LOCUS       NM_001017371           11353 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens Sp3 transcription factor (SP3), transcript variant 2,
            mRNA.
ACCESSION   NM_001017371
VERSION     NM_001017371.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11353)
  AUTHORS   Zheng,B., Geng,Y., Li,Y., Huang,H. and Liu,A.
  TITLE     Specificity protein 1/3 regulate T-cell acute lymphoblastic
            leukemia cell proliferation and apoptosis through beta-catenin by
            acting as targets of miR-495-3p
  JOURNAL   Ann Hematol 103 (8), 2945-2960 (2024)
   PUBMED   38829410
  REMARK    GeneRIF: Specificity protein 1/3 regulate T-cell acute
            lymphoblastic leukemia cell proliferation and apoptosis through
            beta-catenin by acting as targets of miR-495-3p.
REFERENCE   2  (bases 1 to 11353)
  AUTHORS   Tian,P., Du,D., Yang,L., Zhou,N. and Tao,L.
  TITLE     SP3-induced Timeless transcription contributes to cell growth of
            lung adenocarcinoma cells
  JOURNAL   PLoS One 19 (2), e0298295 (2024)
   PUBMED   38354174
  REMARK    GeneRIF: SP3-induced Timeless transcription contributes to cell
            growth of lung adenocarcinoma cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 11353)
  AUTHORS   Chen,L.Y., Chen,L.W., Hung,C.H., Lin,C.L., Wang,S.S. and Chang,P.J.
  TITLE     Caspase-Mediated Cleavage of the Transcription Factor Sp3: Possible
            Relevance to Cancer and the Lytic Cycle of Kaposi's
            Sarcoma-Associated Herpesvirus
  JOURNAL   Microbiol Spectr 10 (1), e0146421 (2022)
   PUBMED   35019687
  REMARK    GeneRIF: Caspase-Mediated Cleavage of the Transcription Factor Sp3:
            Possible Relevance to Cancer and the Lytic Cycle of Kaposi's
            Sarcoma-Associated Herpesvirus.
REFERENCE   4  (bases 1 to 11353)
  AUTHORS   Wen,S., Qin,Y., Wang,R., Yang,L., Zeng,H., Zhu,P., Li,Q., Qiu,Y.,
            Chen,S., Liu,Y., Hou,Y., Tang,X., Liu,M. and Tu,G.
  TITLE     A novel Lnc408 maintains breast cancer stem cell stemness by
            recruiting SP3 to suppress CBY1 transcription and increasing
            nuclear beta-catenin levels
  JOURNAL   Cell Death Dis 12 (5), 437 (2021)
   PUBMED   33934099
  REMARK    GeneRIF: A novel Lnc408 maintains breast cancer stem cell stemness
            by recruiting SP3 to suppress CBY1 transcription and increasing
            nuclear beta-catenin levels.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 11353)
  AUTHORS   Moran,K.M., Crusio,R.H., Chan,C.H., Grekova,M.C. and Richert,J.R.
  TITLE     Human transcription factor Sp3: genomic structure, identification
            of a processed pseudogene, and transcript analysis
  JOURNAL   Gene 341, 235-247 (2004)
   PUBMED   15474306
REFERENCE   6  (bases 1 to 11353)
  AUTHORS   Sapetschnig,A., Koch,F., Rischitor,G., Mennenga,T. and Suske,G.
  TITLE     Complexity of translationally controlled transcription factor Sp3
            isoform expression
  JOURNAL   J Biol Chem 279 (40), 42095-42105 (2004)
   PUBMED   15247228
  REMARK    GeneRIF: four isoforms derive from alternative translational start
            sites at positions 1, 37, 856, and 907; the transcriptional
            activity of all the Sp3 isoforms is regulated by SUMO modification
REFERENCE   7  (bases 1 to 11353)
  AUTHORS   Hernandez,E.M., Johnson,A., Notario,V., Chen,A. and Richert,J.R.
  TITLE     AUA as a translation initiation site in vitro for the human
            transcription factor Sp3
  JOURNAL   J Biochem Mol Biol 35 (3), 273-282 (2002)
   PUBMED   12297010
  REMARK    GeneRIF: Use of non-AUG (AUA) translation initiation site and
            alternate downstream start sites, results in multiple SP3 isoforms.
REFERENCE   8  (bases 1 to 11353)
  AUTHORS   Udvadia,A.J., Templeton,D.J. and Horowitz,J.M.
  TITLE     Functional interactions between the retinoblastoma (Rb) protein and
            Sp-family members: superactivation by Rb requires amino acids
            necessary for growth suppression
  JOURNAL   Proc Natl Acad Sci U S A 92 (9), 3953-3957 (1995)
   PUBMED   7732011
REFERENCE   9  (bases 1 to 11353)
  AUTHORS   Hagen,G., Muller,S., Beato,M. and Suske,G.
  TITLE     Cloning by recognition site screening of two novel GT box binding
            proteins: a family of Sp1 related genes
  JOURNAL   Nucleic Acids Res 20 (21), 5519-5525 (1992)
   PUBMED   1454515
REFERENCE   10 (bases 1 to 11353)
  AUTHORS   Kingsley,C. and Winoto,A.
  TITLE     Cloning of GT box-binding proteins: a novel Sp1 multigene family
            regulating T-cell receptor gene expression
  JOURNAL   Mol Cell Biol 12 (10), 4251-4261 (1992)
   PUBMED   1341900
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY070137.1, M97191.2,
            AB209334.1, BQ010796.1, AC093399.6 and AC106900.3.
            
            On Jun 2, 2019 this sequence version replaced NM_001017371.4.
            
            Summary: This gene belongs to a family of Sp1 related genes that
            encode transcription factors that regulate transcription by binding
            to consensus GC- and GT-box regulatory elements in target genes.
            This protein contains a zinc finger DNA-binding domain and several
            transactivation domains, and has been reported to function as a
            bifunctional transcription factor that either stimulates or
            represses the transcription of numerous genes. Transcript variants
            encoding different isoforms have been described for this gene, and
            one has been reported to initiate translation from a non-AUG (AUA)
            start codon. Additional isoforms, resulting from the use of
            alternate downstream translation initiation sites, have also been
            noted. A related pseudogene has been identified on chromosome 13.
            [provided by RefSeq, Feb 2010].
            
            Transcript Variant: This variant (2) is missing exons 1 and 2 found
            in transcript variant 1, and has a different 5' end. It initiates
            translation from a non-AUG (AUA) start site, and encodes an isoform
            (2) with a shorter N-terminus compared to isoform 1. Alternative
            translation initiation from downstream, in-frame AUG start codons
            produces shorter isoforms.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.156243.1,
                                           SRR14038191.3481328.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            non-AUG initiation codon :: PMID: 12297010
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-330               AY070137.1         340-669
            331-1306            M97191.2           281-1256
            1307-2057           AY070137.1         1646-2396
            2058-3591           AB209334.1         1861-3394
            3592-5158           AB209334.1         3396-4962
            5159-5669           BQ010796.1         17-527              c
            5670-7894           AC093399.6         1-2225              c
            7895-11353          AC106900.3         144039-147497       c
FEATURES             Location/Qualifiers
     source          1..11353
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q31.1"
     gene            1..11353
                     /gene="SP3"
                     /gene_synonym="SPR2"
                     /note="Sp3 transcription factor"
                     /db_xref="GeneID:6670"
                     /db_xref="HGNC:HGNC:11208"
                     /db_xref="MIM:601804"
     exon            1..120
                     /gene="SP3"
                     /gene_synonym="SPR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..2187
                     /gene="SP3"
                     /gene_synonym="SPR2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     non-AUG (AUA) translation initiation codon; specificity
                     protein 3; GC-binding transcription factor Sp3"
                     /codon_start=1
                     /transl_except=(pos:46..48,aa:Met)
                     /product="transcription factor Sp3 isoform 2"
                     /protein_id="NP_001017371.3"
                     /db_xref="CCDS:CCDS46452.1"
                     /db_xref="GeneID:6670"
                     /db_xref="HGNC:HGNC:11208"
                     /db_xref="MIM:601804"
                     /translation="MGPPSPGDDEEEAAAAAGAPAAAGATGDLASAQLGGAPNRWEVL
                     SATPTTIKDEAGNLVQIPSAATSSGQYVLPLQNLQNQQIFSVAPGSDSSNGTVSSVQY
                     QVIPQIQSADGQQVQIGFTGSSDNGGINQESSQIQIIPGSNQTLLASGTPSANIQNLI
                     PQTGQVQVQGVAIGGSSFPGQTQVVANVPLGLPGNITFVPINSVDLDSLGLSGSSQTM
                     TAGINADGHLINTGQAMDSSDNSERTGERVSPDINETNTDTDLFVPTSSSSQLPVTID
                     STGILQQNTNSLTTSSGQVHSSDLQGNYIQSPVSEETQAQNIQVSTAQPVVQHLQLQE
                     SQQPTSQAQIVQGITPQTIHGVQASGQNISQQALQNLQLQLNPGTFLIQAQTVTPSGQ
                     VTWQTFQVQGVQNLQNLQIQNTAAQQITLTPVQTLTLGQVAAGGAFTSTPVSLSTGQL
                     PNLQTVTVNSIDSAGIQLHPGENADSPADIRIKEEEPDPEEWQLSGDSTLNTNDLTHL
                     RVQVVDEEGDQQHQEGKRLRRVACTCPNCKEGGGRGTNLGKKKQHICHIPGCGKVYGK
                     TSHLRAHLRWHSGERPFVCNWMYCGKRFTRSDELQRHRRTHTGEKKFVCPECSKRFMR
                     SDHLAKHIKTHQNKKGIHSSSTVLASVEAARDDTLITAGGTTLILANIQQGSVSGIGT
                     VNTSATSNQDILTNTEIPLQLVTVSGNETME"
     exon            121..1480
                     /gene="SP3"
                     /gene_synonym="SPR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1673
                     /gene="SP3"
                     /gene_synonym="SPR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1870
                     /gene="SP3"
                     /gene_synonym="SPR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1871..11353
                     /gene="SP3"
                     /gene_synonym="SPR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3571..3576
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SP3"
                     /gene_synonym="SPR2"
                     /note="hexamer: AATAAA"
     polyA_site      3598
                     /gene="SP3"
                     /gene_synonym="SPR2"
                     /note="major polyA site"
     regulatory      5646..5651
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SP3"
                     /gene_synonym="SPR2"
                     /note="hexamer: ACTAAA"
     polyA_site      5669
                     /gene="SP3"
                     /gene_synonym="SPR2"
     regulatory      11330..11335
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SP3"
                     /gene_synonym="SPR2"
                     /note="hexamer: AATAAA"
     polyA_site      11353
                     /gene="SP3"
                     /gene_synonym="SPR2"
ORIGIN      
        1 actcagccgt caccgctcgc tctgctggcc gctacctgca gcaagatagg gccgccatcg
       61 ccgggcgacg acgaggagga ggcggccgcc gcagccgggg cccccgccgc cgccggagcg
      121 acaggtgatt tggcttctgc acagttagga ggagcaccaa accgatggga ggttttgtca
      181 gccacaccta caactataaa agatgaagct ggtaatctag tccagattcc aagtgctgct
      241 acttcaagtg ggcagtatgt tcttcccctt cagaatttgc agaatcaaca aatattttcc
      301 gttgcaccag gatcagattc atcaaatggt acagtgtcca gtgttcaata tcaagtgata
      361 ccacagatcc agtcagcaga tggtcagcag gttcaaattg gtttcacagg ctcttcagat
      421 aatgggggta taaatcaaga aagcagtcaa attcagatca ttcctggctc taatcaaacc
      481 ttacttgcct ctggaacacc ttctgctaac atccagaatc tcataccaca gactggtcaa
      541 gtccaggttc agggagttgc aattggtggt tcatcttttc ctggtcaaac ccaagtagtt
      601 gctaatgtgc ctcttggtct gccaggaaat attacgtttg taccaatcaa tagtgtcgat
      661 ctagattctt tgggactctc gggcagttct cagacaatga ctgcaggcat taatgccgac
      721 ggacatttga taaacacagg acaagctatg gatagttcag acaattcaga aaggactggt
      781 gagcgggttt ctcctgatat taatgaaact aatactgata cagatttatt tgtgccaaca
      841 tcctcttcat cacagttgcc tgttacgata gatagtacag gtatattaca acaaaacaca
      901 aatagcttga ctacatctag tgggcaggtt cattcttcag atcttcaggg aaattatatc
      961 cagtcgcctg tttctgaaga gacacaggca cagaatattc aggtttctac agcacagcct
     1021 gttgtacagc atctacaact tcaagagtct cagcagccaa ccagtcaagc ccaaattgtg
     1081 caaggtatta caccacagac aatccatggt gtgcaagcca gtggtcaaaa tatatcacaa
     1141 caggctttgc aaaatcttca gttgcagctg aatcctggaa cctttttaat tcaggcacag
     1201 acagtgaccc cttctggaca ggtaacttgg caaacgtttc aagtacaagg ggtccagaac
     1261 ttgcagaatt tgcaaataca gaatactgct gcccaacaaa taactttgac gcctgttcaa
     1321 accctcacac ttggtcaagt tgcggcaggt ggagccttca cttcaactcc agttagtcta
     1381 agcactggtc agttgccaaa tctacaaaca gttacagtga actctataga ttctgctggt
     1441 atacagctac atccaggaga gaatgctgac agtcctgcag atattaggat caaggaagaa
     1501 gaacctgatc ctgaagagtg gcagctcagt ggtgattcta ccttgaatac caatgaccta
     1561 acacacttaa gagtacaggt ggtagatgaa gaaggggacc aacaacatca agaaggaaaa
     1621 agacttcgga gggtagcttg cacctgtccc aactgtaaag aaggtggtgg aagaggtacc
     1681 aatcttggga aaaagaagca acacatttgt catataccag gatgtggtaa agtctatggg
     1741 aagacctcac atctgagagc tcatctgcgt tggcattctg gagaacgccc ttttgtttgt
     1801 aactggatgt actgtggtaa aagatttact cgaagtgatg aattacagag gcacagaaga
     1861 acacatacag gtgagaagaa atttgtttgt ccagaatgtt caaaacgctt tatgagaagt
     1921 gaccaccttg ccaaacatat taaaacacac cagaataaaa aaggtattca ctctagcagt
     1981 acagtgctgg catctgtgga agctgcgcga gatgatactt tgattactgc aggaggaaca
     2041 acgcttatcc ttgcaaatat tcaacaaggt tctgtttcag ggataggaac tgttaatact
     2101 tccgccacca gcaatcaaga tatccttacc aacactgaaa tacctttaca gcttgtcaca
     2161 gtttctggaa atgagacaat ggagtaaata ttacacaaat acttattcat tgtggttatt
     2221 tttatacagt agtgagaaga atattgttcc taagttctta gatatctttt tattgatgtg
     2281 caaaaatttt tggattgaca gtaacttggt tatacatgac actgaaatgc cttactttgt
     2341 atgatattcc atagtatatt aaaaatggta aaattgcatg ggttttgtag gtacttttgg
     2401 aatctagaag aaatgaaatt ttaccaagtt atataaagag aaaattgaat ttaacaatgc
     2461 gaatggtagt ctaaccaaat gcatcaatcc tgtgtggttt agtgtaaaaa tgagaacatg
     2521 ttggtattta tctattgtaa gataaaaaag ctggtgggtg aaagaaatca tgttatgata
     2581 aaaaattttg taattttctt gatgactgga atttttatta tgcataactg acaaatcaag
     2641 tttccaagca aatgttacat agtgtaggct ttacttagct tatcaatttg tcattttgaa
     2701 gctaattatt ttaattaggt taactatgta caatatttta agcattactc ttgtaagatt
     2761 ttgaaaacta cattttaaca tggaactcta gggatagtca ccttttaaat cctgttgaaa
     2821 agccatgttt aagatttaat ttgccaaaat aatgtcttgt taatattctt tcaataacga
     2881 agttgggcaa tataaccaat gtttaaaaaa gtttaaaatg tataagttga ggcatttggg
     2941 tggtaagaga atgttatagt gaattatccc ttttcttgac tattggagga ccaaaaaaat
     3001 aaggtgtatt gcgtcttagc agtgattttt atccaatctt gtttccaaaa accatgtctc
     3061 ccagggcctt aaaagccatc atgtaaatta ccagtaaagt gtaacatatg caaacataac
     3121 aaaatcactt ccatagtgac gatactccaa ccatatggat attagtcata gaagaactag
     3181 aggttttatg atattttttt aagtcttttt tttttttgtc taggtagtca gtctgcactt
     3241 aaatatcaat cattttcctt ttttgcttct tcccttaaaa tttatatgta tccagtacat
     3301 ttaattgaga agcgtatgtt ttttattatg ctgtattttc tttttatttt ttaattattg
     3361 tttatatttt caattcaaaa atgtacaaaa taaagttaca ttgctggtct tgtaagagct
     3421 atacagtttt cctaaatgta tacctgtaac tgcagcagtt cacctatttc aaaaatttgg
     3481 aattctgttc atttgttatt cttaagacca cctcaaattt aaaggctacc ttattgtacg
     3541 tttaaagtgt attataacag tgtggtagtt aataaaacac tatttttttt tcttttgagt
     3601 ttgttgtatt cctatgcata aaaaatattg cagtggtatg gggtaagaat tggtggttta
     3661 tttttcttca acttggcttt ttatttttag attcttgatt ttagacactg aattgtaaac
     3721 aggcatttat ttgaagaaga gatatataga gacactggtc atttactaat tttttaccta
     3781 gagtaaataa gaatgagctt attaaataaa atttttgaaa aaaagtctta gcccttagcc
     3841 cacattgatt catatcagtt ttatcagtac cattttgcaa tttttttgtt ttccgtttta
     3901 aagcaatgca gaatattttg atttatcgaa aacctgaatt tacattaaga ctcctgaaaa
     3961 tgataagaca agcgttggta accatggcag gagttacttg aaaaagttgc ctttgaattt
     4021 gcatgtgttt catcattata aaggcagagt aggaggaaag agtattaatg tgattgtgta
     4081 ttgtagatgt tttaaagtaa aaatcaagtt tcttaacaca tgtatacagt gggggtaaag
     4141 atgtccattt tctgttttcc aggcccagtc tgactctgtc tgtaatacct gattgcattg
     4201 gagaactcta gacacgcata aacatggaca gtttttctaa atgtgagact taagcctgtg
     4261 atgtaaaata ggaagttcta cttggaataa tataaaggaa ccactagaat ttacaattat
     4321 tttgaagtta cagggattag attttgaatc ttaaaatcct ttaggtaatt tttagaattt
     4381 ttaaattaag attaatgtga agagaattaa gtgagcagca ggtggttcac ttgagcaaac
     4441 tgcccattaa gtcagattaa accatttgaa tgatagtaga gatgttttaa gtaatactgg
     4501 atttttacag taagtttatg gtgtactttg aatcgatagg tgtccatgca tattttatga
     4561 attcgtggag aatgaatgca atgaagaaag taagtagtct tgaaaattat ttaaataaag
     4621 ttgtagattt ttttagtgcc ccctaggaat atattagtga actttggaac ttttaccaaa
     4681 gttatgtaac ctcagtgtag ataattttaa atatttctat ttttatattt taaaatgttg
     4741 aatatactct ggaaacaaca tttgaagatt tgctctgatg tcaacttttt ctggttataa
     4801 aacctattag tattgtgtat aattctcagg gtaggtatac tctaataggt gttttgtcaa
     4861 ttgctttatt tttgtaaagg ctagagttag tgcatattga atatatttat gtacaaataa
     4921 ttcctgttgt aacatttagt ggacgcgatt atctgtatac ctcaaatttt aatttaagaa
     4981 agtatcactt aaagagcatc tcattttcta tagattgagg cttaattact gaaaagtgac
     5041 tcaaccaaaa agcacataac cttttaaagg agctacacct accgcagaaa gtcagatgcc
     5101 ctgtaaataa ctttggtctt tcaaaatagt ggcaatgctt aagatactta aaaatacaca
     5161 tacatataag ctgaaagcat gtcaagccta tttcatagaa aatagttctt aaacagtatt
     5221 gttcattaga aattgctggg gagcatttta gagattccat aggcctggta gccacctcag
     5281 cttactaaat caacatctct ggagatggag tgtatatgtg ttttgaaaca gctgctcaag
     5341 tggttctgtt aaacactcct gcgttacaat cacttaaaat agagcaagca tccccttagg
     5401 ctcttaattg tagtttaaat tccagtactg cctactcaga cccaaaagtt ttgttttatg
     5461 aaaaatttgt attgtgttca atattgtttg aaatttgggg ttgttgcata aatgattatg
     5521 gaataacatt tggttttaaa ataatataaa ctgacatgtt atgctacctg ttacacaatt
     5581 tggttttcag ttttaattat atgaagctgg taacaatcgt ttttgttgta aaagaattat
     5641 ttttcactaa acagtatgtt taaaactgac tgccatgaat gagtactaag tcttttgttg
     5701 tctgacaata agcacaaaac aaattaattg atatctttgg tacaaatttg atatttttgt
     5761 gaaatcacct cataatttta tttagtgttg aagaaacaac attggcccct tgccttgttc
     5821 agacagattt gcgtataatg taaatatata tattagtggc agaaacaaag tactgtagaa
     5881 acctagaaga gggagaattc tgcatgaagt ctgggaaact cagcagaaat ggcgtttgca
     5941 aaggtacagt gtggtatgtt gggtgatggg ggactttgtg agggacagag tggaaaaatt
     6001 tttaagaggg gctgccaaat tgcaaaagag aagaattttt tttgtcagtg attcctagtc
     6061 tttttggaat cctacacctt ctccccagaa aaattcattc tagtccaggg tttattgttt
     6121 gttttttccc tatatttgac agggtctgtc tctgtcacac agtgcagtgg tgcaatcatg
     6181 gcttactgca gactccactt actggtctca agcaatcctc cccacttcgg cctcttaagt
     6241 agcttggacc acaggtgcac accaccatgc tcagttaatt ttaatttgtt ttgtagagat
     6301 ggggtctcac tatattgcct aggctggtct tgaattcctg ggctcaagtg atccttccac
     6361 ctctgcctcc caaagtgttg ggattatagg cgtgagccac cacgcttggc caaatctgga
     6421 gtctaaaggg tatacaaggt tttttttttt cccatgttgg cttttatttg atgttataaa
     6481 gtcttcatga tatgaatata ttttttaaaa aggtgtcatg tatattgtca tgtaacatga
     6541 ttcatgccac ttcattgtat taaatacgtt taagatacag tttttgatgt taagaatgat
     6601 atcctgagaa ggcctatctc cttcagtcct tttccccatt tttcaccttt taactcttgc
     6661 ttctgaatct atgctaagct acttactaga tgtgtgatat tggtagtttt cttaccttaa
     6721 aacctcattt tcatcatcca tgaagaggct aacaatagta ctccctgttg ataggattgt
     6781 tgtattaaaa tataagcatt cagcatagtg cctgacttaa cggtagagat tcaaatggta
     6841 acctccttcc aatgccttcc tcccccctta actctggaga ttccattttt ctgtagtgaa
     6901 gtgttttaga attttcattg tttgactatg gttcatacat tgatttttcc aaaatgagaa
     6961 gaagtcttat ttctaatgca aaaatgtgaa aagaacagtt ggaacctaaa gtgatagtgg
     7021 atgaagtgtc tgaagtgact gccctatcag aaaaggatgg aataagaaga aaagactgaa
     7081 gcacctaaat gtgtattttc ttgaggaaat tacacccctg tgtaagagtc tatcctattt
     7141 gaacatttct aaaaaccagc cgaagaatct tcaggttcat tgcgactgaa agataaagtc
     7201 tagcactgaa gtggttttta agattaggaa aggccatcag agaaatgcag ttatttctcc
     7261 cctccatcct tcccccacaa aaaaaagtct aagcctccga ttaatcgaca acaacgaaat
     7321 acaggaagta ttggcttagt gaccttttag gatatctgtc cgacttacat cccttctctg
     7381 agcattactt tctgccacct tccgtgagga gctgttcaga aatcagacaa ggagtggaca
     7441 tctggtcaaa gttgagccaa ttagatgatt tctcctgaga atttggaatt ggaaaactga
     7501 tgtcttggga ggtcacatct ggaacataca tgggaggcag agaaagcaaa gatgacattc
     7561 aaccccagaa gaaaaagaaa atggctttct tgattcctga taacttggca gtgtttgttc
     7621 cagtgtcttg catttcacta tctgcatttc atcctcctgg ggttccacaa gatagcctta
     7681 aaaccttaca gagagactcc ccaacttagt tttttcttaa gtcagaaggc tgttacttgc
     7741 taccaaataa tgccaactaa gacaactgag gtacagtata ttctctcgta aaacaccata
     7801 gagttgatga cttgatccta tagaaaaggg tccccaaccc ctgggccaca gaccggtact
     7861 ggtccctggt ctgtgaggaa ccacctgggc cacagactgg tcctggtccc tggtctgtga
     7921 ggaaccaggc catacagcag gaggtaagcg agcattcctg cctgagctct gcctcctgtc
     7981 agatgagcca caacattaga ttctcatagg agtgcgaacc ccgttgtgaa ccccgcatgc
     8041 gagggatcta ggtagtgccc tccttaagag aatctaatgt ctgatgatct gaggtagagc
     8101 agtttcatcc tacaaccatc cccacccccc gacccccatc catgaaaaaa ttgtcttcct
     8161 caaaactagt ccctggtgcc aaaaagtttg gggaccgccg tcctaggaaa taccaacaaa
     8221 aagtcacgtt tattgcctgc caagtgagtc aggtttagac aaggcagaac ttagtatata
     8281 gcttggatga atcagaaagg gtgggccttg aaagactggt agaatgtgtc caagaaaact
     8341 gattaaaagc cttagaagtc cctctacagt ttcaggacgc cctcttaaca gatggctgta
     8401 tctttatctg tggttggtct tgtggaatac tgactttctg ccagcattag cctgtgtttc
     8461 tatgtcacac caagtcacgt atattttcat tgtgtgttag gactcagaat aggtttgggt
     8521 ctttctttta attatgtata cccaattact tagtcctcct cacaccctga tcctttaaaa
     8581 attcttaagt tgtgttaatt gcatttttct caattctact cctagtaact ctgtgtgttt
     8641 ttttccatct ttattcattt agtaaagttg aaacctttca tagcataata tagtgattaa
     8701 gtgcataggt ttgggactta gacacacatg ggcttgcttg tctcccagtt ctgccgctta
     8761 ccacctatgt gacctttcac tctttacctt tccactctta gcctgttctc taactataaa
     8821 atgagaatga tgctagcgtc atcttcatag agtgattatg gagataaata agttaatgca
     8881 tgtaaaccac tttccataat gcctggcaca tattatatta tgtattagta aatgtaagca
     8941 ctggaagaat cagtagtctt cctacacttg aaaatagttg tcttcaacta ttgttgtatt
     9001 aatgagttaa ttcaccttgt taagtcacct tgatccacct aattgtcagc caacatttat
     9061 taacgaaact gctagtattc gtattgtgcc ttttttatta tgaaacattt caagaataca
     9121 gaaaaatgca gaaaacaatg taacaaatac ctaagtatct atcacccaac ttttatagtc
     9181 ttatttttac ctatatattt tttcttttag aaaggaatga tcacagttgt gcctgaaatc
     9241 tgtatagccc tgtctcattt catttgtctc cctttaccca cataagtaat tgcagctctg
     9301 aatttgatgt ttatcagaat gataccatga gtggttttat atccttatta tatgtatgca
     9361 tacctaggat tgtttttctg attttgaaac ttcatataaa tggtatcatt ctgtacaaaa
     9421 ccttctggga cttgttttac cactcatgtt tttgagatgt atccacacta ccatctttct
     9481 ctaaatcatt catttaaatg ctgtagttca ttgaataagt ttatcacaat gtatccattt
     9541 tcttcttgat gagcatctca gttatttcca atttttgact tataaacaat gctgcaatga
     9601 aataattgac atatttcctt gtgtacatgt gagcatttct tgagatatgt atctagaact
     9661 tgaatcactg gccaacagga tattcttaat cttcagtttc accagatact tccaaattga
     9721 tctccataac atgcatacca aattatattc ctaccagcca tttataggag ttcacatttt
     9781 ttccataccc tcccaatcct gccttggcag atatgttttt tccaatgaat aacaatgaaa
     9841 ttttgttttg ggatttgaca aaatgattct agattcatct ggaagaaaag caagtataag
     9901 taagaaattt aaaagggacc tgaaaaacta agcaatggat atatttaaaa attggtacca
     9961 gtagggataa ccaaatattt gttaactgta gcagaaacaa tgcatgtttt tctcactggt
    10021 tccaccttct atctctcagt caagccctgc ccaggtgtgg tagtcctcat agtctctcac
    10081 tgtaggggtc ttctcacata gtagaccact ctcttgagtt gaatattgaa aagaaggctt
    10141 ggccgggggc agtggctcat gcctgtggtc ccagcacttt gggaagctga gtcgagcgga
    10201 ttgcttgagg tcagcagttc gagagcagcc tgactaacat ggtgatgaaa agtacaaaat
    10261 tagctggggg tggtggcgca tgcctgcaat cccagctact cgggaggctg aggcacgaga
    10321 atcgcttgaa cgcaggaggc ataggttgca gtgagccgag attgcaccac tgcactccag
    10381 cctgggcgac agagcaagat ttcgtctcaa aaaaaaaaaa aaaaaaaaaa aaggcttaag
    10441 tccaactaac tgtttccctg ctgttcattt tatccaacgg ctggggatat aggctactgc
    10501 acatgatggg ttgatggatg tgaaatgata actcatgact ttaattctaa tttttctata
    10561 ttctggtgag gttgagcata tttttacaag ttcataatcc attttcctct gatgggagtt
    10621 gcctgtttga atcctttgcc cacttgcttt ttggggttat ttgcaatttt ttgcattgat
    10681 cttcaaacat tcttaattaa tcccaggtac atattatttt atatataaga tatattttag
    10741 agatatatag gctgatagta tcttttctca gtctaaggct tatcttttaa ttttgtttat
    10801 ggtgttttgt gtgtgttgtt ttgcagaagt tttattgtat ctgaattgtg gcttttgtgt
    10861 cttaagaaat tctttaccta ctgtcataaa aatttttgtc taaaaatttt atgattttgc
    10921 ctttctattt atcttgttaa ttcactttga aattactttt gtttatggca taaagtccat
    10981 tattttccat atggataatc agttgtctta gcagtttatt gaatggtcca acgtttccct
    11041 gctgattata atgccctctc tgttatttat cctaaattct tgacatccgg taaggaagtc
    11101 tcctctgccc acccttctct gtatttcaaa atggttttga ctgttcttga ccccttgctc
    11161 tttctgtgaa ctttaggatt aaatgattat gtagaattaa acaatcgggt taaggttttt
    11221 tattagaatt acattgaatc tatagattaa tttggggaaa gaatgttatc tttctatcca
    11281 tgataattct gtatctctcc attaattcaa gtctttaatg gtttttaaaa ataaattatt
    11341 gtctctttga aaa
//
