LOCUS       NM_022661                408 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens SPANX family member C (SPANXC), mRNA.
ACCESSION   NM_022661 XM_001713760
VERSION     NM_022661.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 408)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 408)
  AUTHORS   Salvatorelli,L., Puzzo,L., Russo,A., Reibaldi,M., Longo,A.,
            Ragusa,M., Aldo,C., Rappazzo,G., Caltabiano,R. and Salemi,M.
  TITLE     Immunoexpression of SPANX-C in metastatic uveal melanoma
  JOURNAL   Pathol Res Pract 215 (7), 152431 (2019)
   PUBMED   31072624
  REMARK    GeneRIF: Our study examined SPANX-C expression levels in primary
            uveal melanoma both with and without metastasis to assess if they
            can be used to predict metastasis. A significantly high expression
            of SPANX-C was seen in patients with metastasis compared to
            patients without metastasis.
REFERENCE   3  (bases 1 to 408)
  AUTHORS   Maine,E.A., Westcott,J.M., Prechtl,A.M., Dang,T.T., Whitehurst,A.W.
            and Pearson,G.W.
  TITLE     The cancer-testis antigens SPANX-A/C/D and CTAG2 promote breast
            cancer invasion
  JOURNAL   Oncotarget 7 (12), 14708-14726 (2016)
   PUBMED   26895102
  REMARK    GeneRIF: High SPANXC expression is associated with breast cancer
            invasion.
REFERENCE   4  (bases 1 to 408)
  AUTHORS   Song,M.H., Choi,K.U., Shin,D.H., Lee,C.H. and Lee,S.Y.
  TITLE     Identification of the cancer/testis antigens AKAP3 and CTp11 by
            SEREX in hepatocellular carcinoma
  JOURNAL   Oncol Rep 28 (5), 1792-1798 (2012)
   PUBMED   22941507
  REMARK    GeneRIF: study reports the isolation of AKAP3 and CTp11
            Cancer/testis antigens from hepatocellular carcinoma patient sera
REFERENCE   5  (bases 1 to 408)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   6  (bases 1 to 408)
  AUTHORS   Salemi,M., Calogero,A.E., Di Benedetto,D., Cosentino,A., Barone,N.,
            Rappazzo,G. and Vicari,E.
  TITLE     Expression of SPANX proteins in human-ejaculated spermatozoa and
            sperm precursors
  JOURNAL   Int J Androl 27 (3), 134-139 (2004)
   PUBMED   15139967
  REMARK    GeneRIF: SPANXC was found in ejaculated spermatozoa and spermatids.
REFERENCE   7  (bases 1 to 408)
  AUTHORS   Westbrook,V.A., Schoppee,P.D., Diekman,A.B., Klotz,K.L.,
            Allietta,M., Hogan,K.T., Slingluff,C.L., Patterson,J.W.,
            Frierson,H.F., Irvin,W.P. Jr., Flickinger,C.J., Coppola,M.A. and
            Herr,J.C.
  TITLE     Genomic organization, incidence, and localization of the SPAN-x
            family of cancer-testis antigens in melanoma tumors and cell lines
  JOURNAL   Clin Cancer Res 10 (1 Pt 1), 101-112 (2004)
   PUBMED   14734458
REFERENCE   8  (bases 1 to 408)
  AUTHORS   Zendman,A.J., Zschocke,J., van Kraats,A.A., de Wit,N.J.,
            Kurpisz,M., Weidle,U.H., Ruiter,D.J., Weiss,E.H. and van
            Muijen,G.N.
  TITLE     The human SPANX multigene family: genomic organization, alignment
            and expression in male germ cells and tumor cell lines
  JOURNAL   Gene 309 (2), 125-133 (2003)
   PUBMED   12758128
REFERENCE   9  (bases 1 to 408)
  AUTHORS   Westbrook,V.A., Diekman,A.B., Naaby-Hansen,S., Coonrod,S.A.,
            Klotz,K.L., Thomas,T.S., Norton,E.J., Flickinger,C.J. and Herr,J.C.
  TITLE     Differential nuclear localization of the cancer/testis-associated
            protein, SPAN-X/CTp11, in transfected cells and in 50% of human
            spermatozoa
  JOURNAL   Biol Reprod 64 (1), 345-358 (2001)
   PUBMED   11133693
REFERENCE   10 (bases 1 to 408)
  AUTHORS   Zendman,A.J., Cornelissen,I.M., Weidle,U.H., Ruiter,D.J. and van
            Muijen,G.N.
  TITLE     CTp11, a novel member of the family of human cancer/testis antigens
  JOURNAL   Cancer Res 59 (24), 6223-6229 (1999)
   PUBMED   10626816
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC234777.4 and BC103960.1.
            
            On May 17, 2019 this sequence version replaced NM_022661.3.
            
            Summary: Temporally regulated transcription and translation of
            several testis-specific genes is required to initiate the series of
            molecular and morphological changes in the male germ cell lineage
            necessary for the formation of mature spermatozoa. This gene is a
            member of the SPANX family, which is located in a gene cluster on
            chromosome X. The SPANX genes encode differentially expressed
            testis-specific proteins that localize to various subcellular
            compartments. This particular gene encodes a protein that localizes
            to the nucleus and is expressed in highly metastatic cell lines,
            making the protein a potential diagnostic and prognostic marker.
            The protein belongs to a family of cancer/testis antigens and
            represents a potential target for cancer immunotherapy. [provided
            by RefSeq, Jul 2008].
            
            CCDS Note: The coding region has been updated to represent the
            sequence of the GRCh38 reference genome assembly, which results in
            eight non-synonymous substitutions in the coding region.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC103960.1, DRR138507.15869.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149178 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358993.3/ ENSP00000351884.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                AC234777.4         58307-58333
            28-183              BC103960.1         1-156
            184-387             BC103960.1         158-361
            388-408             AC234777.4         59341-59361
FEATURES             Location/Qualifiers
     source          1..408
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq27.2"
     gene            1..408
                     /gene="SPANXC"
                     /gene_synonym="CT11.3; CTp11; SPANX-C; SPANX-E; SPANXE"
                     /note="SPANX family member C"
                     /db_xref="GeneID:64663"
                     /db_xref="HGNC:HGNC:14331"
                     /db_xref="MIM:300330"
     exon            1..132
                     /gene="SPANXC"
                     /gene_synonym="CT11.3; CTp11; SPANX-C; SPANX-E; SPANXE"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..354
                     /gene="SPANXC"
                     /gene_synonym="CT11.3; CTp11; SPANX-C; SPANX-E; SPANXE"
                     /note="cancer/testis antigen family 11, member 3; sperm
                     protein associated with the nucleus, X chromosome, family
                     member C; cancer-testis-associated protein CTp11;
                     cancer/testis-associated protein of 11 kD; SPAN-Xc
                     protein; cancer/testis antigen 11.3; nuclear-associated
                     protein SPAN-Xc; Nuclear-associated protein SPAN-Xe; Sperm
                     protein associated with the nucleus on the X chromosome E"
                     /codon_start=1
                     /product="sperm protein associated with the nucleus on the
                     X chromosome C"
                     /protein_id="NP_073152.2"
                     /db_xref="CCDS:CCDS14673.1"
                     /db_xref="GeneID:64663"
                     /db_xref="HGNC:HGNC:14331"
                     /db_xref="MIM:300330"
                     /translation="MDKQSSAGGVKRSVPCDSNEANEMMPETSSGYSDPQPAPKKLKT
                     SESSTILVVRYRRNVKRTSPEELVNDHARENRINPLQMEEEEFMEIMVEIPAK"
     exon            133..408
                     /gene="SPANXC"
                     /gene_synonym="CT11.3; CTp11; SPANX-C; SPANX-E; SPANXE"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actgcgaaga ttcaaaacct acaaaagcct gccgctgaca ttgaagaacc aatatataca
       61 atggacaaac aatccagtgc cggcggggtg aagaggagcg tcccctgtga ttccaacgag
      121 gccaacgaga tgatgccgga gacctcgagt gggtactcag acccgcaacc tgctccgaaa
      181 aaactaaaaa catctgagtc ctcgaccata ctagtggttc gctacaggag gaacgtgaaa
      241 agaacatctc cagaggaact ggtgaatgac cacgcccgag agaacagaat caaccccctc
      301 caaatggagg aggaggaatt catggaaata atggttgaaa tacctgcaaa gtagcaagaa
      361 gctacatctc tcaaccttgg gcaatgaaaa taaagtttga gaagctga
//
