LOCUS       NM_003118               3451 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens secreted protein acidic and cysteine rich (SPARC),
            transcript variant 1, mRNA.
ACCESSION   NM_003118
VERSION     NM_003118.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3451)
  AUTHORS   Togo,A., Mitsuzuka,K., Hanawa,S., Nakajima,R., Izumi,K., Sato,K.
            and Ishimoto,H.
  TITLE     Downregulation of SPARC Expression Enhances the Fusion of BeWo
            Choriocarcinoma Cells
  JOURNAL   Reprod Sci 31 (8), 2342-2353 (2024)
   PUBMED   38728000
  REMARK    GeneRIF: Downregulation of SPARC Expression Enhances the Fusion of
            BeWo Choriocarcinoma Cells.
REFERENCE   2  (bases 1 to 3451)
  AUTHORS   Xiao,G., Wei,Y., Xie,R., Tsang,Y., Gu,J., Shen,D., Ding,M.,
            Yuan,J., Xu,D. and Fei,J.
  TITLE     Citric acid promotes SPARC release in pancreatic cancer cells and
            inhibits the progression of pancreatic tumors in mice on a high-fat
            diet
  JOURNAL   FEBS J 291 (8), 1699-1718 (2024)
   PUBMED   38245817
  REMARK    GeneRIF: Citric acid promotes SPARC release in pancreatic cancer
            cells and inhibits the progression of pancreatic tumors in mice on
            a high-fat diet.
REFERENCE   3  (bases 1 to 3451)
  AUTHORS   Poomsawat,S., Choakdeewanitthumrong,S., Sanguansin,S., Meesakul,O.
            and Kosanwat,T.
  TITLE     Immunohistochemical expression of SPARC in odontogenic keratocysts:
            a comparative study with other odontogenic cysts
  JOURNAL   BMC Oral Health 24 (1), 223 (2024)
   PUBMED   38347494
  REMARK    GeneRIF: Immunohistochemical expression of SPARC in odontogenic
            keratocysts: a comparative study with other odontogenic cysts.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3451)
  AUTHORS   Chekhun,V., Borikun,T., Zadvornyi,T., Mushii,O., Stakhovsky,E.,
            Vitruk,Y. and Lukianova,N.
  TITLE     Osteonectin (SPARC) prognostic value in prostate cancer
  JOURNAL   Pathol Res Pract 254, 155053 (2024)
   PUBMED   38199134
  REMARK    GeneRIF: Osteonectin (SPARC) prognostic value in prostate cancer.
REFERENCE   5  (bases 1 to 3451)
  AUTHORS   Liu,C., Zheng,C., Shen,X., Liang,L. and Li,Q.
  TITLE     Serum CRP interacts with SPARC and regulate immune response in
            severe cases of COVID-19 infection
  JOURNAL   Front Immunol 14, 1259381 (2023)
   PUBMED   38077346
  REMARK    GeneRIF: Serum CRP interacts with SPARC and regulate immune
            response in severe cases of COVID-19 infection.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3451)
  AUTHORS   Breton-Gorius,J., Clezardin,P., Guichard,J., Debili,N., Malaval,L.,
            Vainchenker,W., Cramer,E.M. and Delmas,P.D.
  TITLE     Localization of platelet osteonectin at the internal face of the
            alpha-granule membranes in platelets and megakaryocytes
  JOURNAL   Blood 79 (4), 936-941 (1992)
   PUBMED   1737102
REFERENCE   7  (bases 1 to 3451)
  AUTHORS   Raines,E.W., Lane,T.F., Iruela-Arispe,M.L., Ross,R. and Sage,E.H.
  TITLE     The extracellular glycoprotein SPARC interacts with
            platelet-derived growth factor (PDGF)-AB and -BB and inhibits the
            binding of PDGF to its receptors
  JOURNAL   Proc Natl Acad Sci U S A 89 (4), 1281-1285 (1992)
   PUBMED   1311092
REFERENCE   8  (bases 1 to 3451)
  AUTHORS   Mundlos,S., Schwahn,B., Reichert,T. and Zabel,B.
  TITLE     Distribution of osteonectin mRNA and protein during human embryonic
            and fetal development
  JOURNAL   J Histochem Cytochem 40 (2), 283-291 (1992)
   PUBMED   1552170
REFERENCE   9  (bases 1 to 3451)
  AUTHORS   Kelm,R.J. Jr. and Mann,K.G.
  TITLE     Human platelet osteonectin: release, surface expression, and
            partial characterization
  JOURNAL   Blood 75 (5), 1105-1113 (1990)
   PUBMED   2306517
REFERENCE   10 (bases 1 to 3451)
  AUTHORS   Young,M.F., Day,A.A., Dominquez,P., McQuillan,C.I., Fisher,L.W. and
            Termine,J.D.
  TITLE     Structure and expression of osteonectin mRNA in human tissue
  JOURNAL   Connect Tissue Res 24 (1), 17-28 (1990)
   PUBMED   2338025
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC072457.1 and BQ018477.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_003118.3.
            
            Summary: This gene encodes a cysteine-rich acidic matrix-associated
            protein. The encoded protein is required for the collagen in bone
            to become calcified but is also involved in extracellular matrix
            synthesis and promotion of changes to cell shape. The gene product
            has been associated with tumor suppression but has also been
            correlated with metastasis based on changes to cell shape which can
            promote tumor cell invasion. Three transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Jun 2015].
            
            Transcript Variant: This variant (1) encodes the predominant
            isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.1238461.1, BC072457.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000231061.9/ ENSP00000231061.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3100              BC072457.1         42-3141
            3101-3451           BQ018477.1         15-365              c
FEATURES             Location/Qualifiers
     source          1..3451
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q33.1"
     gene            1..3451
                     /gene="SPARC"
                     /gene_synonym="BM-40; OI17; ON; ONT"
                     /note="secreted protein acidic and cysteine rich"
                     /db_xref="GeneID:6678"
                     /db_xref="HGNC:HGNC:11219"
                     /db_xref="MIM:182120"
     exon            1..51
                     /gene="SPARC"
                     /gene_synonym="BM-40; OI17; ON; ONT"
                     /inference="alignment:Splign:2.1.0"
     exon            52..121
                     /gene="SPARC"
                     /gene_synonym="BM-40; OI17; ON; ONT"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..976
                     /gene="SPARC"
                     /gene_synonym="BM-40; OI17; ON; ONT"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; basement-membrane protein 40; secreted protein,
                     acidic, cysteine-rich (osteonectin)"
                     /codon_start=1
                     /product="SPARC isoform 1 precursor"
                     /protein_id="NP_003109.1"
                     /db_xref="CCDS:CCDS4318.1"
                     /db_xref="GeneID:6678"
                     /db_xref="HGNC:HGNC:11219"
                     /db_xref="MIM:182120"
                     /translation="MRAWIFFLLCLAGRALAAPQQEALPDETEVVEETVAEVTEVSVG
                     ANPVQVEVGEFDDGAEETEEEVVAENPCQNHHCKHGKVCELDENNTPMCVCQDPTSCP
                     APIGEFEKVCSNDNKTFDSSCHFFATKCTLEGTKKGHKLHLDYIGPCKYIPPCLDSEL
                     TEFPLRMRDWLKNVLVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAGDHPVELLAR
                     DFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLD
                     NDKYIALDEWAGCFGIKQKDIDKDLVI"
     exon            122..184
                     /gene="SPARC"
                     /gene_synonym="BM-40; OI17; ON; ONT"
                     /inference="alignment:Splign:2.1.0"
     exon            185..272
                     /gene="SPARC"
                     /gene_synonym="BM-40; OI17; ON; ONT"
                     /inference="alignment:Splign:2.1.0"
     exon            273..394
                     /gene="SPARC"
                     /gene_synonym="BM-40; OI17; ON; ONT"
                     /inference="alignment:Splign:2.1.0"
     exon            395..515
                     /gene="SPARC"
                     /gene_synonym="BM-40; OI17; ON; ONT"
                     /inference="alignment:Splign:2.1.0"
     exon            516..649
                     /gene="SPARC"
                     /gene_synonym="BM-40; OI17; ON; ONT"
                     /inference="alignment:Splign:2.1.0"
     exon            650..798
                     /gene="SPARC"
                     /gene_synonym="BM-40; OI17; ON; ONT"
                     /inference="alignment:Splign:2.1.0"
     exon            799..947
                     /gene="SPARC"
                     /gene_synonym="BM-40; OI17; ON; ONT"
                     /inference="alignment:Splign:2.1.0"
     exon            948..3451
                     /gene="SPARC"
                     /gene_synonym="BM-40; OI17; ON; ONT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2085..2090
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPARC"
                     /gene_synonym="BM-40; OI17; ON; ONT"
                     /note="hexamer: AATAAA"
     polyA_site      2111
                     /gene="SPARC"
                     /gene_synonym="BM-40; OI17; ON; ONT"
                     /note="major polyA site"
     regulatory      3077..3082
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPARC"
                     /gene_synonym="BM-40; OI17; ON; ONT"
                     /note="hexamer: AATAAA"
     polyA_site      3100
                     /gene="SPARC"
                     /gene_synonym="BM-40; OI17; ON; ONT"
                     /note="major polyA site"
     regulatory      3425..3430
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPARC"
                     /gene_synonym="BM-40; OI17; ON; ONT"
                     /note="hexamer: AATAAA"
     polyA_site      3451
                     /gene="SPARC"
                     /gene_synonym="BM-40; OI17; ON; ONT"
ORIGIN      
        1 agactgcccg gagagcgcgc tctgcctgcc gcctgcctgc ctgccactga gggttcccag
       61 caccatgagg gcctggatct tctttctcct ttgcctggcc gggagggcct tggcagcccc
      121 tcagcaagaa gccctgcctg atgagacaga ggtggtggaa gaaactgtgg cagaggtgac
      181 tgaggtatct gtgggagcta atcctgtcca ggtggaagta ggagaatttg atgatggtgc
      241 agaggaaacc gaagaggagg tggtggcgga aaatccctgc cagaaccacc actgcaaaca
      301 cggcaaggtg tgcgagctgg atgagaacaa cacccccatg tgcgtgtgcc aggaccccac
      361 cagctgccca gcccccattg gcgagtttga gaaggtgtgc agcaatgaca acaagacctt
      421 cgactcttcc tgccacttct ttgccacaaa gtgcaccctg gagggcacca agaagggcca
      481 caagctccac ctggactaca tcgggccttg caaatacatc cccccttgcc tggactctga
      541 gctgaccgaa ttccccctgc gcatgcggga ctggctcaag aacgtcctgg tcaccctgta
      601 tgagagggat gaggacaaca accttctgac tgagaagcag aagctgcggg tgaagaagat
      661 ccatgagaat gagaagcgcc tggaggcagg agaccacccc gtggagctgc tggcccggga
      721 cttcgagaag aactataaca tgtacatctt ccctgtacac tggcagttcg gccagctgga
      781 ccagcacccc attgacgggt acctctccca caccgagctg gctccactgc gtgctcccct
      841 catccccatg gagcattgca ccacccgctt tttcgagacc tgtgacctgg acaatgacaa
      901 gtacatcgcc ctggatgagt gggccggctg cttcggcatc aagcagaagg atatcgacaa
      961 ggatcttgtg atctaaatcc actccttcca cagtaccgga ttctctcttt aaccctcccc
     1021 ttcgtgtttc ccccaatgtt taaaatgttt ggatggtttg ttgttctgcc tggagacaag
     1081 gtgctaacat agatttaagt gaatacatta acggtgctaa aaatgaaaat tctaacccaa
     1141 gacatgacat tcttagctgt aacttaacta ttaaggcctt ttccacacgc attaatagtc
     1201 ccatttttct cttgccattt gtagctttgc ccattgtctt attggcacat gggtggacac
     1261 ggatctgctg ggctctgcct taaacacaca ttgcagcttc aacttttctc tttagtgttc
     1321 tgtttgaaac taatacttac cgagtcagac tttgtgttca tttcatttca gggtcttggc
     1381 tgcctgtggg cttccccagg tggcctggag gtgggcaaag ggaagtaaca gacacacgat
     1441 gttgtcaagg atggttttgg gactagaggc tcagtggtgg gagagatccc tgcagaaccc
     1501 accaaccaga acgtggtttg cctgaggctg taactgagag aaagattctg gggctgtgtt
     1561 atgaaaatat agacattctc acataagccc agttcatcac catttcctcc tttacctttc
     1621 agtgcagttt cttttcacat taggctgttg gttcaaactt ttgggagcac ggactgtcag
     1681 ttctctggga agtggtcagc gcatcctgca gggcttctcc tcctctgtct tttggagaac
     1741 cagggctctt ctcaggggct ctagggactg ccaggctgtt tcagccagga aggccaaaat
     1801 caagagtgag atgtagaaag ttgtaaaata gaaaaagtgg agttggtgaa tcggttgttc
     1861 tttcctcaca tttggatgat tgtcataagg tttttagcat gttcctcctt ttcttcaccc
     1921 tccccttttt tcttctatta atcaagagaa acttcaaagt taatgggatg gtcggatctc
     1981 acaggctgag aactcgttca cctccaagca tttcatgaaa aagctgcttc ttattaatca
     2041 tacaaactct caccatgatg tgaagagttt cacaaatcct tcaaaataaa aagtaatgac
     2101 ttagaaactg ccttcctggg tgatttgcat gtgtcttagt cttagtcacc ttattatcct
     2161 gacacaaaaa cacatgagca tacatgtcta cacatgacta cacaaatgca aacctttgca
     2221 aacacattat gcttttgcac acacacacct gtacacacac accggcatgt ttatacacag
     2281 ggagtgtatg gttcctgtaa gcactaagtt agctgttttc atttaatgac ctgtggttta
     2341 acccttttga tcactaccac cattatcagc accagactga gcagctatat ccttttatta
     2401 atcatggtca ttcattcatt cattcattca caaaatattt atgatgtatt tactctgcac
     2461 caggtcccat gccaagcact ggggacacag ttatggcaaa gtagacaaag catttgttca
     2521 tttggagctt agagtccagg aggaatacat tagataatga cacaatcaaa tataaattgc
     2581 aagatgtcac aggtgtgatg aagggagagt aggagagacc atgagtatgt gtaacaggag
     2641 gacacagcat tattctagtg ctgtactgtt ccgtacggca gccactaccc acatgtaact
     2701 ttttaagatt taaatttaaa ttagttaaca ttcaaaacgc agctccccaa tcacactagc
     2761 aacatttcaa gtgcttgaga gccatgcatg attagtggtt accctattga ataggtcaga
     2821 agtagaatct tttcatcatc acagaaagtt ctattggaca gtgctcttct agatcatcat
     2881 aagactacag agcacttttc aaagctcatg catgttcatc atgttagtgt cgtattttga
     2941 gctggggttt tgagactccc cttagagata gagaaacaga cccaagaaat gtgctcaatt
     3001 gcaatgggcc acatacctag atctccagat gtcatttccc ctctcttatt ttaagttatg
     3061 ttaagattac taaaacaata aaagctccta aaaaatcaaa ctgtattctg gtgttctctt
     3121 ctacacagtg ggagggcgag cagtaggaga gattggccca tttggtgctg gccatttgag
     3181 gaatgcaagc ccagcactag tctcataatc tctaggaatc tgtagagaga ggaattgaag
     3241 taaatttcag cattggctca ttcagtcatt cggcgacatt catcaggtac ctgcaatgtg
     3301 ttaggggatc ttatgagtag gcagcgtgcg tgatccttgc tcccctggag ctttctaaca
     3361 ttctagcagg cagaccacac ataaatttgc aatactgttt ctgataaaaa cgtgctgtaa
     3421 aggaaataaa gcagagaact atcatggaaa a
//
