LOCUS       NM_001009614             697 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens SPANX family member N1 (SPANXN1), mRNA.
ACCESSION   NM_001009614
VERSION     NM_001009614.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 697)
  AUTHORS   Westbrook,V.A., Schoppee,P.D., Vanage,G.R., Klotz,K.L.,
            Diekman,A.B., Flickinger,C.J., Coppola,M.A. and Herr,J.C.
  TITLE     Hominoid-specific SPANXA/D genes demonstrate differential
            expression in individuals and protein localization to a distinct
            nuclear envelope domain during spermatid morphogenesis
  JOURNAL   Mol Hum Reprod 12 (11), 703-716 (2006)
   PUBMED   17012309
REFERENCE   2  (bases 1 to 697)
  AUTHORS   Kouprina,N., Mullokandov,M., Rogozin,I.B., Collins,N.K.,
            Solomon,G., Otstot,J., Risinger,J.I., Koonin,E.V., Barrett,J.C. and
            Larionov,V.
  TITLE     The SPANX gene family of cancer/testis-specific antigens: rapid
            evolution and amplification in African great apes and hominids
  JOURNAL   Proc Natl Acad Sci U S A 101 (9), 3077-3082 (2004)
   PUBMED   14973187
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL713923.2, DQ336118.1 and
            AL356499.16.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_001009614.2.
            
            Summary: This gene represents one of several duplicated family
            members that are located on chromosome X. This gene family encodes
            proteins that play a role in spermiogenesis. These proteins
            represent a specific subgroup of cancer/testis-associated antigens,
            and they may be candidates for tumor vaccines. This family member
            belongs to a subgroup of related genes that are present in all
            primates and rats and mice, and thus, it represents one of the
            ancestral family members. [provided by RefSeq, May 2010].
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ336118.1, DQ336119.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370493.4/ ENSP00000359524.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                AL713923.2         64448-64531
            85-694              DQ336118.1         1-610
            695-695             AL356499.16        8317-8317
            696-697             DQ336118.1         612-613
FEATURES             Location/Qualifiers
     source          1..697
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq27.3"
     gene            1..697
                     /gene="SPANXN1"
                     /gene_synonym="CT11.6"
                     /note="SPANX family member N1"
                     /db_xref="GeneID:494118"
                     /db_xref="HGNC:HGNC:33174"
                     /db_xref="MIM:300664"
     exon            1..159
                     /gene="SPANXN1"
                     /gene_synonym="CT11.6"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..303
                     /gene="SPANXN1"
                     /gene_synonym="CT11.6"
                     /note="cancer/testis antigen family 11, member 6;
                     nuclear-associated protein SPAN-Xn1"
                     /codon_start=1
                     /product="sperm protein associated with the nucleus on the
                     X chromosome N1"
                     /protein_id="NP_001009614.1"
                     /db_xref="CCDS:CCDS35421.1"
                     /db_xref="GeneID:494118"
                     /db_xref="HGNC:HGNC:33174"
                     /db_xref="MIM:300664"
                     /translation="MEQPTSSINGEKRKSPCESNNENDEMQETPNRDLAPEPSLKKMK
                     TSEYSTVLAFCYRKAKKIHSNQLENDQS"
     exon            160..697
                     /gene="SPANXN1"
                     /gene_synonym="CT11.6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcctcctgg gaagcttcaa tacagctgtg caagtctgga gtctacaaga gcctactata
       61 gacattctac aaccaaccag aatcatggaa cagcccactt caagcatcaa tggggagaag
      121 aggaagagcc cctgtgaatc caacaatgaa aatgatgaga tgcaggagac accaaacagg
      181 gacttagccc ccgaaccgag tttgaaaaag atgaaaacgt cagaatattc aacagtatta
      241 gcgttttgct acaggaaagc taagaaaata cattcaaatc aactggagaa tgaccagtcc
      301 tgagagaact ccatcaatcc agtccaagag gaggaggacg aaggcctaga ctcagctgaa
      361 ggatcttcaa agcaggatga agacctagac ttacctgaag gcctagactc agctgaagga
      421 tcttcaaagc aggatgaaga cctagactta cctgaaggat cttcaaagca gaatgaagac
      481 ctaggcttac ctgaaggatc ttcaaagcag gatgaagacc tagacttacc tgaaggatct
      541 tcacaggagg ataaagacgt agaattacct gaaggatctt cacaggagga tgaagaccta
      601 gagaaaaagc gatcatctag gtcaagaaat gaaatcgaaa tttcagaaat tacagaaatt
      661 ctccaaggaa ggagccagat aaataaatat tctgatt
//
