LOCUS       NM_001130528            8276 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens sperm associated antigen 9 (SPAG9), transcript variant
            1, mRNA.
ACCESSION   NM_001130528
VERSION     NM_001130528.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8276)
  AUTHORS   Bassey-Archibong,B.I., Rajendra Chokshi,C., Aghaei,N.,
            Kieliszek,A.M., Tatari,N., McKenna,D., Singh,M., Kalpana
            Subapanditha,M., Parmar,A., Mobilio,D., Savage,N., Lam,F.,
            Tokar,T., Provias,J., Lu,Y., Chafe,S.C., Swanton,C., Hynds,R.E.,
            Venugopal,C. and Singh,S.K.
  TITLE     An HLA-G/SPAG9/STAT3 axis promotes brain metastases
  JOURNAL   Proc Natl Acad Sci U S A 120 (8), e2205247120 (2023)
   PUBMED   36780531
  REMARK    GeneRIF: An HLA-G/SPAG9/STAT3 axis promotes brain metastases.
REFERENCE   2  (bases 1 to 8276)
  AUTHORS   Ramadan,R.A., Morsy,H., Samir,M., Shamseya,M., Shalaby,M. and
            El-Attar,E.A.
  TITLE     Significance of cancer testis-associated antigens (SPAG9 and
            FBXO39) in colon cancer
  JOURNAL   Indian J Cancer 59 (3), 394-401 (2022)
   PUBMED   34380828
  REMARK    GeneRIF: Significance of cancer testis-associated antigens (SPAG9
            and FBXO39) in colon cancer.
REFERENCE   3  (bases 1 to 8276)
  AUTHORS   Del Sarto,J., Gerlt,V., Friedrich,M.E., Anhlan,D., Wixler,V.,
            Teixeira,M.M., Boergeling,Y. and Ludwig,S.
  TITLE     Phosphorylation of JIP4 at S730 Presents Antiviral Properties
            against Influenza A Virus Infection
  JOURNAL   J Virol 95 (20), e0067221 (2021)
   PUBMED   34319782
  REMARK    GeneRIF: Phosphorylation of JIP4 at S730 Presents Antiviral
            Properties against Influenza A Virus Infection.
REFERENCE   4  (bases 1 to 8276)
  AUTHORS   Gowrishankar,S., Lyons,L., Rafiq,N.M., Roczniak-Ferguson,A., De
            Camilli,P. and Ferguson,S.M.
  TITLE     Overlapping roles of JIP3 and JIP4 in promoting axonal transport of
            lysosomes in human iPSC-derived neurons
  JOURNAL   Mol Biol Cell 32 (11), 1094-1103 (2021)
   PUBMED   33788575
  REMARK    GeneRIF: Overlapping roles of JIP3 and JIP4 in promoting axonal
            transport of lysosomes in human iPSC-derived neurons.
REFERENCE   5  (bases 1 to 8276)
  AUTHORS   Li,W., Wang,F., Shi,J., Feng,Q., Chen,Y., Qi,X., Wang,C., Lu,H.,
            Lu,Z., Jia,X., Yan,Q., Gao,S.J. and Lu,C.
  TITLE     Sperm associated antigen 9 promotes oncogenic KSHV-encoded
            interferon regulatory factor-induced cellular transformation and
            angiogenesis by activating the JNK/VEGFA pathway
  JOURNAL   PLoS Pathog 16 (8), e1008730 (2020)
   PUBMED   32776977
  REMARK    GeneRIF: Sperm associated antigen 9 promotes oncogenic KSHV-encoded
            interferon regulatory factor-induced cellular transformation and
            angiogenesis by activating the JNK/VEGFA pathway.
            Erratum:[PLoS Pathog. 2022 Jan 7;18(1):e1010232. doi:
            10.1371/journal.ppat.1010232.. PMID: 34995339]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8276)
  AUTHORS   Bouwmeester,T., Bauch,A., Ruffner,H., Angrand,P.O., Bergamini,G.,
            Croughton,K., Cruciat,C., Eberhard,D., Gagneur,J., Ghidelli,S.,
            Hopf,C., Huhse,B., Mangano,R., Michon,A.M., Schirle,M., Schlegl,J.,
            Schwab,M., Stein,M.A., Bauer,A., Casari,G., Drewes,G., Gavin,A.C.,
            Jackson,D.B., Joberty,G., Neubauer,G., Rick,J., Kuster,B. and
            Superti-Furga,G.
  TITLE     A physical and functional map of the human TNF-alpha/NF-kappa B
            signal transduction pathway
  JOURNAL   Nat Cell Biol 6 (2), 97-105 (2004)
   PUBMED   14743216
  REMARK    Erratum:[Nat Cell Biol. 2004 May;6(5):465]
REFERENCE   7  (bases 1 to 8276)
  AUTHORS   Yasuoka,H., Ihn,H., Medsger,T.A. Jr., Hirakata,M., Kawakami,Y.,
            Ikeda,Y. and Kuwana,M.
  TITLE     A novel protein highly expressed in testis is overexpressed in
            systemic sclerosis fibroblasts and targeted by autoantibodies
  JOURNAL   J Immunol 171 (12), 6883-6890 (2003)
   PUBMED   14662895
  REMARK    GeneRIF: Testicular antigen PHET is an auutoantigen recognized by
            sera from systemic sclerosis (SSc) patients with extensive fibrotic
            changes; the autoantibody response to PHET is induced by ectopic
            overexpression of PHET in dermal fibroblasts of SSc patients.
REFERENCE   8  (bases 1 to 8276)
  AUTHORS   Lee,C.M., Onesime,D., Reddy,C.D., Dhanasekaran,N. and Reddy,E.P.
  TITLE     JLP: A scaffolding protein that tethers JNK/p38MAPK signaling
            modules and transcription factors
  JOURNAL   Proc Natl Acad Sci U S A 99 (22), 14189-14194 (2002)
   PUBMED   12391307
REFERENCE   9  (bases 1 to 8276)
  AUTHORS   Ichijo,H.
  TITLE     From receptors to stress-activated MAP kinases
  JOURNAL   Oncogene 18 (45), 6087-6093 (1999)
   PUBMED   10557099
  REMARK    Review article
REFERENCE   10 (bases 1 to 8276)
  AUTHORS   Shankar,S., Mohapatra,B. and Suri,A.
  TITLE     Cloning of a novel human testis mRNA specifically expressed in
            testicular haploid germ cells, having unique palindromic sequences
            and encoding a leucine zipper dimerization motif
  JOURNAL   Biochem Biophys Res Commun 243 (2), 561-565 (1998)
   PUBMED   9480848
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005839.1, AK091921.1,
            BC146755.1 and AC005920.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001130528.2.
            
            Summary: This gene encodes a member of the cancer testis antigen
            gene family. The encoded protein functions as a scaffold protein
            that structurally organizes mitogen-activated protein kinases and
            mediates c-Jun-terminal kinase signaling. This protein also binds
            to kinesin-1 and may be involved in microtubule-based membrane
            transport. This protein may play a role in tumor growth and
            development. Alternate splicing results in multiple transcript
            variants. [provided by RefSeq, Oct 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC153878.1, AB011088.3 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262013.12/ ENSP00000262013.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC005839.1         47349-47351         c
            4-25                AK091921.1         1-22
            26-4462             BC146755.1         1-4437
            4463-8276           AC005920.1         62450-66263         c
FEATURES             Location/Qualifiers
     source          1..8276
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.33"
     gene            1..8276
                     /gene="SPAG9"
                     /gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
                     PHET; PIG6"
                     /note="sperm associated antigen 9"
                     /db_xref="GeneID:9043"
                     /db_xref="HGNC:HGNC:14524"
                     /db_xref="MIM:605430"
     exon            1..515
                     /gene="SPAG9"
                     /gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
                     PHET; PIG6"
                     /inference="alignment:Splign:2.1.0"
     CDS             213..4178
                     /gene="SPAG9"
                     /gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
                     PHET; PIG6"
                     /note="isoform 1 is encoded by transcript variant 1; sperm
                     surface protein; cancer/testis antigen 89;
                     JNK/SAPK-associated protein; JNK interacting protein;
                     c-Jun NH2-terminal kinase-associated leucine zipper
                     protein; Max-binding protein; C-Jun-amino-terminal
                     kinase-interacting protein 4; proliferation-inducing gene
                     6; lung cancer oncogene 4; sunday driver 1; protein highly
                     expressed in testis; human lung cancer oncogene 6 protein;
                     mitogen-activated protein kinase 8-interacting protein 4;
                     C-Jun N-terminal kinase protein-associated leucine-zipper
                     protein"
                     /codon_start=1
                     /product="C-Jun-amino-terminal kinase-interacting protein
                     4 isoform 1"
                     /protein_id="NP_001124000.1"
                     /db_xref="CCDS:CCDS45740.1"
                     /db_xref="GeneID:9043"
                     /db_xref="HGNC:HGNC:14524"
                     /db_xref="MIM:605430"
                     /translation="MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDE
                     EVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEK
                     FIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALH
                     QRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTP
                     DAQKGGETPGSEQWKFQELSQPRSHTSLKVSNSPEPQKAVEQEDELSDVSQGGSKATT
                     PASTANSDVATIPTDTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAE
                     NEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSG
                     LIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQG
                     ELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEM
                     ARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNT
                     TKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQ
                     KREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQVTNGQGENKMKNLPVPVYLRPLDEKD
                     TSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLDTEGSKQRSASQSSLDKLDQE
                     LKEQQKELKNQEELSSLVWICTSTHSATKVLIIDAVQPGNILDSFTVCNSHVLCIASV
                     PGARETDYPAGEDLSESGQVDKASLCGSMTSNSSAETDSLLGGITVVGCSAEGVTGAA
                     TSPSTNGASPVMDKPPEMEAENSEVDENVPTAEEATEATEGNAGSAEDTVDISQTGVY
                     TEHVFTDPLGVQIPEDLSPVYQSSNDSDAYKDQISVLPNEQDLVREEAQKMSSLLPTM
                     WLGAQNGCLYVHSSVAQWRKCLHSIKLKDSILSIVHVKGIVLVALADGTLAIFHRGVD
                     GQWDLSNYHLLDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKIEKSFDAHPRK
                     ESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPYVSKMLGTGKLGFSFV
                     RITALMVSCNRLWVGTGNGVIISIPLTETNKTSGVPGNRPGSVIRVYGDENSDKVTPG
                     TFIPYCSMAHAQLCFHGHRDAVKFFVAVPGQVISPQSSSSGTDLTGDKAGPSAQEPGS
                     QTPLKSMLVISGGEGYIDFRMGDEGGESELLGEDLPLEPSVTKAERSHLIVWQVMYGN
                     E"
     exon            516..636
                     /gene="SPAG9"
                     /gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
                     PHET; PIG6"
                     /inference="alignment:Splign:2.1.0"
     exon            637..707
                     /gene="SPAG9"
                     /gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
                     PHET; PIG6"
                     /inference="alignment:Splign:2.1.0"
     exon            708..802
                     /gene="SPAG9"
                     /gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
                     PHET; PIG6"
                     /inference="alignment:Splign:2.1.0"
     exon            803..953
                     /gene="SPAG9"
                     /gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
                     PHET; PIG6"
                     /inference="alignment:Splign:2.1.0"
     exon            954..995
                     /gene="SPAG9"
                     /gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
                     PHET; PIG6"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1203
                     /gene="SPAG9"
                     /gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
                     PHET; PIG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1303
                     /gene="SPAG9"
                     /gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
                     PHET; PIG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1425
                     /gene="SPAG9"
                     /gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
                     PHET; PIG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1483
                     /gene="SPAG9"
                     /gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
                     PHET; PIG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1636
                     /gene="SPAG9"
                     /gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
                     PHET; PIG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1688
                     /gene="SPAG9"
                     /gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
                     PHET; PIG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1819
                     /gene="SPAG9"
                     /gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
                     PHET; PIG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1876
                     /gene="SPAG9"
                     /gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
                     PHET; PIG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1877..2050
                     /gene="SPAG9"
                     /gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
                     PHET; PIG6"
                     /inference="alignment:Splign:2.1.0"
     exon            2051..2180
                     /gene="SPAG9"
                     /gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
                     PHET; PIG6"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2270
                     /gene="SPAG9"
                     /gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
                     PHET; PIG6"
                     /inference="alignment:Splign:2.1.0"
     exon            2271..2438
                     /gene="SPAG9"
                     /gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
                     PHET; PIG6"
                     /inference="alignment:Splign:2.1.0"
     exon            2439..2610
                     /gene="SPAG9"
                     /gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
                     PHET; PIG6"
                     /inference="alignment:Splign:2.1.0"
     exon            2611..2829
                     /gene="SPAG9"
                     /gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
                     PHET; PIG6"
                     /inference="alignment:Splign:2.1.0"
     exon            2830..3025
                     /gene="SPAG9"
                     /gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
                     PHET; PIG6"
                     /inference="alignment:Splign:2.1.0"
     exon            3026..3151
                     /gene="SPAG9"
                     /gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
                     PHET; PIG6"
                     /inference="alignment:Splign:2.1.0"
     exon            3152..3232
                     /gene="SPAG9"
                     /gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
                     PHET; PIG6"
                     /inference="alignment:Splign:2.1.0"
     exon            3233..3300
                     /gene="SPAG9"
                     /gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
                     PHET; PIG6"
                     /inference="alignment:Splign:2.1.0"
     exon            3301..3449
                     /gene="SPAG9"
                     /gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
                     PHET; PIG6"
                     /inference="alignment:Splign:2.1.0"
     exon            3450..3621
                     /gene="SPAG9"
                     /gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
                     PHET; PIG6"
                     /inference="alignment:Splign:2.1.0"
     exon            3622..3735
                     /gene="SPAG9"
                     /gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
                     PHET; PIG6"
                     /inference="alignment:Splign:2.1.0"
     exon            3736..3912
                     /gene="SPAG9"
                     /gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
                     PHET; PIG6"
                     /inference="alignment:Splign:2.1.0"
     exon            3913..4062
                     /gene="SPAG9"
                     /gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
                     PHET; PIG6"
                     /inference="alignment:Splign:2.1.0"
     exon            4063..8276
                     /gene="SPAG9"
                     /gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
                     PHET; PIG6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8253..8258
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPAG9"
                     /gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
                     PHET; PIG6"
                     /note="hexamer: TATAAA"
     polyA_site      8276
                     /gene="SPAG9"
                     /gene_synonym="CT89; HLC-6; HLC4; HLC6; JIP-4; JIP4; JLP;
                     PHET; PIG6"
                     /note="major polyA site"
ORIGIN      
        1 ggcagttggt gcagcggcgg ttggggtgag agcgcctacg ccacccctcc cctcctccgg
       61 ccccggcccc caccccgccg ggcccagccc cagccccggc ccgggctcca gccctagtac
      121 ccgtcccagc ccgagtcggg tccgtcccgt gcgggcaggt gccgcccctc tgccggcgac
      181 gccccgggcc gcccgcccgt ccgcttgcca ccatggagct ggaggacggt gtggtgtatc
      241 aggaggagcc cggcggctcc ggggccgtga tgtcggagcg ggtgtccggc ctggccggct
      301 ccatctaccg cgagttcgag cggcttatcg ggcgctatga cgaggaggtg gtcaaagagc
      361 tgatgccgct ggtggtggct gtgctggaga acctggactc ggtgttcgcg caggaccagg
      421 agcaccaggt ggagctggag ctgctgcggg acgacaacga gcagctcatc acccagtacg
      481 agcgggagaa ggcgctgcgc aagcacgctg aggagaaatt cattgaattt gaagactctc
      541 aagaacagga aaaaaaggac ttacagaccc gagtggaatc tttagaatct caaacaagac
      601 aacttgagct gaaagcgaaa aactatgctg accagattag cagacttgaa gaaagagaag
      661 cagaactgaa gaaggaatat aatgcattac atcaaagaca cactgagatg atccataatt
      721 atatggaaca tttagaaaga acaaaacttc atcagctctc agggagtgat caactagaat
      781 ccacagctca tagtagaatt agaaaagaac gccctatatc attaggaatt ttcccattac
      841 ctgctggaga tggattgctt acacctgatg ctcagaaagg aggagagacc cctggatctg
      901 agcaatggaa atttcaggaa ttaagtcaac cacgttctca taccagcctg aaggtcagca
      961 atagtcctga acctcagaag gctgtagaac aggaggatga gctttctgat gttagccaag
     1021 gcggatctaa agctaccact ccagcatcaa cagctaattc agatgtggca acaattccta
     1081 ctgatactcc cttaaaggaa gaaaacgaag gatttgtgaa ggttacagat gcgccaaata
     1141 aatcagagat aagcaaacac attgaagtac aggtagccca ggaaactaga aatgtatcta
     1201 ctggctctgc tgaaaatgaa gaaaagtcag aagttcaagc aatcatcgaa tctactcctg
     1261 agctggatat ggacaaagat ctcagtggat ataaaggttc aagcactccc accaaaggca
     1321 tagagaacaa agcttttgat cgcaatacag aatctctctt tgaagaactg tcttcagctg
     1381 gctcaggcct aataggagat gtggatgaag gagcagattt actaggaatg ggtcgggaag
     1441 ttgagaatct tatattagaa aatacacaac tgttggaaac caaaaatgct ttgaacatag
     1501 tgaagaatga tttgatagca aaagtggatg aactgacctg tgagaaagat gtgctgcaag
     1561 gggaattgga ggctgtgaag caagccaaac tgaaactaga ggaaaagaac agagaattgg
     1621 aggaagagct taggaaagct cgggcagaag ctgaagatgc aaggcaaaaa gcaaaagatg
     1681 acgatgatag tgatattccc acagcccaga ggaaacggtt tactagagta gaaatggccc
     1741 gtgttctcat ggagcgaaac cagtataaag agagattgat ggagcttcag gaagctgttc
     1801 gatggacaga gatgattcgg gcatcacgag aaaatccagc catgcaggaa aaaaaaaggt
     1861 caagcatttg gcagtttttc agccgacttt tcagctcctc aagtaacacg actaagaagc
     1921 ctgaaccacc tgttaatctg aagtacaatg cacccacgtc tcatgttact ccgtccgtca
     1981 agaaaagaag cagcacctta tctcagctcc ctggggataa gtccaaagcc tttgatttcc
     2041 ttagtgaaga aactgaagct agtttagcct cacgcagaga acaaaagaga gagcagtatc
     2101 gtcaggtaaa agcacatgtt cagaaggaag acggtagagt gcaggctttt ggctggagtc
     2161 tgcctcagaa gtacaaacag gtaaccaatg gtcaaggtga aaataagatg aaaaatttac
     2221 ctgtgcctgt ctatctcaga cctctggatg aaaaagatac atcaatgaag ctgtggtgtg
     2281 ctgttggagt caatttatct ggtgggaaga ccagagatgg tggttctgtt gttggagcaa
     2341 gtgtatttta caaggatgtt gctggtttgg atacagaagg cagtaaacag cgaagtgcct
     2401 ctcagagtag tttagataag ttagatcagg aacttaagga acagcagaag gagttaaaaa
     2461 atcaagaaga attatccagt ctagtttgga tctgtaccag cactcattcg gctacaaaag
     2521 ttcttattat tgatgctgtt caacctggca acatcctaga cagtttcact gtttgcaact
     2581 ctcatgttct gtgcattgca agtgtgccag gtgcacgaga aacagactac cctgcaggag
     2641 aagatctttc agaatctggt caggtagaca aagcatcttt atgtggaagt atgacaagca
     2701 acagctcagc agagacagac agcctgttag gaggcatcac agtggttggt tgttctgcag
     2761 aaggtgtgac gggagctgcc acttccccta gtacaaatgg tgcttctcca gtgatggata
     2821 aaccaccaga aatggaagca gaaaatagtg aggttgatga aaatgttcca acagcagaag
     2881 aagcaactga agctacagaa gggaatgcgg ggtcagctga agacacagtg gacatctccc
     2941 aaactggcgt ctacacagag catgtcttta cagatccttt gggagttcag atcccagaag
     3001 acctctcccc agtgtatcag tcgagcaatg actcagatgc atataaagat caaatatcag
     3061 tactgccaaa tgaacaagac ttggtgagag aagaagccca gaaaatgagt agtcttttac
     3121 caactatgtg gcttggagct caaaatggct gtttgtatgt ccattcatct gtagcccagt
     3181 ggaggaaatg tctccattcc attaaactta aagattcgat tctcagtatt gtacacgtga
     3241 agggaatcgt gttagtagcc ctggctgacg gcacccttgc aatctttcac agaggagtgg
     3301 atgggcagtg ggatttgtca aactatcacc tcttagacct tggacggcct catcattcca
     3361 tccgttgcat gactgtggta catgacaaag tctggtgtgg ctataggaac aaaatctatg
     3421 tggtgcagcc aaaggccatg aaaatagaga aatcttttga tgcacatccc aggaaggaga
     3481 gccaagtgcg acagcttgcg tgggtggggg atggcgtgtg ggtctccatt cgcttggatt
     3541 ctacgctccg tctctatcat gcacacactt atcaacatct acaggatgtg gacattgagc
     3601 cttatgtaag caaaatgtta ggtactggaa aactgggctt ctcttttgtg agaattacag
     3661 ctcttatggt gtcttgtaat cgtttgtggg tggggacagg aaatggtgtc attatctcca
     3721 tcccattgac agaaacaaat aaaacctcag gtgtaccagg aaatcgtcct ggaagtgtaa
     3781 tccgtgtata tggtgatgaa aacagtgata aagtgactcc agggacattt ataccctatt
     3841 gttcaatggc acatgcacag ctttgcttcc atgggcaccg ggatgctgtg aaattctttg
     3901 tggcagtccc aggtcaagtc atcagcccac aaagtagcag tagtggcacg gatctgacgg
     3961 gtgacaaagc agggccatct gcacaggagc ctggtagtca gacgcccttg aagtctatgc
     4021 ttgtcatcag tggaggagag ggctacatcg acttccgaat gggtgatgaa ggtggagaat
     4081 cagaacttct tggagaggat cttccacttg aaccttctgt caccaaagca gaaaggagtc
     4141 acttgatagt gtggcaagtg atgtatggca atgagtgagc ccatgggaaa caggtggaga
     4201 tggggaagcc gtctcttctg catggtttat tttccctcta tccttttatt taatgctctt
     4261 ttgtgagata agtttcacca cataatgtgt gagcattttt tcctgttaac tttatattac
     4321 aaaatccgtt ctaccataac aatacagagg aactagctgt gttactgcac cagtgttata
     4381 ggtaacttca gtatattatg aacaaatcaa agaatgttta cttcctgcaa actggtgaat
     4441 tatagaaagc aatccagatg tggtttactc tgccacagtc taatgtcatt cacttcattt
     4501 gatggggtca cttgttagct gtcactaata atggaattaa tgggaaacac ttgataaatg
     4561 aaactgtacc gttaaataca atagctgagt tttccccagt gtattgtaaa attgacacac
     4621 actaatacaa gatggattat caggatgtat ctaaatgtcc cgagagggtt aaaagctaac
     4681 tgtaaattac tttaactttc actttcaaat ctgacaaatc ttgtttatat ggtatataaa
     4741 actttgtttt catcagattt gggggggttt tatattaaag aaattaagac tacactattt
     4801 aaataaacgt ttcctgtttc tgacttatta gagctctaaa gtttatgagg cctacttctc
     4861 tgaatattct gatgggtttt ttttgagacc agtctcattt tcatactgac atgtctgaaa
     4921 gatttattat ttataaagct taggacatac tctgggaagc ttagaagata cttcagcact
     4981 gggaggattt tttaaaggaa atgtgttttg tatttcttgt accagagaat ggtgatgttg
     5041 attgagtttt ttccatgtaa aaaatgtact tgtttgccaa atgttcctag attgctctta
     5101 acctgttaat acaagtaaaa ctgtagtggg gatggagtct ggcctaagta cagaatgagg
     5161 gatttaatta gaaaagttat tttcttttgt tctgtatcaa actgcagaac agctatatac
     5221 ttggtatttt gtacgtgaat aacgttttag cttttgtgcc cttttgagct tgaagggtta
     5281 tcctcaaagg ggaaaactat gaaggggaag aagacaaacc taagatacca taaagtaaag
     5341 gttgacatta catattttca ttcacaatgc ccattaaaaa aaaaaaatag gttgggcatg
     5401 gtggctcacg cctgtaatcc caacacttta ggaggctgag gcagatggat tgcttgagcc
     5461 caggagttca agaccagcct gggcaacatg gcgaaaccct gtctctacca aaaaaaaaaa
     5521 acaaaataaa ttaaccgggt gtggtggcac atgcctgtag tcccagctac ttgggaggct
     5581 gaggtgggag gatgacctgg gcccaggagg tggaggttgc agtgagcctt gatagcacca
     5641 ctgcactcca gcctgggtga cggagcaaga ccctgtctca aaacagacaa acaagcaaaa
     5701 aatagattaa agtctggatt tcactgattt tcttgcttaa taagtttttt aaaaccacga
     5761 tgctgcaatt ttttccctct caagcttctt gaaaatgtgt gatttaccct tttttatcta
     5821 ttactctagg caaagctaaa tatgattttt tttttttttt ttgagacgga gtctggctct
     5881 gttgcccagg ctggaatgca gtggtgcgat ctcagctcac tgcaacctcc acctctcagg
     5941 ttcaagtagt tctcctgcct cagcctccca agtagctggg attacaggtg tgtgccaccc
     6001 tgcccagcta atttttgtat ttttagtaga gacagggttt caccacattg gccaggctgg
     6061 tctcaaactc ctgacctcag atgatctacc cgccttggcc tcccgaagtg cttgaattac
     6121 aggcgtgagc ccccgcgccg gtccgaagca aagctaaatg taattttatg tactgtttta
     6181 acagtataaa cctatgggat aaaggccccc aatcatcaga aggactactg aaaagaaaag
     6241 aaagcaaacg tagatgtcaa attgtctaaa cattcttaag taccactgat tttttttttc
     6301 tggactatta tacaaagatg tctgtaaaaa gtataccagt ggcttttatg catatacacg
     6361 attaggctag attgtgaagt acatgggatt tcatgagcca gaggaggcat ttggatccat
     6421 tgggccacat gtgactataa gcacattgtg tacacaataa aattgtagcc actcatgtat
     6481 taaaactgtt ttggtaaaag ctgtattaaa agaataattt tttgcttgag ctacttagtc
     6541 acttttttgc agggcaccaa aatgtaggct acttttccat agcttgtttg ctatgttttt
     6601 atttcatctt aaatctgagc catttttggc aatatctttt aaaaaatcat tattaaacat
     6661 ttattggaaa tgttgtatag attcacaaga aagagacacc aaagtgtttg ggaattttaa
     6721 tcccaagaag taaacatccc agagtcagat cccatttgct gttgttcagc catgtttgta
     6781 tgactgaatg taatttagga aatcaggagt tagagatgaa aaatacaaac atgtcaaatg
     6841 gttgtaattg ctttttttga acttactggc tttaacttaa gtaatatagg tgtgtagttg
     6901 ttttatctaa agatgtcaga ttatctgtgg ccctgttaat taactgcagg gaccagagag
     6961 aggacaaaaa tgcctgtata atttgcttta aaggcttgtc cttatgtttg taatttcagt
     7021 taaatatttt ctacagattg cttcacttcc cctttccccc aataacaagt tcatattctt
     7081 gtaatgttta ctttggtcaa cgtggtaatt tttggaagaa aatgccaaaa tgtaagcttc
     7141 tcacaagcag caaaggaatg taactgcctg tagctaccac atcaagggag agaagaggct
     7201 tgcgtacttt gggttgatct cactgtacaa aaaaagtgta cccctattgg aagaaataag
     7261 gaatacttga aggtttctcc tttttttaca cttgagtcat gtgcaaggtt gaaccatatg
     7321 aaattgccag tgttcaacca ttgctgatct gcaaaagcga caatatcata tgcctcaacc
     7381 taacacttac tcttaaatgc aggttaaaat ctctgtgagg caaagggata atattctcta
     7441 ggaactcact tttgagagta tttttctcta acccatgtgg atctaaattt taaaaatagg
     7501 aatgaatctc ttaattgcag cttgtggaga gtataaaaca ttttgagcac aatatgcagc
     7561 acataacttt tcagattgtg tttgcataga aaaggttaaa atcaattctt tcagttactg
     7621 tattgttcat ttcttgtaaa ggtcttccta catttgagac gagacccttt aacataggct
     7681 gccttagtaa caaaataaaa cagatgtgtc ataatattaa ctgtcctaaa gaacatgtgt
     7741 cttgcaaatg ccatggaact gaatatttat ttccttgtga gtattatgac cgttaccaaa
     7801 ggactcaacc agatttaggg ctcttcttaa ttgatcatgt tcagaaaggg actcatttgg
     7861 tcccactttg taacatggga agagtagaag agaaaattaa atgtggaaat cataaatgct
     7921 tttctaacag ggttatgcta ttctgtaaca ctaaatgtct gtcttttctc ttaaaagatt
     7981 aagttttatt aattttgtca tacatttctc tatttgaata tatcttaacc attttatgtt
     8041 ccaaattcgt tttttgtcca agacattcta tcagaatttt acttgcctct ataatctgaa
     8101 aaatgggttc tagaatgtcc cacttgctgt ctcttagagg ctgagcttca tttctatgag
     8161 caaagagctc atttagcaat gtagttattt cagtatttat ttctattatg gaatccctgg
     8221 ggttcagaat gtaactttgt acatgagata tatataaata tgtatatgaa catgta
//
