LOCUS       NM_174927                873 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens spermatogenesis associated 19 (SPATA19), transcript
            variant 1, mRNA; nuclear genes for mitochondrial products.
ACCESSION   NM_174927
VERSION     NM_174927.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 873)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 873)
  AUTHORS   Wong,K.K., Hussain,F.A., Loo,S.K. and Lopez,J.I.
  TITLE     Cancer/testis antigen SPATA19 is frequently expressed in benign
            prostatic hyperplasia and prostate cancer
  JOURNAL   APMIS 125 (12), 1092-1101 (2017)
   PUBMED   28972294
  REMARK    GeneRIF: Investigated SPATA19 protein expression patterns in a
            panel of non-malignant samples and primary prostate cancer with or
            without benign prostatic hyperplasia tissues. SPATA19 was absent in
            all non-malignant tissues investigated (n=14) except testis and
            prostate tissues.
REFERENCE   3  (bases 1 to 873)
  AUTHORS   Mi,Y., Shi,Z. and Li,J.
  TITLE     Spata19 is critical for sperm mitochondrial function and male
            fertility
  JOURNAL   Mol Reprod Dev 82 (11), 907-913 (2015)
   PUBMED   26265198
REFERENCE   4  (bases 1 to 873)
  AUTHORS   Ghafouri-Fard,S., Ousati Ashtiani,Z., Sabah Golian,B.,
            Hasheminasab,S.M. and Modarressi,M.H.
  TITLE     Expression of two testis-specific genes, SPATA19 and LEMD1, in
            prostate cancer
  JOURNAL   Arch Med Res 41 (3), 195-200 (2010)
   PUBMED   20682177
  REMARK    GeneRIF: Of the prostate cancer samples, 10, 10, 23 and 40% showed
            ODF1, ODF2, LEMD1 and SPATA19 specific bands, respectively, but
            none of the BPH samples expressed any of these genes.
REFERENCE   5  (bases 1 to 873)
  AUTHORS   Ghafouri-Fard,S., Abbasi,A., Moslehi,H., Faramarzi,N., Taba Taba
            Vakili,S., Mobasheri,M.B. and Modarressi,M.H.
  TITLE     Elevated expression levels of testis-specific genes TEX101 and
            SPATA19 in basal cell carcinoma and their correlation with clinical
            and pathological features
  JOURNAL   Br J Dermatol 162 (4), 772-779 (2010)
   PUBMED   19886887
  REMARK    GeneRIF: The SPATA19 and TEX101 genes may be possible targets for
            cancer immunotherapy and novel markers for early detection of basal
            cell carcinoma.
REFERENCE   6  (bases 1 to 873)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   7  (bases 1 to 873)
  AUTHORS   Matsuoka,Y., Iguchi,N., Kitamura,K., Nishimura,H., Manabe,H.,
            Miyagawa,Y., Koga,M., Matsumiya,K., Okuyama,A., Tanaka,H. and
            Nishimune,Y.
  TITLE     Cloning and characterization of a mouse spergen-1 localized in
            sperm mitochondria
  JOURNAL   Int J Androl 27 (3), 152-160 (2004)
   PUBMED   15139970
REFERENCE   8  (bases 1 to 873)
  AUTHORS   Miyamoto,T., Sengoku,K., Hasuike,S., Takuma,N., Hayashi,H.,
            Yamashita,T. and Ishikawa,M.
  TITLE     Isolation and expression analysis of the human testis-specific
            gene, SPERGEN-1, a spermatogenic cell-specific gene-1
  JOURNAL   J Assist Reprod Genet 20 (2), 101-104 (2003)
   PUBMED   12688595
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX096445.1, BC058039.1 and AP001979.7.
            
            On Nov 23, 2018 this sequence version replaced NM_174927.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.383883.1,
                                           SRR5189667.113596.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874, SAMEA2149178
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000299140.8/ ENSP00000299140.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                BX096445.1         26-37
            13-602              BC058039.1         5-594
            603-603             AP001979.7         44004-44004         c
            604-873             BC058039.1         596-865
FEATURES             Location/Qualifiers
     source          1..873
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q25"
     gene            1..873
                     /gene="SPATA19"
                     /gene_synonym="CT132; SPAS1; spergen1"
                     /note="spermatogenesis associated 19"
                     /db_xref="GeneID:219938"
                     /db_xref="HGNC:HGNC:30614"
                     /db_xref="MIM:609805"
     exon            1..145
                     /gene="SPATA19"
                     /gene_synonym="CT132; SPAS1; spergen1"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..571
                     /gene="SPATA19"
                     /gene_synonym="CT132; SPAS1; spergen1"
                     /note="spermatogenic specific-gene1; cancer/testis antigen
                     132; spergen-1; spermatogenesis-associated protein 19,
                     mitochondrial; spermatogenic cell-specific gene 1 protein;
                     testis secretory sperm-binding protein Li 243mP"
                     /codon_start=1
                     /product="spermatogenesis-associated protein 19,
                     mitochondrial precursor"
                     /protein_id="NP_777587.1"
                     /db_xref="CCDS:CCDS8493.1"
                     /db_xref="GeneID:219938"
                     /db_xref="HGNC:HGNC:30614"
                     /db_xref="MIM:609805"
                     /translation="MIITTWIVYILARKGVGLPFLPITSSDIDVVESEAVSVLHHWLK
                     KTEEEASRGIKEKLSINHPSQGVREKMSTDSPPTHGQDIHVTRDVVKHHLSKSDLLAN
                     QSQEVLEERTRIQFIRWSHTRIFQVPSEMTEDIMRDRIEQVRRSISRLTDVSAQDFSM
                     RPSSSDC"
     exon            146..202
                     /gene="SPATA19"
                     /gene_synonym="CT132; SPAS1; spergen1"
                     /inference="alignment:Splign:2.1.0"
     exon            203..334
                     /gene="SPATA19"
                     /gene_synonym="CT132; SPAS1; spergen1"
                     /inference="alignment:Splign:2.1.0"
     exon            335..426
                     /gene="SPATA19"
                     /gene_synonym="CT132; SPAS1; spergen1"
                     /inference="alignment:Splign:2.1.0"
     exon            427..504
                     /gene="SPATA19"
                     /gene_synonym="CT132; SPAS1; spergen1"
                     /inference="alignment:Splign:2.1.0"
     exon            505..580
                     /gene="SPATA19"
                     /gene_synonym="CT132; SPAS1; spergen1"
                     /inference="alignment:Splign:2.1.0"
     exon            581..873
                     /gene="SPATA19"
                     /gene_synonym="CT132; SPAS1; spergen1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      847..852
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPATA19"
                     /gene_synonym="CT132; SPAS1; spergen1"
                     /note="hexamer: AATAAA"
     polyA_site      873
                     /gene="SPATA19"
                     /gene_synonym="CT132; SPAS1; spergen1"
                     /note="major polyA site"
ORIGIN      
        1 ataggagttc tcaggcagct tcaatggaag gagggagcca agaagggggc ctggtataca
       61 ttcaaagatg ataattacga catggattgt gtatattctt gctcggaaag gtgtagggct
      121 tcccttccta ccaataacca gttcggacat tgacgttgtg gaaagtgagg ctgtgtctgt
      181 actacatcat tggttgaaaa aaacagaaga agaggcttct cggggcataa aggaaaagct
      241 gtccatcaac cacccttccc agggtgtaag ggagaagatg tccactgact cccctcccac
      301 ccatggccag gacatccacg tgaccagaga tgtggtgaag caccacctct ctaagtctga
      361 tttgttggca aaccagagcc aagaggtcct agaggagaga acacgaatcc agttcataag
      421 atggagccac actcgtatct tccaagtgcc aagtgagatg acagaggaca tcatgcgaga
      481 tcgaatagag caggtgagac gaagcatatc ccgtcttaca gatgtctcag ctcaggactt
      541 cagtatgaga ccctcctcct cagactgctg agagcaacag atggagcttt gggaacgcgg
      601 agaacagtgg ggttacaggg agtcatcatc agccctaccc cttggccaac cacatctccc
      661 tgctgtgtcc cctgggcatt tctctacctc ccaggtggaa gtccttcagg gtccagcagc
      721 aacctgtatc agaagaacat ccttctctgc ttgacctgaa gaagggccag acctgggcag
      781 aaagactcca gcaggtgagc tcttcatgcg acagtgtcag cactggagtc ttcttgctga
      841 actgcgaata aagagatgtg ctgtttaaca acc
//
