LOCUS       NM_001009613             452 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens SPANX family member N4 (SPANXN4), mRNA.
ACCESSION   NM_001009613 XM_497169
VERSION     NM_001009613.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 452)
  AUTHORS   Westbrook,V.A., Schoppee,P.D., Vanage,G.R., Klotz,K.L.,
            Diekman,A.B., Flickinger,C.J., Coppola,M.A. and Herr,J.C.
  TITLE     Hominoid-specific SPANXA/D genes demonstrate differential
            expression in individuals and protein localization to a distinct
            nuclear envelope domain during spermatid morphogenesis
  JOURNAL   Mol Hum Reprod 12 (11), 703-716 (2006)
   PUBMED   17012309
REFERENCE   2  (bases 1 to 452)
  AUTHORS   Kouprina,N., Mullokandov,M., Rogozin,I.B., Collins,N.K.,
            Solomon,G., Otstot,J., Risinger,J.I., Koonin,E.V., Barrett,J.C. and
            Larionov,V.
  TITLE     The SPANX gene family of cancer/testis-specific antigens: rapid
            evolution and amplification in African great apes and hominids
  JOURNAL   Proc Natl Acad Sci U S A 101 (9), 3077-3082 (2004)
   PUBMED   14973187
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC130503.1 and AL137840.12.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 13, 2020 this sequence version replaced NM_001009613.3.
            
            Summary: This gene represents one of several duplicated family
            members that are located on the X chromosome. This gene family
            encodes proteins that play a role in spermiogenesis. These proteins
            represent a specific subgroup of cancer/testis-associated antigens,
            and they may be candidates for tumor vaccines. This family member
            belongs to a subgroup of related genes that are present in all
            primates and rats and mice, and thus, it represents one of the
            ancestral family members. [provided by RefSeq, Sep 2009].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC130505.1, DQ336126.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000446864.2/ ENSP00000405210.1
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-421               BC130503.1         11-431
            422-452             AL137840.12        53452-53482
FEATURES             Location/Qualifiers
     source          1..452
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq27.3"
     gene            1..452
                     /gene="SPANXN4"
                     /gene_synonym="CT11.9"
                     /note="SPANX family member N4"
                     /db_xref="GeneID:441525"
                     /db_xref="HGNC:HGNC:33177"
                     /db_xref="MIM:300667"
     exon            1..165
                     /gene="SPANXN4"
                     /gene_synonym="CT11.9"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..387
                     /gene="SPANXN4"
                     /gene_synonym="CT11.9"
                     /note="cancer/testis antigen family 11, member 9;
                     nuclear-associated protein SPAN-Xn4"
                     /codon_start=1
                     /product="sperm protein associated with the nucleus on the
                     X chromosome N4"
                     /protein_id="NP_001009613.1"
                     /db_xref="CCDS:CCDS48178.1"
                     /db_xref="GeneID:441525"
                     /db_xref="HGNC:HGNC:33177"
                     /db_xref="MIM:300667"
                     /translation="MEEPTSSTNENKMKSPCESNKRKVDKKKKNLHRASAPEQSLKET
                     EKAKYPTLVFYCRKNKKRNSNQLENNQPTESSTDPIKEKGDLDISAGSPQDGGQN"
     exon            166..452
                     /gene="SPANXN4"
                     /gene_synonym="CT11.9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      429..434
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPANXN4"
                     /gene_synonym="CT11.9"
                     /note="hexamer: AATAAA"
     polyA_site      452
                     /gene="SPANXN4"
                     /gene_synonym="CT11.9"
                     /note="major polyA site"
ORIGIN      
        1 gacagcccac tggaaagctt caatacagct gtggaaatct gcaccctaga agatcctagt
       61 acagaaattc tacaaccaac cataatcatg gaagagccaa cttccagcac caacgagaat
      121 aaaatgaaga gcccctgtga atctaacaaa agaaaagttg acaagaagaa gaagaatctg
      181 cacagagcct cagcccctga acagagtttg aaagagacag aaaaagcaaa atatccaaca
      241 ttagtgtttt actgcaggaa gaataagaaa agaaattcaa atcaactgga gaataaccag
      301 cctacagaga gctccactga tccaatcaaa gagaaaggag acctagacat atctgcagga
      361 tctccacagg atggtgggca gaattagtcc aaattggaca aatcatcacc actgatggcg
      421 atgattacaa taaaatcagt ttgaggagct ga
//
