LOCUS       NM_001316897            2242 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens sperm acrosome associated 9 (SPACA9), transcript
            variant 1, mRNA.
ACCESSION   NM_001316897 XM_005272164
VERSION     NM_001316897.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2242)
  AUTHORS   Chen,E., Yang,F., Li,Q., Li,T., Yao,D., Cao,L. and Yang,J.
  TITLE     Loss of Tumor Suppressor C9orf9 Promotes Metastasis in Colorectal
            Cancer
  JOURNAL   Biomolecules 13 (2), 312 (2023)
   PUBMED   36830681
  REMARK    GeneRIF: Loss of Tumor Suppressor C9orf9 Promotes Metastasis in
            Colorectal Cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2242)
  AUTHORS   Gui,M., Croft,J.T., Zabeo,D., Acharya,V., Kollman,J.M.,
            Burgoyne,T., Hoog,J.L. and Brown,A.
  TITLE     SPACA9 is a lumenal protein of human ciliary singlet and doublet
            microtubules
  JOURNAL   Proc Natl Acad Sci U S A 119 (41), e2207605119 (2022)
   PUBMED   36191189
  REMARK    GeneRIF: SPACA9 is a lumenal protein of human ciliary singlet and
            doublet microtubules.
REFERENCE   3  (bases 1 to 2242)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2242)
  AUTHORS   Bhattacharya,R., Devi,M.S., Dhople,V.M. and Jesudasan,R.A.
  TITLE     A mouse protein that localizes to acrosome and sperm tail is
            regulated by Y-chromosome
  JOURNAL   BMC Cell Biol 14, 50 (2013)
   PUBMED   24256100
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2242)
  AUTHORS   Fong,K.W., Leung,J.W., Li,Y., Wang,W., Feng,L., Ma,W., Liu,D.,
            Songyang,Z. and Chen,J.
  TITLE     MTR120/KIAA1383, a novel microtubule-associated protein, promotes
            microtubule stability and ensures cytokinesis
  JOURNAL   J Cell Sci 126 (Pt 3), 825-837 (2013)
   PUBMED   23264731
REFERENCE   6  (bases 1 to 2242)
  AUTHORS   Casabonne,D., Reina,O., Benavente,Y., Becker,N., Maynadie,M.,
            Foretova,L., Cocco,P., Gonzalez-Neira,A., Nieters,A., Boffetta,P.,
            Middeldorp,J.M. and de Sanjose,S.
  TITLE     Single nucleotide polymorphisms of matrix metalloproteinase 9
            (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus
            in chronic lymphocytic leukemia: results from the European
            case-control study EpiLymph
  JOURNAL   Haematologica 96 (2), 323-327 (2011)
   PUBMED   21048031
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-environment interaction. (HuGE Navigator)
REFERENCE   7  (bases 1 to 2242)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK075259.1 and BC012940.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001316897.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a). Variants 1 and 2
            both encode the same isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075259.1, SRR1803611.115202.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356311.10/ ENSP00000348659.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-997               AK075259.1         1-997
            998-2242            BC012940.1         955-2199
FEATURES             Location/Qualifiers
     source          1..2242
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.13"
     gene            1..2242
                     /gene="SPACA9"
                     /gene_synonym="C9orf9; Mast"
                     /note="sperm acrosome associated 9"
                     /db_xref="GeneID:11092"
                     /db_xref="HGNC:HGNC:1367"
                     /db_xref="MIM:618552"
     exon            1..117
                     /gene="SPACA9"
                     /gene_synonym="C9orf9; Mast"
                     /inference="alignment:Splign:2.1.0"
     exon            118..298
                     /gene="SPACA9"
                     /gene_synonym="C9orf9; Mast"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..823
                     /gene="SPACA9"
                     /gene_synonym="C9orf9; Mast"
                     /note="isoform a is encoded by transcript variant 1; Rsb66
                     homolog; sperm acrosome-associated protein 9"
                     /codon_start=1
                     /product="sperm acrosome-associated protein 9 isoform a"
                     /protein_id="NP_001303826.1"
                     /db_xref="CCDS:CCDS83434.1"
                     /db_xref="GeneID:11092"
                     /db_xref="HGNC:HGNC:1367"
                     /db_xref="MIM:618552"
                     /translation="MNEVKESLRSIEQKYKLFQQQQLTFTAALEHCRENAHDKIRPIS
                     SIGQVQSYMEHYCNSSTDRRVLLMFLDICSELNKLCQHFEAVHSGTPVTNNLLEKCKT
                     LVSQSNDLSSLRAKYPHDVVNHLSCDEARNHYGGVVSLIPLILDLMKEWIAHSEKLPR
                     KVLQHVSEPQAHQESTRGAARPAQAIGTQPRATKHKCRQLTKASLKPRGCSKPPWRPP
                     GGKL"
     exon            299..501
                     /gene="SPACA9"
                     /gene_synonym="C9orf9; Mast"
                     /inference="alignment:Splign:2.1.0"
     exon            502..2242
                     /gene="SPACA9"
                     /gene_synonym="C9orf9; Mast"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2222..2227
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPACA9"
                     /gene_synonym="C9orf9; Mast"
                     /note="hexamer: AATAAA"
     polyA_site      2242
                     /gene="SPACA9"
                     /gene_synonym="C9orf9; Mast"
                     /note="major polyA site"
ORIGIN      
        1 ctcgcctccc aagtcctgga acgggcctcc ccaccctccg gggcaccgac actcacggag
       61 tcactccaac ttctctgggt gctccgtgga gcgaagagcg ctctaggaca agcaaggatt
      121 cctcttctcc tgtaaatgac cacagaggaa gacaatgaat gaggtgaaag aatcccttcg
      181 cagcatcgag cagaagtaca agctcttcca gcagcagcag ctcaccttca ccgccgctct
      241 ggagcactgc agggagaacg cccacgacaa gatccggccc atctccagca ttggacaggt
      301 gcagagctac atggaacact actgcaacag ctccacagac cggcgggttc tgctcatgtt
      361 cctggacatc tgttcagagc tgaataagct ctgccagcac tttgaggccg tgcactctgg
      421 caccccagtc accaacaacc tcctggagaa atgcaaaacc ctcgttagcc aaagcaacga
      481 cttaagcagc ctcagagcaa aataccctca tgatgtggtg aaccacctca gctgtgacga
      541 ggcccggaac cactacggcg gcgtggtcag cctcatcccc ctcatcctag acttaatgaa
      601 agaatggatc gcccactccg agaagttgcc gcgcaaggtg ctgcagcacg tgagtgagcc
      661 ccaggcgcac caggagagca ccaggggagc cgctcgtcct gcccaggcca tagggaccca
      721 gcccagggcc actaaacaca agtgtagaca gctcacaaaa gccagcctca aacccagggg
      781 atgttcaaaa ccaccctgga ggcctcctgg tgggaaattg taactcagag ccaggagctc
      841 cgtcggcgga gagctttgct gtttaatttg gattttactg gttggtcctt ttttcactgg
      901 tacccatgga ccctgccact tactaacccc aagggaatca gccaatatat tactgagact
      961 tcctctctct cttcttgctt taacttcttt tttttttgag acggagtctc gctctgtcgc
     1021 ccaggctgga gtgcggtggc gcaacctcgg ctcactgcaa cctccgcctc ccaggttcac
     1081 gccattctcc tgcctcagcc tcccaagtag ctgggactac aggcgcccac cacctcgcct
     1141 ggctaatttt ttgtattttt agtagagaca gcgtttcacc atgttagcca ggatggtctc
     1201 aatctcctga cctcatgatc taccctcgtg atcggcctcc caaagtgctg ggattacagg
     1261 cgtgagccac agcgcccggc cctcttgctt taacttctaa catttccact tctaagcatc
     1321 aggctccgtg ctgatgaaga ggaaacccac ttacagaagt tgcccaaaca ggatggtgtg
     1381 gtagagggtc ccaggagggc actgaactgt cacctaggtc ctctttgagc cacatccggc
     1441 tccagtgcca cgcctgtccc tgctgcgggc tgcagttttg cagagggtga tcaagctgga
     1501 gaccatctgc tccttgcccc accaccagcc ccaactgtag gcaaggcaca cgctgtttgc
     1561 gagccaggga tgctcccctc caggatggag tgggggtcgg catgtggaac tcagcgtgtt
     1621 tattttttta ttttttgaga tggagtttca ctctgtctcc caggctggag tgcagtggca
     1681 cgatcttggc tcactgcaac ctccacctcc aggttcaagc gattctcctg cctcagcctc
     1741 ctgagtagct ggaattacag gcgcccacca ccccacctgg ctaatttata tatatatata
     1801 ttttttagta gagacggggc ttcaccacgt tggccaggct ggtcttgaac tcctgacctc
     1861 aactggtcca cccgcctcgg cctcccaaag tgctgggatt acaggtgtga gccacggcac
     1921 ctggccagaa ctcagtagtg tgtttagttc tctggaccac agccaaaggg gaataaactc
     1981 acctttcctt cgcctttact tgggagaggg agaccatgac agaagccaga attctgattt
     2041 tgtggctcct gagcaagggc gatgacctgg ttttcacagc gtagtcgaac cccaaacatt
     2101 gtaaaatgtg tccctggctt ctgagcttgc ccaaagtaat gtctgactgt tggtttttcc
     2161 cttcacaggg gacgacttag cttctgtatt attgttgctt cctcaggggg agacagtcaa
     2221 gaataaaaag tattctacca cc
//
