LOCUS       NM_003111              11714 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens Sp3 transcription factor (SP3), transcript variant 1,
            mRNA.
ACCESSION   NM_003111 XM_092672
VERSION     NM_003111.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11714)
  AUTHORS   Zheng,B., Geng,Y., Li,Y., Huang,H. and Liu,A.
  TITLE     Specificity protein 1/3 regulate T-cell acute lymphoblastic
            leukemia cell proliferation and apoptosis through beta-catenin by
            acting as targets of miR-495-3p
  JOURNAL   Ann Hematol 103 (8), 2945-2960 (2024)
   PUBMED   38829410
  REMARK    GeneRIF: Specificity protein 1/3 regulate T-cell acute
            lymphoblastic leukemia cell proliferation and apoptosis through
            beta-catenin by acting as targets of miR-495-3p.
REFERENCE   2  (bases 1 to 11714)
  AUTHORS   Tian,P., Du,D., Yang,L., Zhou,N. and Tao,L.
  TITLE     SP3-induced Timeless transcription contributes to cell growth of
            lung adenocarcinoma cells
  JOURNAL   PLoS One 19 (2), e0298295 (2024)
   PUBMED   38354174
  REMARK    GeneRIF: SP3-induced Timeless transcription contributes to cell
            growth of lung adenocarcinoma cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 11714)
  AUTHORS   Chen,L.Y., Chen,L.W., Hung,C.H., Lin,C.L., Wang,S.S. and Chang,P.J.
  TITLE     Caspase-Mediated Cleavage of the Transcription Factor Sp3: Possible
            Relevance to Cancer and the Lytic Cycle of Kaposi's
            Sarcoma-Associated Herpesvirus
  JOURNAL   Microbiol Spectr 10 (1), e0146421 (2022)
   PUBMED   35019687
  REMARK    GeneRIF: Caspase-Mediated Cleavage of the Transcription Factor Sp3:
            Possible Relevance to Cancer and the Lytic Cycle of Kaposi's
            Sarcoma-Associated Herpesvirus.
REFERENCE   4  (bases 1 to 11714)
  AUTHORS   Wen,S., Qin,Y., Wang,R., Yang,L., Zeng,H., Zhu,P., Li,Q., Qiu,Y.,
            Chen,S., Liu,Y., Hou,Y., Tang,X., Liu,M. and Tu,G.
  TITLE     A novel Lnc408 maintains breast cancer stem cell stemness by
            recruiting SP3 to suppress CBY1 transcription and increasing
            nuclear beta-catenin levels
  JOURNAL   Cell Death Dis 12 (5), 437 (2021)
   PUBMED   33934099
  REMARK    GeneRIF: A novel Lnc408 maintains breast cancer stem cell stemness
            by recruiting SP3 to suppress CBY1 transcription and increasing
            nuclear beta-catenin levels.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 11714)
  AUTHORS   Moran,K.M., Crusio,R.H., Chan,C.H., Grekova,M.C. and Richert,J.R.
  TITLE     Human transcription factor Sp3: genomic structure, identification
            of a processed pseudogene, and transcript analysis
  JOURNAL   Gene 341, 235-247 (2004)
   PUBMED   15474306
REFERENCE   6  (bases 1 to 11714)
  AUTHORS   Sapetschnig,A., Koch,F., Rischitor,G., Mennenga,T. and Suske,G.
  TITLE     Complexity of translationally controlled transcription factor Sp3
            isoform expression
  JOURNAL   J Biol Chem 279 (40), 42095-42105 (2004)
   PUBMED   15247228
  REMARK    GeneRIF: four isoforms derive from alternative translational start
            sites at positions 1, 37, 856, and 907; the transcriptional
            activity of all the Sp3 isoforms is regulated by SUMO modification
REFERENCE   7  (bases 1 to 11714)
  AUTHORS   Hernandez,E.M., Johnson,A., Notario,V., Chen,A. and Richert,J.R.
  TITLE     AUA as a translation initiation site in vitro for the human
            transcription factor Sp3
  JOURNAL   J Biochem Mol Biol 35 (3), 273-282 (2002)
   PUBMED   12297010
  REMARK    GeneRIF: Use of non-AUG (AUA) translation initiation site and
            alternate downstream start sites, results in multiple SP3 isoforms.
REFERENCE   8  (bases 1 to 11714)
  AUTHORS   Udvadia,A.J., Templeton,D.J. and Horowitz,J.M.
  TITLE     Functional interactions between the retinoblastoma (Rb) protein and
            Sp-family members: superactivation by Rb requires amino acids
            necessary for growth suppression
  JOURNAL   Proc Natl Acad Sci U S A 92 (9), 3953-3957 (1995)
   PUBMED   7732011
REFERENCE   9  (bases 1 to 11714)
  AUTHORS   Hagen,G., Muller,S., Beato,M. and Suske,G.
  TITLE     Cloning by recognition site screening of two novel GT box binding
            proteins: a family of Sp1 related genes
  JOURNAL   Nucleic Acids Res 20 (21), 5519-5525 (1992)
   PUBMED   1454515
REFERENCE   10 (bases 1 to 11714)
  AUTHORS   Kingsley,C. and Winoto,A.
  TITLE     Cloning of GT box-binding proteins: a novel Sp1 multigene family
            regulating T-cell receptor gene expression
  JOURNAL   Mol Cell Biol 12 (10), 4251-4261 (1992)
   PUBMED   1341900
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC016737.8, AC093399.6 and
            AC106900.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Oct 10, 2020 this sequence version replaced NM_003111.4.
            
            Summary: This gene belongs to a family of Sp1 related genes that
            encode transcription factors that regulate transcription by binding
            to consensus GC- and GT-box regulatory elements in target genes.
            This protein contains a zinc finger DNA-binding domain and several
            transactivation domains, and has been reported to function as a
            bifunctional transcription factor that either stimulates or
            represses the transcription of numerous genes. Transcript variants
            encoding different isoforms have been described for this gene, and
            one has been reported to initiate translation from a non-AUG (AUA)
            start codon. Additional isoforms, resulting from the use of
            alternate downstream translation initiation sites, have also been
            noted. A related pseudogene has been identified on chromosome 13.
            [provided by RefSeq, Feb 2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1). Alternative
            translation initiation from downstream, in-frame start codons
            produces shorter isoforms.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.2925973.1,
                                           SRR18074967.3188339.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000310015.12/ ENSP00000310301.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            regulatory uORF        :: PMID: 15247228
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-209               AC016737.8         29461-29669         c
            210-358             AC016737.8         28701-28849         c
            359-481             AC016737.8         28057-28179         c
            482-1841            AC016737.8         19169-20528         c
            1842-2034           AC093399.6         14360-14552         c
            2035-2231           AC093399.6         8837-9033           c
            2232-8255           AC093399.6         1-6024              c
            8256-11714          AC106900.3         144039-147497       c
FEATURES             Location/Qualifiers
     source          1..11714
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q31.1"
     gene            1..11714
                     /gene="SP3"
                     /gene_synonym="SPR2"
                     /note="Sp3 transcription factor"
                     /db_xref="GeneID:6670"
                     /db_xref="HGNC:HGNC:11208"
                     /db_xref="MIM:601804"
     exon            1..209
                     /gene="SP3"
                     /gene_synonym="SPR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      156..185
                     /regulatory_class="uORF"
                     /gene="SP3"
                     /gene_synonym="SPR2"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:15247228]"
                     /note="this uORF is predicted to encode a 9 aa peptide
                     (PMID:15247228)"
     CDS             203..2548
                     /gene="SP3"
                     /gene_synonym="SPR2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     specificity protein 3; GC-binding transcription factor
                     Sp3"
                     /codon_start=1
                     /product="transcription factor Sp3 isoform 1"
                     /protein_id="NP_003102.1"
                     /db_xref="CCDS:CCDS2254.1"
                     /db_xref="GeneID:6670"
                     /db_xref="HGNC:HGNC:11208"
                     /db_xref="MIM:601804"
                     /translation="MTAPEKPVKQEEMAALDVDSGGGGGGGGGHGEYLQQQQQHGNGA
                     VAAAAAAQDTQPSPLALLAATCSKIGPPSPGDDEEEAAAAAGAPAAAGATGDLASAQL
                     GGAPNRWEVLSATPTTIKDEAGNLVQIPSAATSSGQYVLPLQNLQNQQIFSVAPGSDS
                     SNGTVSSVQYQVIPQIQSADGQQVQIGFTGSSDNGGINQESSQIQIIPGSNQTLLASG
                     TPSANIQNLIPQTGQVQVQGVAIGGSSFPGQTQVVANVPLGLPGNITFVPINSVDLDS
                     LGLSGSSQTMTAGINADGHLINTGQAMDSSDNSERTGERVSPDINETNTDTDLFVPTS
                     SSSQLPVTIDSTGILQQNTNSLTTSSGQVHSSDLQGNYIQSPVSEETQAQNIQVSTAQ
                     PVVQHLQLQESQQPTSQAQIVQGITPQTIHGVQASGQNISQQALQNLQLQLNPGTFLI
                     QAQTVTPSGQVTWQTFQVQGVQNLQNLQIQNTAAQQITLTPVQTLTLGQVAAGGAFTS
                     TPVSLSTGQLPNLQTVTVNSIDSAGIQLHPGENADSPADIRIKEEEPDPEEWQLSGDS
                     TLNTNDLTHLRVQVVDEEGDQQHQEGKRLRRVACTCPNCKEGGGRGTNLGKKKQHICH
                     IPGCGKVYGKTSHLRAHLRWHSGERPFVCNWMYCGKRFTRSDELQRHRRTHTGEKKFV
                     CPECSKRFMRSDHLAKHIKTHQNKKGIHSSSTVLASVEAARDDTLITAGGTTLILANI
                     QQGSVSGIGTVNTSATSNQDILTNTEIPLQLVTVSGNETME"
     exon            210..358
                     /gene="SP3"
                     /gene_synonym="SPR2"
                     /inference="alignment:Splign:2.1.0"
     exon            359..481
                     /gene="SP3"
                     /gene_synonym="SPR2"
                     /inference="alignment:Splign:2.1.0"
     exon            482..1841
                     /gene="SP3"
                     /gene_synonym="SPR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..2034
                     /gene="SP3"
                     /gene_synonym="SPR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2035..2231
                     /gene="SP3"
                     /gene_synonym="SPR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2232..11714
                     /gene="SP3"
                     /gene_synonym="SPR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3932..3937
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SP3"
                     /gene_synonym="SPR2"
                     /note="hexamer: AATAAA"
     polyA_site      3959
                     /gene="SP3"
                     /gene_synonym="SPR2"
                     /note="major polyA site"
     regulatory      6007..6012
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SP3"
                     /gene_synonym="SPR2"
                     /note="hexamer: ACTAAA"
     polyA_site      6030
                     /gene="SP3"
                     /gene_synonym="SPR2"
     regulatory      11691..11696
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SP3"
                     /gene_synonym="SPR2"
                     /note="hexamer: AATAAA"
     polyA_site      11714
                     /gene="SP3"
                     /gene_synonym="SPR2"
ORIGIN      
        1 gtcaccctct tccccccttt tgggctggag gctccacctt ttgtgtttcc cgcacagtca
       61 atcaaaatag gaaaaaaaaa tccccggacc gctccggccg tgtccgccgc cgcttcccgc
      121 atcctctccc gccgccgccg ccttcgctcc tcaccatgtg taaggcggcg gggagccccg
      181 cctgaggtgc cctaaacaca ctatgaccgc tcccgaaaag cccgtgaaac aagaggaaat
      241 ggctgccttg gacgtggata gcggcggcgg cggtggcggc ggcggcggcc acggcgagta
      301 tctgcagcag cagcaacagc acggaaacgg tgcggtggcg gcggcagcgg cggcccagga
      361 cactcagccg tcaccgctcg ctctgctggc cgctacctgc agcaagatag ggccgccatc
      421 gccgggcgac gacgaggagg aggcggccgc cgcagccggg gcccccgccg ccgccggagc
      481 gacaggtgat ttggcttctg cacagttagg aggagcacca aaccgatggg aggttttgtc
      541 agccacacct acaactataa aagatgaagc tggtaatcta gtccagattc caagtgctgc
      601 tacttcaagt gggcagtatg ttcttcccct tcagaatttg cagaatcaac aaatattttc
      661 cgttgcacca ggatcagatt catcaaatgg tacagtgtcc agtgttcaat atcaagtgat
      721 accacagatc cagtcagcag atggtcagca ggttcaaatt ggtttcacag gctcttcaga
      781 taatgggggt ataaatcaag aaagcagtca aattcagatc attcctggct ctaatcaaac
      841 cttacttgcc tctggaacac cttctgctaa catccagaat ctcataccac agactggtca
      901 agtccaggtt cagggagttg caattggtgg ttcatctttt cctggtcaaa cccaagtagt
      961 tgctaatgtg cctcttggtc tgccaggaaa tattacgttt gtaccaatca atagtgtcga
     1021 tctagattct ttgggactct cgggcagttc tcagacaatg actgcaggca ttaatgccga
     1081 cggacatttg ataaacacag gacaagctat ggatagttca gacaattcag aaaggactgg
     1141 tgagcgggtt tctcctgata ttaatgaaac taatactgat acagatttat ttgtgccaac
     1201 atcctcttca tcacagttgc ctgttacgat agatagtaca ggtatattac aacaaaacac
     1261 aaatagcttg actacatcta gtgggcaggt tcattcttca gatcttcagg gaaattatat
     1321 ccagtcgcct gtttctgaag agacacaggc acagaatatt caggtttcta cagcacagcc
     1381 tgttgtacag catctacaac ttcaagagtc tcagcagcca accagtcaag cccaaattgt
     1441 gcaaggtatt acaccacaga caatccatgg tgtgcaagcc agtggtcaaa atatatcaca
     1501 acaggctttg caaaatcttc agttgcagct gaatcctgga acctttttaa ttcaggcaca
     1561 gacagtgacc ccttctggac aggtaacttg gcaaacgttt caagtacaag gggtccagaa
     1621 cttgcagaat ttgcaaatac agaatactgc tgcccaacaa ataactttga cgcctgttca
     1681 aaccctcaca cttggtcaag ttgcggcagg tggagccttc acttcaactc cagttagtct
     1741 aagcactggt cagttgccaa atctacaaac agttacagtg aactctatag attctgctgg
     1801 tatacagcta catccaggag agaatgctga cagtcctgca gatattagga tcaaggaaga
     1861 agaacctgat cctgaagagt ggcagctcag tggtgattct accttgaata ccaatgacct
     1921 aacacactta agagtacagg tggtagatga agaaggggac caacaacatc aagaaggaaa
     1981 aagacttcgg agggtagctt gcacctgtcc caactgtaaa gaaggtggtg gaagaggtac
     2041 caatcttggg aaaaagaagc aacacatttg tcatatacca ggatgtggta aagtctatgg
     2101 gaagacctca catctgagag ctcatctgcg ttggcattct ggagaacgcc cttttgtttg
     2161 taactggatg tactgtggta aaagatttac tcgaagtgat gaattacaga ggcacagaag
     2221 aacacataca ggtgagaaga aatttgtttg tccagaatgt tcaaaacgct ttatgagaag
     2281 tgaccacctt gccaaacata ttaaaacaca ccagaataaa aaaggtattc actctagcag
     2341 tacagtgctg gcatctgtgg aagctgcgcg agatgatact ttgattactg caggaggaac
     2401 aacgcttatc cttgcaaata ttcaacaagg ttctgtttca gggataggaa ctgttaatac
     2461 ttccgccacc agcaatcaag atatccttac caacactgaa atacctttac agcttgtcac
     2521 agtttctgga aatgagacaa tggagtaaat attacacaaa tacttattca ttgtggttat
     2581 ttttatacag tagtgagaag aatattgttc ctaagttctt agatatcttt ttattgatgt
     2641 gcaaaaattt ttggattgac agtaacttgg ttatacatga cactgaaatg ccttactttg
     2701 tatgatattc catagtatat taaaaatggt aaaattgcat gggttttgta ggtacttttg
     2761 gaatctagaa gaaatgaaat tttaccaagt tatataaaga gaaaattgaa tttaacaatg
     2821 cgaatggtag tctaaccaaa tgcatcaatc ctgtgtggtt tagtgtaaaa atgagaacat
     2881 gttggtattt atctattgta agataaaaaa gctggtgggt gaaagaaatc atgttatgat
     2941 aaaaaatttt gtaattttct tgatgactgg aatttttatt atgcataact gacaaatcaa
     3001 gtttccaagc aaatgttaca tagtgtaggc tttacttagc ttatcaattt gtcattttga
     3061 agctaattat tttaattagg ttaactatgt acaatatttt aagcattact cttgtaagat
     3121 tttgaaaact acattttaac atggaactct agggatagtc accttttaaa tcctgttgaa
     3181 aagccatgtt taagatttaa tttgccaaaa taatgtcttg ttaatattct ttcaataacg
     3241 aagttgggca atataaccaa tgtttaaaaa agtttaaaat gtataagttg aggcatttgg
     3301 gtggtaagag aatgttatag tgaattatcc cttttcttga ctattggagg accaaaaaaa
     3361 taaggtgtat tgcgtcttag cagtgatttt tatccaatct tgtttccaaa aaccatgtct
     3421 cccagggcct taaaagccat catgtaaatt accagtaaag tgtaacatat gcaaacataa
     3481 caaaatcact tccatagtga cgatactcca accatatgga tattagtcat agaagaacta
     3541 gaggttttat gatatttttt taagtctttt ttttttttgt ctaggtagtc agtctgcact
     3601 taaatatcaa tcattttcct tttttgcttc ttcccttaaa atttatatgt atccagtaca
     3661 tttaattgag aagcgtatgt tttttattat gctgtatttt ctttttattt tttaattatt
     3721 gtttatattt tcaattcaaa aatgtacaaa ataaagttac attgctggtc ttgtaagagc
     3781 tatacagttt tcctaaatgt atacctgtaa ctgcagcagt tcacctattt caaaaatttg
     3841 gaattctgtt catttgttat tcttaagacc acctcaaatt taaaggctac cttattgtac
     3901 gtttaaagtg tattataaca gtgtggtagt taataaaaca ctattttttt ttcttttgag
     3961 tttgttgtat tcctatgcat aaaaaatatt gcagtggtat ggggtaagaa ttggtggttt
     4021 atttttcttc aacttggctt tttattttta gattcttgat tttagacact gaattgtaaa
     4081 caggcattta tttgaagaag agatatatag agacactggt catttactaa ttttttacct
     4141 agagtaaata agaatgagct tattaaataa aatttttgaa aaaaagtctt agcccttagc
     4201 ccacattgat tcatatcagt tttatcagta ccattttgca atttttttgt tttccgtttt
     4261 aaagcaatgc agaatatttt gatttatcga aaacctgaat ttacattaag actcctgaaa
     4321 atgataagac aagcgttggt aaccatggca ggagttactt gaaaaagttg cctttgaatt
     4381 tgcatgtgtt tcatcattat aaaggcagag taggaggaaa gagtattaat gtgattgtgt
     4441 attgtagatg ttttaaagta aaaatcaagt ttcttaacac atgtatacag tgggggtaaa
     4501 gatgtccatt ttctgttttc caggcccagt ctgactctgt ctgtaatacc tgattgcatt
     4561 ggagaactct agacacgcat aaacatggac agtttttcta aatgtgagac ttaagcctgt
     4621 gatgtaaaat aggaagttct acttggaata atataaagga accactagaa tttacaatta
     4681 ttttgaagtt acagggatta gattttgaat cttaaaatcc tttaggtaat ttttagaatt
     4741 tttaaattaa gattaatgtg aagagaatta agtgagcagc aggtggttca cttgagcaaa
     4801 ctgcccatta agtcagatta aaccatttga atgatagtag agatgtttta agtaatactg
     4861 gatttttaca gtaagtttat ggtgtacttt gaatcgatag gtgtccatgc atattttatg
     4921 aattcgtgga gaatgaatgc aatgaagaaa gtaagtagtc ttgaaaatta tttaaataaa
     4981 gttgtagatt tttttagtgc cccctaggaa tatattagtg aactttggaa cttttaccaa
     5041 agttatgtaa cctcagtgta gataatttta aatatttcta tttttatatt ttaaaatgtt
     5101 gaatatactc tggaaacaac atttgaagat ttgctctgat gtcaactttt tctggttata
     5161 aaacctatta gtattgtgta taattctcag ggtaggtata ctctaatagg tgttttgtca
     5221 attgctttat ttttgtaaag gctagagtta gtgcatattg aatatattta tgtacaaata
     5281 attcctgttg taacatttag tggacgcgat tatctgtata cctcaaattt taatttaaga
     5341 aagtatcact taaagagcat ctcattttct atagattgag gcttaattac tgaaaagtga
     5401 ctcaaccaaa aagcacataa ccttttaaag gagctacacc taccgcagaa agtcagatgc
     5461 cctgtaaata actttggtct ttcaaaatag tggcaatgct taagatactt aaaaatacac
     5521 atacatataa gctgaaagca tgtcaagcct atttcataga aaatagttct taaacagtat
     5581 tgttcattag aaattgctgg ggagcatttt agagattcca taggcctggt agccacctca
     5641 gcttactaaa tcaacatctc tggagatgga gtgtatatgt gttttgaaac agctgctcaa
     5701 gtggttctgt taaacactcc tgcgttacaa tcacttaaaa tagagcaagc atccccttag
     5761 gctcttaatt gtagtttaaa ttccagtact gcctactcag acccaaaagt tttgttttat
     5821 gaaaaatttg tattgtgttc aatattgttt gaaatttggg gttgttgcat aaatgattat
     5881 ggaataacat ttggttttaa aataatataa actgacatgt tatgctacct gttacacaat
     5941 ttggttttca gttttaatta tatgaagctg gtaacaatcg tttttgttgt aaaagaatta
     6001 tttttcacta aacagtatgt ttaaaactga ctgccatgaa tgagtactaa gtcttttgtt
     6061 gtctgacaat aagcacaaaa caaattaatt gatatctttg gtacaaattt gatatttttg
     6121 tgaaatcacc tcataatttt atttagtgtt gaagaaacaa cattggcccc ttgccttgtt
     6181 cagacagatt tgcgtataat gtaaatatat atattagtgg cagaaacaaa gtactgtaga
     6241 aacctagaag agggagaatt ctgcatgaag tctgggaaac tcagcagaaa tggcgtttgc
     6301 aaaggtacag tgtggtatgt tgggtgatgg gggactttgt gagggacaga gtggaaaaat
     6361 ttttaagagg ggctgccaaa ttgcaaaaga gaagaatttt ttttgtcagt gattcctagt
     6421 ctttttggaa tcctacacct tctccccaga aaaattcatt ctagtccagg gtttattgtt
     6481 tgttttttcc ctatatttga cagggtctgt ctctgtcaca cagtgcagtg gtgcaatcat
     6541 ggcttactgc agactccact tactggtctc aagcaatcct ccccacttcg gcctcttaag
     6601 tagcttggac cacaggtgca caccaccatg ctcagttaat tttaatttgt tttgtagaga
     6661 tggggtctca ctatattgcc taggctggtc ttgaattcct gggctcaagt gatccttcca
     6721 cctctgcctc ccaaagtgtt gggattatag gcgtgagcca ccacgcttgg ccaaatctgg
     6781 agtctaaagg gtatacaagg tttttttttt tcccatgttg gcttttattt gatgttataa
     6841 agtcttcatg atatgaatat attttttaaa aaggtgtcat gtatattgtc atgtaacatg
     6901 attcatgcca cttcattgta ttaaatacgt ttaagataca gtttttgatg ttaagaatga
     6961 tatcctgaga aggcctatct ccttcagtcc ttttccccat ttttcacctt ttaactcttg
     7021 cttctgaatc tatgctaagc tacttactag atgtgtgata ttggtagttt tcttacctta
     7081 aaacctcatt ttcatcatcc atgaagaggc taacaatagt actccctgtt gataggattg
     7141 ttgtattaaa atataagcat tcagcatagt gcctgactta acggtagaga ttcaaatggt
     7201 aacctccttc caatgccttc ctcccccctt aactctggag attccatttt tctgtagtga
     7261 agtgttttag aattttcatt gtttgactat ggttcataca ttgatttttc caaaatgaga
     7321 agaagtctta tttctaatgc aaaaatgtga aaagaacagt tggaacctaa agtgatagtg
     7381 gatgaagtgt ctgaagtgac tgccctatca gaaaaggatg gaataagaag aaaagactga
     7441 agcacctaaa tgtgtatttt cttgaggaaa ttacacccct gtgtaagagt ctatcctatt
     7501 tgaacatttc taaaaaccag ccgaagaatc ttcaggttca ttgcgactga aagataaagt
     7561 ctagcactga agtggttttt aagattagga aaggccatca gagaaatgca gttatttctc
     7621 ccctccatcc ttcccccaca aaaaaaagtc taagcctccg attaatcgac aacaacgaaa
     7681 tacaggaagt attggcttag tgacctttta ggatatctgt ccgacttaca tcccttctct
     7741 gagcattact ttctgccacc ttccgtgagg agctgttcag aaatcagaca aggagtggac
     7801 atctggtcaa agttgagcca attagatgat ttctcctgag aatttggaat tggaaaactg
     7861 atgtcttggg aggtcacatc tggaacatac atgggaggca gagaaagcaa agatgacatt
     7921 caaccccaga agaaaaagaa aatggctttc ttgattcctg ataacttggc agtgtttgtt
     7981 ccagtgtctt gcatttcact atctgcattt catcctcctg gggttccaca agatagcctt
     8041 aaaaccttac agagagactc cccaacttag ttttttctta agtcagaagg ctgttacttg
     8101 ctaccaaata atgccaacta agacaactga ggtacagtat attctctcgt aaaacaccat
     8161 agagttgatg acttgatcct atagaaaagg gtccccaacc cctgggccac agaccggtac
     8221 tggtccctgg tctgtgagga accacctggg ccacagactg gtcctggtcc ctggtctgtg
     8281 aggaaccagg ccatacagca ggaggtaagc gagcattcct gcctgagctc tgcctcctgt
     8341 cagatgagcc acaacattag attctcatag gagtgcgaac cccgttgtga accccgcatg
     8401 cgagggatct aggtagtgcc ctccttaaga gaatctaatg tctgatgatc tgaggtagag
     8461 cagtttcatc ctacaaccat ccccaccccc cgacccccat ccatgaaaaa attgtcttcc
     8521 tcaaaactag tccctggtgc caaaaagttt ggggaccgcc gtcctaggaa ataccaacaa
     8581 aaagtcacgt ttattgcctg ccaagtgagt caggtttaga caaggcagaa cttagtatat
     8641 agcttggatg aatcagaaag ggtgggcctt gaaagactgg tagaatgtgt ccaagaaaac
     8701 tgattaaaag ccttagaagt ccctctacag tttcaggacg ccctcttaac agatggctgt
     8761 atctttatct gtggttggtc ttgtggaata ctgactttct gccagcatta gcctgtgttt
     8821 ctatgtcaca ccaagtcacg tatattttca ttgtgtgtta ggactcagaa taggtttggg
     8881 tctttctttt aattatgtat acccaattac ttagtcctcc tcacaccctg atcctttaaa
     8941 aattcttaag ttgtgttaat tgcatttttc tcaattctac tcctagtaac tctgtgtgtt
     9001 tttttccatc tttattcatt tagtaaagtt gaaacctttc atagcataat atagtgatta
     9061 agtgcatagg tttgggactt agacacacat gggcttgctt gtctcccagt tctgccgctt
     9121 accacctatg tgacctttca ctctttacct ttccactctt agcctgttct ctaactataa
     9181 aatgagaatg atgctagcgt catcttcata gagtgattat ggagataaat aagttaatgc
     9241 atgtaaacca ctttccataa tgcctggcac atattatatt atgtattagt aaatgtaagc
     9301 actggaagaa tcagtagtct tcctacactt gaaaatagtt gtcttcaact attgttgtat
     9361 taatgagtta attcaccttg ttaagtcacc ttgatccacc taattgtcag ccaacattta
     9421 ttaacgaaac tgctagtatt cgtattgtgc cttttttatt atgaaacatt tcaagaatac
     9481 agaaaaatgc agaaaacaat gtaacaaata cctaagtatc tatcacccaa cttttatagt
     9541 cttattttta cctatatatt ttttctttta gaaaggaatg atcacagttg tgcctgaaat
     9601 ctgtatagcc ctgtctcatt tcatttgtct ccctttaccc acataagtaa ttgcagctct
     9661 gaatttgatg tttatcagaa tgataccatg agtggtttta tatccttatt atatgtatgc
     9721 atacctagga ttgtttttct gattttgaaa cttcatataa atggtatcat tctgtacaaa
     9781 accttctggg acttgtttta ccactcatgt ttttgagatg tatccacact accatctttc
     9841 tctaaatcat tcatttaaat gctgtagttc attgaataag tttatcacaa tgtatccatt
     9901 ttcttcttga tgagcatctc agttatttcc aatttttgac ttataaacaa tgctgcaatg
     9961 aaataattga catatttcct tgtgtacatg tgagcatttc ttgagatatg tatctagaac
    10021 ttgaatcact ggccaacagg atattcttaa tcttcagttt caccagatac ttccaaattg
    10081 atctccataa catgcatacc aaattatatt cctaccagcc atttatagga gttcacattt
    10141 tttccatacc ctcccaatcc tgccttggca gatatgtttt ttccaatgaa taacaatgaa
    10201 attttgtttt gggatttgac aaaatgattc tagattcatc tggaagaaaa gcaagtataa
    10261 gtaagaaatt taaaagggac ctgaaaaact aagcaatgga tatatttaaa aattggtacc
    10321 agtagggata accaaatatt tgttaactgt agcagaaaca atgcatgttt ttctcactgg
    10381 ttccaccttc tatctctcag tcaagccctg cccaggtgtg gtagtcctca tagtctctca
    10441 ctgtaggggt cttctcacat agtagaccac tctcttgagt tgaatattga aaagaaggct
    10501 tggccggggg cagtggctca tgcctgtggt cccagcactt tgggaagctg agtcgagcgg
    10561 attgcttgag gtcagcagtt cgagagcagc ctgactaaca tggtgatgaa aagtacaaaa
    10621 ttagctgggg gtggtggcgc atgcctgcaa tcccagctac tcgggaggct gaggcacgag
    10681 aatcgcttga acgcaggagg cataggttgc agtgagccga gattgcacca ctgcactcca
    10741 gcctgggcga cagagcaaga tttcgtctca aaaaaaaaaa aaaaaaaaaa aaaggcttaa
    10801 gtccaactaa ctgtttccct gctgttcatt ttatccaacg gctggggata taggctactg
    10861 cacatgatgg gttgatggat gtgaaatgat aactcatgac tttaattcta atttttctat
    10921 attctggtga ggttgagcat atttttacaa gttcataatc cattttcctc tgatgggagt
    10981 tgcctgtttg aatcctttgc ccacttgctt tttggggtta tttgcaattt tttgcattga
    11041 tcttcaaaca ttcttaatta atcccaggta catattattt tatatataag atatatttta
    11101 gagatatata ggctgatagt atcttttctc agtctaaggc ttatctttta attttgttta
    11161 tggtgttttg tgtgtgttgt tttgcagaag ttttattgta tctgaattgt ggcttttgtg
    11221 tcttaagaaa ttctttacct actgtcataa aaatttttgt ctaaaaattt tatgattttg
    11281 cctttctatt tatcttgtta attcactttg aaattacttt tgtttatggc ataaagtcca
    11341 ttattttcca tatggataat cagttgtctt agcagtttat tgaatggtcc aacgtttccc
    11401 tgctgattat aatgccctct ctgttattta tcctaaattc ttgacatccg gtaaggaagt
    11461 ctcctctgcc cacccttctc tgtatttcaa aatggttttg actgttcttg accccttgct
    11521 ctttctgtga actttaggat taaatgatta tgtagaatta aacaatcggg ttaaggtttt
    11581 ttattagaat tacattgaat ctatagatta atttggggaa agaatgttat ctttctatcc
    11641 atgataattc tgtatctctc cattaattca agtctttaat ggtttttaaa aataaattat
    11701 tgtctctttg aaaa
//
