LOCUS       NM_032417                682 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens SPANX family member D (SPANXD), mRNA.
ACCESSION   NM_032417 NM_145665
VERSION     NM_032417.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 682)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 682)
  AUTHORS   Maine,E.A., Westcott,J.M., Prechtl,A.M., Dang,T.T., Whitehurst,A.W.
            and Pearson,G.W.
  TITLE     The cancer-testis antigens SPANX-A/C/D and CTAG2 promote breast
            cancer invasion
  JOURNAL   Oncotarget 7 (12), 14708-14726 (2016)
   PUBMED   26895102
  REMARK    GeneRIF: High SPANXD expression is associated with breast cancer
            invasion.
REFERENCE   3  (bases 1 to 682)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   4  (bases 1 to 682)
  AUTHORS   Hansen,S., Eichler,E.E., Fullerton,S.M. and Carrell,D.
  TITLE     SPANX gene variation in fertile and infertile males
  JOURNAL   Syst Biol Reprod Med 55, 18-26 (2010)
   PUBMED   20073942
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 682)
  AUTHORS   Kouprina,N., Noskov,V.N., Solomon,G., Otstot,J., Isaacs,W., Xu,J.,
            Schleutker,J. and Larionov,V.
  TITLE     Mutational analysis of SPANX genes in families with X-linked
            prostate cancer
  JOURNAL   Prostate 67 (8), 820-828 (2007)
   PUBMED   17373721
REFERENCE   6  (bases 1 to 682)
  AUTHORS   Westbrook,V.A., Schoppee,P.D., Vanage,G.R., Klotz,K.L.,
            Diekman,A.B., Flickinger,C.J., Coppola,M.A. and Herr,J.C.
  TITLE     Hominoid-specific SPANXA/D genes demonstrate differential
            expression in individuals and protein localization to a distinct
            nuclear envelope domain during spermatid morphogenesis
  JOURNAL   Mol Hum Reprod 12 (11), 703-716 (2006)
   PUBMED   17012309
REFERENCE   7  (bases 1 to 682)
  AUTHORS   Kouprina,N., Pavlicek,A., Noskov,V.N., Solomon,G., Otstot,J.,
            Isaacs,W., Carpten,J.D., Trent,J.M., Schleutker,J., Barrett,J.C.,
            Jurka,J. and Larionov,V.
  TITLE     Dynamic structure of the SPANX gene cluster mapped to the prostate
            cancer susceptibility locus HPCX at Xq27
  JOURNAL   Genome Res 15 (11), 1477-1486 (2005)
   PUBMED   16251457
REFERENCE   8  (bases 1 to 682)
  AUTHORS   Westbrook,V.A., Schoppee,P.D., Diekman,A.B., Klotz,K.L.,
            Allietta,M., Hogan,K.T., Slingluff,C.L., Patterson,J.W.,
            Frierson,H.F., Irvin,W.P. Jr., Flickinger,C.J., Coppola,M.A. and
            Herr,J.C.
  TITLE     Genomic organization, incidence, and localization of the SPAN-x
            family of cancer-testis antigens in melanoma tumors and cell lines
  JOURNAL   Clin Cancer Res 10 (1 Pt 1), 101-112 (2004)
   PUBMED   14734458
REFERENCE   9  (bases 1 to 682)
  AUTHORS   Zendman,A.J., Zschocke,J., van Kraats,A.A., de Wit,N.J.,
            Kurpisz,M., Weidle,U.H., Ruiter,D.J., Weiss,E.H. and van
            Muijen,G.N.
  TITLE     The human SPANX multigene family: genomic organization, alignment
            and expression in male germ cells and tumor cell lines
  JOURNAL   Gene 309 (2), 125-133 (2003)
   PUBMED   12758128
REFERENCE   10 (bases 1 to 682)
  AUTHORS   Westbrook,V.A., Diekman,A.B., Naaby-Hansen,S., Coonrod,S.A.,
            Klotz,K.L., Thomas,T.S., Norton,E.J., Flickinger,C.J. and Herr,J.C.
  TITLE     Differential nuclear localization of the cancer/testis-associated
            protein, SPAN-X/CTp11, in transfected cells and in 50% of human
            spermatozoa
  JOURNAL   Biol Reprod 64 (1), 345-358 (2001)
   PUBMED   11133693
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM554791.1, AC240443.2 and
            AI808260.1.
            
            On May 17, 2019 this sequence version replaced NM_032417.3.
            
            Summary: Temporally regulated transcription and translation of
            several testis-specific genes is required to initiate the series of
            molecular and morphological changes in the male germ cell lineage
            necessary for the formation of mature spermatozoa. This gene is a
            member of the SPANX family of cancer/testis-associated genes, which
            are located in a cluster on chromosome X. The SPANX genes encode
            differentially expressed testis-specific proteins that localize to
            various subcellular compartments. This particular gene encodes a
            sperm protein that is associated with the nucleus but, although a
            role in spermatogenesis is suggested, the specific function of this
            family member has not yet been determined. Polymorphisms in this
            gene may be associated with prostate cancer susceptibility.
            [provided by RefSeq, Apr 2014].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BM554791.1, CB106942.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149178 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370515.3/ ENSP00000359546.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               BM554791.1         1-100
            101-101             AC240443.2         70250-70250
            102-666             BM554791.1         102-666
            667-682             AI808260.1         13-28               c
FEATURES             Location/Qualifiers
     source          1..682
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq27.2"
     gene            1..682
                     /gene="SPANXD"
                     /gene_synonym="CT11.3; CT11.4; dJ171K16.1; SPANX-C;
                     SPANX-D; SPANX-E; SPANXC; SPANXE"
                     /note="SPANX family member D"
                     /db_xref="GeneID:64648"
                     /db_xref="HGNC:HGNC:14332"
                     /db_xref="MIM:300670"
     exon            1..406
                     /gene="SPANXD"
                     /gene_synonym="CT11.3; CT11.4; dJ171K16.1; SPANX-C;
                     SPANX-D; SPANX-E; SPANXC; SPANXE"
                     /inference="alignment:Splign:2.1.0"
     CDS             335..628
                     /gene="SPANXD"
                     /gene_synonym="CT11.3; CT11.4; dJ171K16.1; SPANX-C;
                     SPANX-D; SPANX-E; SPANXC; SPANXE"
                     /note="cancer/testis antigen family 11, member 4; sperm
                     protein associated with the nucleus, X chromosome, family
                     member D; SPANX family, member E; sperm protein associated
                     with the nucleus, X chromosome, family member E; Sperm
                     protein associated with the nucleus on the X chromosome C;
                     Cancer/testis antigen 11.3; Cancer/testis-associated
                     protein CTp11; Nuclear-associated protein SPAN-Xc;
                     nuclear-associated protein SPAN-Xe; cancer/testis antigen
                     11.4; nuclear-associated protein SPAN-Xd"
                     /codon_start=1
                     /product="sperm protein associated with the nucleus on the
                     X chromosome D"
                     /protein_id="NP_115793.1"
                     /db_xref="CCDS:CCDS14675.1"
                     /db_xref="GeneID:64648"
                     /db_xref="HGNC:HGNC:14332"
                     /db_xref="MIM:300670"
                     /translation="MDKQSSAGGVKRSVPCDSNEANEMMPETSSGYSDPQPAPKKLKT
                     SESSTILVVRYRRNFKRTSPEELVNDHARKNRINPLQMEEEEFMEIMVEIPAK"
     exon            407..682
                     /gene="SPANXD"
                     /gene_synonym="CT11.3; CT11.4; dJ171K16.1; SPANX-C;
                     SPANX-D; SPANX-E; SPANXC; SPANXE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      663..668
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPANXD"
                     /gene_synonym="CT11.3; CT11.4; dJ171K16.1; SPANX-C;
                     SPANX-D; SPANX-E; SPANXC; SPANXE"
                     /note="hexamer: AATAAA"
     polyA_site      682
                     /gene="SPANXD"
                     /gene_synonym="CT11.3; CT11.4; dJ171K16.1; SPANX-C;
                     SPANX-D; SPANX-E; SPANXC; SPANXE"
                     /note="major polyA site"
ORIGIN      
        1 attaaacatg gagaaatgag gagcggcggc agatcggttt gggatgcatc ttcaggggat
       61 gctgaaacaa cagcagcatt tggtttgctc tacacccctg tcacccctcg cccgcaagcc
      121 cagggagtgg tcagcagtgg ggctttgtga cgtcgaagcc accctagggc tgccattggc
      181 tgggacactg cctgtatgat caaacaaagc tcaagggtgt ggctttgcct tgtcaccagg
      241 agggtataca tagggagggc aagagctccg ggccactgag aagattcaaa acctacaaaa
      301 gcctgccgct gacattgaag aaccaatata tacaatggac aaacaatcca gtgccggcgg
      361 ggtgaagagg agcgtcccct gtgattccaa cgaggccaac gagatgatgc cggagacctc
      421 gagtgggtac tcagacccgc aacctgctcc gaaaaaacta aaaacatctg agtcctcgac
      481 catactagtg gttcgctaca ggaggaactt taaaagaaca tctccagagg aactggtgaa
      541 tgaccacgcc cgaaagaaca gaatcaaccc cctccaaatg gaggaggagg aattcatgga
      601 aataatggtt gaaatacctg caaagtagca agaagctaca tctctcaacc ttgggcaatg
      661 acaataaagt ttgagaagct ga
//
