LOCUS       NM_017425               3604 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens sperm autoantigenic protein 17 (SPA17), mRNA.
ACCESSION   NM_017425
VERSION     NM_017425.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3604)
  AUTHORS   Afsari,M., Fesahat,F., Talebi,A.R., Agarwal,A., Henkel,R., Zare,F.,
            Gul,M., Iraci,N., Cannarella,R., Makki,M., Anvari,M.,
            Sarcheshmeh,A.A. and Talebi,A.H.
  TITLE     ANXA2, SP17, SERPINA5, PRDX2 genes, and sperm DNA fragmentation
            differentially represented in male partners of infertile couples
            with normal and abnormal sperm parameters
  JOURNAL   Andrologia 54 (10), e14556 (2022)
   PUBMED   36177795
  REMARK    GeneRIF: ANXA2, SP17, SERPINA5, PRDX2 genes, and sperm DNA
            fragmentation differentially represented in male partners of
            infertile couples with normal and abnormal sperm parameters.
REFERENCE   2  (bases 1 to 3604)
  AUTHORS   Dahlin,H.R., Zheng,N. and Scott,J.D.
  TITLE     Beyond PKA: Evolutionary and structural insights that define a
            docking and dimerization domain superfamily
  JOURNAL   J Biol Chem 297 (2), 100927 (2021)
   PUBMED   34256050
REFERENCE   3  (bases 1 to 3604)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 3604)
  AUTHORS   You,H., Dang,G., Lu,B., Zhang,S., Li,C., Wang,L., Hu,Y., Chen,H.,
            Zhang,J. and He,W.
  TITLE     Serum Sp17 Autoantibody Serves as a Potential Specific Biomarker in
            Patients with SAPHO Syndrome
  JOURNAL   J Clin Immunol 41 (3), 565-575 (2021)
   PUBMED   33392854
  REMARK    GeneRIF: Serum Sp17 Autoantibody Serves as a Potential Specific
            Biomarker in Patients with SAPHO Syndrome.
REFERENCE   5  (bases 1 to 3604)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3604)
  AUTHORS   De Jong,A., Buchli,R. and Robbins,D.
  TITLE     Characterization of sperm protein 17 in human somatic and
            neoplastic tissue
  JOURNAL   Cancer Lett 186 (2), 201-209 (2002)
   PUBMED   12213290
  REMARK    GeneRIF: Sp17 has different expression patterns in cancer cell
            lines as compared to normal non-testes tissues and a potential
            pathogenic role in diseased cells
REFERENCE   7  (bases 1 to 3604)
  AUTHORS   Fujita,A., Nakamura,K., Kato,T., Watanabe,N., Ishizaki,T.,
            Kimura,K., Mizoguchi,A. and Narumiya,S.
  TITLE     Ropporin, a sperm-specific binding protein of rhophilin, that is
            localized in the fibrous sheath of sperm flagella
  JOURNAL   J Cell Sci 113 (Pt 1), 103-112 (2000)
   PUBMED   10591629
REFERENCE   8  (bases 1 to 3604)
  AUTHORS   McLeskey,S.B., Dowds,C., Carballada,R., White,R.R. and Saling,P.M.
  TITLE     Molecules involved in mammalian sperm-egg interaction
  JOURNAL   Int Rev Cytol 177, 57-113 (1998)
   PUBMED   9378618
  REMARK    Review article
REFERENCE   9  (bases 1 to 3604)
  AUTHORS   Lea,I.A., Richardson,R.T., Widgren,E.E. and O'Rand,M.G.
  TITLE     Cloning and sequencing of cDNAs encoding the human sperm protein,
            Sp17
  JOURNAL   Biochim Biophys Acta 1307 (3), 263-266 (1996)
   PUBMED   8688458
REFERENCE   10 (bases 1 to 3604)
  AUTHORS   Kong,M., Richardson,R.T., Widgren,E.E. and O'Rand,M.G.
  TITLE     Sequence and localization of the mouse sperm autoantigenic protein,
            Sp17
  JOURNAL   Biol Reprod 53 (3), 579-590 (1995)
   PUBMED   7578682
  REMARK    Erratum:[Biol Reprod 1995 Nov;53(5):1239]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF334735.1 and AP000890.4.
            
            On Feb 27, 2020 this sequence version replaced NM_017425.3.
            
            Summary: This gene encodes a protein present at the cell surface.
            The N-terminus has sequence similarity to human cAMP-dependent
            protein kinase A (PKA) type II alpha regulatory subunit (RIIa)
            while the C-terminus has an IQ calmodulin-binding motif. The
            central portion of the protein has carbohydrate binding motifs and
            likely functions in cell-cell adhesion. The protein was initially
            characterized by its involvement in the binding of sperm to the
            zona pellucida of the oocyte. Recent studies indicate that it is
            also involved in additional cell-cell adhesion functions such as
            immune cell migration and metastasis. A retrotransposed pseudogene
            is present on chromosome 10q22.[provided by RefSeq, Jan 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853563.6502.1,
                                           SRR14038191.2085580.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000227135.7/ ENSP00000227135.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-880               AF334735.1         60-939
            881-3604            AP000890.4         72128-74851
FEATURES             Location/Qualifiers
     source          1..3604
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.2"
     gene            1..3604
                     /gene="SPA17"
                     /gene_synonym="CT22; SP17; SP17-1"
                     /note="sperm autoantigenic protein 17"
                     /db_xref="GeneID:53340"
                     /db_xref="HGNC:HGNC:11210"
                     /db_xref="MIM:608621"
     exon            1..49
                     /gene="SPA17"
                     /gene_synonym="CT22; SP17; SP17-1"
                     /inference="alignment:Splign:2.1.0"
     exon            50..230
                     /gene="SPA17"
                     /gene_synonym="CT22; SP17; SP17-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..532
                     /gene="SPA17"
                     /gene_synonym="CT22; SP17; SP17-1"
                     /note="sperm protein 17; cancer/testis antigen 22"
                     /codon_start=1
                     /product="sperm surface protein Sp17"
                     /protein_id="NP_059121.1"
                     /db_xref="CCDS:CCDS8450.1"
                     /db_xref="GeneID:53340"
                     /db_xref="HGNC:HGNC:11210"
                     /db_xref="MIM:608621"
                     /translation="MSIPFSNTHYRIPQGFGNLLEGLTREILREQPDNIPAFAAAYFE
                     SLLEKREKTNFDPAEWGSKVEDRFYNNHAFEEQEPPEKSDPKQEESQISGKEEETSVT
                     ILDSSEEDKEKEEVAAVKIQAAFRGHIAREEAKKMKTNSLQNEEKEENK"
     exon            231..301
                     /gene="SPA17"
                     /gene_synonym="CT22; SP17; SP17-1"
                     /inference="alignment:Splign:2.1.0"
     exon            302..388
                     /gene="SPA17"
                     /gene_synonym="CT22; SP17; SP17-1"
                     /inference="alignment:Splign:2.1.0"
     exon            389..3604
                     /gene="SPA17"
                     /gene_synonym="CT22; SP17; SP17-1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      660
                     /gene="SPA17"
                     /gene_synonym="CT22; SP17; SP17-1"
     regulatory      850..855
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPA17"
                     /gene_synonym="CT22; SP17; SP17-1"
                     /note="hexamer: AATAAA"
     polyA_site      880
                     /gene="SPA17"
                     /gene_synonym="CT22; SP17; SP17-1"
                     /note="major polyA site"
     regulatory      1476..1481
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SPA17"
                     /gene_synonym="CT22; SP17; SP17-1"
                     /note="hexamer: AATATA"
     polyA_site      1505
                     /gene="SPA17"
                     /gene_synonym="CT22; SP17; SP17-1"
ORIGIN      
        1 aactagaaaa acaaccggaa ccggcggcac cagctcggag agaaaggagg ttccataggc
       61 agttcttacc aagaagatgt cgattccatt ctccaacacc cactaccgaa ttccacaagg
      121 atttgggaat cttcttgaag ggctgacacg cgagattctg agagagcaac cggacaatat
      181 accagctttt gcagcagcct attttgagag ccttctagag aaaagagaga aaaccaactt
      241 tgatccagca gaatggggga gtaaggtaga agaccgcttc tataacaatc atgcattcga
      301 ggagcaagaa ccacctgaga aaagtgatcc taaacaagaa gagtctcaga tatctgggaa
      361 ggaggaagag acatcagtca ccatcttaga ctcttctgag gaagataagg aaaaagaaga
      421 ggttgctgct gtcaaaatcc aagctgcctt ccggggacac atagccagag aggaggcaaa
      481 gaaaatgaaa acaaatagtc ttcaaaatga ggaaaaagag gaaaacaagt gaggacactg
      541 gttttacctc caggaaacat gaaaaataat ccaaatccat caaccttctt attaatgtca
      601 tttcttcctg aggaaggaag atttgatgtt gtgaaataac attcgttact gttgtgaaaa
      661 tctgtcatga gcatttgttt aataagcata ccattgaaac atgccacttg aagatttctc
      721 tgagatcatg agtttgttta cacttgtctc aagcctatct atagagaccc ttggatttag
      781 aattatagaa ctaaagtatc tgagattaca gagatctcag aggttatgtg ttctaactat
      841 tatcaaatga ataaatcctc tctatcacat cccccaaaaa tgttctttag ctcctgtttc
      901 actcctagtg gtaaagaatt tcactgcttt ttaaggatag tctatttaat tttggaattt
      961 ttagaaagat aagctgggac aaaaatctgc ctccttcagc ctggccaaca tggtgaaacc
     1021 ccatgtctac taaaagtaca aaaattggcc aggcgtggtg cgcacacctg taatcccagc
     1081 tactcgggag gctgaggcag gagaatcgct tgaacctggg aagtggaggc tgcagtaagc
     1141 cgagatcgca ccactgcact ccagcctggg cgacagagca agactctgtc tcaaaaacaa
     1201 aacaaaacaa aaaaaagcct ctgcctcctt gtaagtttaa cccactggtt ttcatttatc
     1261 atacatgtat tcaatcattt attgaaaatg tattgagtac tattcatgtg ctgggaatta
     1321 gtagtgaata cttgttctta cactcataca acttacaatg ctttattgtt ttgctctcca
     1381 gaaccacaca gaacaagact aataacatca tattgtaaaa agcaaaagct atcatatcat
     1441 gctgccttct tcagttaaaa cttcccaagt ttttaaatat acaatggtaa tgcctgttta
     1501 acaaactcag aggctttatc tcttttatgt tttcaatgat tcattcaaat ccctagtgcc
     1561 ttagttttag aaagttccgt ctctcctttt tgaggcctct ccacccttga ttgtccaaga
     1621 aactgagggt tcatgtctta gaccaaaggg tgcagttctc ttcccaatac aaaaggtaga
     1681 aagtggagtc ttaccattta gttaatgctg ttgccttcta ccataatgtt gtagcatagt
     1741 ccagcagact gaggtgattc tctggctggt tccaattcct gcctgcacca tagtggatgg
     1801 cccatgattt agttccagga ttacatctct cttggtttat agtcacaaag ccagtgttcc
     1861 cccaaagctt aaaaacaagc caggatggct cagtcctgag gagattctaa aaccaggtct
     1921 atgttgtcac aacaaatact ctcctacaaa cactttgatc cttgtcctag gcttagacat
     1981 gctctttctg caaagcagtt ttatttcagg tgcctcactg cccttccctg gcactgagcc
     2041 tttatcaggc tctgcaacag aggttccccc aagtgatcgc cactcaaaca cagttgattc
     2101 acaccaaccc tttcaaggtt gtggctttca ttctctaatg tccactcata caggcagcct
     2161 ttctccttcc aaaatcttgc tgccactgta gagagtttca tgctagctaa acacaagtct
     2221 ctaatatccc ccttcctctc ctccttaacc cctctcctcc aggcttacag aggaaaagaa
     2281 atcagttctc ctccaggatt ccagctgttc gtccctccca ttccactgaa agcaccagct
     2341 tctaacacct tcccctctca gacagagcca tcctgcttag cggattgtca aggggggacc
     2401 cagaatttat gcaaagactt agattccctg acctggagag atcagaagag gaaaaaaggg
     2461 attttttccc tagtgagtat atagcaggaa aaaaaaaaaa gatgagttag ctttttcagt
     2521 aattctcctg ttatacacat aaagtgacta gcactatgca ttccatacac acacacacac
     2581 acacacagat ctcatggtag tgatattggt agtgaaggag gaaaaggaaa aggtgagcaa
     2641 tggatgtgat attatgagaa caacacatat gaatgacact ttattagaac ttatctggtt
     2701 ttcctcttat ctctctggct gttccttctc aattcccttc actggtaact cttcaactcc
     2761 ccaaccacta aatgctaagt gcccttaggc tcagtctttc gaccccattt ctacactcac
     2821 ttgatttcct gcagtttcat agctttaaaa tccaatcttc ttaatgatca ctcccagacc
     2881 tttctctcct ctgcctgcga acttctatat tcaactgcct acataacatc cccatttgga
     2941 tgtctatagg catctcaaaa gtaacatata aaaaatgaat cctgatattg cccccaaatc
     3001 tgaaacttcc cccacaccca agtttttcca ttcaaaaatg gctgctccat tcttccattt
     3061 gctcaggcca aaaaccttgg attcatcttt aatgcgtcac tttctttcac accccatata
     3121 caatctatca gcaaaacctg tgggctgtac ctataaaata atactcagaa tctgcctact
     3181 tctaaccact tccattgtta ccgccttggt cctagttccc atgatagcct tgtgaattat
     3241 tgcaataacc tatattggcc agtgattatc tcactactac tgcacaaccc attccaaagt
     3301 tagtggttta agacaattat attttctcct gggtctgtag gtcagtggta atgtagctaa
     3361 gctaggctgg actacaatct caaggttagg ttcaggtcag ctctaagctg tgggtttgtg
     3421 ggctgacagg aaggtctgct tcaggctgtg ggcccaaggg tcagctgcag cacagtgcct
     3481 ctgcttcacg tgtccttttc tgagcccctg ctgaaagacg ttatccagga caagctcttc
     3541 tcatgctggt cacagaagac aagcaggaaa acccagcatg caagaatatt tcaagctttt
     3601 gctc
//
