LOCUS       NM_181727               2190 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens spermatogenesis associated 12 (SPATA12), mRNA.
ACCESSION   NM_181727
VERSION     NM_181727.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2190)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2190)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2190)
  AUTHORS   Zhang,Y., Yang,L., Lin,Y., Rong,Z., Liu,X. and Li,D.
  TITLE     SPATA12 and its possible role in DNA damage induced by
            ultraviolet-C
  JOURNAL   PLoS One 8 (10), e78201 (2013)
   PUBMED   24205157
  REMARK    GeneRIF: SPATA12 could be induced under UV-C stress.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2190)
  AUTHORS   Li,D., Lin,Y., Liu,Z., Zhang,Y., Rong,Z. and Liu,X.
  TITLE     Transcriptional regulation of human novel gene SPATA12 promoter by
            AP-1 and HSF
  JOURNAL   Gene 511 (1), 18-25 (2012)
   PUBMED   22981541
  REMARK    GeneRIF: AP-1 is founded to be a potential transcriptional
            activator of SPATA12. The promoter activity of SPATA12 was
            drastically declined after AP-1 binding site mutation or deletion.
REFERENCE   5  (bases 1 to 2190)
  AUTHORS   Dan,L., Lifang,Y. and Guangxiu,L.
  TITLE     Expression and possible functions of a novel gene SPATA12 in human
            testis
  JOURNAL   J Androl 28 (4), 502-512 (2007)
   PUBMED   17251597
  REMARK    GeneRIF: putative function of SPATA12 is to maintain the cell in a
            differentiated state and/or to suppress cell proliferation in the
            human testis.
REFERENCE   6  (bases 1 to 2190)
  AUTHORS   Li,D. and Lu,G.X.
  TITLE     Identification and expression of a novel human testis-specific gene
            by digital differential display
  JOURNAL   Chin Med J (Engl) 117 (12), 1791-1796 (2004)
   PUBMED   15603706
  REMARK    GeneRIF: Didital differential display can be confirmed by SPATA12
            as a novel computational biology-based approach for identification
            of the testis-specific expression of genes.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY221117.1.
            
            On Nov 22, 2018 this sequence version replaced NM_181727.1.
            
            Summary: This gene is expressed primarily in testis and may play a
            role in testicular development and spermatogenesis. The encoded
            protein may be upregulated in response to ultraviolet-C radiation.
            [provided by RefSeq, Dec 2015].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY221117.1, SRR5189667.65815.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334325.2/ ENSP00000335392.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2190              AY221117.1         224-2413
FEATURES             Location/Qualifiers
     source          1..2190
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p14.3"
     gene            1..2190
                     /gene="SPATA12"
                     /gene_synonym="SRG5"
                     /note="spermatogenesis associated 12"
                     /db_xref="GeneID:353324"
                     /db_xref="HGNC:HGNC:23221"
                     /db_xref="MIM:609869"
     exon            1..123
                     /gene="SPATA12"
                     /gene_synonym="SRG5"
                     /inference="alignment:Splign:2.1.0"
     exon            124..2190
                     /gene="SPATA12"
                     /gene_synonym="SRG5"
                     /inference="alignment:Splign:2.1.0"
     CDS             453..1025
                     /gene="SPATA12"
                     /gene_synonym="SRG5"
                     /note="spermatogenesis-related protein 5; testicular
                     tissue protein Li 184"
                     /codon_start=1
                     /product="spermatogenesis-associated protein 12"
                     /protein_id="NP_859078.1"
                     /db_xref="CCDS:CCDS2879.1"
                     /db_xref="GeneID:353324"
                     /db_xref="HGNC:HGNC:23221"
                     /db_xref="MIM:609869"
                     /translation="MSSSALTCGSTLEKSGDTWEMKALDSSRLVPWPPRGLGSSTQHP
                     NKPHCALASCQGPGVLPGAASALPELTFQGDVCQSETCQRYLQAAISLDIAVSQINLL
                     GRPSSPPALLIQQGSCEQVIHNSTPQFLGMEDGDNERTTGWLWRLCEDIDAEPSSTGC
                     SRSNQLTFTEGCFVRSLSTVYSNTHIHTHL"
     regulatory      1031..1036
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPATA12"
                     /gene_synonym="SRG5"
                     /note="hexamer: AATAAT"
     polyA_site      1050
                     /gene="SPATA12"
                     /gene_synonym="SRG5"
                     /note="major polyA site"
     regulatory      1301..1306
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPATA12"
                     /gene_synonym="SRG5"
                     /note="hexamer: ATTAAA"
     polyA_site      1323
                     /gene="SPATA12"
                     /gene_synonym="SRG5"
     regulatory      2171..2176
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPATA12"
                     /gene_synonym="SRG5"
                     /note="hexamer: AATAAA"
     polyA_site      2190
                     /gene="SPATA12"
                     /gene_synonym="SRG5"
ORIGIN      
        1 acagtcactg agaaaattct ttgtgcaggc tcaccttccc ctcatctccc ccactcttcc
       61 tgatcctgca gcgtcagatc ccagcctgca gtatcagacc tcaaaaggag cctctggtgt
      121 cttccaaaag ggaaggaaag agagagaaag ccactggagt tgggcagcgt gggaagctgt
      181 gaaagtggac aagcgtgaaa gagcttccaa gtagtggaaa cagcagaagc aaagatgtga
      241 acatgggaaa acctctgcag tatctgggtg actgtggggt ttggctctgt ttgagcaccc
      301 cgggatgatt ggtggtgggg tgtggctgaa ggtgaattgg aacagtgcac tcagagccag
      361 gttgcaagag tgctgcatgc tcctcaggga ttggctccgg ccaagtgccc cagcctcctt
      421 ttctggagaa ttctgttttt gacttgggcc ccatgtccag ttctgctctg acttgtgggt
      481 ccaccttaga aaagtcagga gacacctggg aaatgaaggc actagactct tccagactcg
      541 ttccatggcc acccagaggc cttgggtcat ccacccaaca tcccaacaaa ccccactgtg
      601 cactggcatc atgccagggt ccaggtgtcc tgccaggagc agcctctgcc ctcccagagc
      661 tgacatttca gggggatgtg tgccaaagtg agacctgtca gagatattta caagcagcca
      721 tctctcttga catcgctgta tcccaaataa atcttctggg aagaccctct tcacctccag
      781 ctctcctgat acagcaaggc agttgtgagc aagttattca taactctaca cctcaatttc
      841 ttggtatgga agatggggat aatgagagga ccacaggatg gttgtggaga ctgtgtgagg
      901 atatagatgc cgagcccagt agcacagggt gcagccgttc aaaccaactg acatttactg
      961 agggctgctt tgtcaggtcc ctctctacag tatactccaa cacacacata cacacacatc
     1021 tgtaatcaat aataatcctg caacatctga gagtctggca gctgtttgtc tgggcctttg
     1081 cacatgctat gccctccctt ccatccccca cccccaccag gggtgactcg tagccatccc
     1141 tttctgcatc ttcttagata tcactttttc caagaagcct ccctgtcaca cttccccaat
     1201 atcacagatg aagaaatcaa gattcagaaa ggttaagtta ctggcacaag gtcacacaat
     1261 ccagatctca tactcttagc ccccggggaa ccttcactgt attaaatgac atcaattgat
     1321 caatcaatcg atcaatcaat gaaagagtgg gaggcatgca tctcctgatc cccgatccta
     1381 tacattttca tctctttatt gtttctatca aagcctgcta agtaattact ttccctctgg
     1441 gtaagtgcca ctaggtgatg aggtgaggta atcaaatgac atagaagagg aaggagtcca
     1501 ctgccagggt aggtgcagtg gagcaagtct tacaatgtgc aggattataa ctccagcaat
     1561 gacccctagg ctcatgctca ttccccaggt ggcagtttca gaacacattg ctcaggtctc
     1621 accctgtaaa tgtaggtacc agccttctag ttgaccatca gaacacacaa cgccaagatc
     1681 ttactccagc cacctgccag gacctggagg gcaggaggag agttctgcct acattgtctc
     1741 attttccctc cccttctgca gtgagataga ccatgtccag tgctcaggag ttgactggcc
     1801 acactgggga gtttgaccac aacattgggc tccatatgca tggaatgagg ttgcatgcaa
     1861 ttgtccatga ggctgctccc tcatttgtct gggtttctgc tccaatgcta tctcctcaga
     1921 aagaccttct ctgactgaag ccagctctgc ctccatccca tcactctgga tctccttccc
     1981 cagcttcatc tccattacac tggccactct ccctcacatc ttattactga tctagttgtc
     2041 tactgtccat ctccaccact gggatgtaaa ctccacaagg gaggaatgct gtcagtttct
     2101 ttgactgctg tgtggtcagt accagggcaa tgcctcgcac agagtagccc tctctcccta
     2161 aatgtttttg aataaatgaa ataaatgagc
//
