LOCUS       NM_138796               5798 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens spermatogenesis associated 17 (SPATA17), transcript
            variant 1, mRNA.
ACCESSION   NM_138796
VERSION     NM_138796.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5798)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 5798)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 5798)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 5798)
  AUTHORS   Nie,D.S., Liu,Y., Juan,H. and Yang,X.
  TITLE     Overexpression of human SPATA17 protein induces germ cell apoptosis
            in transgenic male mice
  JOURNAL   Mol Biol Rep 40 (2), 1905-1910 (2013)
   PUBMED   23079716
  REMARK    GeneRIF: Elevated production of the SPATA17 protein disturbs the
            normal development of male germ cells.
REFERENCE   5  (bases 1 to 5798)
  AUTHORS   Nakabayashi,K., Komaki,G., Tajima,A., Ando,T., Ishikawa,M.,
            Nomoto,J., Hata,K., Oka,A., Inoko,H., Sasazuki,T. and Shirasawa,S.
  CONSRTM   Japanese Genetic Research Group for Eating Disorders (JGRED)
  TITLE     Identification of novel candidate loci for anorexia nervosa at 1q41
            and 11q22 in Japanese by a genome-wide association analysis with
            microsatellite markers
  JOURNAL   J Hum Genet 54 (9), 531-537 (2009)
   PUBMED   19680270
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 5798)
  AUTHORS   Miyamoto,T., Tsujimura,A., Miyagawa,Y., Koh,E., Sakugawa,N.,
            Miyakawa,H., Sato,H., Namiki,M., Okuyama,A. and Sengoku,K.
  TITLE     A single nucleotide polymorphism in SPATA17 may be a genetic risk
            factor for Japanese patients with meiotic arrest
  JOURNAL   Asian J Androl 11 (5), 623-628 (2009)
   PUBMED   19483714
  REMARK    GeneRIF: the frequency of the SNP3 allele was significantly
            elevated in the meiotic arrest group (P < 0.05). This study
            suggests that SPATA17 may play a critical role in human
            spermatogenesis, especially in meiosis.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 5798)
  AUTHORS   Deng,Y., Hu,L.S. and Lu,G.X.
  TITLE     Expression and identification of a novel apoptosis gene Spata17
            (MSRG-11) in mouse spermatogenic cells
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 38 (1), 37-45 (2006)
   PUBMED   16395525
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY963797.1, AL445428.5 and BX109478.1.
            
            On Nov 23, 2018 this sequence version replaced NM_138796.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK098591.1, SRR1803615.178354.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366933.5/ ENSP00000355900.4
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1244              AY963797.1         24-1267
            1245-1849           AL445428.5         49973-50577
            1850-2253           BX109478.1         13-416              c
            2254-5798           AL445428.5         50982-54526
FEATURES             Location/Qualifiers
     source          1..5798
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q41"
     gene            1..5798
                     /gene="SPATA17"
                     /gene_synonym="CFAP305; FAP305; IQCH; MOT17; MSRG-11;
                     MSRG11"
                     /note="spermatogenesis associated 17"
                     /db_xref="GeneID:128153"
                     /db_xref="HGNC:HGNC:25184"
                     /db_xref="MIM:611032"
     exon            1..103
                     /gene="SPATA17"
                     /gene_synonym="CFAP305; FAP305; IQCH; MOT17; MSRG-11;
                     MSRG11"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..1121
                     /gene="SPATA17"
                     /gene_synonym="CFAP305; FAP305; IQCH; MOT17; MSRG-11;
                     MSRG11"
                     /note="IQ motif containing H; spermatogenesis-related
                     protein 11"
                     /codon_start=1
                     /product="spermatogenesis-associated protein 17"
                     /protein_id="NP_620151.1"
                     /db_xref="CCDS:CCDS1519.1"
                     /db_xref="GeneID:128153"
                     /db_xref="HGNC:HGNC:25184"
                     /db_xref="MIM:611032"
                     /translation="MATLARLQARSSTVGNQYYFRNSVVDPFRKKENDAAVKIQSWFR
                     GCQVRAYIRHLNRIVTIIQKWWRSFLGRKQYQLTVQVAYYTMMMNLYNAMAVRIQRRW
                     RGYRVRKYLFNYYYLKEYLKVVSETNDAIRKALEEFAEMKEREEKKANLEREEKKRDY
                     QARKMHYLLSTKQIPGIYNSPFRKEPDPWELQLQKAKPLTHRRPKVKQKDSTSLTDWL
                     ACTSARSFPRSEILPPINRKQCQGPFRDITEVLEQRYRPLEPTLRVAEPIDELKLARE
                     ELRREEWLQNVNDNMFLPFSSYHKNEKYIPSMHLSSKYGPISYKEQFRSENPKKWICD
                     KDFQTVLPSFELFSKYGKLYSKAGQIV"
     exon            104..193
                     /gene="SPATA17"
                     /gene_synonym="CFAP305; FAP305; IQCH; MOT17; MSRG-11;
                     MSRG11"
                     /inference="alignment:Splign:2.1.0"
     exon            194..275
                     /gene="SPATA17"
                     /gene_synonym="CFAP305; FAP305; IQCH; MOT17; MSRG-11;
                     MSRG11"
                     /inference="alignment:Splign:2.1.0"
     exon            276..326
                     /gene="SPATA17"
                     /gene_synonym="CFAP305; FAP305; IQCH; MOT17; MSRG-11;
                     MSRG11"
                     /inference="alignment:Splign:2.1.0"
     exon            327..430
                     /gene="SPATA17"
                     /gene_synonym="CFAP305; FAP305; IQCH; MOT17; MSRG-11;
                     MSRG11"
                     /inference="alignment:Splign:2.1.0"
     exon            431..554
                     /gene="SPATA17"
                     /gene_synonym="CFAP305; FAP305; IQCH; MOT17; MSRG-11;
                     MSRG11"
                     /inference="alignment:Splign:2.1.0"
     exon            555..758
                     /gene="SPATA17"
                     /gene_synonym="CFAP305; FAP305; IQCH; MOT17; MSRG-11;
                     MSRG11"
                     /inference="alignment:Splign:2.1.0"
     exon            759..907
                     /gene="SPATA17"
                     /gene_synonym="CFAP305; FAP305; IQCH; MOT17; MSRG-11;
                     MSRG11"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1040
                     /gene="SPATA17"
                     /gene_synonym="CFAP305; FAP305; IQCH; MOT17; MSRG-11;
                     MSRG11"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1123
                     /gene="SPATA17"
                     /gene_synonym="CFAP305; FAP305; IQCH; MOT17; MSRG-11;
                     MSRG11"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..5798
                     /gene="SPATA17"
                     /gene_synonym="CFAP305; FAP305; IQCH; MOT17; MSRG-11;
                     MSRG11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1226..1231
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPATA17"
                     /gene_synonym="CFAP305; FAP305; IQCH; MOT17; MSRG-11;
                     MSRG11"
                     /note="hexamer: AATAAA"
     regulatory      1233..1238
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPATA17"
                     /gene_synonym="CFAP305; FAP305; IQCH; MOT17; MSRG-11;
                     MSRG11"
                     /note="hexamer: TATAAA"
     polyA_site      1246
                     /gene="SPATA17"
                     /gene_synonym="CFAP305; FAP305; IQCH; MOT17; MSRG-11;
                     MSRG11"
     polyA_site      1252
                     /gene="SPATA17"
                     /gene_synonym="CFAP305; FAP305; IQCH; MOT17; MSRG-11;
                     MSRG11"
                     /note="major polyA site"
     regulatory      2232..2237
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPATA17"
                     /gene_synonym="CFAP305; FAP305; IQCH; MOT17; MSRG-11;
                     MSRG11"
                     /note="hexamer: AATAAA"
     polyA_site      2253
                     /gene="SPATA17"
                     /gene_synonym="CFAP305; FAP305; IQCH; MOT17; MSRG-11;
                     MSRG11"
     regulatory      4188..4193
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPATA17"
                     /gene_synonym="CFAP305; FAP305; IQCH; MOT17; MSRG-11;
                     MSRG11"
                     /note="hexamer: AATAAT"
     polyA_site      4205
                     /gene="SPATA17"
                     /gene_synonym="CFAP305; FAP305; IQCH; MOT17; MSRG-11;
                     MSRG11"
     regulatory      5267..5272
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPATA17"
                     /gene_synonym="CFAP305; FAP305; IQCH; MOT17; MSRG-11;
                     MSRG11"
                     /note="hexamer: AATAAT"
     polyA_site      5288
                     /gene="SPATA17"
                     /gene_synonym="CFAP305; FAP305; IQCH; MOT17; MSRG-11;
                     MSRG11"
     regulatory      5779..5784
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPATA17"
                     /gene_synonym="CFAP305; FAP305; IQCH; MOT17; MSRG-11;
                     MSRG11"
                     /note="hexamer: ATTAAA"
     polyA_site      5798
                     /gene="SPATA17"
                     /gene_synonym="CFAP305; FAP305; IQCH; MOT17; MSRG-11;
                     MSRG11"
ORIGIN      
        1 agtaacacca gttgtaaacc caaggccaag agaccatggc cacgttagcc cggctgcaag
       61 ctaggtcgtc gactgtagga aatcagtact actttaggaa cagtgttgta gatccattta
      121 gaaaaaagga gaatgatgca gcagttaaaa tccaaagctg gtttcgagga tgtcaagttc
      181 gggcatatat caggcattta aacaggattg taacaattat tcaaaaatgg tggagaagtt
      241 tcttaggcag aaagcaatat caactaactg tgcaggtagc atattatact atgatgatga
      301 atctctacaa tgcaatggct gtcaggattc agagacgatg gcgaggctat agggttcgga
      361 agtacctctt taattattat tatttgaaag agtacctgaa agtcgtttca gagaccaatg
      421 atgcaattag gaaggcactg gaggagtttg cagaaatgaa agaaagagaa gagaagaagg
      481 ctaacctcga aagggaagag aagaaaagag attaccaagc ccgaaagatg cattacctcc
      541 tcagcacaaa gcagattcca ggaatataca attcaccctt cagaaaagag cctgatccat
      601 gggagctgca attacagaag gcaaagcctt taacacaccg aagacctaaa gttaagcaga
      661 aggactccac cagccttact gattggctag cttgtacaag cgcccgttct tttcctcggt
      721 ctgaaattct accacctatt aatagaaagc aatgtcaggg gcccttccga gatatcaccg
      781 aagtattaga acaacgctac aggcctttgg agccaacgtt gcgggtggca gaaccaatcg
      841 atgagttaaa gttggccaga gaggagctca gaagagagga atggctgcaa aatgtaaatg
      901 acaatatgtt tttgccattt tcttcatacc ataaaaatga aaagtacatc ccatcaatgc
      961 atttatcaag caagtatggt cctatttctt acaaagaaca attccgaagt gaaaatccta
     1021 agaaatggat ctgtgacaag gatttccaga ctgtattacc atcatttgag ctcttctcaa
     1081 agtatggaaa attatattca aaagctggac agattgtata aaggcgtcag aagaagaaac
     1141 tgaagccatc tgcattttaa aacttaacag ttctgaaagg aaaacacaga tgaagatcct
     1201 gtaggaaata tacttgctat gattcaataa actataaaat tttgtagctc tagtcatgaa
     1261 ttaattattg tgtgtatgta tttgaaatct cttagacata tcttttcaaa caaatactta
     1321 aacttgagtc tgttacctct gagaatgtct gtcacaatca cagcccctgg tgaccaacag
     1381 tgccataaat ggttcccctg aaatacccat attctgaccc catcacccgg gtcacaaatg
     1441 atgacaccag tgctgggtac ccaaattaag ggcgactaac atgtaagtag gatgatgaat
     1501 ggtttgaagt gtaaattgtg tgaaatagtt cagcatgaaa gctctgccct gagaaataat
     1561 gactgattat accagttaga aacccttcag actgttgaac ttgagacaca cagacacaac
     1621 agacacagac tagtgggtgt gggagcagaa gcataggcac tctcaaatag agaagacatt
     1681 tgcaagtctc tgctgccaag ggagcaaaga gataatctcg atgccagggc tgtgtcagat
     1741 cctgcatggc tctgaactac agttggtttc caaaaagctg ggcttttgtg aggtttctgt
     1801 tttttatgcg atgcttagat tttcctggaa tccttggaag ttaactcaac atttgaggtt
     1861 cctatatcct ttaatcccat cccatgtgta tctttacaat aaaacttcct gctagaggta
     1921 tcctgaggga atctttgttt cttgcatctg aagagaataa cactaaactt attgcatatg
     1981 atttgggggt tggatccaat gatagcacag agggacagga aatgtgattt attgaccata
     2041 aaagctttaa tttaaaattg ctggccagcg aaatccagac tctgggaaat gttataggcc
     2101 aaatgatctg tttcttcaac aaataaatta caaaactgag gggaaaaaaa ggaacctatt
     2161 aaaaagacat tatctatcaa tcactgtgtg tgtacagttt tgagctcctg atttaaataa
     2221 acaaattgta aaataaaaga tcttttgaaa caattggaag tttgaacact gattggatat
     2281 tggtggtata aaagaattat tggttttttt taggtgtcat ggtattgttt tggtttacaa
     2341 agttatagat ataaatgttg aaatatttac agatgcagtg atatgttggc tgggatttaa
     2401 tttgaaagtc aaagaagtga gttaaaatac atatactcct cctcttataa tcggttatgt
     2461 gccaataaat ccattgtaaa ttgaaaatat cctaagttga aaatattgta agttaaaaat
     2521 gcatttaata cagctaactt accagacagc ttagcttagc ctcacctacc ttaaatatgc
     2581 tcagaacaca tacgttagcc tatagttggg caaaatcatc taacacaaag cctattttat
     2641 aatattgaac agcccatgta atttattgaa tattgtacta aaagtgaaaa actgaatagt
     2701 tgtatgcata ctcaaagtat ggtttctact gaatgcattg taaaccagaa agtatctgag
     2761 acaatgtttt tttttttttt tttttttttt ttaatttctg agacagagtc tcattctgtc
     2821 acccaggttg gagtgcagtg gcatgaactc agctcactgc aaccttcacc tcccaggctc
     2881 aagcagtcct cccatctcag cctcccaagt agctgggacc acaggcatgg gccaacaagc
     2941 ctggctaaat attttgtact tttggtagac acgggttttt accatgttgt gcaggctggt
     3001 cttgaacgcc tgagctcaag tgatctgcct gcctcggcct cccaaagtac tgggattaca
     3061 ggcatgagtc actgaaccca gccctgagac atgtctcaat tagtttagaa gtttatttgg
     3121 ccaaggttaa ggacatgccc ttgacactgc acctgtcagt acaggtcctg acaacatgtg
     3181 tccaaggtgg tcaagctata caacttggtt ttatacattt taaggagaca taagacatca
     3241 ataaatacat ggaagatgta cattggttca gtctggaaag gcaggatgcc tcaaacttga
     3301 aacaagagaa tggggggtgg gaggatgtgg gagatgcttc caggtcatag ttggagtcaa
     3361 agactttcca attggcaatt ggttcaaaga atttatctaa agacctggaa tccatagaag
     3421 gctttacctg gattaaaata aggggaccaa ggttctcatg cagatgaagc ctccaggtgg
     3481 cagacttcag agagcataga ttgtaaatgt ttcttatctg acttaaaaag gtgtcagact
     3541 cttagtaaat tatctcctgg atcagtgaaa agatgtgaaa aaaggttctc tacagaatgt
     3601 agattttccc cataagagat agcttcgcag ggccattgca aaatatgtca aaaatatata
     3661 ttttagggta aaatgcctca atttatttca aggcctgata tttgtcatgt gatgctatac
     3721 tacagtcagg ctgaaacttg gcatcttatt gctatgaaaa atcttaagat ctctatttta
     3781 atgttaatgc tggtcactgg tgcctgaatt ccaaagggag gagggtataa tgaagcatgt
     3841 ccaattcccc atgccccacc cccaccccca catcctataa tggcctgaac tagtttttca
     3901 ggttaacttt ggaataccct tggccaagaa gaggggtcca tgcagatgtt tggagggggg
     3961 ggtcttaaag ctttattttt agattacagc atattgcttt tgcactatca taaagtaaaa
     4021 acatcataag tcaagccacc ataaatagcg gaccatctgt atatctgaaa gaagatgaac
     4081 caagacttgg ttattgttaa agctgatgat tggctgtatg aagatttact atacaatttt
     4141 gtgtactttt gtaagttctt ggttgtttct aaacttataa caaaataaat aattggccat
     4201 cttcattgga ttgtgaagcc atttcctccc acatgttcgt aaaaatggta gccatggccc
     4261 ctgactgaac ccaggtatga atggccttca ttgattttgt agaccctgac cttctctgtt
     4321 cttccagaga aggtggtact cagataaaaa ctttgaagca ttttattgtt cagaatatga
     4381 ctttgatctt ctcataagac tcaagttttt gaatgcttaa ggctctttat cgctagtgta
     4441 tgtaagtaat atcattgtcc ttaaccacca tctgcctctc cccccagaca cacataagtt
     4501 tatgataact acagaggtgt ccagatgagt aaaaactgcc tttgcattaa ggtgagagaa
     4561 gaccgagatg aaatcttatt agaaaatata actggggaaa gcagtttgtc tgtttctcct
     4621 ggaaaactac tagactacat caacttatat actacttctt ttctatattc tcaatatgag
     4681 ccacttaaga aaattaatga gactttatgt ttgaccaaag ctggtaattc cttgatctta
     4741 ttctccaaac ttgattctga atgactactg accactaaaa acactaagag taccactgtg
     4801 gatgtttaaa aacatacacc ctaagagcct tcagaattag acgcttcaat tcttctgaaa
     4861 tcaaaagtca caccagcttt gctgtagtta atcaggtaat acctttcttc tccactactc
     4921 tctaatttcc ttgagggcaa atattgtctt tcttgataaa tgccctggac ccaacatcta
     4981 acagaatacc tggcataaag tgaaatccat cgaatgtgct aatgataaat aaagaagttc
     5041 aaaaaaatct tttaatagaa gctataaaat agcagataag ctaagtcatt ctcataaaac
     5101 accatttgtc atttgaatgc gtgcattgtg gcctgttact tttaactagt ctcactaatt
     5161 tatagttata tatgatgtag atctagattg tgatgtacac taagtgggtt gatcctgaga
     5221 tcaagctatg attgctgctt gcgtaaagtg ttccttttgg gaaataaata atctttcata
     5281 tctgtaaact ttggtataat tggttattta tgcaatgtat tgttgtggtt gtcaactcaa
     5341 gattgtattc tcatctgggg acattatgaa tcttgttatt ttatcccctt ttttgctctg
     5401 ttttttcaca tttatggcct acctgttaca gctgcacggt atccattttc tgtgctaaat
     5461 tcatctttaa tttattattt tttttcaacc tcagctttta actttgccct gattttctct
     5521 tccattttat tttcacttcc attttaagct ggctcaaagc cttttaggaa caataagtta
     5581 ctgaattata tgaacctatt tgaggtaatg atgatgcctg ggaaggagca gtattgctgg
     5641 atcagaattc actttttcca agttacagat tttaataaac cactgtgcaa agcattagga
     5701 taaattttta ttgaaaattg agtgaatgac tgaacaaatc gctgggtaat gctgtttagg
     5761 ttgttctatt ttccacggat taaattaaat tctatgta
//
