LOCUS       NM_001348107            1605 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens small regulatory polypeptide of amino acid response
            (SPAAR), mRNA.
ACCESSION   NM_001348107 NR_024283 XM_001129749 XM_001130949 XM_001721058
VERSION     NM_001348107.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1605)
  AUTHORS   Hu,J.X., Zheng,Z.Q., Kang,T., Qian,W., Huang,S.H. and Li,B.G.
  TITLE     LncRNA LINC00961 regulates endothelial-mesenchymal transition via
            the PTEN-PI3K-AKT pathway
  JOURNAL   Mol Med Rep 26 (1) (2022)
   PUBMED   35656895
  REMARK    GeneRIF: LncRNA LINC00961 regulates endothelialmesenchymal
            transition via the PTENPI3KAKT pathway.
REFERENCE   2  (bases 1 to 1605)
  AUTHORS   Sui,J., Zhao,Q., Zhang,Y. and Liang,G.
  TITLE     Dysregulated LINC00961 Contributes to the Vitality and Migration of
            NSCLC Via miR-19a-3p/miR-19b-3p/miR-125b-5p
  JOURNAL   DNA Cell Biol 41 (3), 319-329 (2022)
   PUBMED   35244469
  REMARK    GeneRIF: Dysregulated LINC00961 Contributes to the Vitality and
            Migration of NSCLC Via miR-19a-3p/miR-19b-3p/miR-125b-5p.
REFERENCE   3  (bases 1 to 1605)
  AUTHORS   Lee,J., Wacholder,A. and Carvunis,A.R.
  TITLE     Evolutionary Characterization of the Short Protein SPAAR
  JOURNAL   Genes (Basel) 12 (12), 1864 (2021)
   PUBMED   34946813
  REMARK    GeneRIF: Evolutionary Characterization of the Short Protein SPAAR.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1605)
  AUTHORS   Spencer,H.L., Sanders,R., Boulberdaa,M., Meloni,M., Cochrane,A.,
            Spiroski,A.M., Mountford,J., Emanueli,C., Caporali,A., Brittan,M.,
            Rodor,J. and Baker,A.H.
  TITLE     The LINC00961 transcript and its encoded micropeptide, small
            regulatory polypeptide of amino acid response, regulate endothelial
            cell function
  JOURNAL   Cardiovasc Res 116 (12), 1981-1994 (2020)
   PUBMED   31990292
  REMARK    GeneRIF: The LINC00961 transcript and its encoded micropeptide,
            small regulatory polypeptide of amino acid response, regulate
            endothelial cell function.
REFERENCE   5  (bases 1 to 1605)
  AUTHORS   Wu,H., Dai,Y., Zhang,D., Zhang,X., He,Z., Xie,X. and Cai,C.
  TITLE     LINC00961 inhibits the migration and invasion of colon cancer cells
            by sponging miR-223-3p and targeting SOX11
  JOURNAL   Cancer Med 9 (7), 2514-2523 (2020)
   PUBMED   32045135
  REMARK    GeneRIF: LINC00961 inhibits the migration and invasion of colon
            cancer cells by sponging miR-223-3p and targeting SOX11.
REFERENCE   6  (bases 1 to 1605)
  AUTHORS   Chen,D., Zhu,M., Su,H., Chen,J., Xu,X. and Cao,C.
  TITLE     LINC00961 restrains cancer progression via modulating
            epithelial-mesenchymal transition in renal cell carcinoma
  JOURNAL   J Cell Physiol 234 (5), 7257-7265 (2019)
   PUBMED   30367453
  REMARK    GeneRIF: LINC00961 is involved in renal cell carcinoma progression
            by targeting the epithelial-mesenchymal transition pathway.
REFERENCE   7  (bases 1 to 1605)
  AUTHORS   Lu,X.W., Xu,N., Zheng,Y.G., Li,Q.X. and Shi,J.S.
  TITLE     Increased expression of long noncoding RNA LINC00961 suppresses
            glioma metastasis and correlates with favorable prognosis
  JOURNAL   Eur Rev Med Pharmacol Sci 22 (15), 4917-4924 (2018)
   PUBMED   30070327
  REMARK    GeneRIF: Overexpression of LINC00961 significantly suppressed
            glioma cells proliferation, migration, and invasion.
            Mechanistically, we found that overexpression of LINC00961
            inhibited glioma cell epithelial-mesenchymal transition .
REFERENCE   8  (bases 1 to 1605)
  AUTHORS   Jiang,B., Liu,J., Zhang,Y.H., Shen,D., Liu,S., Lin,F., Su,J.,
            Lin,Q.F., Yan,S., Li,Y., Mao,W.D. and Liu,Z.L.
  TITLE     Long noncoding RNA LINC00961 inhibits cell invasion and metastasis
            in human non-small cell lung cancer
  JOURNAL   Biomed Pharmacother 97, 1311-1318 (2018)
   PUBMED   29156520
  REMARK    GeneRIF: decreased LINC00961 might play a key role in non-small
            cell lung cancer (NSCLC) progression, and may serve as a novel
            prognostic marker in human NSCLC
REFERENCE   9  (bases 1 to 1605)
  AUTHORS   Rion,N. and Ruegg,M.A.
  TITLE     LncRNA-encoded peptides: More than translational noise?
  JOURNAL   Cell Res 27 (5), 604-605 (2017)
   PUBMED   28290465
REFERENCE   10 (bases 1 to 1605)
  AUTHORS   Matsumoto,A., Pasut,A., Matsumoto,M., Yamashita,R., Fung,J.,
            Monteleone,E., Saghatelian,A., Nakayama,K.I., Clohessy,J.G. and
            Pandolfi,P.P.
  TITLE     mTORC1 and muscle regeneration are regulated by the
            LINC00961-encoded SPAR polypeptide
  JOURNAL   Nature 541 (7636), 228-232 (2017)
   PUBMED   28024296
  REMARK    GeneRIF: data provide a mechanism by which mTORC1 activation may be
            finely regulated in a tissue-specific manner in response to injury,
            and a paradigm by which lncRNAs encoding small polypeptides like
            SPAR can modulate general biological pathways and processes to
            facilitate tissue-specific requirements, consistent with their
            restricted and highly regulated expression profile
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK056723.1, BC113682.1, AA807870.1 and AL135841.11.
            
            On May 17, 2019 this sequence version replaced NM_001348107.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK056723.1, SRR5189655.86859.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000443779.3/
                                                ENSP00000490187.1
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-366               AK056723.1         8-373
            367-974             BC113682.1         235-842
            975-1292            AK056723.1         982-1299
            1293-1356           AK056723.1         1301-1364
            1357-1540           AA807870.1         66-249              c
            1541-1605           AL135841.11        36224-36288
FEATURES             Location/Qualifiers
     source          1..1605
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.3"
     gene            1..1605
                     /gene="SPAAR"
                     /gene_synonym="LINC00961; SPAR"
                     /note="small regulatory polypeptide of amino acid
                     response"
                     /db_xref="GeneID:158376"
                     /db_xref="HGNC:HGNC:27244"
                     /db_xref="MIM:617627"
     exon            1..75
                     /gene="SPAAR"
                     /gene_synonym="LINC00961; SPAR"
                     /inference="alignment:Splign:2.1.0"
     exon            76..1605
                     /gene="SPAAR"
                     /gene_synonym="LINC00961; SPAR"
                     /inference="alignment:Splign:2.1.0"
     CDS             383..610
                     /gene="SPAAR"
                     /gene_synonym="LINC00961; SPAR"
                     /note="small regulatory polypeptide of amino acids
                     response; long intergenic non-protein coding RNA 961"
                     /codon_start=1
                     /product="small regulatory polypeptide of amino acid
                     response"
                     /protein_id="NP_001335036.2"
                     /db_xref="CCDS:CCDS94407.1"
                     /db_xref="GeneID:158376"
                     /db_xref="HGNC:HGNC:27244"
                     /db_xref="MIM:617627"
                     /translation="METAVIGVVVVLFVVTVAITCVLCCFSCDSRAQDPQGGPGRSFT
                     VATFRQEASLFTGPVRHAQPVPSAQDFWTFM"
     regulatory      1277..1282
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPAAR"
                     /gene_synonym="LINC00961; SPAR"
                     /note="hexamer: AATAAG"
     polyA_site      1296
                     /gene="SPAAR"
                     /gene_synonym="LINC00961; SPAR"
                     /note="major polyA site"
     regulatory      1515..1520
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPAAR"
                     /gene_synonym="LINC00961; SPAR"
                     /note="hexamer: AATAAA"
     polyA_site      1540
                     /gene="SPAAR"
                     /gene_synonym="LINC00961; SPAR"
                     /note="major polyA site"
ORIGIN      
        1 acagaggctg cagcacccag ggaggaacgc cgtggtccct gggacggcca ccaggccagg
       61 aggctgcagc accagggaat ctgtgctcac gtcttccagg acagtgcttc ttctagaagc
      121 tgacatggag ctgaccacag ctcttggagg catggcctga ggcttagaaa atagacagag
      181 atcatctgag atttcagcag tggggccacg tggcagcgcc cgaaggcctg gagcaggagc
      241 gacccaggga ctcagagcag catcttctta ggagacggaa ggagagccgc cggaggagca
      301 cggggcacct gcgatcgcga agagcctcct gttctggatg ggagcgaagg ctccgagagg
      361 acctaaggtt gctcagtggg ccatggaaac ggcagtgatt ggggtggtgg tggtgctgtt
      421 cgtggtgact gtggccatca cctgcgtcct ctgctgcttc agctgtgact caagggccca
      481 ggatcctcag gggggtcctg gccgcagctt cacggtggcc acgtttcgcc aggaagcttc
      541 tctcttcacg gggcctgttc gccatgccca gccagtgcca agtgcccagg acttctggac
      601 cttcatgtga cgcccgagtc cccaggattt gctgtgctga tgggtcagac tcacccgctc
      661 ctcagcaagc cttccctggc cttcccctcc tcccagggcc ttctccctgt ccttcccctc
      721 cagtaacctg tgaacttccc gtctcctccc attccagcct tctgtgccct ccagcctcag
      781 ggatccttgt tattgggaca gcccagctgg ggttgaccca caggatgggg cttaggagag
      841 ctctgaggag tgagtgaaca gacagcgccg gagtgcacgg tgggccggct ctgctgatct
      901 acaccaggaa ctgaaatatc actggaattt attgtaaacg gtgtgcctat gatgctggtt
      961 ctgttgccac ctgggcacgc agcaccctca agtggacatt tctagaaacc gcttcttact
     1021 tgctcctaat tgattacttt tgcacattgc acagaaccca acctcgaggc ctgctccctg
     1081 ccagttgcct gaaatcagcc ctgaaattct gaaaccaaag agctgcttcc tgagaacaag
     1141 ttatttacct tagaattgaa aatgtatatc cttttatggg cctttccaaa tctgattaga
     1201 aaaaccacaa aaggaaacag aagagaaaat aagagccaca gaaagtacaa tatgttttat
     1261 taacaggaaa gccagaaata agatatttta aacatatttt taatgagact ttattgctat
     1321 attccaacag gtcactccta ttcttagaga atgtgaatga cttgtgtcac ttcggagtga
     1381 cagaaaaatc aggaactgaa agataattcc agacaagtta aaatgttatg ttacattcaa
     1441 agctcttgtt ttcatcacaa ataaggggat attcagtttt tattaacaga aaacccattc
     1501 tcccatggcc atggaataaa tgccatgcta tatttaagga gtttggtttg aagggtgcaa
     1561 aattgtgagc ctcctggctc ttatgtctgt atccagccct gaata
//
