LOCUS       NM_003110               3026 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens Sp2 transcription factor (SP2), mRNA.
ACCESSION   NM_003110 NM_138406
VERSION     NM_003110.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3026)
  AUTHORS   Zheng,R., Zhu,P., Gu,J., Ni,B., Sun,H., He,K., Bian,J., Shao,Y. and
            Du,J.
  TITLE     Transcription factor Sp2 promotes TGFB-mediated interstitial cell
            osteogenic differentiation in bicuspid aortic valves through a
            SMAD-dependent pathway
  JOURNAL   Exp Cell Res 411 (1), 112972 (2022)
   PUBMED   34914964
  REMARK    GeneRIF: Transcription factor Sp2 promotes TGFB-mediated
            interstitial cell osteogenic differentiation in bicuspid aortic
            valves through a SMAD-dependent pathway.
REFERENCE   2  (bases 1 to 3026)
  AUTHORS   Da,C.M., Liao,H.Y., Deng,Y.S., Zhao,G.H., Ma,L. and Zhang,H.H.
  TITLE     Transcription Factor SP2 Regulates Ski-mediated Astrocyte
            Proliferation In Vitro
  JOURNAL   Neuroscience 479, 22-34 (2021)
   PUBMED   34687796
  REMARK    GeneRIF: Transcription Factor SP2 Regulates Ski-mediated Astrocyte
            Proliferation In Vitro.
REFERENCE   3  (bases 1 to 3026)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 3026)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 3026)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3026)
  AUTHORS   Bakovic,M., Waite,K.A. and Vance,D.E.
  TITLE     Functional significance of Sp1, Sp2, and Sp3 transcription factors
            in regulation of the murine CTP:phosphocholine cytidylyltransferase
            alpha promoter
  JOURNAL   J Lipid Res 41 (4), 583-594 (2000)
   PUBMED   10744779
REFERENCE   7  (bases 1 to 3026)
  AUTHORS   Rotheneder,H., Geymayer,S. and Haidweger,E.
  TITLE     Transcription factors of the Sp1 family: interaction with E2F and
            regulation of the murine thymidine kinase promoter
  JOURNAL   J Mol Biol 293 (5), 1005-1015 (1999)
   PUBMED   10547281
REFERENCE   8  (bases 1 to 3026)
  AUTHORS   Philipsen,S. and Suske,G.
  TITLE     A tale of three fingers: the family of mammalian Sp/XKLF
            transcription factors
  JOURNAL   Nucleic Acids Res 27 (15), 2991-3000 (1999)
   PUBMED   10454592
  REMARK    Review article
REFERENCE   9  (bases 1 to 3026)
  AUTHORS   Scohy,S., Van Vooren,P., Szpirer,C. and Szpirer,J.
  TITLE     Assignment1 of Sp genes to rat chromosome bands 7q36 (Sp1),
            10q31-->q32.1 (Sp2), 3q24-->q31 (Sp3) and 6q33 (Sp4) and of the SP2
            gene to human chromosome bands 17q21.3-->q22 by in situ
            hybridization
  JOURNAL   Cytogenet Cell Genet 81 (3-4), 273-274 (1998)
   PUBMED   9730617
REFERENCE   10 (bases 1 to 3026)
  AUTHORS   Kingsley,C. and Winoto,A.
  TITLE     Cloning of GT box-binding proteins: a novel Sp1 multigene family
            regulating T-cell receptor gene expression
  JOURNAL   Mol Cell Biol 12 (10), 4251-4261 (1992)
   PUBMED   1341900
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB451570.1, BC016680.2,
            M97190.1 and BC033814.2.
            
            On Nov 23, 2018 this sequence version replaced NM_003110.5.
            
            Summary: This gene encodes a member of the Sp subfamily of Sp/XKLF
            transcription factors. Sp family proteins are sequence-specific
            DNA-binding proteins characterized by an amino-terminal
            trans-activation domain and three carboxy-terminal zinc finger
            motifs. This protein contains the least conserved DNA-binding
            domain within the Sp subfamily of proteins, and its DNA sequence
            specificity differs from the other Sp proteins. It localizes
            primarily within subnuclear foci associated with the nuclear
            matrix, and can activate or in some cases repress expression from
            different promoters. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC033814.2, SRR1163657.302502.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376741.5/ ENSP00000365931.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                DB451570.1         87-107
            22-657              BC016680.2         1-636
            658-1628            M97190.1           619-1589
            1629-2499           BC016680.2         1608-2478
            2500-3026           BC033814.2         2465-2991
FEATURES             Location/Qualifiers
     source          1..3026
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.32"
     gene            1..3026
                     /gene="SP2"
                     /note="Sp2 transcription factor"
                     /db_xref="GeneID:6668"
                     /db_xref="HGNC:HGNC:11207"
                     /db_xref="MIM:601801"
     exon            1..58
                     /gene="SP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..1893
                     /gene="SP2"
                     /codon_start=1
                     /product="transcription factor Sp2"
                     /protein_id="NP_003101.3"
                     /db_xref="CCDS:CCDS11521.2"
                     /db_xref="GeneID:6668"
                     /db_xref="HGNC:HGNC:11207"
                     /db_xref="MIM:601801"
                     /translation="MSDPQTSMAATAAVSPSDYLQPAASTTQDSQPSPLALLAATCSK
                     IGPPAVEAAVTPPAPPQPTPRKLVPIKPAPLPLSPGKNSFGILSSKGNILQIQGSQLS
                     ASYPGGQLVFAIQNPTMINKGTRSNANIQYQAVPQIQASNSQTIQVQPNLTNQIQIIP
                     GTNQAIITPSPSSHKPVPIKPAPIQKSSTTTTPVQSGANVVKLTGGGGNVTLTLPVNN
                     LVNASDTGAPTQLLTESPPTPLSKTNKKARKKSLPASQPPVAVAEQVETVLIETTADN
                     IIQAGNNLLIVQSPGGGQPAVVQQVQVVPPKAEQQQVVQIPQQALRVVQAASATLPTV
                     PQKPSQNFQIQAAEPTPTQVYIRTPSGEVQTVLVQDSPPATAAATSNTTCSSPASRAP
                     HLSGTSKKHSAAILRKERPLPKIAPAGSIISLNAAQLAAAAQAMQTININGVQVQGVP
                     VTITNTGGQQQLTVQNVSGNNLTISGLSPTQIQLQMEQALAGETQPGEKRRRMACTCP
                     NCKDGEKRSGEQGKKKHVCHIPDCGKTFRKTSLLRAHVRLHTGERPFVCNWFFCGKRF
                     TRSDELQRHARTHTGDKRFECAQCQKRFMRSDHLTKHYKTHLVTKNL"
     exon            59..135
                     /gene="SP2"
                     /inference="alignment:Splign:2.1.0"
     exon            136..1110
                     /gene="SP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1423
                     /gene="SP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1598
                     /gene="SP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1792
                     /gene="SP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..3026
                     /gene="SP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2994..2999
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SP2"
                     /note="hexamer: AATAAA"
     polyA_site      3026
                     /gene="SP2"
                     /note="major polyA site"
ORIGIN      
        1 aggctctcgg tggcggcgga ggcggcggag gccagggagg aagatgtcgt aatgagcgat
       61 ccacagacca gcatggctgc cactgctgct gtgagtccca gtgactacct gcagcctgcc
      121 gcctccacca cccaggactc ccagccatct cccttagccc tgcttgctgc aacatgtagc
      181 aaaattggcc ctccagcagt tgaagctgct gtgacacctc ctgctccccc acagcccaca
      241 ccgcggaaac ttgtccctat caaacctgcc cctctccctc tcagccccgg caagaatagc
      301 tttggaatct tgtcctccaa aggaaatata cttcagattc aggggtcaca actgagcgcc
      361 tcctatcctg gagggcagct ggtgttcgct atccagaatc ccaccatgat caacaaaggg
      421 acccgatcaa atgccaatat ccagtaccag gcggtccctc agattcaggc aagcaattcc
      481 caaaccatcc aagtacagcc caatctcacc aaccagatcc agatcatccc tggcaccaac
      541 caagccatca tcaccccctc accgtccagt cacaagcctg tccccatcaa gccagccccc
      601 atccagaagt cgagtacgac caccaccccc gtgcagagcg gggccaatgt ggtgaagctg
      661 acaggtgggg gcggcaatgt gacgctcact ctgcccgtca acaaccttgt gaacgccagt
      721 gacaccgggg cccctactca gctcctcact gaaagccccc caaccccgct gtctaagact
      781 aacaagaaag caaggaagaa gagccttcct gcctcccagc cccctgtggc tgtggctgag
      841 caggtggaga cggtgctgat cgagaccacc gcggacaaca tcatccaggc aggaaataac
      901 ctgctcattg ttcagagccc tggtgggggc cagccagctg tggtccagca ggtccaggtg
      961 gtgcccccca aggccgagca gcagcaggtg gtacagatcc cccagcaggc tctgcgggtg
     1021 gtgcaggcgg catctgccac cctccccact gtaccccaga agccctccca gaactttcag
     1081 atccaggcag ctgagccgac acctactcag gtctacatcc gcacgccttc cggtgaggtg
     1141 cagacagtcc ttgtccagga cagcccccca gcaacagctg cagccacctc taacaccacc
     1201 tgtagcagcc ctgcatcccg tgctccccat ctgagtggga ccagcaaaaa gcactcagct
     1261 gcaattctcc gaaaagagcg tcccctgcca aagattgccc cagccgggag catcatcagc
     1321 ctgaatgcag cccagttggc ggcagctgcc caggcaatgc agaccatcaa catcaatggt
     1381 gtccaggtcc agggcgtgcc tgtcaccatc accaacacag gcgggcagca gcagctgaca
     1441 gtgcagaatg tttctgggaa caacctgacc atcagtgggc tgagccccac ccagatccag
     1501 ctgcaaatgg aacaagccct ggccggagag acccagcccg gggagaagcg gcgccgcatg
     1561 gcctgcacgt gtcccaactg caaggatggg gagaagaggt ctggagagca gggcaagaag
     1621 aagcacgtgt gccacatccc cgactgtggc aagacgttcc gtaagacgtc cttgctgcgt
     1681 gcccatgtgc gcctgcacac tggcgagcgg ccctttgtct gcaactggtt cttctgtggg
     1741 aagaggttca cacggagtga cgagctccaa cggcatgctc gcacccacac aggggacaaa
     1801 cgcttcgagt gcgcccagtg tcagaagcgc ttcatgagga gtgaccacct caccaagcat
     1861 tacaagaccc acctggtcac gaagaacttg taaggccaac tgcggcggga ggccctgaag
     1921 atgcagtccc ccacctgtgt cctccctggg cccctggtgg aaaggagccc tgtggctgcc
     1981 ttgggcctgc cctcagcccc actcctgttc tgcaactgtc cccacaggaa ggggctctgt
     2041 tccctgtatt gtcctccttc tgaagcccct tggctctgcc ttggcccttc ccctcaccac
     2101 gagctcccgg cctgcccaga ctgtggacac tggccgtgcc caatgagacg ttctaaacca
     2161 ggacgcgtgg gaacccttat ttccaaagga aaaacatgca tttcactccg tcgaggagca
     2221 aagtgagccc ctacccccca ccccgatccc cgctcccaac actgccggag tcgcgtcatg
     2281 ccatgccccc tctcctgcac ctccctggcc ctgccggcca ctgtggacgc cctggggctt
     2341 ggcacccacc tctggagaaa ctcggggcca cctccactcc atgtgcccag ccccgccaca
     2401 acctctcctc cagcacattc cagctctatt taaaaagtaa agacacccac cgactcctga
     2461 tccccctctt tttctatgga gaacgttgcc ttatactcta cttcagatga tgaacactgt
     2521 gtactgtgtg tgctttaaag aagttttatt taattgctcc cttcttcctt tccttgttat
     2581 tcacctccct gatgcctgct ttcagttgag ggttgggggc aatgatgagc atatgaattt
     2641 tttctcactc tagcaattcc cttttctaaa tgacacagca tttaaactca aatctggatt
     2701 cagataacag cacctgcaca tcctgcacct cctccctctc ccttcacctc acccctgccc
     2761 ggcccaagct ctacttgtgt acagtgtata ttgtataata gacaattgtg tctactacat
     2821 gtttaaaaac acattgcttg ttatttttga ggcttttaaa ttaaacaaaa atccaacttt
     2881 atttttagtt gtaactgctt gaggtatgtt ttatgaatta agtgacagat ttgttatcct
     2941 ttattaacgt actttgttgg tcagcactgg gctgacaaaa attttttctt gctaataaat
     3001 ttagttgcct gaggcaaaat cttcaa
//
