LOCUS       NM_001004323             988 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens sperm acrosome developmental regulator (SPACDR), mRNA.
ACCESSION   NM_001004323 XM_379901
VERSION     NM_001004323.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 988)
  AUTHORS   Celse,T., Cazin,C., Mietton,F., Martinez,G., Martinez,D.,
            Thierry-Mieg,N., Septier,A., Guillemain,C., Beurois,J.,
            Clergeau,A., Mustapha,S.F.B., Kharouf,M., Zoghmar,A., Chargui,A.,
            Papaxanthos,A., Dorphin,B., Foliguet,B., Triki,C., Sifer,C.,
            Lauton,D., Tachdjian,G., Schuler,G., Lejeune,H., Puechberty,J.,
            Bessonnat,J., Pasquier,L., Mery,L., Poulain,M., Chaabouni,M.,
            Sermondade,N., Cabry,R., Benbouhadja,S., Veau,S., Frapsauce,C.,
            Mitchell,V., Achard,V., Satre,V., Hennebicq,S., Zouari,R.,
            Arnoult,C., Kherraf,Z.E., Coutton,C. and Ray,P.F.
  TITLE     Genetic analyses of a large cohort of infertile patients with
            globozoospermia, DPY19L2 still the main actor, GGN confirmed as a
            guest player
  JOURNAL   Hum Genet 140 (1), 43-57 (2021)
   PUBMED   33108537
REFERENCE   2  (bases 1 to 988)
  AUTHORS   Zhang,X., Koga,N., Suzuki,H. and Kato,M.
  TITLE     Promotion of cellular senescence by THG-1/TSC22D4 knockout through
            activation of JUNB
  JOURNAL   Biochem Biophys Res Commun 522 (4), 897-902 (2020)
   PUBMED   31806366
REFERENCE   3  (bases 1 to 988)
  AUTHORS   Oud,M.S., Okutman,O., Hendricks,L.A.J., de Vries,P.F.,
            Houston,B.J., Vissers,L.E.L.M., O'Bryan,M.K., Ramos,L.,
            Chemes,H.E., Viville,S. and Veltman,J.A.
  TITLE     Exome sequencing reveals novel causes as well as new candidate
            genes for human globozoospermia
  JOURNAL   Hum Reprod 35 (1), 240-252 (2020)
   PUBMED   31985809
REFERENCE   4  (bases 1 to 988)
  AUTHORS   Pineau,C., Hikmet,F., Zhang,C., Oksvold,P., Chen,S., Fagerberg,L.,
            Uhlen,M. and Lindskog,C.
  TITLE     Cell Type-Specific Expression of Testis Elevated Genes Based on
            Transcriptomics and Antibody-Based Proteomics
  JOURNAL   J Proteome Res 18 (12), 4215-4230 (2019)
   PUBMED   31429579
REFERENCE   5  (bases 1 to 988)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC031966.1.
            
            On Nov 24, 2018 this sequence version replaced NM_001004323.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031966.1, SRR5189667.51628.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000332375.4/ ENSP00000327732.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-988               BC031966.1         12-999
FEATURES             Location/Qualifiers
     source          1..988
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..988
                     /gene="SPACDR"
                     /gene_synonym="C7orf61"
                     /note="sperm acrosome developmental regulator"
                     /db_xref="GeneID:402573"
                     /db_xref="HGNC:HGNC:22135"
                     /db_xref="MIM:619782"
     exon            1..298
                     /gene="SPACDR"
                     /gene_synonym="C7orf61"
                     /inference="alignment:Splign:2.1.0"
     CDS             236..856
                     /gene="SPACDR"
                     /gene_synonym="C7orf61"
                     /note="uncharacterized protein C7orf61"
                     /codon_start=1
                     /product="sperm acrosome developmental regulator"
                     /protein_id="NP_001004323.1"
                     /db_xref="CCDS:CCDS47661.1"
                     /db_xref="GeneID:402573"
                     /db_xref="HGNC:HGNC:22135"
                     /db_xref="MIM:619782"
                     /translation="MVVVMKFFRWVRRAWQRIISWVFFWRQKIKPTISGHPDSKKHSL
                     KKMEKTLQVVETLRLVELPKEAKPKLGESPELADPCVLAKTTEETEVELGQQGQSLLQ
                     LPRTAVKSVSTLMVSALQSGWQMCSWKSSVSSASVSSQVRTQSPLKTPEAELLWEVYL
                     VLWAVRKHLRRLYRRQERHRRHHVRCHAAPRPNPAQSLKLDAQSPL"
     exon            299..622
                     /gene="SPACDR"
                     /gene_synonym="C7orf61"
                     /inference="alignment:Splign:2.1.0"
     exon            623..988
                     /gene="SPACDR"
                     /gene_synonym="C7orf61"
                     /inference="alignment:Splign:2.1.0"
     regulatory      967..972
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPACDR"
                     /gene_synonym="C7orf61"
                     /note="hexamer: AATAAA"
     polyA_site      988
                     /gene="SPACDR"
                     /gene_synonym="C7orf61"
                     /note="major polyA site"
ORIGIN      
        1 cctacttcga ctcctctccc tgtcccaggg aggggagaaa aggtctggga ttcattgcca
       61 ggaggggctt cccccaggat ttcctacttc tttctttact gctgtgcttg aagctcacag
      121 gagacccctc aagaggtggt caccggccca cagcccaccc catcccccac ccgccacccc
      181 caccgtacca aatgctagct ctgccctttc ttctgtgttt ttcccatcaa gagagatggt
      241 tgtggtcatg aagttcttcc gatgggttag acgggcttgg caaaggatta tttcctgggt
      301 tttcttctgg aggcaaaaaa ttaaaccaac catctcagga caccctgact ccaagaaaca
      361 ctcattgaag aagatggaga agactctcca ggtggttgag actttgaggt tggtcgagct
      421 cccaaaagag gctaagccca agttgggtga gtcccccgag ctggcagatc cctgcgtgtt
      481 ggccaagact acagaggaga ccgaggtgga gctgggccaa cagggccaat ccctactgca
      541 gctgccgagg acggccgtca agtctgtctc cacgctcatg gtctctgccc tgcagagcgg
      601 ctggcagatg tgcagctgga agtcatcagt gagttctgcc tcagtcagct cccaagtgag
      661 gacgcagtca cctttgaaga ctccggaggc tgagttgctg tgggaggtgt acctggtgct
      721 gtgggccgtt cggaaacacc tgcgccggct gtaccgcagg caggagaggc acagacggca
      781 ccacgtccga tgccatgctg ccccccgacc caacccggct cagtccctga aactggatgc
      841 ccaaagtccc ctctaggggg aaccccagac ccttagagag tcctgacctc actcttacct
      901 ggggtcccat atcagcccct tcattccatg tattccagtt gtaaaacaag tatcaaaata
      961 ttgggaaata aatatcagat agttctga
//
