LOCUS       NM_001009615             707 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens SPANX family member N2 (SPANXN2), mRNA.
ACCESSION   NM_001009615
VERSION     NM_001009615.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 707)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 707)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 707)
  AUTHORS   Westbrook,V.A., Schoppee,P.D., Vanage,G.R., Klotz,K.L.,
            Diekman,A.B., Flickinger,C.J., Coppola,M.A. and Herr,J.C.
  TITLE     Hominoid-specific SPANXA/D genes demonstrate differential
            expression in individuals and protein localization to a distinct
            nuclear envelope domain during spermatid morphogenesis
  JOURNAL   Mol Hum Reprod 12 (11), 703-716 (2006)
   PUBMED   17012309
REFERENCE   4  (bases 1 to 707)
  AUTHORS   Kouprina,N., Mullokandov,M., Rogozin,I.B., Collins,N.K.,
            Solomon,G., Otstot,J., Risinger,J.I., Koonin,E.V., Barrett,J.C. and
            Larionov,V.
  TITLE     The SPANX gene family of cancer/testis-specific antigens: rapid
            evolution and amplification in African great apes and hominids
  JOURNAL   Proc Natl Acad Sci U S A 101 (9), 3077-3082 (2004)
   PUBMED   14973187
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL500522.10 and AC239921.3.
            
            On Aug 9, 2021 this sequence version replaced NM_001009615.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DB496702.1, DQ336115.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000598475.2/ ENSP00000470584.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-162               AL500522.10        55973-56134         c
            163-707             AC239921.3         2426-2970
FEATURES             Location/Qualifiers
     source          1..707
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq27.3"
     gene            1..707
                     /gene="SPANXN2"
                     /gene_synonym="CT11.7; SPANX-N2"
                     /note="SPANX family member N2"
                     /db_xref="GeneID:494119"
                     /db_xref="HGNC:HGNC:33175"
                     /db_xref="MIM:300665"
     exon            1..162
                     /gene="SPANXN2"
                     /gene_synonym="CT11.7; SPANX-N2"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..627
                     /gene="SPANXN2"
                     /gene_synonym="CT11.7; SPANX-N2"
                     /note="cancer/testis antigen family 11, member 7;
                     nuclear-associated protein SPAN-Xn2"
                     /codon_start=1
                     /product="sperm protein associated with the nucleus on the
                     X chromosome N2"
                     /protein_id="NP_001009615.1"
                     /db_xref="CCDS:CCDS35419.1"
                     /db_xref="GeneID:494119"
                     /db_xref="HGNC:HGNC:33175"
                     /db_xref="MIM:300665"
                     /translation="MEQPTSSTNGEKRKSPCESNNKKNDEMQEAPNRVLAPKQSLQKT
                     KTIEYLTIIVYYYRKHTKINSNQLEKDQSRENSINPVQEEEDEGLDSAEGSSQEDEDL
                     DSSEGSSQEDEDLDSSEGSSQEDEDLDSSEGSSQEDEDLDSSEGSSQEDEDLDPPEGS
                     SQEDEDLDSSEGSSQEGGED"
     exon            163..707
                     /gene="SPANXN2"
                     /gene_synonym="CT11.7; SPANX-N2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      683..688
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPANXN2"
                     /gene_synonym="CT11.7; SPANX-N2"
                     /note="hexamer: AATAAA"
     polyA_site      707
                     /gene="SPANXN2"
                     /gene_synonym="CT11.7; SPANX-N2"
                     /note="major polyA site"
ORIGIN      
        1 atcctcctgg caagcttcaa tatagctgtg gaagtctgca gtctacaaga gcctactata
       61 gacattctac aaccaagcag aatcatggaa cagccgactt caagcaccaa tggggagaag
      121 aggaagagcc cctgtgaatc caataacaaa aaaaatgatg agatgcagga ggcaccgaac
      181 agggtcttag cccccaaaca gagcttgcaa aagacaaaaa caatagaata tctaacaata
      241 atagtgtatt actacaggaa gcatacgaaa ataaattcaa atcaactgga gaaggaccag
      301 tcccgagaga actccatcaa tccagtccaa gaggaggagg acgaaggcct agactcagct
      361 gaaggatctt cacaggagga cgaagacctg gactcatctg aaggatcttc acaggaggac
      421 gaagacctgg actcatctga aggatcttca caggaggacg aagacctgga ctcatctgaa
      481 ggatcttcac aggaggacga agacctggac tcatctgaag gatcttcaca ggaggacgaa
      541 gacctggacc cacctgaagg atcttcacag gaggacgaag acctagactc atctgaagga
      601 tcttcacagg agggtgggga ggactagtca aacatggaga aaccaaattg gacaaatcct
      661 cactaccaat ggcgatgatt acaataaaat caagtttgag gagctga
//
