loss of cognate
            antigen restimulation, not IL-7-dependent signals, and is
            immediately preceded by PD-1 upregulation to unprecedented levels.
REFERENCE   7  (bases 1 to 4043)
  AUTHORS   Capon,F., Bijlmakers,M.J., Wolf,N., Quaranta,M., Huffmeier,U.,
            Allen,M., Timms,K., Abkevich,V., Gutin,A., Smith,R., Warren,R.B.,
            Young,H.S., Worthington,J., Burden,A.D., Griffiths,C.E., Hayday,A.,
            Nestle,F.O., Reis,A., Lanchbury,J., Barker,J.N. and Trembath,R.C.
  TITLE     Identification of ZNF313/RNF114 as a novel psoriasis susceptibility
            gene
  JOURNAL   Hum Mol Genet 17 (13), 1938-1945 (2008)
   PUBMED   18364390
REFERENCE   8  (bases 1 to 4043)
  AUTHORS   Liliana Slongo,M., Zotti,L. and Onisto,M.
  TITLE     Cloning and characterization of the promoter region of human spata2
            (spermatogenesis-associated protein 2) gene
  JOURNAL   Biochim Biophys Acta 1625 (2), 192-196 (2003)
   PUBMED   12531478
  REMARK    GeneRIF: cloning and base sequence of the promoter region
REFERENCE   9  (bases 1 to 4043)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   10 (bases 1 to 4043)
  AUTHORS   Graziotto,R., Foresta,C., Scannapieco,P., Zeilante,P., Russo,A.,
            Negro,A., Salmaso,R. and Onisto,M.
  TITLE     cDNA cloning and characterization of PD1: a novel human testicular
            protein with different expressions in various testiculopathies
  JOURNAL   Exp Cell Res 248 (2), 620-626 (1999)
   PUBMED   10222154
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK295536.1, BC009481.2, AL031685.18 and N62318.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006038.3.
            
            Transcript Variant: This variant (1) and variant 2 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.445800.1, AB018300.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2156266 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000289431.10/ ENSP00000289431.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               AK295536.1         15-164
            151-2605            BC009481.2         72-2526
            2606-3898           AL031685.18        57144-58436         c
            3899-4043           N62318.1           16-160              c
FEATURES             Location/Qualifiers
     source          1..4043
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.13"
     gene            1..4043
                     /gene="SPATA2"
                     /gene_synonym="PD1; PPP1R145; tamo"
                     /note="spermatogenesis associated 2"
                     /db_xref="GeneID:9825"
                     /db_xref="HGNC:HGNC:14681"
                     /db_xref="MIM:607662"
     exon            1..150
                     /gene="SPATA2"
                     /gene_synonym="PD1; PPP1R145; tamo"
                     /inference="alignment:Splign:2.1.0"
     exon            151..588
                     /gene="SPATA2"
                     /gene_synonym="PD1; PPP1R145; tamo"
                     /inference="alignment:Splign:2.1.0"
     CDS             253..1815
                     /gene="SPATA2"
                     /gene_synonym="PD1; PPP1R145; tamo"
                     /note="spermatogenesis associated PD1;
                     spermatogenesis-associated protein PD1; protein
                     phosphatase 1, regulatory subunit 145"
                     /codon_start=1
                     /product="spermatogenesis-associated protein 2"
                     /protein_id="NP_006029.1"
                     /db_xref="CCDS:CCDS13422.1"
                     /db_xref="GeneID:9825"
                     /db_xref="HGNC:HGNC:14681"
                     /db_xref="MIM:607662"
                     /translation="MGKPSSMDTKFKDDLFRKYVQFHESKVDTTTSRQRPGSDECLRV
                     AASTLLSLHKVDPFYRFRLIQFYEVVESSLRSLSSSSLRALHGAFSMLETVGINLFLY
                     PWKKEFRSIKTYTGPFVYYVKSTLLEEDIRAILSCMGYTPELGTAYKLRELVETLQVK
                     MVSFELFLAKVECEQMLEIHSQVKDKGYSELDIVSERKSSAEDVRGCSDALRRRAEGR
                     EHLTASMSRVALQKSASERAAKDYYKPRVTKPSRSVDAYDSYWESRKPPLKASLSLRK
                     EPVATDVGDDLKDEIIRPSPSLLTMASSPHGSPDVLPPASPSNGPALLRGTYFSTQDD
                     VDLYTDSEPRATYRRQDALRPDVWLLRNDAHSLYHKRSPPAKESALSKCQSCGLSCSS
                     SLCQRCDSLLTCPPASKPSAFPSKASTHDSLAHGASLREKYPGQTQGLDRLPHLHSKS
                     KPSTTPTSRCGFCNRPGATNTCTQCSKVSCDACLSAYHYDPCYKKSELHKFMPNNQLN
                     YKSTQLSHLVYR"
     exon            589..4043
                     /gene="SPATA2"
                     /gene_synonym="PD1; PPP1R145; tamo"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2588..2593
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPATA2"
                     /gene_synonym="PD1; PPP1R145; tamo"
                     /note="hexamer: AATAAA"
     polyA_site      2605
                     /gene="SPATA2"
                     /gene_synonym="PD1; PPP1R145; tamo"
                     /note="major polyA site"
     regulatory      4020..4025
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPATA2"
                     /gene_synonym="PD1; PPP1R145; tamo"
                     /note="hexamer: AATAAA"
     polyA_site      4043
                     /gene="SPATA2"
                     /gene_synonym="PD1; PPP1R145; tamo"
ORIGIN      
        1 gtttccgggt cgctgctggc ccccgggtac tggtctcagt acccctgcag ccggccggag
       61 aggctagagc ccgacggggc ccggctccgg cggcagccgc gcctctcgct tgcttccctc
      121 ggccgggccg tcctcggcgg cagtgtcagg agcactccgc tggtccaggc ggcaacatgt
      181 ccatgctttt agtgatgtcc ctgcctctaa tccagaagcc atggaggaga taaggtagcc
      241 cccctcgatc ggatggggaa gcccagttca atggatacta aattcaagga tgacttattt
      301 cggaagtacg tgcagttcca tgagagcaaa gtggatacca ccaccagcag gcagcggcct
      361 ggcagcgatg agtgcctgcg ggtggcagcc tcaaccctgc tcagcctgca caaggtggat
      421 cccttttatc gattccggct gatccagttc tatgaggtgg tggagagctc cttgcgctcg
      481 ctcagctcct ctagcctgcg ggctctgcac ggcgccttca gcatgctgga gacggtgggc
      541 atcaacctct tcctctaccc gtggaagaag gaattcagaa gcatcaagac ctacacgggc
      601 ccttttgttt attatgtcaa gtcgacatta ctggaagagg acatccgagc catcctgagc
      661 tgcatgggct acacacctga gctgggcact gcatacaagc tcagagagct cgtggagacc
      721 ctccaggtga agatggtctc ctttgagctc tttctggcca aagtcgagtg tgagcagatg
      781 ctagaaatcc actcacaagt gaaggacaag ggctactccg agctggacat tgtgagcgag
      841 cgcaagagca gtgcagagga tgtgcgcggc tgctcggacg ccctgcggcg gcgggcagag
      901 ggccgggagc acctgacggc ctccatgtca cgagtggcac tccagaagtc ggccagcgag
      961 cgggcggcca aggactacta caagccccgc gtgaccaagc cctcgaggtc agtggatgcc
     1021 tatgacagct actgggagag ccggaagcca cccctgaagg cctcattgag tcttcggaag
     1081 gagcctgtgg caacggatgt gggggacgac ctcaaggatg agatcatccg cccatcccct
     1141 tcgctgctga ccatggccag ctccccccac ggcagcccgg atgtgcttcc acccgcctcc
     1201 cccagcaacg gcccggccct gctgcgcggt acctacttct ccactcagga tgacgtggat
     1261 ctgtacacag actctgaacc cagggccacc taccgtcggc aggatgctct gcggccggat
     1321 gtgtggctgc tcagaaacga tgcccactcc ctctaccaca agcgctcgcc ccctgccaaa
     1381 gagtccgccc tctccaagtg ccaaagctgc gggctgtcct gcagctcctc cctctgccag
     1441 cgctgtgaca gcctgctcac ctgtcctcca gcttccaagc ccagcgcctt ccccagcaag
     1501 gcctcgactc atgacagcct ggcccacggg gcatctctgc gggagaagta cccaggccag
     1561 actcagggcc tcgaccgcct cccgcacctt cactccaaat ccaagccctc caccacgccc
     1621 acttcccgct gtggcttctg caaccgccca ggcgccacca acacctgcac ccagtgttca
     1681 aaagtctcat gtgacgcctg cctcagcgct taccattatg acccctgcta caaaaagagt
     1741 gagctgcaca agttcatgcc caacaaccag ctgaactaca agtccaccca gctctcccat
     1801 ctcgtgtaca gatagaccgg cctcgcccct tccagctcca agggctacat caaccgacct
     1861 ttcgggtttc acggtgaaga agtactaacg cattgatctc agaggcggag gcctgcactt
     1921 gaccatgtag gtggcagaga tcgtgggctg gctgtgtcca cgtgggagtt cacttagcga
     1981 ctcagatatc tcaaccaatg gctgctttgt tgtctgacaa gggagaaggt ggcacttccg
     2041 ttcagattca ttttgctaat ctctccactc cctgttcagt tggttctttt tttggggttt
     2101 tgttttgttt tgttttgttg ttttgttttt tcctttaaag aggatttctg tctctgggac
     2161 cctcgctgca cctacccctc ccattgcaaa gccaacttgg actgggaagg gcccttcagg
     2221 tcaccaaaca tccacctgga gcggcgagct agaggcctgt tggcttgtga aatgagccct
     2281 cctgccacac ggggcctctc ccaaaggctc atcccttggc cgcccccttc ctaaacacaa
     2341 ggatccccag ctggactccc caccccctgg cttccccacc tctccaggtg tcaaaggtga
     2401 accgagtcca gtattagctg aatgtcattt cgtacaccac agctcagtca gcccatggcc
     2461 ttcgtgaact ttgctccaac acactgatgt gtgggcttcc cacagcagga ctgacttccc
     2521 cctttctgtt gtttgcacat gcccctctta ctgtactgtc aatagatatt tttgagattt
     2581 atttttaaat aaatattcaa cttgctgtgt gtttcaacgt ggttaaaaaa atgaattatg
     2641 tagctattta ttaaatgccc tgggttcttt agtcttccaa gggagggcct cgcgcccatt
     2701 cgtgttgtat cctccactca ctatggcccg aggggagagg agagtttggg gcagggagga
     2761 acagacatga agcctccttt tcttgagctg gtggagagcc actgtcttcc ctgcagtaac
     2821 tatctataca cctacctcca gtgtgcactt agggggtgag cgcgggtgtc gaggtctgtg
     2881 tgtctgcaga ctgctaacct atgacaattc agggacctca cctgtcggac ctatagcttg
     2941 ctgagcagga accttgcact tcacacttct tgagtctcgt ttcagaagga aaatcatttg
     3001 ggattcctac tgcccctcca tctcaatcct cttctcttca ccagtttcca ggactcatct
     3061 gcaacatttg caatcttttt gcactaaaag tgggcaggag tcggcatgtg cccatcagag
     3121 agacggctcc tcagatgctc agctaagcct aagcgcttcc aagcctgaag gccccttcag
     3181 cttctcatgt gaattaccaa cccctggatt ttccttgtgg gggtacaaga gcaggagtgg
     3241 ggcaagagtt tgaaaataaa gccgcttcct tgtgaactaa ctatatttta gccataactg
     3301 tttgtgatgt acacaatgtt aagggattta tatgcagtgg gcttttctgg gagaaagtta
     3361 ttcagctctt gagcaagttt aagtctggct gaatcctgag gccactgtga atttgctgat
     3421 gttcttccaa ctcagttgag tgattttaag gttttccaaa tcttctatgg ctctcttttt
     3481 aatatatata tatatatata tatatatata tatatatata tatatatata tctatctggt
     3541 agatcacatg tagatgtaca gtgtgtatat taagctgaat ttcaaccaac tttattacta
     3601 agaccagcct agcagggcat tcatctttga tgttcttcct tttcacattt cagaatcggc
     3661 aatgcctggc ccactcctga gagctctagt tttctagttt tccatttcca gattgcgcca
     3721 gcattacagt aactaactct ttctaaccaa ccgtgatgcc acgtaactta ccctatggac
     3781 aaaagcagga atgactaaca catcctagga gggaaagtcc agtgtacctg tcatcacgga
     3841 cgcactgtgg tcacagactg gaatacgaaa tactacagcc ctgctcccag gtgtgcatct
     3901 tactggatga ggttgctgtg attgagatag ttaaatacat gctaatttaa aaatgcagat
     3961 gttttacatt tgatttctac caagagttga aatgttgaga gatgattaaa aataataata
     4021 ataaagtgtc ttccattgtt aaa
//
