LOCUS       NM_003112               6077 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens Sp4 transcription factor (SP4), transcript variant 1,
            mRNA.
ACCESSION   NM_003112
VERSION     NM_003112.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6077)
  AUTHORS   Wei,L., Deng,C., Zhang,B., Wang,G., Meng,Y. and Qin,H.
  TITLE     SP4 Facilitates Esophageal Squamous Cell Carcinoma Progression by
            Activating PHF14 Transcription and Wnt/Beta-Catenin Signaling
  JOURNAL   Mol Cancer Res 22 (1), 55-69 (2024)
   PUBMED   37768180
  REMARK    GeneRIF: SP4 Facilitates Esophageal Squamous Cell Carcinoma
            Progression by Activating PHF14 Transcription and Wnt/Beta-Catenin
            Signaling.
REFERENCE   2  (bases 1 to 6077)
  AUTHORS   Dai,X., Luo,S., Guo,S., Zhou,W. and Song,W.
  TITLE     Sp4 Regulates PTTG1IP Gene Transcription and Expression
  JOURNAL   DNA Cell Biol 41 (12), 1053-1062 (2022)
   PUBMED   36383136
  REMARK    GeneRIF: Sp4 Regulates PTTG1IP Gene Transcription and Expression.
REFERENCE   3  (bases 1 to 6077)
  AUTHORS   Zhang,Q., Huo,J.H., Guo,L., Wang,L., Wang,C. and Li,M.
  TITLE     Common and rare variants within SP4 exert distinct molecular
            mechanisms contributing to the risk of schizophrenia
  JOURNAL   Psychiatry Res 318, 114948 (2022)
   PUBMED   36372009
  REMARK    GeneRIF: Common and rare variants within SP4 exert distinct
            molecular mechanisms contributing to the risk of schizophrenia.
REFERENCE   4  (bases 1 to 6077)
  AUTHORS   Cui,Y., Wang,W., Luo,P., Feng,Y., Mi,C. and Jia,A.
  TITLE     The genetic polymorphisms in the SP4 gene and the risk of gastric
            cancer
  JOURNAL   Future Oncol 18 (36), 3993-4004 (2022)
   PUBMED   36346067
  REMARK    GeneRIF: The genetic polymorphisms in the SP4 gene and the risk of
            gastric cancer.
REFERENCE   5  (bases 1 to 6077)
  AUTHORS   Gu,T., Pan,H., Zhang,F., Wang,L. and Cheng,Z.
  TITLE     The FOXP4-AS1/miR-3130-3p/SP4 feedback loop is associated with
            prostate cancer
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 68 (10), 161-166 (2022)
   PUBMED   37114256
  REMARK    GeneRIF: The FOXP4-AS1/miR-3130-3p/SP4 feedback loop is associated
            with prostate cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6077)
  AUTHORS   Suske,G.
  TITLE     The Sp-family of transcription factors
  JOURNAL   Gene 238 (2), 291-300 (1999)
   PUBMED   10570957
  REMARK    Review article
REFERENCE   7  (bases 1 to 6077)
  AUTHORS   Hagen,G., Dennig,J., Preiss,A., Beato,M. and Suske,G.
  TITLE     Functional analyses of the transcription factor Sp4 reveal
            properties distinct from Sp1 and Sp3
  JOURNAL   J Biol Chem 270 (42), 24989-24994 (1995)
   PUBMED   7559627
REFERENCE   8  (bases 1 to 6077)
  AUTHORS   Kalff-Suske,M., Kunz,J., Grzeschik,K.H. and Suske,G.
  TITLE     Human Sp4 transcription factor gene (SP4) maps to chromosome 7p15
  JOURNAL   Genomics 26 (3), 631-633 (1995)
   PUBMED   7607696
REFERENCE   9  (bases 1 to 6077)
  AUTHORS   Majello,B., De Luca,P., Hagen,G., Suske,G. and Lania,L.
  TITLE     Different members of the Sp1 multigene family exert opposite
            transcriptional regulation of the long terminal repeat of HIV-1
  JOURNAL   Nucleic Acids Res 22 (23), 4914-4921 (1994)
   PUBMED   7800480
REFERENCE   10 (bases 1 to 6077)
  AUTHORS   Hagen,G., Muller,S., Beato,M. and Suske,G.
  TITLE     Cloning by recognition site screening of two novel GT box binding
            proteins: a family of Sp1 related genes
  JOURNAL   Nucleic Acids Res 20 (21), 5519-5525 (1992)
   PUBMED   1454515
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK289728.1, AC004595.1 and
            BF438799.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_003112.4.
            
            Summary: The protein encoded by this gene is a transcription factor
            that can bind to the GC promoter region of a variety of genes,
            including those of the photoreceptor signal transduction system.
            The encoded protein binds to the same sites in promoter CpG islands
            as does the transcription factor SP1, although its expression is
            much more restricted compared to that of SP1. This gene may be
            involved in bipolar disorder and schizophrenia. [provided by
            RefSeq, May 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.151414.1,
                                           SRR1660803.26530.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000222584.8/ ENSP00000222584.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2706              AK289728.1         50-2755
            2707-5799           AC004595.1         102119-105211
            5800-6077           BF438799.1         5-282               c
FEATURES             Location/Qualifiers
     source          1..6077
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p15.3"
     gene            1..6077
                     /gene="SP4"
                     /gene_synonym="HF1B; SPR-1"
                     /note="Sp4 transcription factor"
                     /db_xref="GeneID:6671"
                     /db_xref="HGNC:HGNC:11209"
                     /db_xref="MIM:600540"
     exon            1..176
                     /gene="SP4"
                     /gene_synonym="HF1B; SPR-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..2524
                     /gene="SP4"
                     /gene_synonym="HF1B; SPR-1"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="transcription factor Sp4 isoform 1"
                     /protein_id="NP_003103.2"
                     /db_xref="CCDS:CCDS5373.1"
                     /db_xref="GeneID:6671"
                     /db_xref="HGNC:HGNC:11209"
                     /db_xref="MIM:600540"
                     /translation="MSDQKKEEEEEAAAAAAMATEGGKTSEPENNNKKPKTSGSQDSQ
                     PSPLALLAATCSKIGTPGENQATGQQQIIIDPSQGLVQLQNQPQQLELVTTQLAGNAW
                     QLVASTPPASKENNVSQPASSSSSSSSSNNGSASPTKTKSGNSSTPGQFQVIQVQNPS
                     GSVQYQVIPQLQTVEGQQIQINPTSSSSLQDLQGQIQLISAGNNQAILTAANRTASGN
                     ILAQNLANQTVPVQIRPGVSIPLQLQTLPGTQAQVVTTLPINIGGVTLALPVINNVAA
                     GGGTGQVGQPAATADSGTSNGNQLVSTPTNTTTSASTMPESPSSSTTCTTTASTSLTS
                     SDTLVSSADTGQYASTSASSSERTIEESQTPAATESEAQSSSQLQPNGMQNAQDQSNS
                     LQQVQIVGQPILQQIQIQQPQQQIIQAIPPQSFQLQSGQTIQTIQQQPLQNVQLQAVN
                     PTQVLIRAPTLTPSGQISWQTVQVQNIQSLSNLQVQNAGLSQQLTITPVSSSGGTTLA
                     QIAPVAVAGAPITLNTAQLASVPNLQTVSVANLGAAGVQVQGVPVTITSVAGQQQGQD
                     GVKVQQATIAPVTVAVGGIANATIGAVSPDQLTQVHLQQGQQTSDQEVQPGKRLRRVA
                     CSCPNCREGEGRGSNEPGKKKQHICHIEGCGKVYGKTSHLRAHLRWHTGERPFICNWM
                     FCGKRFTRSDELQRHRRTHTGEKRFECPECSKRFMRSDHLSKHVKTHQNKKGGGTALA
                     IVTSGELDSSVTEVLGSPRIVTVAAISQDSNPATPNVSTNMEEF"
     exon            177..292
                     /gene="SP4"
                     /gene_synonym="HF1B; SPR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            293..1847
                     /gene="SP4"
                     /gene_synonym="HF1B; SPR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..2076
                     /gene="SP4"
                     /gene_synonym="HF1B; SPR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2077..2276
                     /gene="SP4"
                     /gene_synonym="HF1B; SPR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2277..6077
                     /gene="SP4"
                     /gene_synonym="HF1B; SPR-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5994..5999
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SP4"
                     /gene_synonym="HF1B; SPR-1"
                     /note="hexamer: ATTAAA"
     polyA_site      6001
                     /gene="SP4"
                     /gene_synonym="HF1B; SPR-1"
                     /note="major polyA site"
     polyA_site      6016
                     /gene="SP4"
                     /gene_synonym="HF1B; SPR-1"
                     /note="major polyA site"
     regulatory      6052..6057
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SP4"
                     /gene_synonym="HF1B; SPR-1"
                     /note="hexamer: AATAAA"
     polyA_site      6077
                     /gene="SP4"
                     /gene_synonym="HF1B; SPR-1"
ORIGIN      
        1 acagcccagc ggcggccatt cgcggaaaaa gaggcagagc ctgtgccagc tacagcctcc
       61 tccgagccac cgcgggcggg cgggaccggc ctctcctccc gcctcgcccc cacccccacc
      121 cacctctatc ccagtgtctc cgtctgaggg tttgtcctgt taatgcggga tgagcgatca
      181 gaagaaggag gaggaggagg aggcggcagc ggcagcggcg atggctacag aaggagggaa
      241 aacctctgag ccagagaata acaataaaaa acccaaaacc tcaggctccc aggactctca
      301 gccctctcct ctggctttac tggcagctac ttgcagcaaa atagggactc ctggtgaaaa
      361 tcaagcaact ggacaacaac aaattattat agatccaagt caaggattgg tgcaacttca
      421 aaatcaacca caacagctag aactggtaac aacgcaactt gctggaaacg cttggcaact
      481 tgttgcctcc actcctcctg cttcaaaaga gaataacgtt tctcaaccag cctctagttc
      541 gtctagttct tccagcagta ataacgggag tgcatctcct acaaaaacta aatcaggtaa
      601 ttcttccacc cctggtcaat ttcaagtcat acaagtacaa aatccaagtg gtagtgtaca
      661 gtaccaagta attccacaac ttcagacagt ggaaggtcaa caaattcaaa tcaatccaac
      721 tagtagttca tctctacagg atttgcaggg tcaaattcag ctcatttctg caggtaataa
      781 tcaagctata ctcacagctg ctaacaggac agcttctggg aatattcttg ctcaaaacct
      841 ggcaaatcag acagttccgg tccaaattag acctggtgtt tcaataccac tgcagttaca
      901 gactcttcct ggtactcagg ctcaagttgt aacaacccta ccaattaaca ttggaggagt
      961 gactctagct ttgccagtga taaacaacgt ggctgccgga ggagggactg ggcaggttgg
     1021 ccagcctgct gctactgctg atagtgggac ttccaatggg aatcaattag tttccacacc
     1081 caccaacacc actacttctg ccagtactat gccagaatct ccctcctcct ccactacctg
     1141 cacaaccact gcttcaacgt ctttgacaag cagtgacaca ttagtgagct cagcagatac
     1201 tggccagtat gcaagcacat cagccagtag ttctgaacgc accattgaag aatctcaaac
     1261 acctgctgct actgagtctg aagcccagag ctccagtcag cttcagccta atggaatgca
     1321 gaatgcacag gatcaatcaa attctcttca gcaggtgcaa attgtaggcc aacctatctt
     1381 acagcagatc cagatccaac agcctcagca acagatcatt caggctattc caccacagtc
     1441 gtttcaactc cagtcagggc agacgattca gaccatccag cagcagcctt tacagaatgt
     1501 tcaacttcaa gcagtaaatc cgactcaggt gcttatcagg gctccaactt taacaccttc
     1561 agggcaaatc agttggcaaa ctgtacaggt tcagaatatt cagagtcttt caaatttgca
     1621 agttcagaat gctgggttat cccaacaatt aaccatcacc ccagtgtctt caagtggtgg
     1681 cacaactctt gctcagattg ctcctgtggc tgttgctggt gccccaataa ctttgaatac
     1741 tgcccagctt gcatcagtgc ctaaccttca gacagtgagc gttgccaacc tgggtgctgc
     1801 aggtgttcaa gtgcagggag ttcccgttac aatcactagt gttgcaggtc agcagcaagg
     1861 acaagatgga gtaaaagtcc agcaagctac tatagctcct gtaactgtag cagttggagg
     1921 aattgctaat gccacgatag gtgctgttag tcctgaccaa ctcacacaag tgcatttgca
     1981 gcaaggccag cagacttctg atcaagaggt acaacctggc aagaggcttc gaagagttgc
     2041 ctgttcctgt cctaattgta gggaaggaga aggaagaggc agtaatgaac caggaaaaaa
     2101 gaagcagcat atctgtcata ttgaaggatg tggtaaagtt tatggcaaaa catctcattt
     2161 acgagcacat cttcgctggc atactggaga aagacctttt atatgcaact ggatgttttg
     2221 tggcaaaaga ttcacacgga gtgatgagct ccagagacat agaagaaccc atacaggtga
     2281 aaagagattt gaatgcccgg aatgttctaa aaggtttatg cggagtgatc atctctccaa
     2341 acatgtcaaa acgcaccaga ataaaaaagg tggtgggaca gctcttgcca ttgttacctc
     2401 gggagaactg gactcatctg ttacagaggt gcttggctcc ccaagaattg tcacagttgc
     2461 agccatttct caagattcga atccagcaac tcccaatgtt tcaaccaaca tggaagaatt
     2521 ctgaaaagtt atttataaca gagacctcta gtgctgcact tgtttacaca cctttgaaaa
     2581 tctggaaatg ggctggtcaa gtggattaca gagtaggaaa ttatgttttc attcttggct
     2641 tctttaagta ttccagggtt tggggtcaac acgtgaagtg ttgaatttta aaaaatacaa
     2701 aaagcagact gatgtactgg aaacagaaaa gtatttcctc catactataa gttgtagttg
     2761 tttggaaata tatcacataa cctttataca gaatcttccc atctcttaat atcatgtgtt
     2821 aacatgttta aaaagacctt agtagtttgc aggctggacc ttaattggac ttattttctt
     2881 tgaaagtact ttgttataaa ttcagtcagt aataatttac gtgtattctt tttctctata
     2941 gcacagaaaa cagatagtta actgatgata gggataatac tgtatttcct tagcttgatt
     3001 tttggaaaat caaccgaaaa tagtttggcc gtcttttcta aatgttagaa attcttcaac
     3061 agttgaatta ggtaagttcc aaaacagtaa tctgagatgc atctcagatc tttattacca
     3121 ctacattata gtagtgtgta tgcagacaat cagtgaagtc caattacttt ctccatttgg
     3181 agacacaaga ggaacataga gttaaatctt aggttaaatt ttaggttgac accttaggaa
     3241 aatgctggga aaaaaatggt taaaacaaaa ctcatcatag cttcagaaaa ataaaatgag
     3301 gcatcttaac atgcaatgtt ctaaagttag gattgattat attcctaacc ctaggttgaa
     3361 ccacaaaatt tcatttaaaa tgtttatatt tggaaatatt tgcatagagt gtaaattgtt
     3421 ctgtagtttc atattttgta aatatgagtt atgttgacaa tgtgcagaat tctttatgct
     3481 ttgatgtggt agccaaagaa agaattacac ttttttccaa ggccagcaga aaattctctt
     3541 ttaactacat tgtaattctt gttttcctct actaaaaatt ggccagtccc attttatttc
     3601 tagtgctatg taagaaggta attaggaatt ataacacagt aatgttttta tgttacatca
     3661 ataactgaat tttccctaaa aattagccta atatataata gatatattat gaagcaaaac
     3721 ttttattttt gaaaaggcag aataattttc agtgaagtaa gtgactaaag aaaaaaacta
     3781 tattattgtt tatgcaaggg tcttacagga aagggtcttt tttttttttt ttttgagatg
     3841 gagtctcgct ctcttgccca ggctggagtg caatggcacg atctcagctt actgcaaccg
     3901 ccgcctccca ggttcaagcg attctcctgt cttagcctcc tgagtagctg ggattaacag
     3961 gcgcctgcca ccatgcctgg ctaatttttg tatttttagt agagacaggg tttcgccatg
     4021 ttggccaggc tggtttcaaa ctcctgacct caggtgatct gcccacctcg gcctcccaga
     4081 gtgctgggat tacaggcatg agccaccatg cccggctagg aaagggtctt actaggaaag
     4141 atggccaaaa gtttcatatg aaaaaaattg gattataaac cagtaactta aatattaata
     4201 aggatatttt atgttttaaa aaagtattta cacagaatca taatcagtga aattgaccat
     4261 ttgaaaacta aaagttttta cctacctgct caatttatta acatcattgc tttggggact
     4321 gtttgaatat aggtacgtgt tttcttgtgc attctctata atttcaggaa aagtactaat
     4381 gcgaattctc ttccaaaatt gtgatgtttc ttgtattttt gatgaaggag aaatactgta
     4441 atgatcactg tttacactat gtacacttta ggccagccct ttgtagcgtt atataaaact
     4501 gaaggtcttt tgtgctttca gtttgtataa aaaagctttg agattaaagg aaaaaaaaaa
     4561 tttttacact gtggttataa atttcaagtt tcttaaagct tttgtagact tgtaacagag
     4621 tctttaaatt taagttggat tttgtaaatt gttttgtata ttttatttaa tgtactctta
     4681 acaactgatg tatctggctt taaaacatca gaattggttt gttgttttgt ttggtacaga
     4741 ggagcatttg gtagtgttca ttttaatttt attatatagg agctgaaaca tcaaatatat
     4801 attttatcta tcattatgct acacaatcag tgctataaat ttttttatgc aaagaaactt
     4861 tcttaatgtt ttaatcatgt ttcctcagag tgacactttt tgttgttgtt aataccaagt
     4921 atgaacactc tgcatcatta ttccatgaac cagttctaat gcaaacctat gtatgtccat
     4981 tagaaatgga agttattttt taatcaacaa tgaggcctat tataaattta tcagatgaat
     5041 ctagatagct ttatagcata taaaatatgt taatttgtgt tagcaggtgc acatttcacc
     5101 actgaaatta gaaatatttt gacagtctgt tctgcatacc attctgagtc tacttttctg
     5161 tctttagaag aatcgtaaat ttcagtgtcc tttatttgac tcagtgggat atagctgtta
     5221 taagtaatag ggcacagatg tgcagtagag tcttgtttaa tggcatttca ctgttcattc
     5281 cctttaccac cgttataaaa cttttcttta ttgtaattat cagtgcaaag ctatgtattt
     5341 atcatggtaa aactccagtg ttagaatagt tttttcttac agtatacttt ctttggttag
     5401 gtttgtgtat gtgttgctga ttacattaga acttgatgtt aagtcattta tcacactctc
     5461 atgagagcag taataaaagt gtgtaatcta ggagaaaaag ttaatttgtc aaacttagat
     5521 aagcatgatg tttaggtcct atttttcaat tttataactg ttttattgca acaatatttg
     5581 tatttaagtc tccattttaa tgccttgtgg tgttttttta tgcatgtcac taagttgtca
     5641 tcccacataa attgatgtgc agcatagggt attaaatcta cataatgatt ttaaaacaga
     5701 aatagttgat ggtaaaatgt aaatgttttg caaaaattcc ttataaaaag ttttgtagta
     5761 acatttcact tgtaaatttt ttttgtaaaa aaaaaaaaat gaaaaaaaaa gatgaatcca
     5821 gaaaaaaacc tgtttcccat attctagaat ttagacaatt attctgccag caaagcctct
     5881 ggggctgtaa ttgacatttt tacagtgctg atttgtataa aatttgtttt ttgtggattt
     5941 ggaaataaaa tcatgtacaa gttgttgcct gcaataacaa ttgcaagtaa cctattaaaa
     6001 attcccttga gtttaacatg tttcatttaa ttatgtatac tataaagcag caataaatta
     6061 tttgaactat caaccta
//
