LOCUS       NM_004890               1005 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens sperm associated antigen 7 (SPAG7), mRNA.
ACCESSION   NM_004890
VERSION     NM_004890.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1005)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1005)
  AUTHORS   Bens,S., Zichner,T., Stutz,A.M., Caliebe,A., Wagener,R., Hoff,K.,
            Korbel,J.O., von Bismarck,P. and Siebert,R.
  TITLE     SPAG7 is a candidate gene for the periodic fever, aphthous
            stomatitis, pharyngitis and adenopathy (PFAPA) syndrome
  JOURNAL   Genes Immun 15 (3), 190-194 (2014)
   PUBMED   24452265
  REMARK    GeneRIF: SPAG7 is a candidate gene for the periodic fever, aphthous
            stomatitis, pharyngitis and adenopathy (PFAPA) syndrome.
REFERENCE   3  (bases 1 to 1005)
  AUTHORS   Lehner,B., Semple,J.I., Brown,S.E., Counsell,D., Campbell,R.D. and
            Sanderson,C.M.
  TITLE     Analysis of a high-throughput yeast two-hybrid system and its use
            to predict the function of intracellular proteins encoded within
            the human MHC class III region
  JOURNAL   Genomics 83 (1), 153-167 (2004)
   PUBMED   14667819
REFERENCE   4  (bases 1 to 1005)
  AUTHORS   Beaton,S., Cleary,A., ten Have,J. and Bradley,M.P.
  TITLE     Cloning and characterization of a fox sperm protein FSA-1
  JOURNAL   Reprod Fertil Dev 6 (6), 761-770 (1994)
   PUBMED   7624517
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP308951.1 and BC011934.2.
            
            On Nov 22, 2018 this sequence version replaced NM_004890.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011934.2, AF047437.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000206020.8/ ENSP00000206020.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                BP308951.1         21-31
            12-1005             BC011934.2         1-994
FEATURES             Location/Qualifiers
     source          1..1005
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.2"
     gene            1..1005
                     /gene="SPAG7"
                     /gene_synonym="ACRP; FSA-1"
                     /note="sperm associated antigen 7"
                     /db_xref="GeneID:9552"
                     /db_xref="HGNC:HGNC:11216"
                     /db_xref="MIM:610056"
     exon            1..98
                     /gene="SPAG7"
                     /gene_synonym="ACRP; FSA-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..697
                     /gene="SPAG7"
                     /gene_synonym="ACRP; FSA-1"
                     /codon_start=1
                     /product="sperm-associated antigen 7"
                     /protein_id="NP_004881.2"
                     /db_xref="CCDS:CCDS42240.1"
                     /db_xref="GeneID:9552"
                     /db_xref="HGNC:HGNC:11216"
                     /db_xref="MIM:610056"
                     /translation="MADLLGSILSSMEKPPSLGDQETRRKAREQAARLKKLQEQEKQQ
                     KVEFRKRMEKEVSDFIQDSGQIKKKFQPMNKIERSILHDVVEVAGLTSFSFGEDDDCR
                     YVMIFKKEFAPSDEELDSYRRGEEWDPQKAEEKRKLKELAQRQEEEAAQQGPVVVSPA
                     SDYKDKYSHLIGKGAAKDAAHMLQANKTYGCVPVANKRDTRSIEEAMNEIRAKKRLRQ
                     SGEELPPTS"
     exon            99..166
                     /gene="SPAG7"
                     /gene_synonym="ACRP; FSA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            167..255
                     /gene="SPAG7"
                     /gene_synonym="ACRP; FSA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            256..340
                     /gene="SPAG7"
                     /gene_synonym="ACRP; FSA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            341..430
                     /gene="SPAG7"
                     /gene_synonym="ACRP; FSA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            431..587
                     /gene="SPAG7"
                     /gene_synonym="ACRP; FSA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            588..1005
                     /gene="SPAG7"
                     /gene_synonym="ACRP; FSA-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      985..990
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPAG7"
                     /gene_synonym="ACRP; FSA-1"
                     /note="hexamer: AATAAA"
     polyA_site      1005
                     /gene="SPAG7"
                     /gene_synonym="ACRP; FSA-1"
                     /note="major polyA site"
ORIGIN      
        1 agtcactccc aagatggcgg acctactggg ctccatcctg agctccatgg agaagccacc
       61 cagcctcggt gaccaggaga ctcggcgcaa ggcccgagaa caggccgccc gcctgaagaa
      121 actacaagag caagagaaac aacagaaagt ggagtttcgt aaaaggatgg agaaggaggt
      181 gtcagatttc attcaagaca gtgggcagat caagaaaaag tttcagccaa tgaacaagat
      241 cgagaggagc atactacatg atgtggtgga agtggctggc ctgacatcct tctcctttgg
      301 ggaagatgat gactgtcgct atgtcatgat cttcaaaaag gagtttgcac cctcagatga
      361 agagctagac tcttaccgtc gtggagagga atgggacccc cagaaggctg aggagaagcg
      421 gaagctgaag gagctggccc agaggcaaga ggaggaggca gcccagcagg ggcctgtggt
      481 ggtgagccct gccagcgact acaaggacaa gtacagccac ctcatcggca agggagcagc
      541 caaagacgca gcccacatgc tacaggccaa taagacctac ggctgtgtgc ccgtggccaa
      601 taagagggac acacgctcca ttgaagaggc tatgaatgag atcagagcca agaagcgtct
      661 gcggcagagt ggggaagagt tgccgccaac ctcctaggcg ccccgcccag ctccctttga
      721 cccctggggc agggcagggg gcagggagag acaaggctgc tgctattaga gcccatcctg
      781 gagccccacc tctgaaccac ctcctaccag ctgtccctca ggctggggga aaacaggtgt
      841 ttgatttgtc accgttggag cttggatatg tgcgtggcat gtgtgtgtgt gtgtgagagt
      901 gtgaatgcac aggtgggtat ttaatctgta ttattccccg ttcttggaat tttcttcccc
      961 atggggctgg ggtactttac attcaataaa tactgtttaa cccaa
//
