LOCUS       NM_004684               2778 bp    mRNA    linear   PRI 27-MAY-2024
DEFINITION  Homo sapiens SPARC like 1 (SPARCL1), transcript variant 2, mRNA.
ACCESSION   NM_004684
VERSION     NM_004684.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2778)
  AUTHORS   Zhao,G., Gentile,M.E., Xue,L., Cosgriff,C.V., Weiner,A.I.,
            Adams-Tzivelekidis,S., Wong,J., Li,X., Kass-Gergi,S., Holcomb,N.P.,
            Basal,M.C., Stewart,K.M., Planer,J.D., Cantu,E., Christie,J.D.,
            Crespo,M.M., Mitchell,M.J., Meyer,N.J. and Vaughan,A.E.
  TITLE     Vascular endothelial-derived SPARCL1 exacerbates viral pneumonia
            through pro-inflammatory macrophage activation
  JOURNAL   Nat Commun 15 (1), 4235 (2024)
   PUBMED   38762489
  REMARK    GeneRIF: Vascular endothelial-derived SPARCL1 exacerbates viral
            pneumonia through pro-inflammatory macrophage activation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2778)
  AUTHORS   Chen,M., Zheng,W. and Fang,L.
  TITLE     Identifying liver metastasis-related hub genes in breast cancer and
            characterizing SPARCL1 as a potential prognostic biomarker
  JOURNAL   PeerJ 11, e15311 (2023)
   PUBMED   37180578
  REMARK    GeneRIF: Identifying liver metastasis-related hub genes in breast
            cancer and characterizing SPARCL1 as a potential prognostic
            biomarker.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2778)
  AUTHORS   Nunez-delMoral,A., Bianchi,P.C., Brocos-Mosquera,I., Anesio,A.,
            Palombo,P., Camarini,R., Cruz,F.C., Callado,L.F., Vialou,V. and
            Erdozain,A.M.
  TITLE     The Matricellular Protein Hevin Is Involved in Alcohol Use Disorder
  JOURNAL   Biomolecules 13 (2), 234 (2023)
   PUBMED   36830603
  REMARK    GeneRIF: The Matricellular Protein Hevin Is Involved in Alcohol Use
            Disorder.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2778)
  AUTHORS   Shen,C., Han,L., Liu,B., Zhang,G., Cai,Z., Yin,X., Yin,Y., Chen,Z.
            and Zhang,B.
  TITLE     The KDM6A-SPARCL1 axis blocks metastasis and regulates the tumour
            microenvironment of gastrointestinal stromal tumours by inhibiting
            the nuclear translocation of p65
  JOURNAL   Br J Cancer 126 (10), 1457-1469 (2022)
   PUBMED   35136209
  REMARK    GeneRIF: The KDM6A-SPARCL1 axis blocks metastasis and regulates the
            tumour microenvironment of gastrointestinal stromal tumours by
            inhibiting the nuclear translocation of p65.
REFERENCE   5  (bases 1 to 2778)
  AUTHORS   Jiang,Q., Wang,H., Yuan,D., Qian,X., Ma,X., Yan,M. and Xing,W.
  TITLE     Circular_0086414 induces SPARC like 1 (SPARCL1) production to
            inhibit esophageal cancer cell proliferation, invasion and
            glycolysis and induce cell apoptosis by sponging miR-1290
  JOURNAL   Bioengineered 13 (5), 12099-12114 (2022)
   PUBMED   35549806
  REMARK    GeneRIF: Circular_0086414 induces SPARC like 1 (SPARCL1) production
            to inhibit esophageal cancer cell proliferation, invasion and
            glycolysis and induce cell apoptosis by sponging miR-1290.
REFERENCE   6  (bases 1 to 2778)
  AUTHORS   Hambrock,H.O., Nitsche,D.P., Hansen,U., Bruckner,P., Paulsson,M.,
            Maurer,P. and Hartmann,U.
  TITLE     SC1/hevin. An extracellular calcium-modulated protein that binds
            collagen I
  JOURNAL   J Biol Chem 278 (13), 11351-11358 (2003)
   PUBMED   12538579
REFERENCE   7  (bases 1 to 2778)
  AUTHORS   Claeskens,A., Ongenae,N., Neefs,J.M., Cheyns,P., Kaijen,P.,
            Cools,M. and Kutoh,E.
  TITLE     Hevin is down-regulated in many cancers and is a negative regulator
            of cell growth and proliferation
  JOURNAL   Br J Cancer 82 (6), 1123-1130 (2000)
   PUBMED   10735494
REFERENCE   8  (bases 1 to 2778)
  AUTHORS   Girard,J.P. and Springer,T.A.
  TITLE     Modulation of endothelial cell adhesion by hevin, an acidic protein
            associated with high endothelial venules
  JOURNAL   J Biol Chem 271 (8), 4511-4517 (1996)
   PUBMED   8626806
REFERENCE   9  (bases 1 to 2778)
  AUTHORS   Girard,J.P. and Springer,T.A.
  TITLE     Cloning from purified high endothelial venule cells of hevin, a
            close relative of the antiadhesive extracellular matrix protein
            SPARC
  JOURNAL   Immunity 2 (1), 113-123 (1995)
   PUBMED   7600298
REFERENCE   10 (bases 1 to 2778)
  AUTHORS   Schraml,P., Shipman,R., Stulz,P. and Ludwig,C.U.
  TITLE     cDNA subtraction library construction using a magnet-assisted
            subtraction technique (MAST)
  JOURNAL   Trends Genet 9 (3), 70-71 (1993)
   PUBMED   8488563
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC403565.1, AK304494.1, BC022484.1, X86693.1, DA283085.1 and
            BC033721.1.
            
            On Aug 11, 2020 this sequence version replaced NM_004684.5.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X82157.1, BC033721.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2157437
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000282470.11/ ENSP00000282470.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 DC403565.1         128-131
            5-298               AK304494.1         1-294
            299-357             BC022484.1         132-190
            358-478             X86693.1           337-457
            479-723             DA283085.1         309-553
            724-1977            X86693.1           703-1956
            1978-2011           BC033721.1         1880-1913
            2012-2778           X86693.1           1991-2757
FEATURES             Location/Qualifiers
     source          1..2778
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q22.1"
     gene            1..2778
                     /gene="SPARCL1"
                     /gene_synonym="MAST 9; MAST9; PIG33; SC1"
                     /note="SPARC like 1"
                     /db_xref="GeneID:8404"
                     /db_xref="HGNC:HGNC:11220"
                     /db_xref="MIM:606041"
     exon            1..332
                     /gene="SPARCL1"
                     /gene_synonym="MAST 9; MAST9; PIG33; SC1"
                     /inference="alignment:Splign:2.1.0"
     exon            333..397
                     /gene="SPARCL1"
                     /gene_synonym="MAST 9; MAST9; PIG33; SC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             344..2338
                     /gene="SPARCL1"
                     /gene_synonym="MAST 9; MAST9; PIG33; SC1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 2; proliferation-inducing protein 33; high
                     endothelial venule protein; SPARC-like protein 1;
                     SPARC-like 1 (hevin)"
                     /codon_start=1
                     /product="SPARC-like protein 1 isoform 1 precursor"
                     /protein_id="NP_004675.3"
                     /db_xref="CCDS:CCDS3622.1"
                     /db_xref="GeneID:8404"
                     /db_xref="HGNC:HGNC:11220"
                     /db_xref="MIM:606041"
                     /translation="MKTGLFFLCLLGTAAAIPTNARLLSDHSKPTAETVAPDNTAIPS
                     LRAEAEENEKETAVSTEDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQED
                     SDGHLSVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKR
                     EENQEQPRNYSHHQLNRSSKHSQGLRDQGNQEQDPNISNGEEEEEKEPGEVGTHNDNQ
                     ERKTELPREHANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEM
                     EEENASNVNKHIQETEWQSQEGKTGLEAISNHKETEEKTVSEALLMEPTDDGNTTPRN
                     HGVDDDGDDDGDDGGTDGPRHSASDDYFIPSQAFLEAERAQSIAYHLKIEEQREKVHE
                     NENIGTTEPGEHQEAKKAENSSNEEETSSEGNMRVHAVDSCMSFQCKRGHICKADQQG
                     KPHCVCQDPVTCPPTKPLDQVCGTDNQTYASSCHLFATKCRLEGTKKGHQLQLDYFGA
                     CKSIPTCTDFEVIQFPLRMRDWLKNILMQLYEANSEHAGYLNEKQRNKVKKIYLDEKR
                     LLAGDHPIDLLLRDFKKNYHMYVYPVHWQFSELDQHPMDRVLTHSELAPLRASLVPME
                     HCITRFFEECDPNKDKHITLKEWGHCFGIKEEDIDENLLF"
     exon            398..544
                     /gene="SPARCL1"
                     /gene_synonym="MAST 9; MAST9; PIG33; SC1"
                     /inference="alignment:Splign:2.1.0"
     exon            545..1561
                     /gene="SPARCL1"
                     /gene_synonym="MAST 9; MAST9; PIG33; SC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1634
                     /gene="SPARCL1"
                     /gene_synonym="MAST 9; MAST9; PIG33; SC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1753
                     /gene="SPARCL1"
                     /gene_synonym="MAST 9; MAST9; PIG33; SC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..1874
                     /gene="SPARCL1"
                     /gene_synonym="MAST 9; MAST9; PIG33; SC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..2011
                     /gene="SPARCL1"
                     /gene_synonym="MAST 9; MAST9; PIG33; SC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..2160
                     /gene="SPARCL1"
                     /gene_synonym="MAST 9; MAST9; PIG33; SC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2309
                     /gene="SPARCL1"
                     /gene_synonym="MAST 9; MAST9; PIG33; SC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2310..2778
                     /gene="SPARCL1"
                     /gene_synonym="MAST 9; MAST9; PIG33; SC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2754..2759
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPARCL1"
                     /gene_synonym="MAST 9; MAST9; PIG33; SC1"
                     /note="hexamer: AATAAA"
     polyA_site      2778
                     /gene="SPARCL1"
                     /gene_synonym="MAST 9; MAST9; PIG33; SC1"
                     /note="major polyA site"
ORIGIN      
        1 aagcactgcc tgtaaagccc tcgcatgaga ggccagcctg ctagggaaat ccaggaatct
       61 gcaacaaaaa cgatgacagt ctgaaatact ctctggtgcc aacctccaaa ttctcgtctg
      121 tcacttcaga cccccactag ttgacagagc agcagaattt caactccagt agacttgaat
      181 atgcctctgg gcaaagaagc agagctaacg aggaaaggga tttaaagagt ttttcttggg
      241 tgtttgtcaa acttttattc cctgtctgtg tgcagagggg attcaacttc aatttttctg
      301 cagtggctct gggtccagcc ccttacttaa agatctggaa agcatgaaga ctgggctttt
      361 tttcctatgt ctcttgggaa ctgcagctgc aatcccgaca aatgcaagat tattatctga
      421 tcattccaaa ccaactgctg aaacggtagc acctgacaac actgcaatcc ccagtttaag
      481 ggctgaagct gaagaaaatg aaaaagaaac agcagtatcc acagaagacg attcccacca
      541 taaggctgaa aaatcatcag tactaaagtc aaaagaggaa agccatgaac agtcagcaga
      601 acagggcaag agttctagcc aagagctggg attgaaggat caagaggaca gtgatggtca
      661 cttaagtgtg aatttggagt atgcaccaac tgaaggtaca ttggacataa aagaagatat
      721 gagtgagcct caggagaaaa aactctcaga gaacactgat tttttggctc ctggtgttag
      781 ttccttcaca gattctaacc aacaagaaag tatcacaaag agagaggaaa accaagaaca
      841 acctagaaat tattcacatc atcagttgaa caggagcagt aaacatagcc aaggcctaag
      901 ggatcaagga aaccaagagc aggatccaaa tatttccaat ggagaagagg aagaagaaaa
      961 agagccaggt gaagttggta cccacaatga taaccaagaa agaaagacag aattgcccag
     1021 ggagcatgct aacagcaagc aggaggaaga caatacccaa tctgatgata ttttggaaga
     1081 gtctgatcaa ccaactcaag taagcaagat gcaggaggat gaatttgatc agggtaacca
     1141 agaacaagaa gataactcca atgcagaaat ggaagaggaa aatgcatcga acgtcaataa
     1201 gcacattcaa gaaactgaat ggcagagtca agagggtaaa actggcctag aagctatcag
     1261 caaccacaaa gagacagaag aaaagactgt ttctgaggct ctgctcatgg aacctactga
     1321 tgatggtaat accacgccca gaaatcatgg agttgatgat gatggcgatg atgatggcga
     1381 tgatggcggc actgatggcc ccaggcacag tgcaagtgat gactacttca tcccaagcca
     1441 ggcctttctg gaggccgaga gagctcaatc cattgcctat cacctcaaaa ttgaggagca
     1501 aagagaaaaa gtacatgaaa atgaaaatat aggtaccact gagcctggag agcaccaaga
     1561 ggccaagaaa gcagagaact catcaaatga ggaggaaacg tcaagtgaag gcaacatgag
     1621 ggtgcatgct gtggattctt gcatgagctt ccagtgtaaa agaggccaca tctgtaaggc
     1681 agaccaacag ggaaaacctc actgtgtctg ccaggatcca gtgacttgtc ctccaacaaa
     1741 accccttgat caagtttgtg gcactgacaa tcagacctat gctagttcct gtcatctatt
     1801 cgctactaaa tgcagactgg aggggaccaa aaaggggcat caactccagc tggattattt
     1861 tggagcctgc aaatctattc ctacttgtac ggactttgaa gtgattcagt ttcctctacg
     1921 gatgagagac tggctcaaga atatcctcat gcagctttat gaagccaact ctgaacacgc
     1981 tggttatcta aatgagaagc agagaaataa agtcaagaaa atttacctgg atgaaaagag
     2041 gcttttggct ggggaccatc ccattgatct tctcttaagg gactttaaga aaaactacca
     2101 catgtatgtg tatcctgtgc actggcagtt tagtgaactt gaccaacacc ctatggatag
     2161 agtcttgaca cattctgaac ttgctcctct gcgagcatct ctggtgccca tggaacactg
     2221 cataacccgt ttctttgagg agtgtgaccc caacaaggat aagcacatca ccctgaagga
     2281 gtggggccac tgctttggaa ttaaagaaga ggacatagat gaaaatctct tgttttgaac
     2341 gaagatttta aagaactcaa ctttccagca tcctcctctg ttctaaccac ttcagaaata
     2401 tatgcagctg tgatacttgt agatttatat ttagcaaaat gttagcatgt atgacaagac
     2461 aatgagagta attgcttgac aacaacctat gcaccaggta tttaacatta actttggaaa
     2521 caaaaatgta caattaagta aagtcaacat atgcaaaata ctgtacattg tgaacagaag
     2581 tttaattcat agtaatttca ctctctgcat tgacttatga gataattaat gattaaacta
     2641 ttaatgataa aaataatgca tttgtattgt tcataatatc atgtgcactt caagaaaatg
     2701 gaatgctact cttttgtggt ttacgtgtat tattttcaat atcttaatac cctaataaag
     2761 agtccataaa aatccaaa
//
