LOCUS       NM_001003845            2047 bp    mRNA    linear   PRI 23-MAR-2024
DEFINITION  Homo sapiens Sp5 transcription factor (SP5), mRNA.
ACCESSION   NM_001003845 XM_371581
VERSION     NM_001003845.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2047)
  AUTHORS   Liu,S., Chen,X., Zhang,L. and Lu,B.
  TITLE     CPT1A mediates the succinylation of SP5 which activates
            transcription of PDPK1 to promote the viability and glycolysis of
            prostate cancer cells
  JOURNAL   Cancer Biol Ther 25 (1), 2329372 (2024)
   PUBMED   38494680
  REMARK    GeneRIF: CPT1A mediates the succinylation of SP5 which activates
            transcription of PDPK1 to promote the viability and glycolysis of
            prostate cancer cells.
REFERENCE   2  (bases 1 to 2047)
  AUTHORS   Zhi,Y., Gao,Q., Wang,Z., Dong,Y., Guan,Y., Yuan,J. and Zhang,Z.
  TITLE     Circular RNA circSP5 promotes liver metastasis of colorectal cancer
            via SP5-mediated BAMBI transcription
  JOURNAL   Funct Integr Genomics 23 (3), 275 (2023)
   PUBMED   37596430
  REMARK    GeneRIF: Circular RNA circSP5 promotes liver metastasis of
            colorectal cancer via SP5-mediated BAMBI transcription.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2047)
  AUTHORS   Huggins,I.J., Bos,T., Gaylord,O., Jessen,C., Lonquich,B.,
            Puranen,A., Richter,J., Rossdam,C., Brafman,D., Gaasterland,T. and
            Willert,K.
  TITLE     The WNT target SP5 negatively regulates WNT transcriptional
            programs in human pluripotent stem cells
  JOURNAL   Nat Commun 8 (1), 1034 (2017)
   PUBMED   29044119
  REMARK    GeneRIF: SP5 negatively regulates WNT3a transcriptional programs in
            human pluripotent stem cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2047)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   5  (bases 1 to 2047)
  AUTHORS   Chen,Y., Guo,Y., Ge,X., Itoh,H., Watanabe,A., Fujiwara,T.,
            Kodama,T. and Aburatani,H.
  TITLE     Elevated expression and potential roles of human Sp5, a member of
            Sp transcription factor family, in human cancers
  JOURNAL   Biochem Biophys Res Commun 340 (3), 758-766 (2006)
   PUBMED   16380080
  REMARK    GeneRIF: human Sp5 is a member of Sp transcription factor family
            with a role in human cancers
REFERENCE   6  (bases 1 to 2047)
  AUTHORS   Suske,G., Bruford,E. and Philipsen,S.
  TITLE     Mammalian SP/KLF transcription factors: bring in the family
  JOURNAL   Genomics 85 (5), 551-556 (2005)
   PUBMED   15820306
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC007405.6, CN275885.1, AB096175.1, BQ064677.1 and AW450640.1.
            
            On May 17, 2019 this sequence version replaced NM_001003845.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB096175.1, DRR138524.1160346.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375281.4/ ENSP00000364430.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AC007405.6         174056-174065       c
            11-14               CN275885.1         6-9
            15-1527             AB096175.1         1-1513
            1528-1869           BQ064677.1         402-743
            1870-1957           AW450640.1         17-104              c
            1958-2047           AC007405.6         171324-171413       c
FEATURES             Location/Qualifiers
     source          1..2047
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q31.1"
     gene            1..2047
                     /gene="SP5"
                     /note="Sp5 transcription factor"
                     /db_xref="GeneID:389058"
                     /db_xref="HGNC:HGNC:14529"
                     /db_xref="MIM:609391"
     exon            1..227
                     /gene="SP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..1373
                     /gene="SP5"
                     /codon_start=1
                     /product="transcription factor Sp5"
                     /protein_id="NP_001003845.1"
                     /db_xref="CCDS:CCDS33322.1"
                     /db_xref="GeneID:389058"
                     /db_xref="HGNC:HGNC:14529"
                     /db_xref="MIM:609391"
                     /translation="MAAVAVLRNDSLQAFLQDRTPSASPDLGKHSPLALLAATCSRIG
                     QPGAAAPPDFLQVPYDPALGSPSRLFHPWTADMPAHSPGALPPPHPSLGLTPQKTHLQ
                     PSFGAAHELPLTPPADPSYPYEFSPVKMLPSSMAALPASCAPAYVPYAAQAALPPGYS
                     NLLPPPPPPPPPPTCRQLSPNPAPDDLPWWSIPQAGAGPGASGVPGSGLSGACAGAPH
                     APRFPASAAAAAAAAAALQRGLVLGPSDFAQYQSQIAALLQTKAPLAATARRCRRCRC
                     PNCQAAGGAPEAEPGKKKQHVCHVPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCG
                     KSFTRSDELQRHLRTHTGEKRFACPECGKRFMRSDHLAKHVKTHQNKKLKVAEAGVKR
                     EDARDL"
     exon            228..2047
                     /gene="SP5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1827..1832
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SP5"
                     /note="hexamer: AATAAA"
     polyA_site      1857
                     /gene="SP5"
     regulatory      1913..1918
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SP5"
                     /note="hexamer: AATAAA"
     polyA_site      1957
                     /gene="SP5"
                     /note="major polyA site"
ORIGIN      
        1 agaccgcgcg cggggcgagc gagcggggcg cggcgagggg caagggcggg gagggccccg
       61 gcgctcagag caggcgccag ggaggcaggc tgggcggccc ttcgtcctcg ccttcgggtg
      121 tccatgcctc ggcggcggcg tcccgctccg cagccagggg cctgcaagcc gtagccatgg
      181 ccgcggtggc cgtcctccgg aacgactcgc tgcaggcctt tctccaggac cgcaccccca
      241 gcgcctcccc ggacctgggc aagcactcgc ccctggcatt gctggccgcc acctgtagcc
      301 gcatcggcca gccgggcgcg gcggcgcccc cggacttcct gcaggtgccc tacgaccccg
      361 cgctgggctc accctccagg ctcttccacc cgtggaccgc cgacatgccg gcgcactcgc
      421 caggcgcact gccgcccccg catcccagct tggggctgac gccgcagaag acgcacctgc
      481 agccgtcctt cggggctgcg cacgagcttc cccttacacc ccccgccgac ccctcgtacc
      541 cctacgagtt ctcgccggtc aagatgctgc cctcgagcat ggcggctctg cccgccagct
      601 gcgcgcccgc ctacgtgccc tacgcggcgc aggccgcgct gccgccaggc tactccaacc
      661 tgctgcctcc gccgccgcca ccgcccccgc cgcccacctg ccgccagttg tcacccaacc
      721 cggcccccga cgacctcccg tggtggagca tcccgcaggc gggcgccggg ccgggggcct
      781 ccggggttcc gggaagcggc ctctccggcg cctgtgccgg ggccccccac gcgccccgct
      841 tccccgcctc tgcggccgct gctgctgcgg ccgccgccgc cctacaaaga ggcctggtgt
      901 tgggcccgtc ggactttgcg cagtaccaga gccagatcgc cgcgctgctg cagaccaagg
      961 cccccctggc ggccacggcc aggaggtgcc gccgctgccg ctgtcccaac tgccaggcgg
     1021 cgggcggcgc ccccgaggcg gagccgggga agaagaagca gcacgtgtgc cacgtgccgg
     1081 gctgcggcaa ggtgtacggg aagacgtcgc acctgaaggc gcacctgcgc tggcacacgg
     1141 gcgagcgacc cttcgtgtgc aactggctct tctgcgggaa gagcttcacg cgctcggacg
     1201 agctgcagcg gcacctgcgg actcacacgg gcgagaagcg ctttgcctgt cccgagtgcg
     1261 gcaagcgctt catgcgcagc gaccacctcg cgaagcacgt caagactcac cagaataaga
     1321 agctcaaagt cgctgaggcc ggggttaagc gggaggacgc gcgggacctg tgagccctcc
     1381 cggaggtgga cccccttccc agcacctctg cgagagatcc ggggacctgt gggcagctgg
     1441 cggaggggag actcagcaga cggaccctct ccgttgcctg cctcccaaaa tggagccagg
     1501 cttccaactt ccgctgcctt cggacatagg gacccagttc ccaggagcgg ggaggtaggg
     1561 ttggggctgg ggcatttgga ttgtaattgg gagctctgcc gtacgccagg gcggttccaa
     1621 actctaaacc gttcccaccg tcagggagac ctacagtttc gggggaccac cctggtctgg
     1681 ccttgtatat aggaaatgct gctgaactga atagaaagga acttgggaga tttgaaacag
     1741 tgctcgggtt ttcgctagga ccggtttggg ctttgtacag gttatttaat agctttgtta
     1801 aagataatta taataattat aacattaata aaaatgttgc ttttgtcttc agctccatgc
     1861 agagctacag catgatatgt ctctgtaaag tgatcagcag ttgcagcgtg aaaataaata
     1921 ctttaactca ggggtcacta caggaagacc ccgttgagcc ggtctcattt gatcttttct
     1981 tcttctgggt ggctgtacta agcggtcggg tttccccggg aatttgatgg ttcctatagt
     2041 ctgcctg
//
